Downregulation of XIAP and induction of apoptosis by the synthetic cyclin-dependent kinase inhibitor GW8510 in non-small cell lung cancer cells.

abstract：:Although daunomycin and adriamycin are considered effective antitumor drugs and have been used in the clinic for over 40 years, their mechanism of action is still a matter of debate. We investigated the influence of daunomycin on interaction between linker or core histones and DNA in live HeLa cells in vitro, using im...

journal_title：Cancer biology & therapy

authors： Wójcik K,Zarębski M,Cossarizza A,Dobrucki JW

更新日期：2013-09-01 00:00:00

abstract：:Every year, 12,000 people in the U.S. die from renal cell carcinoma. Current therapies include partial or complete nephrectomy or treatments such as administration of IFN-alpha and/or interleukins that are moderately effective, at best. Moreover, the current therapies are invasive and inefficient and new therapies are...

journal_title：Cancer biology & therapy

authors： VanOosten RL,Moore JM,Karacay B,Griffith TS

更新日期：2005-10-01 00:00:00

abstract：:Cytotoxic chemotherapeutic drugs, especially when used in combination, are widely employed to treat a variety of cancers in patients but often lead to serious symptoms that negatively affect physical functioning and quality of life. There is compelling evidence that implicates cytotoxic chemotherapy-induced inflammati...

journal_title：Cancer biology & therapy

authors： Wong J,Tran LT,Magun EA,Magun BE,Wood LJ

更新日期：2014-10-01 00:00:00

abstract：:Interdigitating dendritic cell sarcoma is an extremely rare tumor. The diagnosis is difficult and is based on clinical, pathological and immunohistochemical evaluation. Differential diagnosis includes melanoma, mesenchymal and hematological malignancies. The mainstay of treatment is surgery for limited disease and dif...

journal_title：Cancer biology & therapy

authors： Di Liso E,Pennelli N,Lodovichetti G,Ghiotto C,Dei Tos AP,Conte P,Bonanno L

更新日期：2015-01-01 00:00:00

abstract：:Historically, ErbB3 has been overlooked within the ErbB receptor family due to its perceived lack of tyrosine kinase activity. We have previously demonstrated that in pancreatic cancer ErbB3 is the preferred dimerization partner of EGFR, ErbB3 protein expression level directly correlates with the anti-proliferative ef...

journal_title：Cancer biology & therapy

authors： Liles JS,Arnoletti JP,Tzeng CW,Howard JH,Kossenkov AV,Kulesza P,Heslin MJ,Frolov A

更新日期：2010-09-15 00:00:00

abstract：INTRODUCTION:Malignant cells are capable of an unlimited number of cell divisions, either through production of telomerase, or through the alternate lengthening of telomere (ALT) mechanism. Yeast cells with genomic instability have been shown to survive in the absence of telomerase by increased recombination events. We...

journal_title：Cancer biology & therapy

authors： Landen CN,Klingelhutz A,Coffin JE,Sorosky JI,Sood AK

更新日期：2004-12-01 00:00:00

abstract：:The recurrence of colorectal cancer after chemotherapy is the leading cause of its high mortality. We propose that elucidating the mechanisms of tumor regrowth after chemotherapy in tumor-bearing mice may provide new insights into tumor relapse in cancer patients. We firstly report the identification of a chemokine, C...

journal_title：Cancer biology & therapy

authors： Zhang Y,Gao J,Wang X,Deng S,Ye H,Guan W,Wu M,Zhu S,Yu Y,Han W

更新日期：2015-01-01 00:00:00

abstract：:SEPT9 is a mammalian septin family member. There is growing evidence that SEPT9 plays a role in cancer. The protein product, SEPT9_V1, associates with microtubules and interacts with hypoxia-inducible factor (HIF)-1alpha, the regulated subunit of the key transcription factor HIF-1. HIF-1 transcriptional activity is th...

