Increased frequency of circulating invariant natural killer T cells in malignant pleural mesothelioma patients.


:Invariant natural killer T (iNKT) cells are a distinct subset of human T cells, which expresses an invariant T cell receptor Vα24 Jα18 and recognizes glycolipid antigens in the context of CD1d molecules. iNKT cells exert pivotal regulatory roles in many immune responses, including antitumor immune responses. Alterations in iNKT cell frequency, phenotype, and activation state have been reported in cancer patients. No data are available on the iNKT cells in malignant pleural mesothelioma (MPM), a rare, but very aggressive, malignancy of the pleura with a very poor prognosis. Here, we studied the frequency, phenotype, and cytokine profile of circulating iNKT cells in MPM patients, and correlated results with tumor histological types (epithelioid, sarcomatoid, biphasic) and clinical stages (I-III). We found that the iNKT cell frequency was significantly increased in MPM patients with epithelioid and sarcomatoid types in comparison with healthy volunteers (HV); only three biphasic mesotheliomas were available in this study, thus no conclusions can be drawn for this MPM type. The increased frequency significantly correlates with the clinical stage of tumor with the highest value at the stage III in both epithelioid and sarcomatoid subtypes. According to the histological types, we measured changes in the frequencies of CD4⁺ CD8⁺ (DP) and CD4⁻CD8⁻ (DN), but not in the cytokine profiles (IFN-γ/IL-4 expression). These results demonstrate that the frequency of iNKT cells is increased in MPM patients and that this increase correlates with MPM type and stage.


Cancer Biol Ther


Cancer biology & therapy


Altomare E,Fallarini S,Biaggi G,Gattoni E,Botta M,Lombardi G




Has Abstract


2012-07-01 00:00:00














  • The Par-4-GRP78 TRAIL, more twists and turns.

    abstract::GRP78, also referred to as BiP, is an essential molecular chaperone and a master regulator of the unfolded protein response. Traditionally, GRP78 is regarded as localized in the lumen of the endoplasmic reticulum (ER). However, recent findings revealed that a subfraction of GRP78 can localize to the surface of specifi...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Lee AS

    更新日期:2009-11-01 00:00:00

  • 5-hydroxymethylcytosine: a new insight into epigenetics in cancer.

    abstract::DNA methylation at the 5 position of cytosine (5-mC) has emerged as a key epigenetic marker that plays essential roles in various biological and pathological processes. 5-mC can be converted to 5-hydroxymethylcytosine (5-hmC) by the ten-eleven translocation (TET) family proteins, which is now widely recognized as the ...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章,评审


    authors: Ye C,Li L

    更新日期:2014-01-01 00:00:00

  • Apoptotic response to 5-fluorouracil treatment is mediated by reduced polyamines, non-autocrine Fas ligand and induced tumor necrosis factor receptor 2.

    abstract::5-fluorouracil (5-FU) is the major chemotherapeutic agent for treatment of colorectal carcinoma, but the molecular mechanisms of response and resistance are not understood completely. We therefore studied the 5-FU dose response and time course of gene expression transcriptome changes in colon carcinoma cell lines that...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Zhang W,Ramdas L,Shen W,Song SW,Hu L,Hamilton SR

    更新日期:2003-09-01 00:00:00

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    abstract::PRL-1 (phosphatase of regenerating liver-1), PRL-2 and PRL-3 are protein tyrosine phosphatases with a C-terminal prenylation motif that are localized to the inner leaflet of the plasma membrane and early endosomes. A variety of metastatic PRL-overexpressing cancers have been reported. Therefore, the three PRL-phosphat...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Guo K,Tang JP,Tan CP,Wang H,Zeng Q

    更新日期:2008-05-01 00:00:00

  • Sunitinib and PF-562,271 (FAK/Pyk2 inhibitor) effectively block growth and recovery of human hepatocellular carcinoma in a rat xenograft model.

    abstract:EXPERIMENTAL DESIGN:To investigate the antitumor effect of sunitinib and FAK/Pyk2 tyrosine kinase inhibitor (PF-562,271)combination therapy in vivo, utilizing human hepatocellular carcinoma (HCC) cells Huh7.5. Nude rats were inoculated subcutaneously with Huh7.5 hepatoma cells. Dosing for Phase 1 was initiated on day 5...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Bagi CM,Christensen J,Cohen DP,Roberts WG,Wilkie D,Swanson T,Tuthill T,Andresen CJ

    更新日期:2009-05-01 00:00:00

  • Characterization of a specific phage-displayed Peptide binding to vasculature of human gastric cancer.

