Interferon-alpha induces TRAIL expression and cell death via an IRF-1-dependent mechanism in human bladder cancer cells.


:Apoptosis induced by interferon-alpha (IFNalpha) is associated with induction of TRAIL in a number of different cell types. Here we examined whether or not TRAIL was required for apoptosis in a model human bladder cancer cell line (UM-UC-12) and defined the molecular mechanisms involved in IFNalpha-induced TRAIL expression. Exposure to IFNalpha resulted in concentration-dependent induction of TRAIL and apoptosis. Inhibition of TRAIL or downstream components of the TRAIL cell death pathway (FADD, caspase-8) via siRNA-mediated knockdown attenuated IFNalpha-induced cell death, thereby implicating TRAIL in the response. IFNalpha induced rapid STAT-1 phosphorylation and DNA binding activity and subsequent accumulation of IRF-1. Transfection with siRNAs directed against STAT-1 or IRF-1 inhibited IFNalpha-induced TRAIL production and cell death, and chromatin immunprecipitation (ChIP) analyses demonstrated that IFNalpha induced direct, time-dependent binding of both transcription factors to the TRAIL promoter. Together, our results demonstrate that IFNalpha induces TRAIL expression via a STAT-1/IRF-1-dependent mechanism in human bladder cancer cells, and this induction of TRAIL plays an important role in IFNalpha-induced cell killing.


Cancer Biol Ther


Cancer biology & therapy


Papageorgiou A,Dinney CP,McConkey DJ




Has Abstract


2007-06-01 00:00:00














  • Signaling pathways in adenoid cystic cancers: implications for treatment.

    abstract::Adenoid cystic cancers (ACC) in the head and neck are rare yet present a clinical dilemma. Although 5-y survivals are excellent, they have a propensity for late recurrences. Most of these cancers are initially treated with surgery followed by radiation. When recurrences happen, treatment options are limited both by th...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Gupta AK,Wilke WW,Taylor EN,Bodeker KL,Hoffman HT,Milhem MM,Buatti JM,Robinson RA

    更新日期:2009-10-01 00:00:00

  • Pre-clinical evaluation of 1-nitroacridine derived chemotherapeutic agent that has preferential cytotoxic activity towards prostate cancer.

    abstract::Chemotherapy in prostate cancer (CaP) even as an adjunct has not been a success. In this communication, we report the pre-clinical efficacy of a nitroacridine derivative, C-1748 (9[2'-hydroxyethylamino]-4-methyl-1-nitroacridine) in CaP cell culture and human xenograft animal models. C-1748, a DNA intercalating agent h...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Tadi K,Ashok BT,Chen Y,Banerjee D,Wysocka-Skrzela B,Konopa J,Darzynkiewicz Z,Tiwari RK

    更新日期:2007-10-01 00:00:00

  • Epigenetic changes activate widespread signals in response to double-strand breaks.

    abstract::Double-strand breaks are one the most severe types of DNA damage with respect to cell survival and the preservation of genomic integrity. Therefore, cells have evolved complex mechanisms including cell cycle regulation, activation of repair pathways and in certain cases induction of apoptosis in response to these lesi...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章,评审


    authors: Karagiannis TC,El-Osta A

    更新日期:2004-07-01 00:00:00

  • HPV epigenetic mechanisms related to Oropharyngeal and Cervix cancers.

    abstract::Human Papilloma Virus infection is very frequent in humans and is mainly transmitted sexually. The majority of infections are transient and asymptomatic, however, if the infection persists, it can occur with a variety of injuries to skin and mucous membranes, depending on the type of HPV involved. Some types of HPV ar...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章,评审


    authors: Di Domenico M,Giovane G,Kouidhi S,Iorio R,Romano M,De Francesco F,Feola A,Siciliano C,Califano L,Giordano A

    更新日期:2018-01-01 00:00:00

  • Chk1 and DNA-PK mediate TPEN-induced DNA damage in a ROS dependent manner in human colon cancer cells.

    abstract::Recently, we showed that the metal chelator TPEN targets colon cancer cells through redox cycling of copper. Here, we studied the DNA damage potential of TPEN and deciphered the role of Chk1, ATM and DNA-PK in TPEN-induced toxicity in 3 human colon cancer cell lines, HCT116, SW480 and HT29. We also investigated the ro...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Rahal ON,Fatfat M,Hankache C,Osman B,Khalife H,Machaca K,Muhtasib HG

    更新日期:2016-11-01 00:00:00

  • Novel surface targets and serum biomarkers from the ovarian cancer vasculature.

