Glycogen synthase kinase-3 beta inhibitors as novel cancer treatments and modulators of antitumor immune responses.

abstract：:In bone metastases, tumor cells interact with the bone microenvironment to induce osteoclastogenesis, leading to bone destruction and the growth factor release.  RANK ligand (RANKL) is essential for osteoclast formation, function, and survival.  Tumor cell-mediated osteolysis is thought to occur ultimately via inducti...

journal_title：Cancer biology & therapy

authors： Holland PM,Miller R,Jones J,Douangpanya H,Piasecki J,Roudier M,Dougall WC

更新日期：2010-04-01 00:00:00

abstract：:We investigated the expression of annexin-1 (ANXA1) in thyroid carcinoma cell lines and in thyroid cancers with a different degree of differentiation. The highest level of ANXA1 expression examined by Western blotting was detected in the papillary carcinoma cells (NPA) and in the follicular cells (WRO). On the other h...

journal_title：Cancer biology & therapy

authors： Petrella A,Festa M,Ercolino SF,Zerilli M,Stassi G,Solito E,Parente L

更新日期：2006-06-01 00:00:00

abstract：:TRA-8, a monoclonal antibody targeting death receptor, has demonstrated high therapeutic effect for triple negative breast cancer (TNBC) in preclinical models. Tamoxifen, the standard of care for ERα-positive breast cancer, induces apoptosis via ERβ, which commonly presents in TNBC cells. The current study investigate...

journal_title：Cancer biology & therapy

authors： Kim H,Samuel SL,Zhai G,Rana S,Taylor M,Umphrey HR,Oelschlager DK,Buchsbaum DJ,Zinn KR

更新日期：2014-08-01 00:00:00

abstract：:The F-box protein Fbw7/Sel-10/hCdc4/Ago, which is known to regulate ubiquitination and degradation of numerous important regulators of cell division and death including Notch, cyclin E, c-Jun and c-Myc, has been recently rediscovered as a p53-dependent tumor suppressor. Delineation of the mechanisms of Fbw7 anti-oncog...

journal_title：Cancer biology & therapy

authors： Fuchs SY

更新日期：2005-05-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) remains a significant cause of morbidity and mortality. There has been a great interest in finding specific genomic changes which contribute to HNSCC tumorigenesis, especially within the chromosome 3p area, where high frequency of LOH (loss of heterozygosity) has been repo...

journal_title：Cancer biology & therapy

authors： Lee DJ,Schönleben F,Banuchi VE,Qiu W,Close LG,Assaad AM,Su GH

更新日期：2010-10-01 00:00:00

abstract：:Most sporadic colorectal cancer reflects acquired mutations in the adenomatous polyposis coli (APC) tumor suppressor gene, while germline heterozygosity for mutant APC produces the autosomal dominant disorder Familial Adenomatous Polyposis (FAP) with a predisposition to colorectal cancer. In these syndromes, loss of h...

journal_title：Cancer biology & therapy

authors： Pattison AM,Barton JR,Entezari AA,Zalewski A,Rappaport JA,Snook AE,Waldman SA

更新日期：2020-09-01 00:00:00

abstract：:Prostate-Specific Membrane Antigen (PSMA) is a glutamate carboxypeptidase II that is highly expressed by both normal and malignant prostate epithelial cells and by the neovasculature of many tumor types but is not expressed by endothelial cells in normal tissue. PSMA possesses the hydrolytic properties of an N-acetyla...

journal_title：Cancer biology & therapy

authors： Mhaka A,Gady AM,Rosen DM,Lo KM,Gillies SD,Denmeade SR

更新日期：2004-06-01 00:00:00

abstract：:It has been reported that the local introduction of a promoter-less DNA containing the complementary DNA (cDNA) sequence of a gene could induce gene-specific silencing in plants. The feasibility of this kind of silencing in human cancer cells is as yet unknown. The current study was designed to investigate the anti-tu...

journal_title：Cancer biology & therapy

authors： Ren XY,Liang ZY,Shi XH,Liu TH

更新日期：2008-10-01 00:00:00

abstract：:The objective of the present study was to evaluate CA19-9 and CK8/18 expression patterns in pancreatic cancer cell lines induced by 5-fluorouracil (5-Fu), and in circulating tumor cells (CTCs) in peripheral blood of patients previously untreated with advanced pancreatic cancer. Furthermore, the goal was to test the re...

journal_title：Cancer biology & therapy

authors： Ren C,Han C,Zhang J,He P,Wang D,Wang B,Zhao P,Zhao X

更新日期：2011-10-15 00:00:00

abstract：BACKGROUND:Mutations that activate the PI3K/AKT/mTOR pathway are relatively common in urothelial (bladder) cancers, but how these pathway mutations affect AKT dependency is not known. We characterized the relationship between AKT pathway mutational status and sensitivity to the effects of the selective AKT kinase inhib...