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    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Zhi M,Wu KC,Dong L,Hao ZM,Deng TZ,Hong L,Liang SH,Zhao PT,Qiao TD,Wang Y,Xu X,Fan DM

    更新日期:2004-12-01 00:00:00

  • Systemic and skin toxicity in Cercopithecus aethiops sabaeus monkeys treated during 26 weeks with a high intravenous dose of the anti- epidermal growth factor receptor monoclonal antibody Nimotuzumab.

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    pub_type: 杂志文章


    authors: Arteaga ME,Ledón N,Casacó A,Pardo B,García M,Boleda M,Viña L,Orphee R,Hernández O,González C,Fuentes D,Rodríguez V,Charro L,Baro F,Macías A,Pérez A,Morales Y,Subirós N,González B,Ramos M,Rodriquez L,Ballester-La

    更新日期:2007-09-01 00:00:00

  • The preclinical evaluation of the dual mTORC1/2 inhibitor INK-128 as a potential anti-colorectal cancer agent.

    abstract::The colorectal cancer is the leading contributor of cancer-related mortality. Mammalian target of rapamycin (mTOR), existing in 2 complexes (mTORC1/2), is frequently dysregulated and constitutively activated in colorectal cancers. It represents an important drug target. Here we found that INK-128, the novel ATP-compet...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Li C,Cui JF,Chen MB,Liu CY,Liu F,Zhang QD,Zou J,Lu PH

    更新日期:2015-01-01 00:00:00

  • Complete and sustained response of adult medulloblastoma to first-line sonic hedgehog inhibition with vismodegib.

    abstract::Medulloblastoma is an aggressive primitive neuroectodermal tumor of the cerebellum that is rare in adults. Medulloblastomas fall into 4 prognostically significant molecular subgroups that are best defined by experimental gene expression profiles: the WNT pathway, sonic hedgehog (SHH) pathway, and subgroups 3 and 4 (no...

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    pub_type: 杂志文章


    authors: Lou E,Schomaker M,Wilson JD,Ahrens M,Dolan M,Nelson AC

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  • Cancer mortality trends between 1988 and 2009 in the metropolitan area of Naples and Caserta, Southern Italy: Results from a joinpoint regression analysis.

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    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Crispo A,Barba M,Malvezzi M,Arpino G,Grimaldi M,Rosso T,Esposito E,Sergi D,Ciliberto G,Giordano A,Montella M

    更新日期:2013-12-01 00:00:00

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    abstract::The present studies sought to further understand how the anti-folate pemetrexed and the multi-kinase inhibitor sorafenib interact to kill tumor cells. Sorafenib activated SRC, and via SRC the drug combination activated ERK1/2. Expression of dominant negative SRC or dominant negative MEK1 abolished drug-induced ERK1/2 ...

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    authors: Bareford MD,Hamed HA,Allegood J,Cruickshanks N,Poklepovic A,Park MA,Ogretmen B,Spiegel S,Grant S,Dent P

    更新日期:2012-07-01 00:00:00

  • STEAP2 is down-regulated in breast cancer tissue and suppresses PI3K/AKT signaling and breast cancer cell invasion in vitro and in vivo.

    abstract::The six-transmembrane epithelial antigen of prostate 2 (STEAP2) protein was identified in advanced prostate cancer, and is highly over-expressed in various types of cancer. This study aimed to investigate the prognostic value and the function of STEAP2 in breast cancer. STEAP2 mRNA and protein expressions in breast no...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Yang Q,Ji G,Li J

    更新日期:2020-01-01 00:00:00

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    abstract::In the immune system, activation of naïve T (Tn) cells into effector T cells (Teff) involves a metabolic switch to glycolysis to promote rapid proliferation and differentiation. In the October issue of The Journal of Clinical Investigation, Sukumar et al. have demonstrated that in CD8(+) memory T (Tems) cells glycolyt...

    journal_title:Cancer biology & therapy

    pub_type: 评论,杂志文章


    authors: Karthikeyan S,Geschwind JF,Ganapathy-Kanniappan S

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  • Post-biopsy rise in serum PSA. A potential tool for the dynamic evaluation of prostate cancer/prostatic intraepithelial neoplasia (PIN).

