Long noncoding RNA MEG3 is downregulated in cervical cancer and affects cell proliferation and apoptosis by regulating miR-21.

abstract：:Although most researchers in biology tend to focus on very specific issues and questions about their preferred gene or pathway, sometimes we face situations in which nature presents us with a remarkable example of a gene with multiple functions. Since the discovery of the early growth response 1 (EGR1) gene in the mid...

journal_title：Cancer biology & therapy

authors： DeLigio JT,Zorio DA

更新日期：2009-10-01 00:00:00

abstract：:We investigated the role of vasculogenic mimicry (VM) in the progression of prostate cancer (PCa). Ninety-six patients who had undergone prostatectomy for treatment of PCa and for whom a complete record of clinical and follow-up data were available were reviewed. VM and matrix metalloproteinase-2 (MMP-2) were detected...

journal_title：Cancer biology & therapy

authors： Liu R,Yang K,Meng C,Zhang Z,Xu Y

更新日期：2012-05-01 00:00:00

abstract：:Apoptosis induced by interferon-alpha (IFNalpha) is associated with induction of TRAIL in a number of different cell types. Here we examined whether or not TRAIL was required for apoptosis in a model human bladder cancer cell line (UM-UC-12) and defined the molecular mechanisms involved in IFNalpha-induced TRAIL expre...

journal_title：Cancer biology & therapy

authors： Papageorgiou A,Dinney CP,McConkey DJ

更新日期：2007-06-01 00:00:00

abstract：:E2F-1, a key transcription factor necessary for cell growth, DNA repair, and differentiation, is an attractive target for development of anticancer drugs in tumors that are E2F "oncogene addicted". We identified a peptide isolated from phage clones that bound tightly to the E2F-1 promoter consensus sequence. The pepti...

journal_title：Cancer biology & therapy

authors： Xie X,Kerrigan JE,Minko T,Garbuzenko O,Lee KC,Scarborough A,Abali EE,Budak-Alpdogan T,Johnson-Farley N,Banerjee D,Scotto KW,Bertino JR

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVE:EphA2 overexpression predicts poor prognosis in endometrial cancer. To explore mechanisms for this association and assess its potential as therapeutic target, the relationship of EphA2 expression to markers of angiogenesis was examined using patient samples and an orthotopic mouse model of uterine cancer. EX...

journal_title：Cancer biology & therapy

authors： Merritt WM,Kamat AA,Hwang JY,Bottsford-Miller J,Lu C,Lin YG,Coffey D,Spannuth WA,Nugent E,Han LY,Landen CN,Nick AM,Stone RL,Coffman K,Bruckheimer E,Broaddus RR,Gershenson DM,Coleman RL,Sood AK

更新日期：2010-12-15 00:00:00

abstract：:We previously reported that the mutant virus of HSV (mtHSV) mediated tumor therapy was efficacious in Balb/c and nude mice. However, it is significant to know whether mtHSV works in HSV-1 tumor seropositive individuals because many patients with HSV-1 seropositivity have been found in clinical trial. Here we asked whe...

journal_title：Cancer biology & therapy

authors： Zhu H,Su Y,Zhou S,Xiao W,Ling W,Hu B,Liu Y,Qi Y

更新日期：2007-05-01 00:00:00

abstract：:A major problem in cancer treatment is the development of resistance to chemotherapeutic agents, multidrug resistance (MDR), associated with increased activity of transmembrane drug transporter proteins which impair cytotoxic treatment by rapidly removing the drugs from the targeted cells. Previously, it has been show...

journal_title：Cancer biology & therapy

authors： Chen Y,Scully M,Petralia G,Kakkar A

更新日期：2014-01-01 00:00:00

abstract：:The mitochondrial production of reactive oxygen species has been implicated in the anticancer activity of furanonaphthoquinone. However, the mechanism of the activation remains elusive. In the current study, we found that treatment of HeLa cells with 2-methyl-5(or -8)-hydroxy-furanonaphthoquinone (FNQ13) induces mitoc...

journal_title：Cancer biology & therapy

authors： Simamura E,Hirai K,Shimada H,Koyama J,Niwa Y,Shimizu S

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Mutations that activate the PI3K/AKT/mTOR pathway are relatively common in urothelial (bladder) cancers, but how these pathway mutations affect AKT dependency is not known. We characterized the relationship between AKT pathway mutational status and sensitivity to the effects of the selective AKT kinase inhib...

journal_title：Cancer biology & therapy

authors： Dickstein RJ,Nitti G,Dinney CP,Davies BR,Kamat AM,McConkey DJ

更新日期：2012-11-01 00:00:00

abstract：:IL-15 has been actively investigated for its potential in tumor immunotherapy. To enhance the anti-tumor activity of IL-15, the novel PFC-1 construct was designed, which comprises the following 3 parts: (1) IL-15Rα fused with IL-15 to enhance IL-15 activity, (2) an Fc fragment to increase protein half-life, and (3) an...