journal_title：Cancer biology & therapy

authors： Dickstein RJ,Nitti G,Dinney CP,Davies BR,Kamat AM,McConkey DJ

更新日期：2012-11-01 00:00:00

abstract：:Small-molecule inhibitors of cyclin-dependent kinases (CDKs) are known to induce cell cycle arrest and apoptosis in certain cancer cells. In order to evaluate the antitumor activity of one such inhibitor, GW8510, against human lung cancers, we analyzed the effects of GW8510 on six nonsmall cell lung cancer (NSCLC) cel...

journal_title：Cancer biology & therapy

authors： Dong F,Guo W,Zhang L,Wu S,Teraishi F,Davis JJ,Fang B

更新日期：2006-02-01 00:00:00

abstract：:The pediatric solid tumor neuroblastoma (NB) often depends on the anti-apoptotic protein, Mcl(-)1, for survival through Mcl(-)1 sequestration of pro-apoptotic Bim. High affinity Mcl(-)1 inhibitors currently do not exist such that novel methods to inhibit Mcl(-)1 clinically are in high demand. Receptor tyrosine kinases...

journal_title：Cancer biology & therapy

authors： Nalluri S,Peirce SK,Tanos R,Abdella HA,Karmali D,Hogarty MD,Goldsmith KC

更新日期：2015-01-01 00:00:00

abstract：:Polo-like kinase 1 (Plk1) is a key cell cycle regulator that is frequently overexpressed in human hepatocellular carcinomas. Blockade of the Plk1 pathway has been reported to be capable of inducing anti-tumor effect. Here, plasmids containing U6 promoter-driven shRNAs against human Plk1 were constructed and transfecte...

journal_title：Cancer biology & therapy

authors： Deng H,Jiang Q,Yang Y,Zhang S,Ma Y,Xie G,Chen X,Qian Z,Wen Y,Li J,Yang J,Chen L,Zhao X,Wei Y

更新日期：2011-02-15 00:00:00

abstract：:Methyl-CpG binding domain protein 1 (MBD1) is a transcriptional regulator that binds methylated CpG islands of tumor suppressor genes and represses their transcription. In a former study, we found high expression of MBD1 in pancreatic cancer cell lines and tissues which may play an important role in the development of...

journal_title：Cancer biology & therapy

authors： Luo G,Jin C,Long J,Fu D,Yang F,Xu J,Yu X,Chen W,Ni Q

更新日期：2009-04-01 00:00:00

abstract：:Melanoma is the deadliest form of skin cancer. In the early stages, melanoma can be treated successfully with surgery alone and survival rates are high, but after metastasis survival rates drop significantly. Therefore, early and correct diagnosis is key for ensuring patients have the best possible prognosis. Melanoma...

journal_title：Cancer biology & therapy

authors： Davis LE,Shalin SC,Tackett AJ

更新日期：2019-01-01 00:00:00

abstract：:Current risk stratification using clinical and pathological parameters in patients with urothelial carcinoma of the bladder (UCB) is insufficient. Additional information on the tumor biology can be derived from molecular biomarkers assessed in surgical UCB specimens and the predictive accuracy of oncologic end points ...

journal_title：Cancer biology & therapy

authors： Bolenz C,Lotan Y

更新日期：2010-09-01 00:00:00

abstract：:Although daunomycin and adriamycin are considered effective antitumor drugs and have been used in the clinic for over 40 years, their mechanism of action is still a matter of debate. We investigated the influence of daunomycin on interaction between linker or core histones and DNA in live HeLa cells in vitro, using im...

journal_title：Cancer biology & therapy

authors： Wójcik K,Zarębski M,Cossarizza A,Dobrucki JW

更新日期：2013-09-01 00:00:00

abstract：:It was well known that cancer-associated fibroblasts (CAFs) were an essential factor in tumor progression. However, the actual mechanism of stromal fibroblasts activation and tumor promoting effects remain unclear. Here, we showed that KLF5 expression was more frequently observed in gastric cancer-associated fibroblas...

journal_title：Cancer biology & therapy

authors： Yang T,Chen M,Yang X,Zhang X,Zhang Z,Sun Y,Xu B,Hua J,He Z,Song Z

更新日期：2017-10-03 00:00:00

abstract：:With the increasing interest in development of cytostatic anticancer drugs, the randomized discontinuation trial (RDT) design has been proved to be useful in the evaluation of their clinical activity. In the June 1, 2006 issue of the Journal of Clinical Oncology, a study by Ratain et al. uses RDT in a phase-II placebo...

journal_title：Cancer biology & therapy

authors： Jain L,Venitz J,Figg WD

更新日期：2006-10-01 00:00:00

abstract：:In order to demonstrate the role of the pituitary tumor transforming gene 1 (PTTG1) in the development of hepatocellular carcinoma (HCC) and its value as a molecular target for cancer therapy, we analyzed the expression of PTTG1 mRNA and protein, and their relation to clinicopathological characteristics and basic fibr...

