Preliminary investigation of the inhibitory effects of the tyroservaltide (YSV) tripeptide on human hepatocarcinoma BEL-7402.

abstract：:In leukemias, the monitoring techniques on the response after the treatment have clinical importance for evaluating new therapeutic approaches and identifying the risk of relapse. In this study, genetic changes before and after chemotherapy in interphase and metaphase nuclei of bone morrow of adults with provisional d...

journal_title：Cancer biology & therapy

authors： Yakut T,Ali R,Egeli U,Ozkalemkas F,Ercan I,Ozçelik T,Ozkocaman V,Yigit B,Tunali A

更新日期：2004-09-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide, and novel effective drugs against NSCLC are urgently needed. Isodon species are rich in ent-kaurane diterpenoids that have been reported to have antitumor bioactivity. Acetyl-macrocalin B (A-macB) is a novel ent-kaurane diterpen...

journal_title：Cancer biology & therapy

authors： Wang JN,Zhang ZR,Che Y,Yuan ZY,Lu ZL,Li Y,Li N,Wan J,Sun HD,Sun N,Puno PT,He J

更新日期：2018-07-03 00:00:00

abstract：:We studied the mechanism of the cytotoxic activity of BZL101, an aqueous extract from the herb Scutellaria barbata D. Don, which is currently in phase II clinical trial in patients with advanced breast cancer. The phase I trial showed favorable toxicity profile and promising efficacy. We report here that BZL101 induce...

journal_title：Cancer biology & therapy

authors： Fong S,Shoemaker M,Cadaoas J,Lo A,Liao W,Tagliaferri M,Cohen I,Shtivelman E

更新日期：2008-04-01 00:00:00

abstract：:Cutaneous T-cell lymphoma (CTCL) displays immunosuppressive properties and phenotypic plasticity. The malignant T cells in CTCL can possess features of immunomodulating regulatory T cells (Treg) and IL-17-producing helper T cells (Th17) depending on the stimuli they receive from antigen presenting cells and other sour...

journal_title：Cancer biology & therapy

authors： Abraham RM,Zhang Q,Odum N,Wasik MA

更新日期：2011-12-15 00:00:00

abstract：:Double-strand breaks are one the most severe types of DNA damage with respect to cell survival and the preservation of genomic integrity. Therefore, cells have evolved complex mechanisms including cell cycle regulation, activation of repair pathways and in certain cases induction of apoptosis in response to these lesi...

journal_title：Cancer biology & therapy

authors： Karagiannis TC,El-Osta A

更新日期：2004-07-01 00:00:00

abstract：:Most sporadic colorectal cancer reflects acquired mutations in the adenomatous polyposis coli (APC) tumor suppressor gene, while germline heterozygosity for mutant APC produces the autosomal dominant disorder Familial Adenomatous Polyposis (FAP) with a predisposition to colorectal cancer. In these syndromes, loss of h...

journal_title：Cancer biology & therapy

authors： Pattison AM,Barton JR,Entezari AA,Zalewski A,Rappaport JA,Snook AE,Waldman SA

更新日期：2020-09-01 00:00:00

abstract：:Multidrug resistance (MDR) is an important cause of treatment failure in acute lymphoblastic leukemia (ALL). The ABC family of membrane transporters is proposed, albeit with controversy, to be involved in this process. The present study aims to investigate the mRNA expression profile of several genes of this family, i...

journal_title：Cancer biology & therapy

authors： Rahgozar S,Moafi A,Abedi M,Entezar-E-Ghaem M,Moshtaghian J,Ghaedi K,Esmaeili A,Montazeri F

更新日期：2014-01-01 00:00:00

abstract：:Adult brain tumors establish an immunosuppressive tumor microenvironment as a modality of immune escape, with several immunotherapies designed to overcome this barrier. However, the relationship between tumor cells and immune cells in pediatric brain tumor patients is not as well-defined. In this study, we sought to d...

journal_title：Cancer biology & therapy

authors： Haberthur K,Brennan K,Hoglund V,Balcaitis S,Chinn H,Davis A,Kreuser S,Winter C,Leary SE,Deutsch GH,Ellenbogen RG,Crane CA

更新日期：2016-12-01 00:00:00

abstract：:Heparan sulfate proteoglycans (HSPGs) play important roles in cancer initiation and progression, by interacting with the signaling pathways that affect proliferation, adhesion, invasion and angiogenesis. These roles suggest the possibility of various strategies of regulation of these molecules. In this review, we demo...

journal_title：Cancer biology & therapy

authors： Onyeisi JOS,Ferreira BZF,Nader HB,Lopes CC

更新日期：2020-12-01 00:00:00

abstract：:Acquired mutations in anaplastic lymphoma kinase (ALK) gene have been implicated as the major resistance mechanism to ALK inhibitors; however, information on the treatment options after acquiring novel ALK secondary mutations is limited. Herein, we report the efficacy of lorlatinib upon the detection of a novel ALK G1...

