Successful treatment using apatinib with or without docetaxel in heavily pretreated advanced non-squamous non-small cell lung cancer: A case report and literature review.

abstract：:Microtubule-active drugs, including paclitaxel (Taxol, PTX), cause mitotic arrest, and this can result in apoptosis. A recently study has reported that PTX mediates apoptosis by upregulating FasL in Jurkat and MDA-231 cells. In contrast to the previous report, we found that anti-FasL antibodies failed to inhibit PTX-i...

journal_title：Cancer biology & therapy

authors： Blagosklonny MV,Robey R,Sheikh MS,Fojo T

更新日期：2002-03-01 00:00:00

abstract：OBJECTIVES:Chemotherapy-induced diarrhea (CID) is a well recognized side effect of cancer treatment. However, the pathophysiology behind this debilitating side effect remains unclear. Irinotecan causes cholinergic and delayed onset diarrhea in patients, in which beta-glucuronidase produced by gut bacteria is thought to...

journal_title：Cancer biology & therapy

authors： Stringer AM,Gibson RJ,Logan RM,Bowen JM,Yeoh AS,Keefe DM

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVES:We herein assessed the influence of Epidermal Growth Factor Receptor (EGFR) gene mutations on EGFR expression levels, downstream mediators such as Akt or ERK, and overall survival in patients with ovarian cancer. STUDY DESIGN:EGFR mutation status was analyzed by direct sequencing in 102 Japanese ovarian can...

journal_title：Cancer biology & therapy

authors： Tanaka Y,Terai Y,Tanabe A,Sasaki H,Sekijima T,Fujiwara S,Yamashita Y,Kanemura M,Ueda M,Sugita M,Franklin WA,Ohmichi M

更新日期：2011-01-01 00:00:00

abstract：:The F-box protein Fbw7/Sel-10/hCdc4/Ago, which is known to regulate ubiquitination and degradation of numerous important regulators of cell division and death including Notch, cyclin E, c-Jun and c-Myc, has been recently rediscovered as a p53-dependent tumor suppressor. Delineation of the mechanisms of Fbw7 anti-oncog...

journal_title：Cancer biology & therapy

authors： Fuchs SY

更新日期：2005-05-01 00:00:00

abstract：:Onconase (Onc), a ribonuclease from oocytes or early embryos of Northern Leopard frog (Rana pipiens), is cytostatic and cytotoxic to a variety of tumor lines in vitro, inhibits growth of tumors in animal in vivo models and is currently in Phase IIIb clinical trials for malignant mesothelioma where it displays antitumo...

journal_title：Cancer biology & therapy

authors： Ita M,Halicka HD,Tanaka T,Kurose A,Ardelt B,Shogen K,Darzynkiewicz Z

更新日期：2008-07-01 00:00:00

abstract：:Multidrug resistance (MDR) is an important cause of treatment failure in acute lymphoblastic leukemia (ALL). The ABC family of membrane transporters is proposed, albeit with controversy, to be involved in this process. The present study aims to investigate the mRNA expression profile of several genes of this family, i...

journal_title：Cancer biology & therapy

authors： Rahgozar S,Moafi A,Abedi M,Entezar-E-Ghaem M,Moshtaghian J,Ghaedi K,Esmaeili A,Montazeri F

更新日期：2014-01-01 00:00:00

abstract：:Ten years ago, a concerted effort from several labs resulted in the cloning of BRCA1, the first of two major hereditary breast/ovarian cancer predisposition genes. Since that time, BRCA1 has been linked to several key nuclear functions connected with the prevention of genomic instability. In particular, BRCA1 function...

journal_title：Cancer biology & therapy

authors： Scully R,Xie A,Nagaraju G

更新日期：2004-06-01 00:00:00

abstract：:Nimotuzumab (h-R3) is a humanized anti-epidermal growth factor receptor monoclonal antibody (mAb) registered for treating head and neck tumours. The present study was designed to evaluate the systemic and skin toxicity of chronic intravenous administration of the h-R3 in a relevant species demonstrated by comparing th...

journal_title：Cancer biology & therapy

authors： Arteaga ME,Ledón N,Casacó A,Pardo B,García M,Boleda M,Viña L,Orphee R,Hernández O,González C,Fuentes D,Rodríguez V,Charro L,Baro F,Macías A,Pérez A,Morales Y,Subirós N,González B,Ramos M,Rodriquez L,Ballester-La

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVES:The key objective of the study was to determine the single and multiple dose toxicity and efficacy of Bismuth-213 labeled PAI2 based targeted alpha therapy by selectively targeting uPA and uPAR in regressing prostate cancer in a nude mouse model. Targeted alpha therapy (TAT) is an experimental therapeutic mo...

journal_title：Cancer biology & therapy

authors： Abbas Rizvi SM,Li Y,Song EY,Qu CF,Raja C,Morgenstern A,Apostolidis C,Allen BJ

更新日期：2006-04-01 00:00:00

abstract：PURPOSE:Optical coherence tomography (OCT) is a minimally invasive, depth-resolved imaging tool that can be implemented in a small diameter endoscope for imaging mouse models of colorectal cancer (CRC). In this study, we utilized ultrahigh resolution (UHR) OCT to serially image the lower colon of azoxymethane (AOM) tre...

