A homologous promoterless K-ras cDNA targeting endogenous K-ras expression inhibits human pancreatic cancer cell growth in vitro and in vivo.

abstract：:Adenoid cystic carcinoma (ACC), a rare salivary gland malignancy, is a histogenetic, morphologic, and clinical heterogeneous disease. Extensive efforts have been made to characterize molecular events associated with these tumors, including the identification of prognostic and predictive biomarkers. Increased copy numb...

journal_title：Cancer biology & therapy

authors： Bell D,Ferrarotto R,Fox MD,Roberts D,Hanna EY,Weber RS,El-Naggar AK

更新日期：2015-01-01 00:00:00

abstract：:Silibinin, derived from milk thistle extract, has been shown to inhibit growth factor receptor-mediated mitogenic and cell survival signaling, and to alter cell cycle regulators. Alteration in pathways regulating cell growth likely account for silibinin's inhibition of tumor growth. Since the epidermal growth factor r...

journal_title：Cancer biology & therapy

authors： Qi L,Singh RP,Lu Y,Agarwal R,Harrison GS,Franzusoff A,Glode LM

更新日期：2003-09-01 00:00:00

abstract：:Acute promyelocytic leukemia (APL) is one of the most fatal hematological malignancies. APL during pregnancy is a rare comorbidity and can lead to adverse outcomes, such as maternal and/or fetal death, without timely and appropriate management. Medical management for APL during pregnancy remains challenging. We report...

journal_title：Cancer biology & therapy

authors： Li H,Han C,Li K,Li J,Wang Y,Xue F

更新日期：2019-01-01 00:00:00

abstract：:Heterotypic hybrids created between dendritic cells (DC) and tumor cells represent an efficient approach for loading DC with tumor-associated antigens (TAA) and DC-tumor hybrid vaccines have shown promising outcomes in various preclinical and clinical studies. Conventional DC-tumor hybrid preparations, however, are un...

journal_title：Cancer biology & therapy

authors： Matsue H,Matsue K,Edelbaum D,Walters M,Morita A,Takashima A

更新日期：2004-11-01 00:00:00

abstract：:Clear cell RCC is the most common, and more likely to metastasize, of the three main histological types of RCC. Pathologic stage is the most important prognostic indicator and nuclear grade can predict outcome within stages of localized RCC. Epithelial tumors are thought to accumulate a series of genetic and epigeneti...

journal_title：Cancer biology & therapy

authors： Gowrishankar B,Ibragimova I,Zhou Y,Slifker MJ,Devarajan K,Al-Saleem T,Uzzo RG,Cairns P

更新日期：2014-03-01 00:00:00

abstract：:Endostatin can inhibit tumor growth by blocking angiogenesis, whereas tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) may function as a soluble cytokine to selectively kill cancer cells without toxicity to most normal cells. To establish the combined anti-tumor therapeutic effect of endostatin and solu...

journal_title：Cancer biology & therapy

authors： Zhang Y,Qu ZH,Cui M,Guo C,Zhang XM,Ma CH,Sun WS

更新日期：2009-03-01 00:00:00

abstract：:The surprising results published by FIRE-3 revealed that the overall survival (OS) of RAS wild-type metastatic colorectal cancer (mCRC) patients treated with Cetuximab(Cmab) and FOLFIRI combination was prolonged to 33.1 months. The substantial increase in testing and treatment costs, however, impose a considerable hea...

journal_title：Cancer biology & therapy

authors： Wen F,Yang Y,Zhang P,Zhang J,Zhou J,Tang R,Chen H,Zheng H,Fu P,Li Q

更新日期：2015-01-01 00:00:00

abstract：:Antiangiogenic or metronomic chemotherapy, the frequent administration of conventional cytotoxic agents at low doses, is believed to target activated tumor endothelial cells. The mechanisms of action of such regimen remain poorly understood. In the March 2004 issue of Cancer Research, Hamano et al. demonstrated that l...