journal_title：Cancer biology & therapy

authors： Chen S,Huang Q,Liu J,Xing J,Zhang N,Liu Y,Wang Z,Li Q

更新日期：2015-01-01 00:00:00

abstract：:Farnesyltransferase inhibitors (FTIs) have been demonstrated to induce growth arrest or apoptosis independent of Ras mutation. Alternatively, Akt has been proposed as a potential target for the FTI's actions. This study investigated whether Lonafarnib was effective in inhibiting the growth of human nonsmall cell lung ...

journal_title：Cancer biology & therapy

authors： Sun SY,Zhou Z,Wang R,Fu H,Khuri FR

更新日期：2004-11-01 00:00:00

abstract：:Although targeted therapy directed toward driver mutations has produced a significant efficacy benefit for patients with non-small cell lung cancer (NSCLC), many patients do not possess mutations associated with the approved targeted drugs. Angiogenic agents play an important role in the therapeutic strategy for advan...

journal_title：Cancer biology & therapy

authors： Wu F,Zhang S,Gao G,Zhao J,Ren S,Zhou C

更新日期：2018-03-04 00:00:00

abstract：:A greater understanding of the molecular basis of breast cancer metastasis will lead to identification of novel therapeutic targets and better treatments. Rap1B is a small GTPase that suppresses the metastasis of breast cancer cells by increasing cell-cell adhesion. In breast cancer, a decrease in Rap1B prenylation an...

journal_title：Cancer biology & therapy

authors： Wilson JM,Lorimer E,Tyburski MD,Williams CL

更新日期：2015-01-01 00:00:00

abstract：:Objective: To investigate the clinicopathologic features and immunophenotype of invasive-stratified mucin-producing carcinoma (ISMC). Methods: We retrospectively analyzed three patients who underwent surgery for pathologically confirmed ISMC from January 2017 to December 2017 in Anyang Tumor Hospital. The pathological...

journal_title：Cancer biology & therapy

authors： Lei R

更新日期：2019-01-01 00:00:00

abstract：:Recent reports have shown that cancer stem cells exist in many malignancies. Side population (SP) cells are used to enrich cancer stem-like cells in many cell lines and fresh tumor specimens. In this study, we cultured primary esophageal squamous cell carcinoma (ESCC) cells from ESCC tissue specimens. SP cells from pr...

journal_title：Cancer biology & therapy

authors： Li H,Gao Q,Guo L,Lu SH

更新日期：2011-06-01 00:00:00

abstract：:It has become a cliché that cancer therapy fails because it does not target rare cancer stem cells (CSCs). Here we are discuss that this is not how therapy fails and not any cancer cell with stem-like properties is CSC. Paradoxically, CSCs must be resting to explain their resistance to therapy yet must be cycling to e...

journal_title：Cancer biology & therapy

authors： Blagosklonny MV

更新日期：2007-11-01 00:00:00

abstract：:The impact of environmental mutagens and carcinogens on the mammary gland has recently received a lot of attention. Among the most generally accepted carcinogenic agents identified as factors that may increase breast cancer incidence are ionizing radiation and elevated estrogen levels. However, the molecular mechanism...

journal_title：Cancer biology & therapy

authors： Kutanzi K,Kovalchuk O

更新日期：2013-07-01 00:00:00

abstract：:The small GTPase Rac1 regulates many cellular processes, including cytoskeletal reorganization, cell migration, proliferation, and survival. Additionally, Rac1 plays a major role in activating NF-κB-mediated transcription. Both Rac1 and NF-κB regulate many properties of the malignant phenotype, including anchorage-ind...

journal_title：Cancer biology & therapy

authors： Gastonguay A,Berg T,Hauser AD,Schuld N,Lorimer E,Williams CL

更新日期：2012-06-01 00:00:00

abstract：:Poor oxygenation is a unique and prevalent feature of solid tumors associated with poor patient prognosis. In part, this is caused by a series of adaptive cellular responses that together have a large impact on gene expression and cell phenotype. HIF plays a key role in this response by activating a transcriptional pr...

journal_title：Cancer biology & therapy

authors： van den Beucken T,Koritzinsky M,Wouters BG

更新日期：2006-07-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is a critical early event in tumorigenesis. The contribution of heparan sulfate (HS) to EMT has not been fully elucidated. HS D-glucosaminyl 3-O-sulfotransferase-3B1 (3-OST-3B1) participates in the final step of HS fine structure biosynthesis, whose involvement in cancer has yet...

journal_title：Cancer biology & therapy

authors： Song K,Li Q,Jiang ZZ,Guo CW,Li P

更新日期：2011-09-01 00:00:00

abstract：:The pediatric solid tumor neuroblastoma (NB) often depends on the anti-apoptotic protein, Mcl(-)1, for survival through Mcl(-)1 sequestration of pro-apoptotic Bim. High affinity Mcl(-)1 inhibitors currently do not exist such that novel methods to inhibit Mcl(-)1 clinically are in high demand. Receptor tyrosine kinases...

