Abstract:
:Double-strand breaks are one the most severe types of DNA damage with respect to cell survival and the preservation of genomic integrity. Therefore, cells have evolved complex mechanisms including cell cycle regulation, activation of repair pathways and in certain cases induction of apoptosis in response to these lesions. The molecular details of many of the cellular responses to double-strand breaks have been well characterized. Our understanding of these responses in the context of chromatin has also progressed recently. In this review, we focus our discussion on the significance of DNA damage-induced chromatin modifications in double-strand break signaling and repair pathways. In particular, findings from recent studies suggest mechanisms by which highly localized double-strand breaks may activate widespread signals throughout the cell by inducing alterations in chromatin structure.
journal_name
Cancer Biol Therjournal_title
Cancer biology & therapyauthors
Karagiannis TC,El-Osta Adoi
10.4161/cbt.3.7.917keywords:
subject
Has Abstractpub_date
2004-07-01 00:00:00pages
617-23issue
7eissn
1538-4047issn
1555-8576pii
917journal_volume
3pub_type
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journal_title:Cancer biology & therapy
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