Abstract:
:Genes playing a role in carcinogenesis have often been identified through analysis of recurrent chromosomal rearrangements. Although such rearrangements are well known in leukemias, lymphomas, and sarcomas, they have not been well characterized in carcinomas. In the October 28, 2005 issue of Science, a study by Tomlins et al. uses bioinformatics techniques to identify candidate oncogenic chromosomal changes based on analysis of outlier gene expression. The authors determined that two ETS transcription factors, ERG and ETV1 were outliers in prostate cancer. The group reports recurrent fusions of the 5' untranslated region of the TMPRSS2 gene to ERG and ETV1 in the majority of prostate cancer samples containing the outlier expression. In cell lines containing the fusion gene, androgen appears to play a role in mediating ETS overexpression. This fusion gene product may play an important role in the development, diagnosis, and treatment of prostate cancer.
journal_name
Cancer Biol Therjournal_title
Cancer biology & therapyauthors
Ahlers CM,Figg WDdoi
10.4161/cbt.5.3.2603keywords:
subject
Has Abstractpub_date
2006-03-01 00:00:00pages
254-5issue
3eissn
1538-4047issn
1555-8576pii
2603journal_volume
5pub_type
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journal_title:Cancer biology & therapy
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journal_title:Cancer biology & therapy
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更新日期:2018-06-03 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2006-10-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Cancer biology & therapy
pub_type: 杂志文章,评审
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更新日期:2006-09-01 00:00:00
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journal_title:Cancer biology & therapy
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pub_type: 杂志文章,评审
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journal_title:Cancer biology & therapy
pub_type: 杂志文章
doi:10.4161/cbt.6.6.4088
更新日期:2007-06-01 00:00:00
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journal_title:Cancer biology & therapy
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更新日期:2015-01-01 00:00:00
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更新日期:2017-03-04 00:00:00
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journal_title:Cancer biology & therapy
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更新日期:2014-01-01 00:00:00
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journal_title:Cancer biology & therapy
pub_type: 杂志文章
doi:10.4161/cbt.7.10.6586
更新日期:2008-10-01 00:00:00
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journal_title:Cancer biology & therapy
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更新日期:2013-01-01 00:00:00
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journal_title:Cancer biology & therapy
pub_type: 杂志文章,评审
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更新日期:2008-09-01 00:00:00
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journal_title:Cancer biology & therapy
pub_type: 杂志文章
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更新日期:2008-02-01 00:00:00
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journal_title:Cancer biology & therapy
pub_type: 杂志文章
doi:10.4161/cbt.6.12.4971
更新日期:2007-12-01 00:00:00