Adenovirus-mediated Ink4a/ARF gene transfer significantly suppressed the growth of pancreatic carcinoma cells.

abstract：:Most sporadic colorectal cancer reflects acquired mutations in the adenomatous polyposis coli (APC) tumor suppressor gene, while germline heterozygosity for mutant APC produces the autosomal dominant disorder Familial Adenomatous Polyposis (FAP) with a predisposition to colorectal cancer. In these syndromes, loss of h...

journal_title：Cancer biology & therapy

authors： Pattison AM,Barton JR,Entezari AA,Zalewski A,Rappaport JA,Snook AE,Waldman SA

更新日期：2020-09-01 00:00:00

abstract：:Any drug selects for drug resistance. But super-antagonistic drug combinations can select for drug sensitivity. This has important application not only for antibacterial therapy but also for cancer therapy: to control cancer with lesser side effects and to eliminate drug-resistant cancer cells, while sparing sensitive...

journal_title：Cancer biology & therapy

authors： Blagosklonny MV

更新日期：2007-07-01 00:00:00

abstract：:5-fluorouracil forms classic (covalent, ternary) complexes consisting of thymidylate synthase, fluoro-deoxyuridine monophosphate, and 5,10-methylene tetrahydrofolate. Despite a high pharmacologic interest in the classic complexes formed in cells treated with fluorouracil anticancer agents, the in vivo stability of the...

journal_title：Cancer biology & therapy

authors： Brody JR,Gallmeier E,Yoshimura K,Hucl T,Kulesza P,Canto MI,Hruban RH,Schulick RD,Kern SE

更新日期：2006-08-01 00:00:00

abstract：:MicroRNAs (miRNAs) are single-stranded, non-coding RNA molecules that regulate gene expression at the post-transcriptional level. Genes encoding miRNAs are located in regions of the genome that are commonly amplified, deleted or rearranged. They are commonly dysregulated in human cancers and known to act as oncogenes ...

journal_title：Cancer biology & therapy

authors： Mongroo PS,Rustgi AK

更新日期：2010-08-01 00:00:00

abstract：:Beneficial bacteria (probiotics) and probiotic-derived factors have the potential to ameliorate disorders of the intestine. The aim of this study was to compare live Streptococcus thermophilus TH-4 (TH-4), dead TH-4 and TH-4 supernatant in rats treated with 5-Fluorouracil. Rats were randomly allocated to five treatmen...

journal_title：Cancer biology & therapy

authors： Whitford EJ,Cummins AG,Butler RN,Prisciandaro LD,Fauser JK,Yazbeck R,Lawrence A,Cheah KY,Wright TH,Lymn KA,Howarth GS

更新日期：2009-03-15 00:00:00

abstract：:Heparan sulfate proteoglycans (HSPGs) play important roles in cancer initiation and progression, by interacting with the signaling pathways that affect proliferation, adhesion, invasion and angiogenesis. These roles suggest the possibility of various strategies of regulation of these molecules. In this review, we demo...

journal_title：Cancer biology & therapy

authors： Onyeisi JOS,Ferreira BZF,Nader HB,Lopes CC

更新日期：2020-12-01 00:00:00

abstract：:Progression of prostate cancer has been associated with EGFR and HER2 activation and to tumor-initiating cells contribution toward chemotherapy resistance. We investigated the efficacy of a dual intervention against EGFR and HER2 to deplete the tumor-initiating cells, optimize the chemotherapy management and prevent t...

journal_title：Cancer biology & therapy

authors： Rossini A,Giussani M,Ripamonti F,Aiello P,Regondi V,Balsari A,Triulzi T,Tagliabue E

更新日期：2020-05-03 00:00:00

abstract：:PRL-1 (phosphatase of regenerating liver-1), PRL-2 and PRL-3 are protein tyrosine phosphatases with a C-terminal prenylation motif that are localized to the inner leaflet of the plasma membrane and early endosomes. A variety of metastatic PRL-overexpressing cancers have been reported. Therefore, the three PRL-phosphat...

journal_title：Cancer biology & therapy

authors： Guo K,Tang JP,Tan CP,Wang H,Zeng Q

更新日期：2008-05-01 00:00:00

abstract：:Melanoma is the deadliest form of skin cancer, which is notoriously aggressive and chemo-resistant, and for which there is little effective treatment available if it goes undetected. Curcumin from the turmeric spice (Curcuma longa) has long been used in Southeast Asian medicine to alleviate ailments and cure an array ...

journal_title：Cancer biology & therapy

authors： Chatterjee SJ,Pandey S

更新日期：2011-01-15 00:00:00

abstract：:Chemotherapy in prostate cancer (CaP) even as an adjunct has not been a success. In this communication, we report the pre-clinical efficacy of a nitroacridine derivative, C-1748 (9[2'-hydroxyethylamino]-4-methyl-1-nitroacridine) in CaP cell culture and human xenograft animal models. C-1748, a DNA intercalating agent h...