journal_title：Cancer biology & therapy

authors： Nalluri S,Peirce SK,Tanos R,Abdella HA,Karmali D,Hogarty MD,Goldsmith KC

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:IL-24 (interleukin-24) is a promising, multi-functional anti-cancer agent able to selectively induce tumor cell apoptosis while sparing normal cells. Additionally, IL-24 can enhance the immune response to tumors and suppress tumor angiogenesis. In this study, we introduced IL-24 into the oncolytic adenovirus...

journal_title：Cancer biology & therapy

authors： Xiao LL,Wu YM,Qian J,Tan Y,Xie GL,Zhang KJ,Wang YG,Jia XY,Liu XY

更新日期：2010-08-01 00:00:00

abstract：:To investigate the diagnostic potential of DNA methylation-based markers in tissue samples of DCIS, we examined the prevalence and extent of methylation in breast ductal carcinoma in situ (DCIS) samples from North American and Korean women. Quantitative multiplex-methylation specific PCR (QM-MSP) of ten genes was perf...

journal_title：Cancer biology & therapy

authors： Lee JS,Fackler MJ,Teo WW,Lee JH,Choi C,Park MH,Yoon JH,Zhang Z,Argani P,Sukumar S

更新日期：2008-09-01 00:00:00

abstract：:Exosomes released from cancer cells support metastasis and growth of recipient cells and increase their resistance to chemotherapy. Therapeutic targeting of exosomes is a promising area in cancer research. Our aim is to test the effect of the mast cell stabilizer ketotifen on exosomes release from cancer cells and how...

journal_title：Cancer biology & therapy

authors： Khan FM,Saleh E,Alawadhi H,Harati R,Zimmermann WH,El-Awady R

更新日期：2018-01-02 00:00:00

abstract：:Tumor formation in immunocompetent hosts is believed to be dependent on the ability of tumor cells to evade the immune system, as suggested by the alterations of expression of the major histocompatibility complex (MHC) and related molecules in a number of cancers. Our previous serial analysis of gene expression (SAGE)...

journal_title：Cancer biology & therapy

authors： Rangel LB,Agarwal R,Sherman-Baust CA,Mello-Coelho Vd,Pizer ES,Ji H,Taub DD,Morin PJ

更新日期：2004-10-01 00:00:00

abstract：:Mutationally activated and oncogenic versions of the ras genes were first identified in human tumors in 1982. This discovery prompted great interest in the development of anti-Ras strategies as novel, target-based approaches for cancer treatment. The three human ras genes represent the most frequently mutated oncogene...

journal_title：Cancer biology & therapy

authors： Cox AD,Der CJ

更新日期：2002-11-01 00:00:00

abstract：:Krüppel-Like Factor 4 (KLF4) functions as a tumor suppressor in some cancers, but its molecular mechanism is not clear. Our recent study also showed that the expression of KLF4 is dramatically reduced in primary lung cancer tissues. To investigate the possible role of KLF4 in lung cancer, we stably transfected KLF4 in...

journal_title：Cancer biology & therapy

authors： Zhou Y,Hofstetter WL,He Y,Hu W,Pataer A,Wang L,Wang J,Zhou Y,Yu L,Fang B,Swisher SG

更新日期：2010-04-01 00:00:00

abstract：:Endostatin can inhibit tumor growth by blocking angiogenesis, whereas tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) may function as a soluble cytokine to selectively kill cancer cells without toxicity to most normal cells. To establish the combined anti-tumor therapeutic effect of endostatin and solu...

journal_title：Cancer biology & therapy

authors： Zhang Y,Qu ZH,Cui M,Guo C,Zhang XM,Ma CH,Sun WS

更新日期：2009-03-01 00:00:00

abstract：:Heat shock proteins (Hsps) modulate several cellular functions and are ubiquitously present in cell. Here, we investigated alterations in the expression of Hsps and explored functional consequences of the same. Moreover, effect of quercetin (Qctn), an inhibitor of Hsps, on chemotherapeutic drugs treatment in hepatoma ...

journal_title：Cancer biology & therapy

authors： Sharma A,Upadhyay AK,Bhat MK

更新日期：2009-11-01 00:00:00

abstract：:Drug resistance has always been the main problem in osteosarcoma treatment, and hypoxia seems to be one of the many causes for drug resistance. Therefore, in this study, we investigated how hypoxia triggers chemotherapy resistance in osteosarcoma. We first screened hypoxia- and normoxia- cultured osteosarcoma cells in...

journal_title：Cancer biology & therapy

authors： Ma Q,Zhang Y,Liu T,Jiang K,Wen Y,Fan Q,Qiu X

更新日期：2017-03-04 00:00:00