journal_title：Cancer biology & therapy

authors： Meng Z,Li T,Wang P,Lizaso A,Huang D

更新日期：2021-01-02 00:00:00

abstract：:The discovery of microRNAs (miRNAs) has opened a new avenue for both diagnosis and treatment of cancers. Accumulating experimental evidences indicate that miRNAs are aberrantly expressed in different tumor types and have a critical role in tumorigenesis. However, the miRNA expression profile in neuroblastoma (NB), one...

journal_title：Cancer biology & therapy

authors： Guo J,Dong Q,Fang Z,Chen X,Lu H,Wang K,Yin Y,Cai X,Zhao N,Chen J,Zen K,Zhang J,Zhang CY

更新日期：2010-03-15 00:00:00

abstract：:Taxol (paclitaxel) and Taxotere (docetaxel) are considered as two of the most important anti-cancer chemotherapy drugs. The cytotoxic action of these drugs has been linked to their ability to inhibit microtubule depolymerization, causing growth arrest and subsequent cell death. Studies by a number of laboratories have...

journal_title：Cancer biology & therapy

authors： Yacoub A,Gilfor D,Hawkins W,Park MA,Hanna D,Hagan MP,Curiel DT,Fisher PB,Grant S,Dent P

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:It has recently been suggested that overexpression of palladin in sporadic pancreatic cancer may contribute to pancreatic cancer's invasive and migratory abilities. This hypothesis was based on reverse transcriptase-polymerase chain reaction analyses of bulk pancreatic tissue, yet pancreatic cancer is a comp...

journal_title：Cancer biology & therapy

authors： Salaria SN,Illei P,Sharma R,Walter KM,Klein AP,Eshleman JR,Maitra A,Schulick R,Winter J,Ouellette MM,Goggins M,Hruban R

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Primary brain tumors have always been associated with high morbidity and mortality. Glioma is the most common type of malignant brain tumors,with a high probability of recurrence after surgical excision and with poor prognosis.The purpose of this study was to compare the therapeutic efficacy of computed tomo...

journal_title：Cancer biology & therapy

authors： Hu X,Qiu H,Zhang L,Zhang W,Ma Y,Qiao Z,Chen D,Han J,Duan G,Zhang F

更新日期：2012-08-01 00:00:00

abstract：:WNT and FGF signaling pathways cross-talk during a variety of cellular processes, such as human colorectal carcinogenesis, mouse mammary tumor virus (MMTV)-induced carcinogenesis, E2A-Pbx-induced leukemogenesis, early embryogenesis, body-axis formation, limb-bud formation, and neurogenesis. Canonical WNT signals are t...

journal_title：Cancer biology & therapy

authors： Katoh M,Katoh M

更新日期：2006-09-01 00:00:00

abstract：PURPOSE:Optical coherence tomography (OCT) is a minimally invasive, depth-resolved imaging tool that can be implemented in a small diameter endoscope for imaging mouse models of colorectal cancer (CRC). In this study, we utilized ultrahigh resolution (UHR) OCT to serially image the lower colon of azoxymethane (AOM) tre...

journal_title：Cancer biology & therapy

authors： Hariri LP,Qiu Z,Tumlinson AR,Besselsen DG,Gerner EW,Ignatenko NA,Povazay B,Hermann B,Sattmann H,McNally J,Unterhuber A,Drexler W,Barton JK

更新日期：2007-11-01 00:00:00

abstract：:With the increasing interest in development of cytostatic anticancer drugs, the randomized discontinuation trial (RDT) design has been proved to be useful in the evaluation of their clinical activity. In the June 1, 2006 issue of the Journal of Clinical Oncology, a study by Ratain et al. uses RDT in a phase-II placebo...

journal_title：Cancer biology & therapy

authors： Jain L,Venitz J,Figg WD

更新日期：2006-10-01 00:00:00

abstract：:Ovarian cancer is a silent killer, and shows early extensive tumor invasion and peritoneal metastasis. The microcirculation of most tumors includes cooperation of pre-existing vessels, intussusceptive microvascular growth, postnatal vasculogenesis, glomeruloid angiogenesis and vasculogenic mimicry (VM). VM is critical...

journal_title：Cancer biology & therapy

authors： Wang JY,Sun T,Zhao XL,Zhang SW,Zhang DF,Gu Q,Wang XH,Zhao N,Qie S,Sun BC

更新日期：2008-05-01 00:00:00

abstract：:The Bin1/Amphiphysin2 gene encodes several alternately spliced BAR adapter proteins that have been implicated in membrane-associated and nuclear processes. Bin1 expression is often attenuated during tumor progression and Bin1 splice isoforms that localize to the nucleus display tumor suppressor properties. While these...

journal_title：Cancer biology & therapy

authors： Muller AJ,DuHadaway JB,Donover PS,Sutanto-Ward E,Prendergast GC

更新日期：2004-12-01 00:00:00

abstract：:Adverse events in platinum-based chemotherapy for patients with advanced non-small cell lung cancer (NSCLC) are major challenges. In this study, we investigated the role of the p53 and MDM2 genes in predicting adverse events in NSCLC patients treated with platinum-based chemotherapy. Specifically, we examined the p53 ...

