Abstract:
:Hepatocellular carcinoma (HCC) is a major health problem worldwide, involving more than 620,000 new cases yearly, with chronic HBV and HCV infection being the most common causes. Because most patients are diagnosed in an advanced state which is usually not amenable to curative therapy, prevention should be the main focus for reducing the HCC incidence and its related morbidity and mortality. Strategies of HCC prevention can focus on each single risk factor, with antiviral therapy against chronic hepatitis B and hepatitis C as well as suppression of the progression of common liver diseases being the most important and effective measures. Bicyclol, a drug that can improve liver function and inhibit HBV replication, may be a useful agent for the chemopreventive of HCC, as indicated by a recent study by Zhu et al. Bicyclol can act on the initiation and promotion stages of hepatocarcinogenesis by preventing malignant transformation of hepatic cells. It may also enhance the liver's capacity of detoxification and inhibit DNA mutations. More clinical studies are needed to further demonstrate the efficacy and molecular mechanisms of this agent on HCC chemoprevention.
journal_name
Cancer Biol Therjournal_title
Cancer biology & therapyauthors
Liu Q,Song Y,Zhou Y,Qiao Ldoi
10.4161/cbt.5.12.3737subject
Has Abstractpub_date
2006-12-01 00:00:00pages
1674-6issue
12eissn
1538-4047issn
1555-8576journal_volume
5pub_type
评论,杂志文章abstract::Imatinib, an ABL tyrosine kinase inhibitor (TKI), has shown clinical efficacy against chronic myeloid leukemia (CML). However, a substantial number of patients develop resistance to imatinib treatment due to the emergence of clones carrying mutations in the protein BCR-ABL. The phosphoinositide 3 kinase (PI3K)/Akt/mam...
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pub_type: 杂志文章,多中心研究
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journal_title:Cancer biology & therapy
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journal_title:Cancer biology & therapy
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更新日期:2006-06-01 00:00:00
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journal_title:Cancer biology & therapy
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doi:10.4161/cbt.9.6.10894
更新日期:2010-03-15 00:00:00
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