Clinical and biological impact of EphA2 overexpression and angiogenesis in endometrial cancer.

abstract：:Current treatment modalities for pancreatic carcinoma afford only modest survival benefits. TRAIL, as a potent and specific inducer of apoptosis in cancer cells, would be a promising new treatment option. However, since not all pancreatic cancer cells respond to TRAIL, further improvements and optimizations are still ...

journal_title：Cancer biology & therapy

authors： Yu R,Albarenque SM,Cool RH,Quax WJ,Mohr A,Zwacka RM

更新日期：2014-01-01 00:00:00

abstract：:Recent reports have shown that cancer stem cells exist in many malignancies. Side population (SP) cells are used to enrich cancer stem-like cells in many cell lines and fresh tumor specimens. In this study, we cultured primary esophageal squamous cell carcinoma (ESCC) cells from ESCC tissue specimens. SP cells from pr...

journal_title：Cancer biology & therapy

authors： Li H,Gao Q,Guo L,Lu SH

更新日期：2011-06-01 00:00:00

abstract：:MicroRNAs (miRNAs), an important class of small regulatory molecules for gene expression, are transcribed by RNA polymerase II. But little is known about the mechanisms that control miRNA expression. Comparing miRNA expression profiles between colon cancer cell line HCT 116 and its derivative, DNA methyltransferase 1 ...

journal_title：Cancer biology & therapy

authors： Han L,Witmer PD,Casey E,Valle D,Sukumar S

更新日期：2007-08-01 00:00:00

abstract：:Current knowledge of changes in the mammary epithelium relevant to breast carcinogenesis is limited to when histological changes are already present because of a lack of biomarkers needed to identify where such molecular changes might be ongoing at earlier during the of decades-long latent stages of breast carcinogene...

journal_title：Cancer biology & therapy

authors： Weisz J,Shearer DA,Murata E,Patrick SD,Han B,Berg A,Clawson GA

更新日期：2012-01-15 00:00:00

abstract：:Methylation induces epigenetic silencing of tumor suppressor genes in human lung cancer. Inhibition of DNA methyltransferases by decitabine (DAC) can demethylate and activate epigenetically silenced tumor suppressor genes. Epigenetic therapy using DAC should be an attractive strategy for lung cancer therapy. FBW7 is a...

journal_title：Cancer biology & therapy

authors： Kim MJ,Chen G,Sica GL,Deng X

更新日期：2021-01-02 00:00:00

abstract：:Metastatic cervical cancer remains a clinical problem. The development of more efficient treatment modalities and the optimal use of chemo- and radiotherapy require better understanding of their impact on regulation of cell survival and apoptosis, but the issue is insufficiently explored. Human papillomavirus (HPV) E6...

journal_title：Cancer biology & therapy

authors： Koivusalo R,Hietanen S

更新日期：2004-11-01 00:00:00

abstract：:One of the most active fields in cancer immunotherapy is the study of bispecific antibodies, which engage immune cells to kill cancer cells. However, a variety of issues are associated with most of current bispecific antibody formats. In this study, we present a novel bispecific antibody, BiSS (Bispecific antibody wit...

journal_title：Cancer biology & therapy

authors： Dong B,Zhou C,He P,Li J,Chen S,Miao J,Li Q,Wang Z

更新日期：2016-04-02 00:00:00

abstract：OBJECTIVES:We herein assessed the influence of Epidermal Growth Factor Receptor (EGFR) gene mutations on EGFR expression levels, downstream mediators such as Akt or ERK, and overall survival in patients with ovarian cancer. STUDY DESIGN:EGFR mutation status was analyzed by direct sequencing in 102 Japanese ovarian can...

journal_title：Cancer biology & therapy

authors： Tanaka Y,Terai Y,Tanabe A,Sasaki H,Sekijima T,Fujiwara S,Yamashita Y,Kanemura M,Ueda M,Sugita M,Franklin WA,Ohmichi M

更新日期：2011-01-01 00:00:00

abstract：:Ovarian cancer is a silent killer, and shows early extensive tumor invasion and peritoneal metastasis. The microcirculation of most tumors includes cooperation of pre-existing vessels, intussusceptive microvascular growth, postnatal vasculogenesis, glomeruloid angiogenesis and vasculogenic mimicry (VM). VM is critical...

journal_title：Cancer biology & therapy

authors： Wang JY,Sun T,Zhao XL,Zhang SW,Zhang DF,Gu Q,Wang XH,Zhao N,Qie S,Sun BC

更新日期：2008-05-01 00:00:00

abstract：:The colorectal cancer is the leading contributor of cancer-related mortality. Mammalian target of rapamycin (mTOR), existing in 2 complexes (mTORC1/2), is frequently dysregulated and constitutively activated in colorectal cancers. It represents an important drug target. Here we found that INK-128, the novel ATP-compet...