journal_title：Cancer biology & therapy

authors： Ng SS,Figg WD

更新日期：2004-12-01 00:00:00

abstract：:The therapeutic efficacy of checkpoint inhibitors across numerous tumor types has resulted in approval for neoplasms such as melanoma and lung cancer. Nivolumab is a fully humanized IgG4 antibody that inhibits immune checkpoint between programmed death 1 (PD-1) on T cells and PD-1 ligand 1 (PD-L1) and ligand 2 (PD-L2)...

journal_title：Cancer biology & therapy

authors： Gupta K,Tiu DY,Tiu J,Aragon-Ching JB

更新日期：2016-01-01 00:00:00

abstract：:Tumors with identical phenotype can have markedly different biologic behavior. The differentiation between hemangioblastoma, a benign vascular brain tumor, and renal cell carcinoma (RCC), a malignant tumor that can metastasize to the brain, is a well-known pathological quandary. We report a 59-year-old female with von...

journal_title：Cancer biology & therapy

authors： Gläsker S,Lonser RR,Okamoto H,Li J,Jaffee H,Oldfield EH,Zhuang Z,Vortmeyer AO

更新日期：2007-03-01 00:00:00

abstract：:A 67-year-old male presented with anasarca and persistent non-pruritic rash of lower extremities. Physical examination was positive for subcutaneous edema with a non-blanching rash of abdomen and lower extremities. Labs showed leukocytosis, lymphocytosis, anemia and thrombocytopenia. He also had acute kidney injury an...

journal_title：Cancer biology & therapy

authors： Wahab A,Kesari K,J Smith S,Liu Y,Barta SK

更新日期：2018-02-01 00:00:00

abstract：:To investigate the diagnostic potential of DNA methylation-based markers in tissue samples of DCIS, we examined the prevalence and extent of methylation in breast ductal carcinoma in situ (DCIS) samples from North American and Korean women. Quantitative multiplex-methylation specific PCR (QM-MSP) of ten genes was perf...

journal_title：Cancer biology & therapy

authors： Lee JS,Fackler MJ,Teo WW,Lee JH,Choi C,Park MH,Yoon JH,Zhang Z,Argani P,Sukumar S

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVES:We herein assessed the influence of Epidermal Growth Factor Receptor (EGFR) gene mutations on EGFR expression levels, downstream mediators such as Akt or ERK, and overall survival in patients with ovarian cancer. STUDY DESIGN:EGFR mutation status was analyzed by direct sequencing in 102 Japanese ovarian can...

journal_title：Cancer biology & therapy

authors： Tanaka Y,Terai Y,Tanabe A,Sasaki H,Sekijima T,Fujiwara S,Yamashita Y,Kanemura M,Ueda M,Sugita M,Franklin WA,Ohmichi M

更新日期：2011-01-01 00:00:00

abstract：:We have previously identified tumor susceptibility gene101 (TSG101), overexpressed in vincristine-resistant human gastric adenocarcinoma cell line SGC7901/VCR using a modified subtractive hybridization method and Western blot. In the present study, we constructed two siRNA eukaryotic expression vectors of TSG101 and t...

journal_title：Cancer biology & therapy

authors： Shen H,Pan Y,Han Z,Hong L,Liu N,Han S,Yao L,Xie H,Zhaxi C,Shi Y,Fan D

更新日期：2004-06-01 00:00:00

abstract：:Hypoxia is an important phenomenon in the tumor microenvironment. Hypoxic tumors are more aggressive and resistant to anti-neoplastic treatments. HIF-1alpha plays a major role in the response of tumors to hypoxia, and it is mainly responsible for the "angiogenic switch". HIF-1alpha contributes to tumor aggressiveness,...