journal_title：Cancer biology & therapy

authors： Hariri LP,Qiu Z,Tumlinson AR,Besselsen DG,Gerner EW,Ignatenko NA,Povazay B,Hermann B,Sattmann H,McNally J,Unterhuber A,Drexler W,Barton JK

更新日期：2007-11-01 00:00:00

abstract：:Numerous tyrosine kinase inhibitors (TKIs) targeting c-Met are currently in clinical trials for several cancers. Their efficacy is limited due to the development of resistance. The present study aims to elucidate this mechanism of c-Met TKI resistance by investigating key mTOR and Wnt signaling proteins in melanoma ce...

journal_title：Cancer biology & therapy

authors： Etnyre D,Stone AL,Fong JT,Jacobs RJ,Uppada SB,Botting GM,Rajanna S,Moravec DN,Shambannagari MR,Crees Z,Girard J,Bertram C,Puri N

更新日期：2014-09-01 00:00:00

abstract：:The hypoxia-inducible factor 1alpha (HIF-1alpha) plays a major role in cancer progression. The role of this transcription factor in prostate cancer development and its transition to a metastatic and androgen refractory state remains to be elucidated. Previous reports have identified the existence of single nucleotide ...

journal_title：Cancer biology & therapy

authors： Chau CH,Permenter MG,Steinberg SM,Retter AS,Dahut WL,Price DK,Figg WD

更新日期：2005-11-01 00:00:00

abstract：:The present studies sought to further understand how the anti-folate pemetrexed and the multi-kinase inhibitor sorafenib interact to kill tumor cells. Sorafenib activated SRC, and via SRC the drug combination activated ERK1/2. Expression of dominant negative SRC or dominant negative MEK1 abolished drug-induced ERK1/2 ...

journal_title：Cancer biology & therapy

authors： Bareford MD,Hamed HA,Allegood J,Cruickshanks N,Poklepovic A,Park MA,Ogretmen B,Spiegel S,Grant S,Dent P

更新日期：2012-07-01 00:00:00

abstract：:Several microRNAs (miRNA) have been implicated in H. pylori related gastric cancer (GC). However, the molecular mechanism of miRNAs in gastric cancer has not been fully understood. In this study, we reported that miR-101 is significantly down-regulated in H. pylori positive tissues and cells and in tumor tissues with ...

journal_title：Cancer biology & therapy

authors： Zhou X,Xia Y,Li L,Zhang G

更新日期：2015-01-01 00:00:00

abstract：:Understanding molecular mechanisms involved in melanoma resistance to drugs is a big challenge. Experimental evidences suggested a correlation between mutational status in B-RAF and melanoma cell susceptibility to drugs, such as paclitaxel, doxorubicin and temozolomide, which generate an accumulation of hydrogen perox...

journal_title：Cancer biology & therapy

authors： Fico A,Alfano D,Valentino A,Vasta V,Cavalcanti E,Travali S,Patriarca EJ,Caputo E

更新日期：2015-01-01 00:00:00

abstract：:Objective: Chimeric antigen receptor T (CAR-T) cell therapy has demonstrated an unprecedented therapeutic efficacy in hematological malignancies; however, its effectiveness in solid tumors remains elusive. In order to enable CAR-T cells more effective to solid tumors, a inverted chimeric cytokine receptor (ICR) was de...

journal_title：Cancer biology & therapy

authors： Weimin S,Abula A,Qianghong D,Wenguang W

更新日期：2020-06-02 00:00:00

abstract：BACKGROUND:Intestinal mucositis is a common and debilitating side-effect of chemotherapy, associated with severe small intestinal inflammation. Marine oils, such as Lyprinol, a lipid extract derived from New Zealand Green-lipped Mussels, rich in long-chain omega-3 polyunsaturated fatty acids (n-3 PUFA), have demonstrat...

journal_title：Cancer biology & therapy

authors： Torres DM,Tooley KL,Butler RN,Smith CL,Geier MS,Howarth GS

更新日期：2008-02-01 00:00:00

abstract：:The six-transmembrane epithelial antigen of prostate 2 (STEAP2) protein was identified in advanced prostate cancer, and is highly over-expressed in various types of cancer. This study aimed to investigate the prognostic value and the function of STEAP2 in breast cancer. STEAP2 mRNA and protein expressions in breast no...

journal_title：Cancer biology & therapy

authors： Yang Q,Ji G,Li J

更新日期：2020-01-01 00:00:00

abstract：:A number of discoveries have clarified the molecular mechanism of apoptosis, thus clarifying the link between apoptosis and therapeutic outcome. Even though apoptosis is thought to play a major role in anticancer therapy, the clinical relevance of induction of apoptosis remains uncertain, particularly in solid tumors....