journal_title：Cancer biology & therapy

authors： Tadi K,Ashok BT,Chen Y,Banerjee D,Wysocka-Skrzela B,Konopa J,Darzynkiewicz Z,Tiwari RK

更新日期：2007-10-01 00:00:00

abstract：:Bone metastases are a common occurrence in patients with breast cancer, lung cancer and prostate cancer. Bone metastases cause considerable morbidity including pain, impaired mobility, pathologic fracture, spinal cord or nerve root compression, bone marrow infiltration and hypercalcemia of malignancy. These complicati...

journal_title：Cancer biology & therapy

authors： Berenson JR,Rajdev L,Broder M

更新日期：2006-09-01 00:00:00

abstract：:Both Pten and Nras are downstream mediators of receptor tyrosine kinase activation that plays important roles in controlling cell survival and proliferation. Here, we investigated whether and how Pten loss cross-talks with Nras activation in driving liver cancer development in mice. Somatic disruption of hepatic Pten ...

journal_title：Cancer biology & therapy

authors： Gao M,Liu D

更新日期：2017-07-03 00:00:00

abstract：:Genes playing a role in carcinogenesis have often been identified through analysis of recurrent chromosomal rearrangements. Although such rearrangements are well known in leukemias, lymphomas, and sarcomas, they have not been well characterized in carcinomas. In the October 28, 2005 issue of Science, a study by Tomlin...

journal_title：Cancer biology & therapy

authors： Ahlers CM,Figg WD

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND INFORMATION:Previous studies have revealed that leptin may be involved in epithelial-mesenchymal transition (EMT), a crucial initiator of cancer progression to facilitate metastatic cascade, increase tumor recurrence, and ultimately cause poor prognosis. However, the underlying mechanism remains unclear. The...

journal_title：Cancer biology & therapy

authors： Wang L,Tang C,Cao H,Li K,Pang X,Zhong L,Dang W,Tang H,Huang Y,Wei L,Su M,Chen T

更新日期：2015-01-01 00:00:00

abstract：:Farnesyltransferase inhibitors (FTIs) have been demonstrated to induce growth arrest or apoptosis independent of Ras mutation. Alternatively, Akt has been proposed as a potential target for the FTI's actions. This study investigated whether Lonafarnib was effective in inhibiting the growth of human nonsmall cell lung ...

journal_title：Cancer biology & therapy

authors： Sun SY,Zhou Z,Wang R,Fu H,Khuri FR

更新日期：2004-11-01 00:00:00

abstract：:In a recent issue of Cancer Biology & Therapy, Vitale et al. introduced the paper of Franco et al. reporting the expression of GPER (a seven-transmembrane-spanning receptor also known as GPR30) on testicular germ cell tumors (TGCTs). The paper commented on the possible pathophysiological role of this G-protein-coupled...

journal_title：Cancer biology & therapy

authors： Chevalier N,Bouskine A,Fenichel P

更新日期：2011-07-01 00:00:00

abstract：:Understanding molecular mechanisms involved in melanoma resistance to drugs is a big challenge. Experimental evidences suggested a correlation between mutational status in B-RAF and melanoma cell susceptibility to drugs, such as paclitaxel, doxorubicin and temozolomide, which generate an accumulation of hydrogen perox...

journal_title：Cancer biology & therapy

authors： Fico A,Alfano D,Valentino A,Vasta V,Cavalcanti E,Travali S,Patriarca EJ,Caputo E

更新日期：2015-01-01 00:00:00

abstract：:The recurrence of colorectal cancer after chemotherapy is the leading cause of its high mortality. We propose that elucidating the mechanisms of tumor regrowth after chemotherapy in tumor-bearing mice may provide new insights into tumor relapse in cancer patients. We firstly report the identification of a chemokine, C...

journal_title：Cancer biology & therapy

authors： Zhang Y,Gao J,Wang X,Deng S,Ye H,Guan W,Wu M,Zhu S,Yu Y,Han W

更新日期：2015-01-01 00:00:00

abstract：:Vitamin D derivatives can induce differentiation of human acute myeloid leukemia (AML) cells. Here, we investigated if the G₁ cell cycle block associated with monocytic differentiation is modulated by the p53 status of the cells treated with 1,25D, alone or with plant antioxidants carnosic acid (C) or silibinin (S), a...

journal_title：Cancer biology & therapy

authors： Thompson T,Danilenko M,Vassilev L,Studzinski GP

更新日期：2010-08-15 00:00:00

abstract：:The chemotherapeutic agents doxorubicin (dox) or 5-fluorouracil (5FU) are used to treat cancer cells as they cause irreparable DNA damage, inducing these aberrant cells to undergo cell death. The mediator of this process is presumed to be in part the tumor suppressor p53 which regulates genes involved in DNA repair an...

journal_title：Cancer biology & therapy

authors： Balmer MT,Katz RD,Liao S,Goodwine JS,Gal S

更新日期：2014-08-01 00:00:00

abstract：:KLF4 is induced upon growth-arrest in vitro and during epithelial maturation in vivo, and is essential for proper cell fate specification of post-mitotic cells. In spite of a normal role in post-mitotic cells, expression is upregulated and constitutive in certain tumor types. KLF4 functions as an oncogene in vitro, an...