journal_title：Cancer biology & therapy

authors： Amir S,Mabjeesh NJ

更新日期：2007-12-01 00:00:00

abstract：:Long standing chronic pancreatitis is a risk factor for developing pancreatic cancer. Inheritance of polymorphisms in SPINK1 and CFTR are associated with an increased risk of developing pancreatitis. The aim of this study was to determine if patients who carry polymorphisms in SPINK1 and CFTR are at increased risk of ...

journal_title：Cancer biology & therapy

authors： Matsubayashi H,Fukushima N,Sato N,Brune K,Canto M,Yeo CJ,Hruban RH,Kern SE,Goggins M

更新日期：2003-11-01 00:00:00

abstract：:Vitamin D derivatives can induce differentiation of human acute myeloid leukemia (AML) cells. Here, we investigated if the G₁ cell cycle block associated with monocytic differentiation is modulated by the p53 status of the cells treated with 1,25D, alone or with plant antioxidants carnosic acid (C) or silibinin (S), a...

journal_title：Cancer biology & therapy

authors： Thompson T,Danilenko M,Vassilev L,Studzinski GP

更新日期：2010-08-15 00:00:00

abstract：:Numerous tyrosine kinase inhibitors (TKIs) targeting c-Met are currently in clinical trials for several cancers. Their efficacy is limited due to the development of resistance. The present study aims to elucidate this mechanism of c-Met TKI resistance by investigating key mTOR and Wnt signaling proteins in melanoma ce...

journal_title：Cancer biology & therapy

authors： Etnyre D,Stone AL,Fong JT,Jacobs RJ,Uppada SB,Botting GM,Rajanna S,Moravec DN,Shambannagari MR,Crees Z,Girard J,Bertram C,Puri N

更新日期：2014-09-01 00:00:00

abstract：:Melanoma is the deadliest form of skin cancer. In the early stages, melanoma can be treated successfully with surgery alone and survival rates are high, but after metastasis survival rates drop significantly. Therefore, early and correct diagnosis is key for ensuring patients have the best possible prognosis. Melanoma...

journal_title：Cancer biology & therapy

authors： Davis LE,Shalin SC,Tackett AJ

更新日期：2019-01-01 00:00:00

abstract：:The screening for BRAF V600E mutation is employed in clinical practice for its prognostic and potentially predictive role in patients with metastatic colorectal carcinoma (mCRC). Little information is available on the sensitivity and specificity of the testing methods to detect this mutation in CRC. By using serial di...

journal_title：Cancer biology & therapy

authors： Roma C,Rachiglio AM,Pasquale R,Fenizia F,Iannaccone A,Tatangelo F,Antinolfi G,Parrella P,Graziano P,Sabatino L,Colantuoni V,Botti G,Maiello E,Normanno N

更新日期：2016-08-02 00:00:00

abstract：:Most sporadic colorectal cancer reflects acquired mutations in the adenomatous polyposis coli (APC) tumor suppressor gene, while germline heterozygosity for mutant APC produces the autosomal dominant disorder Familial Adenomatous Polyposis (FAP) with a predisposition to colorectal cancer. In these syndromes, loss of h...

journal_title：Cancer biology & therapy

authors： Pattison AM,Barton JR,Entezari AA,Zalewski A,Rappaport JA,Snook AE,Waldman SA

更新日期：2020-09-01 00:00:00

abstract：:Chronic arsenic treatment induces epithelial-mesenchymal transition (EMT) and promotes tumorigenicity, but the mechanism is unclear. MiR-100 has been shown to be involved in this biologic process. In this study, we hypothesize that inactivation of miR-100 combined with low concentration of arsenic exposure could promo...

journal_title：Cancer biology & therapy

authors： Yang J,Chen Z,Wang X,Xu M,Fang H,Li F,Liu Y,Jiang Y,Ding Y,Li J,Wang S

更新日期：2017-12-02 00:00:00

abstract：:Chronic myeloid leukemia (CML) progresses from a chronic phase to a deadly blast crisis phase. While it is known that BCR-ABL initiates the disease and that secondary molecular and genetic abnormalities likely contribute to progression of the disease to blast crisis, details regarding the mechanism(s) of blast phase p...