journal_title：Cancer biology & therapy

authors： Diaz-Gonzalez JA,Russell J,Rouzaut A,Gil-Bazo I,Montuenga L

更新日期：2005-10-01 00:00:00

abstract：:Background: Associations between polymorphisms in interleukin-10 (IL-10) and hematological oncology were already explored by many genetic association studies, with controversial findings. The aim of this meta-analysis was to more comprehensively analyze associations between polymorphisms in IL-10 and hematological onc...

journal_title：Cancer biology & therapy

authors： Hong P,Feng WY,Fu LH,Jin J,Fu JP

更新日期：2020-04-02 00:00:00

abstract：:Hypoxia is known to play important role in cancer biology.  In sarcomas, hypoxia-induced protein biomarkers such as Hypoxia Inducible Factor-1a (HIF-1a), vascular endothelial growth factor (VEGF), and Erythropoietin (Epo) have been previously reported in only a few studies.  Moreover, the biologic significance and rel...

journal_title：Cancer biology & therapy

authors： Huang JH,Lee FS,Pasha TL,Sammel MD,Karakousis G,Xu G,Fraker D,Zhang PJ

更新日期：2010-02-01 00:00:00

abstract：:Celecoxib exhibits cancer preventive and therapeutic effects in animal models and clinical trials. It presumably acts through selective inhibition of cyclooxygenase-2 (COX-2) and subsequent reduction of prostaglandin (PG) synthesis. However, the concentrations of celecoxib required for growth inhibition and apoptosis ...

journal_title：Cancer biology & therapy

authors： Sun SY,Schroeder CP,Yue P,Lotan D,Hong WK,Lotan R

更新日期：2005-04-01 00:00:00

abstract：:Farnesyltransferase inhibitors (FTIs) have been demonstrated to induce growth arrest or apoptosis independent of Ras mutation. Alternatively, Akt has been proposed as a potential target for the FTI's actions. This study investigated whether Lonafarnib was effective in inhibiting the growth of human nonsmall cell lung ...

journal_title：Cancer biology & therapy

authors： Sun SY,Zhou Z,Wang R,Fu H,Khuri FR

更新日期：2004-11-01 00:00:00

abstract：:Telomerase is the ribonucleoprotein that enables cancer and stem cells to maintain their telomeres, resulting in unlimited proliferative potential. The catalytic component of telomerase in humans, hTERT, is upregulated in nearly 90% of all cancers, making it the most widely expressed marker of malignancy. With the exc...

journal_title：Cancer biology & therapy

authors： Nguyen B,Elmore LW,Holt SE

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND INFORMATION:Previous studies have revealed that leptin may be involved in epithelial-mesenchymal transition (EMT), a crucial initiator of cancer progression to facilitate metastatic cascade, increase tumor recurrence, and ultimately cause poor prognosis. However, the underlying mechanism remains unclear. The...

journal_title：Cancer biology & therapy

authors： Wang L,Tang C,Cao H,Li K,Pang X,Zhong L,Dang W,Tang H,Huang Y,Wei L,Su M,Chen T

更新日期：2015-01-01 00:00:00

abstract：:Cancer-testis antigens (CTAs) are often specifically expressed in cancer cells and under normal conditions are only considered to be expressed in the germ line cells and the placenta. CTAs are potential targets for cancer immunotherapy and therefore necessitates their expression profiling. The expression profile of LA...

journal_title：Cancer biology & therapy

authors： Forghanifard MM,Gholamin M,Farshchian M,Moaven O,Memar B,Forghani MN,Dadkhah E,Naseh H,Moghbeli M,Raeisossadati R,Abbaszadegan MR

更新日期：2011-08-01 00:00:00

abstract：:Medulloblastoma is an aggressive primitive neuroectodermal tumor of the cerebellum that is rare in adults. Medulloblastomas fall into 4 prognostically significant molecular subgroups that are best defined by experimental gene expression profiles: the WNT pathway, sonic hedgehog (SHH) pathway, and subgroups 3 and 4 (no...