journal_title：Cancer biology & therapy

authors： Zheng D,Chen Y,Gao C,Wei Y,Cao G,Lu N,Hou Y,Jiang X,Wang J

更新日期：2014-01-01 00:00:00

abstract：:The aim of this study was to examine the cytotoxicity and mechanism of apoptosis induction of verotoxin-1 (VT-1) in human glioma cell lines. VT-1 is a member of the shiga-toxin family expressed by some serotypes of Escherichia coli and Shigella dysenteriae. Shiga-toxins have been shown to induce apoptosis by binding t...

journal_title：Cancer biology & therapy

authors： Johansson D,Johansson A,Grankvist K,Andersson U,Henriksson R,Bergström P,Brännström T,Behnam-Motlagh P

更新日期：2006-09-01 00:00:00

abstract：:Antivascular therapy provides a promising method for anticancer therapy. But targeting to gastric cancer vessels is nonselective due in part to the lack of specific cell-surface receptors identified on target vascular cells. Herein we used in vivo screening of phage displayed peptide library to identify some peptides ...

journal_title：Cancer biology & therapy

authors： Zhi M,Wu KC,Dong L,Hao ZM,Deng TZ,Hong L,Liang SH,Zhao PT,Qiao TD,Wang Y,Xu X,Fan DM

更新日期：2004-12-01 00:00:00

abstract：:We developed a DNA aptamer, Ap52, against the shared tumor-specific MAGE-A3111-125 peptide antigen that was used to target multiple types of cancer cells. Here we report the in vivo study of mice implanted with pancreatic tumor cells AsPC-1, which demonstrates accumulation of phosphorothioate-modified Ap52 (ThioAp52) ...

journal_title：Cancer biology & therapy

authors： Wang CY,Lin BL,Chen CH

更新日期：2021-01-02 00:00:00

abstract：:5-fluorouracil (5-FU) is the major chemotherapeutic agent for treatment of colorectal carcinoma, but the molecular mechanisms of response and resistance are not understood completely. We therefore studied the 5-FU dose response and time course of gene expression transcriptome changes in colon carcinoma cell lines that...

journal_title：Cancer biology & therapy

authors： Zhang W,Ramdas L,Shen W,Song SW,Hu L,Hamilton SR

更新日期：2003-09-01 00:00:00

abstract：:Gemcitabine based treatment is currently a standard first line treatment for patients with advanced pancreatic cancer, however overall survival remains poor, and few options are available for patients that fail gemcitabine based therapy. To identify potential molecular targets in gemcitabine refractory pancreatic canc...

journal_title：Cancer biology & therapy

authors： Samulitis BK,Pond KW,Pond E,Cress AE,Patel H,Wisner L,Patel C,Dorr RT,Landowski TH

更新日期：2015-01-01 00:00:00

abstract：:Poor oxygenation is a unique and prevalent feature of solid tumors associated with poor patient prognosis. In part, this is caused by a series of adaptive cellular responses that together have a large impact on gene expression and cell phenotype. HIF plays a key role in this response by activating a transcriptional pr...

journal_title：Cancer biology & therapy

authors： van den Beucken T,Koritzinsky M,Wouters BG

更新日期：2006-07-01 00:00:00

abstract：:Tumors with identical phenotype can have markedly different biologic behavior. The differentiation between hemangioblastoma, a benign vascular brain tumor, and renal cell carcinoma (RCC), a malignant tumor that can metastasize to the brain, is a well-known pathological quandary. We report a 59-year-old female with von...

journal_title：Cancer biology & therapy

authors： Gläsker S,Lonser RR,Okamoto H,Li J,Jaffee H,Oldfield EH,Zhuang Z,Vortmeyer AO

更新日期：2007-03-01 00:00:00

abstract：:The six-transmembrane epithelial antigen of prostate 2 (STEAP2) protein was identified in advanced prostate cancer, and is highly over-expressed in various types of cancer. This study aimed to investigate the prognostic value and the function of STEAP2 in breast cancer. STEAP2 mRNA and protein expressions in breast no...

journal_title：Cancer biology & therapy

authors： Yang Q,Ji G,Li J

更新日期：2020-01-01 00:00:00

abstract：:Retinoids are used in leukemia therapy and chemoprevention of cancers. Treatment of MCF-7 breast carcinoma cells with low doses of retinoids induces gradual proliferation arrest with phenotypic markers of senescence. cDNA microarray hybridization and reverse transcription-polymerase chain reaction analysis showed that...

journal_title：Cancer biology & therapy

authors： Dokmanovic M,Chang BD,Fang J,Roninson IB

更新日期：2002-01-01 00:00:00

abstract：:Circulating tumor cells (CTC) enter the blood from many carcinomas and represent a likely source of metastatic dissemination. In contrast to the peripheral circulation, KRAS mutation- positive CTC thrive in the portal venous blood of patients with pancreatic ductal adenocarcinoma (PDAC). To analyze the essential inter...

journal_title：Cancer biology & therapy

authors： Arnoletti JP,Fanaian N,Reza J,Sause R,Almodovar AJ,Srivastava M,Patel S,Veldhuis PP,Griffith E,Shao YP,Zhu X,Litherland SA

更新日期：2018-01-01 00:00:00