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    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Bhanot S,Gopalakrishnan R,Oliver RT

    更新日期:2003-01-01 00:00:00

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    abstract::Methylthioadenosine phosphorylase (MTAP), a key enzyme in the catabolism of 5'-deoxy-5'-methylthioadenosine (MTA), catalyzes the formation of adenine and 5-methylthioribose-1-phosphate. MTAP is expressed in all cells throughout the body, but a significant percentage of human tumors have lost MTAP expression, thereby m...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Tang B,Testa JR,Kruger WD

    更新日期:2012-09-01 00:00:00

  • Managing bone complications of solid tumors.

    abstract::Bone metastases are a common occurrence in patients with breast cancer, lung cancer and prostate cancer. Bone metastases cause considerable morbidity including pain, impaired mobility, pathologic fracture, spinal cord or nerve root compression, bone marrow infiltration and hypercalcemia of malignancy. These complicati...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章,评审


    authors: Berenson JR,Rajdev L,Broder M

    更新日期:2006-09-01 00:00:00

  • Acquired resistance of lung adenocarcinoma to EGFR-tyrosine kinase inhibitors gefitinib and erlotinib.

    abstract::Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), such as gefitinib and erlotinib, are the first targeted therapy drugs approved for the treatment of advanced non-small-cell lung cancer (NSCLC). Interestingly, treatment with these small molecule, reversible EGFR-TKIs leads to more positive respo...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章,评审


    authors: Xu Y,Liu H,Chen J,Zhou Q

    更新日期:2010-04-15 00:00:00

  • Chronic exposure to chewing tobacco selects for overexpression of stearoyl-CoA desaturase in normal oral keratinocytes.

    abstract::Chewing tobacco is a common practice in certain socio-economic sections of southern Asia, particularly in the Indian subcontinent and has been well associated with head and neck squamous cell carcinoma. The molecular mechanisms of chewing tobacco which leads to malignancy remains unclear. In large majority of studies,...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Nanjappa V,Renuse S,Sathe GJ,Raja R,Syed N,Radhakrishnan A,Subbannayya T,Patil A,Marimuthu A,Sahasrabuddhe NA,Guerrero-Preston R,Somani BL,Nair B,Kundu GC,Prasad TK,Califano JA,Gowda H,Sidransky D,Pandey A,Chatterje

    更新日期:2015-01-01 00:00:00

  • The signal pathways in azoxymethane-induced colon cancer and preventive implications.

    abstract::Colon cancer is the third most common cancer and third most common cause of cancer-related death in the USA according to 2008 American Cancer Society statistics. The carcinogenesis of colon cancer has been associated with both genetics and environmental factors. It has been found that several signal pathways, includin...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章,评审


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  • FGFR genes mutation is an independent prognostic factor and associated with lymph node metastasis in squamous non-small cell lung cancer.

    abstract::Targeting FGFRs is one of the most promising therapeutic strategies in squamous non-small cell lung cancer (SQCC). However, different FGFR genomic aberrations can be associated with distinct biological characteristics that result in different clinical outcomes or therapeutic consequences. Currently, the full spectrum ...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Li JJ,Yan S,Pan Y,Liu Z,Liu Y,Deng Q,Tan Q,Woodward ER,Wu N

    更新日期:2018-01-01 00:00:00

  • ETS-TMPRSS2 fusion gene products in prostate cancer.

    abstract::Genes playing a role in carcinogenesis have often been identified through analysis of recurrent chromosomal rearrangements. Although such rearrangements are well known in leukemias, lymphomas, and sarcomas, they have not been well characterized in carcinomas. In the October 28, 2005 issue of Science, a study by Tomlin...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Ahlers CM,Figg WD

    更新日期:2006-03-01 00:00:00

  • DR4 specific TRAIL variants are more efficacious than wild-type TRAIL in pancreatic cancer.

    abstract::Current treatment modalities for pancreatic carcinoma afford only modest survival benefits. TRAIL, as a potent and specific inducer of apoptosis in cancer cells, would be a promising new treatment option. However, since not all pancreatic cancer cells respond to TRAIL, further improvements and optimizations are still ...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Yu R,Albarenque SM,Cool RH,Quax WJ,Mohr A,Zwacka RM

    更新日期:2014-01-01 00:00:00

  • Enhanced antitumor effect of alectinib in combination with cyclin-dependent kinase 4/6 inhibitor against RET-fusion-positive non-small cell lung cancer cells.

    abstract::Rearranged during transfection (RET) fusion-positive non-small cell lung cancer (NSCLC) accounts for 1% of lung adenocarcinoma. Although small molecule agents with RET kinase inhibitory activity such as alectinib, vandetanib, and cabozantinib have been clinically evaluated in RET-fusion-positive NSCLC, an effective mo...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Fujimura T,Furugaki K,Harada N,Yoshimura Y