    abstract::The molecular phenotype of tumor vasculature is different from normal vasculature, offering new opportunities for diagnosis and therapy of cancer, but the identification of tumor-restricted targets remains a challenge. We investigated 13 tumor vascular markers (TVMs) from 50 candidates identified through expression pr...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Sasaroli D,Gimotty PA,Pathak HB,Hammond R,Kougioumtzidou E,Katsaros D,Buckanovich R,Devarajan K,Sandaltzopoulos R,Godwin AK,Scholler N,Coukos G

    更新日期:2011-08-01 00:00:00

  • Effects of Streptococcus thermophilus TH-4 on intestinal mucositis induced by the chemotherapeutic agent, 5-Fluorouracil (5-FU).

    abstract::Beneficial bacteria (probiotics) and probiotic-derived factors have the potential to ameliorate disorders of the intestine. The aim of this study was to compare live Streptococcus thermophilus TH-4 (TH-4), dead TH-4 and TH-4 supernatant in rats treated with 5-Fluorouracil. Rats were randomly allocated to five treatmen...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Whitford EJ,Cummins AG,Butler RN,Prisciandaro LD,Fauser JK,Yazbeck R,Lawrence A,Cheah KY,Wright TH,Lymn KA,Howarth GS

    更新日期:2009-03-15 00:00:00

  • Hypoxia induced CCR7 expression via HIF-1alpha and HIF-2alpha correlates with migration and invasion in lung cancer cells.

    abstract::Hypoxia, a common phenomenon in human solid tumors, is associated with invasion and metastasis in various tumors. Hypoxia inducible factors (HIFs) are key molecules in the hypoxic response, and regulate the activation of specific genes, which mediate many of the adaptations to hypoxia. CC chemokine receptor 7 (CCR7) h...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Li Y,Qiu X,Zhang S,Zhang Q,Wang E

    更新日期:2009-02-01 00:00:00

  • Therapeutic effect of arsenic trioxide (As2O3) on cervical cancer in vitro and in vivo through apoptosis induction.

    abstract::Arsenic trioxide (As2O3) induces apoptosis in certain types of cancer cells. But the detailed mechanisms of As2O3 efficacy are not completely known. Here we demonstrate that As2O3 has a therapeutic effect on cervical cancer in vitro and in vivo. We investigated the As2O3-induced apoptosis in various cervical cancer ce...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Yu J,Qian H,Li Y,Wang Y,Zhang X,Liang X,Fu M,Lin C

    更新日期:2007-04-01 00:00:00

  • Inhibition of RNA-dependent protein kinase (PKR) leads to cancer cell death and increases chemosensitivity.

    abstract::RNA-dependent protein kinase is an interferon-induced, double-stranded (ds), RNA-activated serine/threonine protein kinase involved in the eukaryotic response to viral infection. While PKR also functions in cellular differentiation, growth control and apoptosis, its role in human cancer remains poorly understood. To e...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Pataer A,Swisher SG,Roth JA,Logothetis CJ,Corn PG

    更新日期:2009-02-01 00:00:00

  • Furanodiene induces G2/M cell cycle arrest and apoptosis through MAPK signaling and mitochondria-caspase pathway in human hepatocellular carcinoma cells.

    abstract::Furanodiene (C15H20O), a pure compound isolated from Traditional Chinese medicine, Curcuma wenyujin, named Ezhu in Chinese, which structure was determined on the basis of NMR, MS and UV spectrum. In this study, we attempted to characterize in detail the signaling cascades resulted from furanodiene-induced apoptosis in...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Xiao Y,Yang FQ,Li SP,Gao JL,Hu G,Lao SC,Conceição EL,Fung KP,Wangl YT,Lee SM

    更新日期:2007-07-01 00:00:00

  • Production of IL-1β by bone marrow-derived macrophages in response to chemotherapeutic drugs: synergistic effects of doxorubicin and vincristine.

    abstract::Cytotoxic chemotherapeutic drugs, especially when used in combination, are widely employed to treat a variety of cancers in patients but often lead to serious symptoms that negatively affect physical functioning and quality of life. There is compelling evidence that implicates cytotoxic chemotherapy-induced inflammati...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Wong J,Tran LT,Magun EA,Magun BE,Wood LJ

    更新日期:2014-10-01 00:00:00

  • CXCL4 mediates tumor regrowth after chemotherapy by suppression of antitumor immunity.

    abstract::The recurrence of colorectal cancer after chemotherapy is the leading cause of its high mortality. We propose that elucidating the mechanisms of tumor regrowth after chemotherapy in tumor-bearing mice may provide new insights into tumor relapse in cancer patients. We firstly report the identification of a chemokine, C...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Zhang Y,Gao J,Wang X,Deng S,Ye H,Guan W,Wu M,Zhu S,Yu Y,Han W

    更新日期:2015-01-01 00:00:00

  • Increased gene copy number of the transcription factor E2F1 in malignant melanoma.