journal_title：Cancer biology & therapy

authors： Huang CC,Liu Z,Li X,Bailey SK,Nail CD,Foster KW,Frost AR,Ruppert JM,Lobo-Ruppert SM

更新日期：2005-12-01 00:00:00

abstract：:Cell adhesion molecules (CAMs) are glycoproteins expressed on the surface of cell membranes. In normal cells, CAMs participate in a variety of biological processes including cell proliferation, migration and differentiation. In tumor cells, CAMs have been reported to function as oncogenes or tumor suppressors, in sign...

journal_title：Cancer biology & therapy

authors： Yoon KJ,Danks MK

更新日期：2009-02-01 00:00:00

abstract：:The presence of tumor-infiltrating lymphocytes (TILs) in epithelial ovarian cancer indicates a host antitumor response and is associated with improved survival. We wished to determine the extent to which TIL density differs from site to site within a given patient. We initially studied multiple paired metastases from ...

journal_title：Cancer biology & therapy

authors： Hagemann AR,Hagemann IS,Cadungog M,Hwang WT,Patel P,Lal P,Hammond R,Gimotty PA,Chu CS,Rubin SC,Birrer MJ,Powell DJ Jr,Feldman MD,Coukos G

更新日期：2011-08-15 00:00:00

abstract：:The molecular regulation of growth and progression of hormone refractory breast and prostate cancers remains challenging. The Division of Cancer Biology, NCI organized a small "think tank" style workshop and invited scientists in relevant areas to assess the state of science on the biology of hormone refractory tumors...

journal_title：Cancer biology & therapy

authors： Mohla S,Stearns V,Sathyamoorthy N,Rosenfeld MG,Nelson P

更新日期：2009-11-01 00:00:00

abstract：INTRODUCTION:Germ-line mutations of the APC gene are associated with familial adenomatous polyposis, and somatic mutations occur frequently in sporadic colorectal cancer. However, to abrogate APC function, both alleles must be inactivated. Recently, it has been demonstrated that epigenetic modification of the APC promo...

journal_title：Cancer biology & therapy

authors： Arnold CN,Goel A,Niedzwiecki D,Dowell JM,Wasserman L,Compton C,Mayer RJ,Bertagnolli MM,Boland CR

更新日期：2004-10-01 00:00:00

abstract：:Bruton's tyrosine kinase (BTK) is a non-receptor tyrosine kinase that has mainly been studied in haematopoietic cells. We have investigated whether BTK is a potential therapeutic target in prostate cancer. We find that BTK is expressed in prostate cells, with the alternate BTK-C isoform predominantly expressed in pros...

journal_title：Cancer biology & therapy

authors： Kokabee L,Wang X,Sevinsky CJ,Wang WL,Cheu L,Chittur SV,Karimipoor M,Tenniswood M,Conklin DS

更新日期：2015-01-01 00:00:00

abstract：:Mortality data by geographic area and trend-based surveillance are particularly relevant in orienting public health decisions targeting specific populations. We analyzed overall and site-specific cancer mortality between 1988 and 2009 in the metropolitan area of Naples and Caserta in southern Italy. Age-standardized m...

journal_title：Cancer biology & therapy

authors： Crispo A,Barba M,Malvezzi M,Arpino G,Grimaldi M,Rosso T,Esposito E,Sergi D,Ciliberto G,Giordano A,Montella M

更新日期：2013-12-01 00:00:00

abstract：:Breast cancers often have deregulated hepatocyte growth factor (HGF) and c-Met signaling that results in increased tumor growth and invasion. Elucidating the mechanism responsible for HGF/c-Met action in breast cancer progression has been difficult as c-Met communicates with a number of secondary receptors that can le...

journal_title：Cancer biology & therapy

authors： Bonine-Summers AR,Aakre ME,Brown KA,Arteaga CL,Pietenpol JA,Moses HL,Cheng N

更新日期：2007-04-01 00:00:00

abstract：:There is an urgent need to develop new strategies to treat ovarian cancer, the most deadly gynecologic malignancy. Histone deacetylase (HDAC) inhibitors are emerging as novel therapeutic drugs in the treatment of a variety of cancers, including those resistant to standard chemotherapy. Since there are multiple HDAC is...

journal_title：Cancer biology & therapy

authors： Khabele D,Son DS,Parl AK,Goldberg GL,Augenlicht LH,Mariadason JM,Rice VM

更新日期：2007-05-01 00:00:00

abstract：:Adenoid cystic carcinoma (ACC), a rare salivary gland malignancy, is a histogenetic, morphologic, and clinical heterogeneous disease. Extensive efforts have been made to characterize molecular events associated with these tumors, including the identification of prognostic and predictive biomarkers. Increased copy numb...

journal_title：Cancer biology & therapy

authors： Bell D,Ferrarotto R,Fox MD,Roberts D,Hanna EY,Weber RS,El-Naggar AK

更新日期：2015-01-01 00:00:00