journal_title：Cancer biology & therapy

authors： Griner LN,Reuther GW

更新日期：2010-11-15 00:00:00

abstract：PURPOSE:Optical coherence tomography (OCT) is a minimally invasive, depth-resolved imaging tool that can be implemented in a small diameter endoscope for imaging mouse models of colorectal cancer (CRC). In this study, we utilized ultrahigh resolution (UHR) OCT to serially image the lower colon of azoxymethane (AOM) tre...

journal_title：Cancer biology & therapy

authors： Hariri LP,Qiu Z,Tumlinson AR,Besselsen DG,Gerner EW,Ignatenko NA,Povazay B,Hermann B,Sattmann H,McNally J,Unterhuber A,Drexler W,Barton JK

更新日期：2007-11-01 00:00:00

abstract：:Chewing tobacco is a common practice in certain socio-economic sections of southern Asia, particularly in the Indian subcontinent and has been well associated with head and neck squamous cell carcinoma. The molecular mechanisms of chewing tobacco which leads to malignancy remains unclear. In large majority of studies,...

journal_title：Cancer biology & therapy

authors： Nanjappa V,Renuse S,Sathe GJ,Raja R,Syed N,Radhakrishnan A,Subbannayya T,Patil A,Marimuthu A,Sahasrabuddhe NA,Guerrero-Preston R,Somani BL,Nair B,Kundu GC,Prasad TK,Califano JA,Gowda H,Sidransky D,Pandey A,Chatterje

更新日期：2015-01-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is a critical early event in tumorigenesis. The contribution of heparan sulfate (HS) to EMT has not been fully elucidated. HS D-glucosaminyl 3-O-sulfotransferase-3B1 (3-OST-3B1) participates in the final step of HS fine structure biosynthesis, whose involvement in cancer has yet...

journal_title：Cancer biology & therapy

authors： Song K,Li Q,Jiang ZZ,Guo CW,Li P

更新日期：2011-09-01 00:00:00

abstract：:Colorectal cancer (CRC) is the third most common form of cancer. Current treatments including chemotherapy, radiotherapy and surgery are all associated with a high risk of complications and are not always successful, highlighting the need to develop new treatment strategies. The ingestion of probiotics, prebiotics or ...

journal_title：Cancer biology & therapy

authors： Geier MS,Butler RN,Howarth GS

更新日期：2006-10-01 00:00:00

abstract：:The serine/threonine protein kinase Aurora A is known to interact with and phosphorylate tumor suppressor p53 at Serine 215 (S215), inhibiting the transcriptional activity of p53. We show that Aurora A positively regulates human p53 protein levels and, using isogenic p53 wild-type and p53-null colorectal carcinoma cel...

journal_title：Cancer biology & therapy

authors： Warnock LJ,Raines SA,Milner J

更新日期：2011-12-15 00:00:00

abstract：:The reported incidence of pancreatic neuroendocrine tumors (PanNETs) has increased, due in large part to improvements in detection and awareness. However, therapeutic options are limited and a critical need exists for understanding a more thorough characterization of the molecular pathology underlying this disease. Th...

journal_title：Cancer biology & therapy

authors： Lin W,Francis JM,Li H,Gao X,Pedamallu CS,Ernst P,Meyerson M

更新日期：2016-12-01 00:00:00

abstract：:Invariant natural killer T (iNKT) cells are a distinct subset of human T cells, which expresses an invariant T cell receptor Vα24 Jα18 and recognizes glycolipid antigens in the context of CD1d molecules. iNKT cells exert pivotal regulatory roles in many immune responses, including antitumor immune responses. Alteratio...