    abstract::Translocations and unique chromosome break points in melanoma will aid in the identification of the genes that are important in the neoplastic process. We have previously shown a unique translocation in malignant melanoma cells der(12)t(12;20). The transcription factor E2F1 maps to 20q11. Increased expression of E2F h...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Nelson MA,Reynolds SH,Rao UN,Goulet AC,Feng Y,Beas A,Honchak B,Averill J,Lowry DT,Senft JR,Jefferson AM,Johnson RC,Sargent LM

    更新日期:2006-04-01 00:00:00

  • Long noncoding RNA MEG3 is downregulated in cervical cancer and affects cell proliferation and apoptosis by regulating miR-21.

    abstract::Recent research has found that long noncoding RNAs (lncRNAs) were involved in various human cancers. However, the role of these lncRNAs in cervical cancer remains unexplored. Therefore, we aimed to investigate the biological function of maternally expressed gene 3 (MEG3), a cancer-related lncRNA, and its underlying me...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Zhang J,Yao T,Wang Y,Yu J,Liu Y,Lin Z

    更新日期:2016-01-01 00:00:00

  • Studies on the inhibition of feline EGFR in squamous cell carcinoma: enhancement of radiosensitivity and rescue of resistance to small molecule inhibitors.

    abstract::This study investigated different methods of EGFR (Epithelial Growth Factor Receptor) targeting in feline squamous cell carcinoma with the ultimate aim of establishing a large animal model of human head and neck cancer. Both small molecule receptor tyrosine kinase inhibitor (TKI) and RNA interference (RNAi) techniques...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Bergkvist GT,Argyle DJ,Pang LY,Muirhead R,Yool DA

    更新日期:2011-06-01 00:00:00

  • Combined endostatin and TRAIL gene transfer suppresses human hepatocellular carcinoma growth and angiogenesis in nude mice.

    abstract::Endostatin can inhibit tumor growth by blocking angiogenesis, whereas tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) may function as a soluble cytokine to selectively kill cancer cells without toxicity to most normal cells. To establish the combined anti-tumor therapeutic effect of endostatin and solu...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Zhang Y,Qu ZH,Cui M,Guo C,Zhang XM,Ma CH,Sun WS

    更新日期:2009-03-01 00:00:00

  • BRAF V600E mutation in metastatic colorectal cancer: Methods of detection and correlation with clinical and pathologic features.

    abstract::The screening for BRAF V600E mutation is employed in clinical practice for its prognostic and potentially predictive role in patients with metastatic colorectal carcinoma (mCRC). Little information is available on the sensitivity and specificity of the testing methods to detect this mutation in CRC. By using serial di...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Roma C,Rachiglio AM,Pasquale R,Fenizia F,Iannaccone A,Tatangelo F,Antinolfi G,Parrella P,Graziano P,Sabatino L,Colantuoni V,Botti G,Maiello E,Normanno N

    更新日期:2016-08-02 00:00:00

  • Multiplying therapies and reducing toxicity in metastatic melanoma.

    abstract::Prior to 2011, only 2 systemic treatments were approved for the treatment of melanoma and these had limited efficacy. In the past 4 years, 6 novel agents have received FDA approval. Herein, we will focus on 4 recently published NEJM papers reporting the results of clinical trials, comprising 4 agents targeting the MAP...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Massey PR,Prasad V,Figg WD,Fojo T

    更新日期:2015-01-01 00:00:00

  • Atorvastatin induces autophagy in prostate cancer PC3 cells through activation of LC3 transcription.

    abstract::Our previous studies have demonstrated that atorvastatin induces autophagy in the androgen receptor negative prostate cancer PC3 cells through inhibition of geranylgeranyl biosynthesis [Parikh et al., Prostate. 70(9): 971-981 (2010)]. This study attempts to elucidate the molecular mechanism underlying atorvastatin-ind...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Toepfer N,Childress C,Parikh A,Rukstalis D,Yang W

    更新日期:2011-10-15 00:00:00

  • The small GTPase ADP-Ribosylation Factor 1 mediates the sensitivity of triple negative breast cancer cells to EGFR tyrosine kinase inhibitors.

    abstract::The clinical use of EGFR-targeted therapy, in triple negative breast cancer patients, has been limited by the development of resistance to these drugs. Although activated signaling molecules contribute to this process, the molecular mechanisms remain relatively unknown. We have previously reported that the small GTPas...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Haines E,Schlienger S,Claing A

    更新日期:2015-01-01 00:00:00

  • Negative regulation of the oncogenic transcription factor FoxM1 by thiazolidinediones and mithramycin.

    abstract::The Forkhead Box transcription factor FoxM1 regulates expression of genes that promote cell cycle progression, and it plays essential roles in the development of liver, lung, prostate and colorectal tumors. Thiazolidinediones (TZDs) activate the peroxisome proliferator-activated receptor gamma (PPARγ), a ligand-activa...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Petrovic V,Costa RH,Lau LF,Raychaudhuri P,Tyner AL