journal_title：Cancer biology & therapy

authors： Lou E,Schomaker M,Wilson JD,Ahrens M,Dolan M,Nelson AC

更新日期：2016-10-02 00:00:00

abstract：:Patients with Fanconi anemia (FA) display a wide variety of defects including bone marrow failure and a high risk of developing cancer. Multiple Fanconi genes exist whose proteins form a complex that along with BRCA1 is important for the translocalization of FANCD2 to nuclear foci. With BRCA2 and RAD51, this complex i...

journal_title：Cancer biology & therapy

authors： Rogers CD,van der Heijden MS,Brune K,Yeo CJ,Hruban RH,Kern SE,Goggins M

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:Peripheral primitive neuroectodermal tumor isolated in the heart, presenting as a primary cardiac tumor is considered as extremely rare. METHODS:We present a 53-year-old Chinese female with a cardiac tumor which was discovered by CT. RESULTS:A hypo-intense tumorous mass was shown extending from the left ve...

journal_title：Cancer biology & therapy

authors： Fan C,Kong D,Tan C,Yang J

更新日期：2017-01-02 00:00:00

abstract：:In leukemias, the monitoring techniques on the response after the treatment have clinical importance for evaluating new therapeutic approaches and identifying the risk of relapse. In this study, genetic changes before and after chemotherapy in interphase and metaphase nuclei of bone morrow of adults with provisional d...

journal_title：Cancer biology & therapy

authors： Yakut T,Ali R,Egeli U,Ozkalemkas F,Ercan I,Ozçelik T,Ozkocaman V,Yigit B,Tunali A

更新日期：2004-09-01 00:00:00

abstract：:Multidrug resistance (MDR) is an important cause of treatment failure in acute lymphoblastic leukemia (ALL). The ABC family of membrane transporters is proposed, albeit with controversy, to be involved in this process. The present study aims to investigate the mRNA expression profile of several genes of this family, i...

journal_title：Cancer biology & therapy

authors： Rahgozar S,Moafi A,Abedi M,Entezar-E-Ghaem M,Moshtaghian J,Ghaedi K,Esmaeili A,Montazeri F

更新日期：2014-01-01 00:00:00

abstract：:Chewing tobacco is a common practice in certain socio-economic sections of southern Asia, particularly in the Indian subcontinent and has been well associated with head and neck squamous cell carcinoma. The molecular mechanisms of chewing tobacco which leads to malignancy remains unclear. In large majority of studies,...

journal_title：Cancer biology & therapy

authors： Nanjappa V,Renuse S,Sathe GJ,Raja R,Syed N,Radhakrishnan A,Subbannayya T,Patil A,Marimuthu A,Sahasrabuddhe NA,Guerrero-Preston R,Somani BL,Nair B,Kundu GC,Prasad TK,Califano JA,Gowda H,Sidransky D,Pandey A,Chatterje

更新日期：2015-01-01 00:00:00

abstract：:Chemotherapy in prostate cancer (CaP) even as an adjunct has not been a success. In this communication, we report the pre-clinical efficacy of a nitroacridine derivative, C-1748 (9[2'-hydroxyethylamino]-4-methyl-1-nitroacridine) in CaP cell culture and human xenograft animal models. C-1748, a DNA intercalating agent h...

journal_title：Cancer biology & therapy

authors： Tadi K,Ashok BT,Chen Y,Banerjee D,Wysocka-Skrzela B,Konopa J,Darzynkiewicz Z,Tiwari RK

更新日期：2007-10-01 00:00:00

abstract：:The cancer stem cell hypothesis suggests that rare populations of tumor-initiating cells may be resistant to therapy, lead to tumor relapse and contribute to poor prognosis for cancer patients. We previously demonstrated the feasibility of p53 pathway restoration in p53-deficient tumor cell populations using small mol...

journal_title：Cancer biology & therapy

authors： Huang C,Zhang XM,Tavaluc RT,Hart LS,Dicker DT,Wang W,El-Deiry WS

更新日期：2009-11-01 00:00:00