journal_title：Cancer biology & therapy

authors： Altomare E,Fallarini S,Biaggi G,Gattoni E,Botta M,Lombardi G

更新日期：2012-07-01 00:00:00

abstract：:Rhabdomyosarcoma (RMS) is an aggressive childhood sarcoma with two distinct subtypes, embryonal (ERMS) and alveolar (ARMS) histologies. More effective treatment is needed to improve outcomes, beyond conventional cytotoxic chemotherapy. The pan-histone deacetylase inhibitor, Suberoylanilide Hydroxamic Acid (SAHA), has ...

journal_title：Cancer biology & therapy

authors： Ghayad SE,Rammal G,Sarkis O,Basma H,Ghamloush F,Fahs A,Karam M,Harajli M,Rabeh W,Mouawad JE,Zalzali H,Saab R

更新日期：2019-01-01 00:00:00

abstract：:Breast cancer is one of the most commonly diagnosed malignancies in women. Despite the remarkable success of mammography screening and use of adjuvant systemic therapy, it is estimated that approximately 200,000 new diagnoses will be made this year and 40,000 deaths will occur due to this disease (American Cancer Soci...

journal_title：Cancer biology & therapy

authors： Rosca EV,Koskimaki JE,Pandey NB,Wolff AC,Popel AS

更新日期：2011-11-01 00:00:00

abstract：:5-fluorouracil forms classic (covalent, ternary) complexes consisting of thymidylate synthase, fluoro-deoxyuridine monophosphate, and 5,10-methylene tetrahydrofolate. Despite a high pharmacologic interest in the classic complexes formed in cells treated with fluorouracil anticancer agents, the in vivo stability of the...

journal_title：Cancer biology & therapy

authors： Brody JR,Gallmeier E,Yoshimura K,Hucl T,Kulesza P,Canto MI,Hruban RH,Schulick RD,Kern SE

更新日期：2006-08-01 00:00:00

abstract：:Ovarian cancer ranks fifth in cancer related deaths for women in USA. The high mortality rate associated with ovarian cancer is due to diagnosis at later stages of disease and the high recurrence rate of 60-80%. Recurrent ovarian cancers are more likely to present as multidrug resistance (MDR) leading to unfavorable r...

journal_title：Cancer biology & therapy

authors： Patel NR,Piroyan A,Ganta S,Morse AB,Candiloro KM,Solon AL,Nack AH,Galati CA,Bora C,Maglaty MA,O'Brien SW,Litwin S,Davis B,Connolly DC,Coleman TP

更新日期：2018-07-03 00:00:00

abstract：:This study aimed to investigate the inhibitory effect of tyroservaltide (YSV) on the human hepatocarcinoma BEL-7402 transplanted into nude mice and to explore its possible anti-tumor mechanism. Nude mice bearing xenografts of the human BEL-7402 hepatoma were given daily i.p. injections of YSV or saline (as a control) ...

journal_title：Cancer biology & therapy

authors： Jia J,Lu R,Qiu S,Li H,Che X,Zhao P,Jin M,Yang H,Lin G,Yao Z

更新日期：2005-09-01 00:00:00

abstract：:Aberrant methylation of tumour suppressor genes is associated with the progression to a blast crisis in chronic myeloid leukaemia (CML). Methyl-CpG-binding domain protein 2 (MBD2) has been studied as a "reader" of DNA methylation in many cancers, but its role in CML is unclear. We constructed cell models of a homozygo...

journal_title：Cancer biology & therapy

authors： Cheng L,Tang Y,Chen X,Zhao L,Liu S,Ma Y,Wang N,Zhou K,Zhou J,Zhou M

更新日期：2018-08-03 00:00:00

abstract：:The early observations by Dr Otto Warburg revealed that fundamentally metabolic differences exist between malignant tumor cells and adjacent normal cells. Many studies have further reported the relationship between altered cellular metabolism and therapeutic outcomes. These observations suggest that targeting the pecu...

journal_title：Cancer biology & therapy

authors： Zhang Y,Yang JM

更新日期：2013-02-01 00:00:00