    更新日期:2020-09-01 00:00:00

  • Pre-clinical evaluation of 1-nitroacridine derived chemotherapeutic agent that has preferential cytotoxic activity towards prostate cancer.

    abstract::Chemotherapy in prostate cancer (CaP) even as an adjunct has not been a success. In this communication, we report the pre-clinical efficacy of a nitroacridine derivative, C-1748 (9[2'-hydroxyethylamino]-4-methyl-1-nitroacridine) in CaP cell culture and human xenograft animal models. C-1748, a DNA intercalating agent h...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Tadi K,Ashok BT,Chen Y,Banerjee D,Wysocka-Skrzela B,Konopa J,Darzynkiewicz Z,Tiwari RK

    更新日期:2007-10-01 00:00:00

  • Polymorphisms of p53 and MDM2 genes are associated with severe toxicities in patients with non-small cell lung cancer.

    abstract::Adverse events in platinum-based chemotherapy for patients with advanced non-small cell lung cancer (NSCLC) are major challenges. In this study, we investigated the role of the p53 and MDM2 genes in predicting adverse events in NSCLC patients treated with platinum-based chemotherapy. Specifically, we examined the p53 ...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Zheng D,Chen Y,Gao C,Wei Y,Cao G,Lu N,Hou Y,Jiang X,Wang J

    更新日期:2014-01-01 00:00:00

  • The differences of regulatory networks between papillary and anaplastic thyroid carcinoma: an integrative transcriptomics study.

    abstract:BACKGROUND:Unlike papillary thyroid cancer (PTC), anaplastic thyroid carcinoma (ATC) is extremely aggressive and rapidly lethal without effective therapies. However, the differences of master regulators and regulatory networks between PTC and ATC remain unclear. Methods: Three representative datasets comprising 32 ATC,...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Pan Z,Li L,Qian Y,Ge X,Hu X,Zhang Y,Ge M,Huang P

    更新日期:2020-09-01 00:00:00

  • Phase II trial of single agent Val-boroPro (Talabostat) inhibiting Fibroblast Activation Protein in patients with metastatic colorectal cancer.

    abstract:PURPOSE:Fibroblast Activation Protein (FAP) is a tumor fibroblast protease that has been shown to potentiate colorectal cancer growth. The clinical impact of FAP inhibition was tested using Val-boroPro (Talabostat), the first clinical inhibitor of FAP enzymatic activity, in a phase II study of patients with metastatic ...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Narra K,Mullins SR,Lee HO,Strzemkowski-Brun B,Magalong K,Christiansen VJ,McKee PA,Egleston B,Cohen SJ,Weiner LM,Meropol NJ,Cheng JD

    更新日期:2007-11-01 00:00:00

  • All-trans-retinoic acid antagonizes the Hedgehog pathway by inducing patched.

    abstract::Male germ cell tumors (GCTs) are a model for a curable solid tumor. GCTs can differentiate into mature teratomas. Embryonal carcinomas (ECs) represent the stem cell compartment of GCTs and are the malignant counterpart to embryonic stem (ES) cells. GCTs and EC cells are useful to investigate differentiation therapy an...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Busch AM,Galimberti F,Nehls KE,Roengvoraphoj M,Sekula D,Li B,Guo Y,Direnzo J,Fiering SN,Spinella MJ,Robbins DJ,Memoli VA,Freemantle SJ,Dmitrovsky E

    更新日期:2014-04-01 00:00:00

  • FBXO4 loss facilitates carcinogen induced papilloma development in mice.

    abstract::Cyclin D1 is frequently overexpressed in esophageal squamous cell carcinoma (ESCC) and is considered a key driver of this disease. Mutations in FBXO4, F-box specificity factor that directs SCF-mediated ubiquitylation of cyclin D1, occur in ESCC with concurrent overexpression of cyclin D1 suggesting a potential tumor s...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Lian Z,Lee EK,Bass AJ,Wong KK,Klein-Szanto AJ,Rustgi AK,Diehl JA

    更新日期:2015-01-01 00:00:00

  • β-Adrenergic receptors suppress Rap1B prenylation and promote the metastatic phenotype in breast cancer cells.

    abstract::A greater understanding of the molecular basis of breast cancer metastasis will lead to identification of novel therapeutic targets and better treatments. Rap1B is a small GTPase that suppresses the metastasis of breast cancer cells by increasing cell-cell adhesion. In breast cancer, a decrease in Rap1B prenylation an...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Wilson JM,Lorimer E,Tyburski MD,Williams CL

    更新日期:2015-01-01 00:00:00