Growth inhibitory effects of gastric cancer cells with an increase in S phase and alkaline phosphatase activity repression by aloe-emodin.

Abstract:

:Aloe-emodin is a novel active compound found in the root and rhizome of Rheum palmatum. To investigate the effects and mechanisms of aloe-emodin on human gastric cancer, MGC-803 cells were treated with 2.5, 5, 10, 20 and 40 microM aloe-emodin for 1-5 d. The results showed that aloe-emodin inhibited the growth of cancer cells in a dose-dependent manner with an increase in S phase and in the proportion of cells cycling at a higher ploidy level (>G2/M). Moreover, the alkaline phosphatase (ALP) activity, an indicator of cell differentiation, was found decreased. This is one of the first to focus on the effect of ALP activity in human gastric carcinomas cells treated by aloe-emodin. These results indicate that aloe-emodin has a potential value for the treatment of gastric cancer and its mechanisms are by means of cell cycle interruption and induce differentiation.

journal_name

Cancer Biol Ther

journal_title

Cancer biology & therapy

authors

Guo J,Xiao B,Zhang S,Liu D,Liao Y,Sun Q

doi

10.4161/cbt.6.1.3553

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

85-8

issue

1

eissn

1538-4047

issn

1555-8576

pii

3553

journal_volume

6

pub_type

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