journal_title：Cancer biology & therapy

authors： Liang M,Chen X,Liu W,Li S,Li C,Jiang L,Lv S

更新日期：2011-02-01 00:00:00

abstract：:Adenoid cystic carcinoma (ACC), a rare salivary gland malignancy, is a histogenetic, morphologic, and clinical heterogeneous disease. Extensive efforts have been made to characterize molecular events associated with these tumors, including the identification of prognostic and predictive biomarkers. Increased copy numb...

journal_title：Cancer biology & therapy

authors： Bell D,Ferrarotto R,Fox MD,Roberts D,Hanna EY,Weber RS,El-Naggar AK

更新日期：2015-01-01 00:00:00

abstract：:Multiple myeloma (MM) is an incurable B-cell malignancy characterized by accumulation of malignant plasma cells in the bone marrow and by recurrent or persistent infections. Toll-like receptors (TLRs) are essential in the host defense against infections. The aim of this study was to investigate TLR initiated responses...

journal_title：Cancer biology & therapy

authors： Bao H,Lu P,Li Y,Wang L,Li H,He D,Yang Y,Zhao Y,Yang L,Wang M,Yi Q,Cai Z

更新日期：2011-01-01 00:00:00

abstract：:Long standing chronic pancreatitis is a risk factor for developing pancreatic cancer. Inheritance of polymorphisms in SPINK1 and CFTR are associated with an increased risk of developing pancreatitis. The aim of this study was to determine if patients who carry polymorphisms in SPINK1 and CFTR are at increased risk of ...

journal_title：Cancer biology & therapy

authors： Matsubayashi H,Fukushima N,Sato N,Brune K,Canto M,Yeo CJ,Hruban RH,Kern SE,Goggins M

更新日期：2003-11-01 00:00:00

abstract：:Silibinin, derived from milk thistle extract, has been shown to inhibit growth factor receptor-mediated mitogenic and cell survival signaling, and to alter cell cycle regulators. Alteration in pathways regulating cell growth likely account for silibinin's inhibition of tumor growth. Since the epidermal growth factor r...

journal_title：Cancer biology & therapy

authors： Qi L,Singh RP,Lu Y,Agarwal R,Harrison GS,Franzusoff A,Glode LM

更新日期：2003-09-01 00:00:00

abstract：:Medulloblastoma is an aggressive primitive neuroectodermal tumor of the cerebellum that is rare in adults. Medulloblastomas fall into 4 prognostically significant molecular subgroups that are best defined by experimental gene expression profiles: the WNT pathway, sonic hedgehog (SHH) pathway, and subgroups 3 and 4 (no...

journal_title：Cancer biology & therapy

authors： Lou E,Schomaker M,Wilson JD,Ahrens M,Dolan M,Nelson AC

更新日期：2016-10-02 00:00:00

abstract：:SUMO (small ubiquitin-related modifier) represents a class of ubiquitin-like proteins that is conjugated, like ubiquitin, by a set of enzymes to cellular regulatory proteins, including oncogenes and tumor suppressor genes, that play key roles in the control of cell growth, differentiation and apoptosis. SUMO conjugati...

journal_title：Cancer biology & therapy

authors： Alarcon-Vargas D,Ronai Z

更新日期：2002-05-01 00:00:00

abstract：:Head and neck cancer arises from a series of molecular alterations progressive from dysplasia to carcinoma in situ, and finally invasive carcinoma. Risk factors associated with head and neck cancer include tobacco, alcohol and viral infection. There are genetic alterations in pre-cancerous cells that contribute to tra...

journal_title：Cancer biology & therapy

authors： Klein JD,Grandis JR

更新日期：2010-01-01 00:00:00

abstract：:For years, the growth inhibitory effects of the tumor suppressor p53 were thought to be antagonized predominantly by the ubiquitin ligase, MDM2. It has long been established that MDM2 physically associates with p53 and targets this tumor suppressor for proteasomal degradation. In light of recent findings, it now appea...

journal_title：Cancer biology & therapy

authors： Corcoran CA,Huang Y,Sheikh MS

更新日期：2004-08-01 00:00:00

abstract：:Increasing evidence demonstrated that long non-coding RNA ANRIL serves as a fatal oncogene in many cancers, including nasopharyngeal carcinoma (NPC). However, little is known whether ANRIL regulated NPC cell radioresistance. Quantitative real-time PCR (qRT-PCR) was performed to examine the expression of lncRNA ANRIL a...

journal_title：Cancer biology & therapy

authors： Hu X,Jiang H,Jiang X

更新日期：2017-05-04 00:00:00

abstract：:Angiogenesis inhibitors belong to a new class of drugs. Many of these drugs are in clinical trials to treat cancer, while others have recently received FDA approval. However, angiogenesis inhibitors operate by different mechanisms than conventional cytotoxic chemotherapies, and require different guidelines for their o...

journal_title：Cancer biology & therapy

authors： Folkman J

更新日期：2003-07-01 00:00:00