    更新日期:2010-06-15 00:00:00

  • Chimeric cytokine receptor enhancing PSMA-CAR-T cell-mediated prostate cancer regression.

    abstract::Objective: Chimeric antigen receptor T (CAR-T) cell therapy has demonstrated an unprecedented therapeutic efficacy in hematological malignancies; however, its effectiveness in solid tumors remains elusive. In order to enable CAR-T cells more effective to solid tumors, a inverted chimeric cytokine receptor (ICR) was de...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Weimin S,Abula A,Qianghong D,Wenguang W

    更新日期:2020-06-02 00:00:00

  • Targeting of two aspects of metabolism in breast cancer treatment.

    abstract::Deregulated metabolism is gaining recognition as a hallmark of cancer cells, and is being explored for therapeutic potential. The Warburg effect is a metabolic phenotype that occurs in 90% of tumors, where glycolysis is favored despite the presence of oxygen. Dichloroacetate (DCA) is a pyruvate dehydrogenase kinase (P...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Gang BP,Dilda PJ,Hogg PJ,Blackburn AC

    更新日期:2014-01-01 00:00:00

  • Detection of apoptotic circulating tumor cells in advanced pancreatic cancer following 5-fluorouracil chemotherapy.

    abstract::The objective of the present study was to evaluate CA19-9 and CK8/18 expression patterns in pancreatic cancer cell lines induced by 5-fluorouracil (5-Fu), and in circulating tumor cells (CTCs) in peripheral blood of patients previously untreated with advanced pancreatic cancer. Furthermore, the goal was to test the re...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Ren C,Han C,Zhang J,He P,Wang D,Wang B,Zhao P,Zhao X

    更新日期:2011-10-15 00:00:00

  • Binding and inhibition of drug transport proteins by heparin: a potential drug transporter modulator capable of reducing multidrug resistance in human cancer cells.

    abstract::A major problem in cancer treatment is the development of resistance to chemotherapeutic agents, multidrug resistance (MDR), associated with increased activity of transmembrane drug transporter proteins which impair cytotoxic treatment by rapidly removing the drugs from the targeted cells. Previously, it has been show...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Chen Y,Scully M,Petralia G,Kakkar A

    更新日期:2014-01-01 00:00:00

  • The combination of 5-fluorouracil plus p53 pathway restoration is associated with depletion of p53-deficient or mutant p53-expressing putative colon cancer stem cells.

    abstract::The cancer stem cell hypothesis suggests that rare populations of tumor-initiating cells may be resistant to therapy, lead to tumor relapse and contribute to poor prognosis for cancer patients. We previously demonstrated the feasibility of p53 pathway restoration in p53-deficient tumor cell populations using small mol...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Huang C,Zhang XM,Tavaluc RT,Hart LS,Dicker DT,Wang W,El-Deiry WS

    更新日期:2009-11-01 00:00:00

  • Remarkable enhancement of cytotoxicity of onconase and cepharanthine when used in combination on various tumor cell lines.

    abstract::Onconase (Onc), a ribonuclease from oocytes or early embryos of Northern Leopard frog (Rana pipiens), is cytostatic and cytotoxic to a variety of tumor lines in vitro, inhibits growth of tumors in animal in vivo models and is currently in Phase IIIb clinical trials for malignant mesothelioma where it displays antitumo...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Ita M,Halicka HD,Tanaka T,Kurose A,Ardelt B,Shogen K,Darzynkiewicz Z

    更新日期:2008-07-01 00:00:00

  • TMPRSS4 correlates with colorectal cancer pathological stage and regulates cell proliferation and self-renewal ability.

    abstract::Transmembrane protease/serine 4 (TMPRSS4) is a member of the type II transmembrane serine protease (TTSP) family and it was found highly expressed in several cancers. This study aims to evaluate the expression of TMPRSS4 in colorectal cancer (CRC) and investigate its role in proliferation and self-renewal of colon can...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Huang A,Zhou H,Zhao H,Quan Y,Feng B,Zheng M

    更新日期:2014-03-01 00:00:00

  • Proteomic profiling: a novel method for differential diagnosis?

    abstract::Tumors with identical phenotype can have markedly different biologic behavior. The differentiation between hemangioblastoma, a benign vascular brain tumor, and renal cell carcinoma (RCC), a malignant tumor that can metastasize to the brain, is a well-known pathological quandary. We report a 59-year-old female with von...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Gläsker S,Lonser RR,Okamoto H,Li J,Jaffee H,Oldfield EH,Zhuang Z,Vortmeyer AO

    更新日期:2007-03-01 00:00:00