journal_title：Cancer biology & therapy

authors： Li C,Cui JF,Chen MB,Liu CY,Liu F,Zhang QD,Zou J,Lu PH

更新日期：2015-01-01 00:00:00

abstract：:Farnesyl transferase inhibitors (FTIs) exhibit limited cytotoxic effects against human cancer cells, perhaps explaining the limited efficacy of FTIs in clinical trials. Learning how these well-tolerated drugs trigger p53-independent apoptosis in mouse models of cancer might therefore benefit efforts to leverage their ...

journal_title：Cancer biology & therapy

authors： Kamasani U,Duhadaway JB,Alberts AS,Prendergast GC

更新日期：2007-09-01 00:00:00

abstract：:Resistance to apoptosis is one reason for the poor response of malignant brain tumors to therapy. The PPARgamma-modulating drug Troglitazone downregulates the anti-apoptotic FLIP protein and sensitizes glioblastoma cells to apoptosis induced by the death ligand TRAIL. To investigate the molecular basis of an experimen...

journal_title：Cancer biology & therapy

authors： Grund K,Ahmadi R,Jung F,Funke V,Gdynia G,Benner A,Sykora J,Walczak H,Joos S,Felsberg J,Reifenberger G,Wiestler OD,Herold-Mende C,Roth W

更新日期：2008-12-01 00:00:00

abstract：:SUMO (small ubiquitin-related modifier) represents a class of ubiquitin-like proteins that is conjugated, like ubiquitin, by a set of enzymes to cellular regulatory proteins, including oncogenes and tumor suppressor genes, that play key roles in the control of cell growth, differentiation and apoptosis. SUMO conjugati...

journal_title：Cancer biology & therapy

authors： Alarcon-Vargas D,Ronai Z

更新日期：2002-05-01 00:00:00

abstract：:The development of microarray technology has allowed researchers to measure expression levels of thousands of genes simultaneously. Analysis of these data requires the best normalization and statistical approaches to account for the biological and technical variability inherent in the technique. To approach this probl...

journal_title：Cancer biology & therapy

authors： Singhal S,Kyvernitis CG,Johnson SW,Kaiser LR,Liebman MN,Albelda SM

更新日期：2003-07-01 00:00:00

abstract：:Both Pten and Nras are downstream mediators of receptor tyrosine kinase activation that plays important roles in controlling cell survival and proliferation. Here, we investigated whether and how Pten loss cross-talks with Nras activation in driving liver cancer development in mice. Somatic disruption of hepatic Pten ...

journal_title：Cancer biology & therapy

authors： Gao M,Liu D

更新日期：2017-07-03 00:00:00

abstract：:Epidemiological studies suggest that obesity increases the risk of developing several cancers, including melanoma. Obesity increases the expression of angiogenic factors, such as leptin, that may contribute to tumor growth. However, a direct cause and effect relationship between obesity and tumor growth has not been c...

journal_title：Cancer biology & therapy

authors： Brandon EL,Gu JW,Cantwell L,He Z,Wallace G,Hall JE

更新日期：2009-10-01 00:00:00

abstract：:The clinical use of EGFR-targeted therapy, in triple negative breast cancer patients, has been limited by the development of resistance to these drugs. Although activated signaling molecules contribute to this process, the molecular mechanisms remain relatively unknown. We have previously reported that the small GTPas...

journal_title：Cancer biology & therapy

authors： Haines E,Schlienger S,Claing A

更新日期：2015-01-01 00:00:00

abstract：:Chronic arsenic treatment induces epithelial-mesenchymal transition (EMT) and promotes tumorigenicity, but the mechanism is unclear. MiR-100 has been shown to be involved in this biologic process. In this study, we hypothesize that inactivation of miR-100 combined with low concentration of arsenic exposure could promo...

journal_title：Cancer biology & therapy

authors： Yang J,Chen Z,Wang X,Xu M,Fang H,Li F,Liu Y,Jiang Y,Ding Y,Li J,Wang S

更新日期：2017-12-02 00:00:00

abstract：:Peroxisome Proliferator-Activated Receptors (PPARs) are ligand-activated intracellular transcription factors, members of the nuclear hormone receptor superfamily. The PPAR subfamily consist of three subtypes encoded by distinct genes denoted PPARalpha, PPARbeta/delta, and PPARgamma. The peroxisome proliferator-activat...