journal_title：Cancer biology & therapy

authors： Kim R,Emi M,Tanabe K

更新日期：2006-11-01 00:00:00

abstract：:Cell adhesion molecules (CAMs) are glycoproteins expressed on the surface of cell membranes. In normal cells, CAMs participate in a variety of biological processes including cell proliferation, migration and differentiation. In tumor cells, CAMs have been reported to function as oncogenes or tumor suppressors, in sign...

journal_title：Cancer biology & therapy

authors： Yoon KJ,Danks MK

更新日期：2009-02-01 00:00:00

abstract：:Fluids of body cavities result in a series of pathophysiological events associated with non-malignant and malignant conditions that lead to the formation of exudative effusion. Diagnosis of effusion from the patients is frequently troublesome for the cytologist because of the differentiation and biological behavior of...

journal_title：Cancer biology & therapy

authors： Cora T,Acar H,Ceran S,Bodur S

更新日期：2005-02-01 00:00:00

abstract：:The presence of tumor-infiltrating lymphocytes (TILs) in epithelial ovarian cancer indicates a host antitumor response and is associated with improved survival. We wished to determine the extent to which TIL density differs from site to site within a given patient. We initially studied multiple paired metastases from ...

journal_title：Cancer biology & therapy

authors： Hagemann AR,Hagemann IS,Cadungog M,Hwang WT,Patel P,Lal P,Hammond R,Gimotty PA,Chu CS,Rubin SC,Birrer MJ,Powell DJ Jr,Feldman MD,Coukos G

更新日期：2011-08-15 00:00:00

abstract：:Copy-number variants such as germ-line deletions and amplifications are associated with inherited genetic disorders including familial cancer. The gene or genes responsible for the majority of familial clustering of pancreatic cancer have not been identified. We used representational oligonucleotide microarray analysi...

journal_title：Cancer biology & therapy

authors： Lucito R,Suresh S,Walter K,Pandey A,Lakshmi B,Krasnitz A,Sebat J,Wigler M,Klein AP,Brune K,Palmisano E,Maitra A,Goggins M,Hruban RH

更新日期：2007-10-01 00:00:00

abstract：:Aloe-emodin is a novel active compound found in the root and rhizome of Rheum palmatum. To investigate the effects and mechanisms of aloe-emodin on human gastric cancer, MGC-803 cells were treated with 2.5, 5, 10, 20 and 40 microM aloe-emodin for 1-5 d. The results showed that aloe-emodin inhibited the growth of cance...

journal_title：Cancer biology & therapy

authors： Guo J,Xiao B,Zhang S,Liu D,Liao Y,Sun Q

更新日期：2007-01-01 00:00:00

abstract：:Transmembrane protease/serine 4 (TMPRSS4) is a member of the type II transmembrane serine protease (TTSP) family and it was found highly expressed in several cancers. This study aims to evaluate the expression of TMPRSS4 in colorectal cancer (CRC) and investigate its role in proliferation and self-renewal of colon can...

journal_title：Cancer biology & therapy

authors： Huang A,Zhou H,Zhao H,Quan Y,Feng B,Zheng M

更新日期：2014-03-01 00:00:00

abstract：:With the increasing interest in development of cytostatic anticancer drugs, the randomized discontinuation trial (RDT) design has been proved to be useful in the evaluation of their clinical activity. In the June 1, 2006 issue of the Journal of Clinical Oncology, a study by Ratain et al. uses RDT in a phase-II placebo...

journal_title：Cancer biology & therapy

authors： Jain L,Venitz J,Figg WD

更新日期：2006-10-01 00:00:00

abstract：:Decreased requirements for mitogens and diminished sensitivity to antiproliferative signals are among the hallmarks of human cancer. These attributes are due, at least partly, to mutations that directly or indirectly compromise the function of the retinoblastoma tumor suppressor protein (pRB), which is a negative regu...

journal_title：Cancer biology & therapy

authors： Kaelin WG Jr

更新日期：2003-07-01 00:00:00

abstract：PURPOSE:The sensitivity of lung cancer to gefitinib has been found to be associated with mutations at the tyrosine kinase domain of epidermal growth factor receptor (EGFR), yet similar observations are not available in other solid tumors. We recently identified mutations in the EGFR kinase domain in primary esophageal ...

journal_title：Cancer biology & therapy

authors： Guo M,Liu S,Herman JG,Zhuang H,Lu F

更新日期：2006-02-01 00:00:00

abstract：:Colorectal cancer (CRC) is the third most common form of cancer. Current treatments including chemotherapy, radiotherapy and surgery are all associated with a high risk of complications and are not always successful, highlighting the need to develop new treatment strategies. The ingestion of probiotics, prebiotics or ...

journal_title：Cancer biology & therapy

authors： Geier MS,Butler RN,Howarth GS

更新日期：2006-10-01 00:00:00

abstract：:Recent trends in cancer therapy have begun emphasizing the use of precision medicine, especially genetic tools, in the evaluation of malignancies and decision-making. Prostate cancer is a malignancy where the benefits and utility of screening and early treatment are still heavily controversial. A recent paper in the N...

journal_title：Cancer biology & therapy

authors： Hauke RJ Jr,Sissung TM,Figg WD

更新日期：2017-08-03 00:00:00