journal_title：Cancer biology & therapy

authors： Mansure JJ,Nassim R,Kassouf W

更新日期：2009-04-01 00:00:00

abstract：:Poor oxygenation is a unique and prevalent feature of solid tumors associated with poor patient prognosis. In part, this is caused by a series of adaptive cellular responses that together have a large impact on gene expression and cell phenotype. HIF plays a key role in this response by activating a transcriptional pr...

journal_title：Cancer biology & therapy

authors： van den Beucken T,Koritzinsky M,Wouters BG

更新日期：2006-07-01 00:00:00

abstract：:Recent trends in cancer therapy have begun emphasizing the use of precision medicine, especially genetic tools, in the evaluation of malignancies and decision-making. Prostate cancer is a malignancy where the benefits and utility of screening and early treatment are still heavily controversial. A recent paper in the N...

journal_title：Cancer biology & therapy

authors： Hauke RJ Jr,Sissung TM,Figg WD

更新日期：2017-08-03 00:00:00

abstract：:Prior to 2011, only 2 systemic treatments were approved for the treatment of melanoma and these had limited efficacy. In the past 4 years, 6 novel agents have received FDA approval. Herein, we will focus on 4 recently published NEJM papers reporting the results of clinical trials, comprising 4 agents targeting the MAP...

journal_title：Cancer biology & therapy

authors： Massey PR,Prasad V,Figg WD,Fojo T

更新日期：2015-01-01 00:00:00

abstract：:The discovery of microRNAs (miRNAs) has opened a new avenue for both diagnosis and treatment of cancers. Accumulating experimental evidences indicate that miRNAs are aberrantly expressed in different tumor types and have a critical role in tumorigenesis. However, the miRNA expression profile in neuroblastoma (NB), one...

journal_title：Cancer biology & therapy

authors： Guo J,Dong Q,Fang Z,Chen X,Lu H,Wang K,Yin Y,Cai X,Zhao N,Chen J,Zen K,Zhang J,Zhang CY

更新日期：2010-03-15 00:00:00

abstract：:Long standing chronic pancreatitis is a risk factor for developing pancreatic cancer. Inheritance of polymorphisms in SPINK1 and CFTR are associated with an increased risk of developing pancreatitis. The aim of this study was to determine if patients who carry polymorphisms in SPINK1 and CFTR are at increased risk of ...

journal_title：Cancer biology & therapy

authors： Matsubayashi H,Fukushima N,Sato N,Brune K,Canto M,Yeo CJ,Hruban RH,Kern SE,Goggins M

更新日期：2003-11-01 00:00:00

abstract：:Exosomes released from cancer cells support metastasis and growth of recipient cells and increase their resistance to chemotherapy. Therapeutic targeting of exosomes is a promising area in cancer research. Our aim is to test the effect of the mast cell stabilizer ketotifen on exosomes release from cancer cells and how...

journal_title：Cancer biology & therapy

authors： Khan FM,Saleh E,Alawadhi H,Harati R,Zimmermann WH,El-Awady R

更新日期：2018-01-02 00:00:00

abstract：:Between 1955 and 1963 millions of people were worldwide vaccinated with polio-vaccines that were contaminated with the simian virus 40 (SV40). This tumor-inducing virus has subsequently been detected in several human tumors. In Austria, polio mass vaccination started in winter 1961/62 with a presumably SV40-free Briti...

journal_title：Cancer biology & therapy

authors： Leithner A,Weinhaeusel A,Windhager R,Schlegl R,Waldner P,Lang S,Dominkus M,Zoubek A,Popper HH,Haas OA

更新日期：2002-07-01 00:00:00

abstract：:Resistance of tumors due to restricted drug accumulation and reversal of DNA lesions in tumor cells as well as normal tissue toxicity limit the efficacy of topoisomerase inhibition based anticancer drugs. It has been proposed that selective inhibition of energy dependent repair processes and enhanced retention of drug...

journal_title：Cancer biology & therapy

authors： Dwarakanath BS,Khaitan D,Ravindranath T

更新日期：2004-09-01 00:00:00

abstract：:Adverse events in platinum-based chemotherapy for patients with advanced non-small cell lung cancer (NSCLC) are major challenges. In this study, we investigated the role of the p53 and MDM2 genes in predicting adverse events in NSCLC patients treated with platinum-based chemotherapy. Specifically, we examined the p53 ...

journal_title：Cancer biology & therapy

authors： Zheng D,Chen Y,Gao C,Wei Y,Cao G,Lu N,Hou Y,Jiang X,Wang J

更新日期：2014-01-01 00:00:00

abstract：:The delivery of cell-based vaccines that exploit natural mechanisms of antigen presentation represents a promising approach for immunotherapy of cancer. This strategy tests the hypothesis that ex vivo manipulation and reinjection of cellular products can induce immune responses and circumvent immune incompetence to ac...

journal_title：Cancer biology & therapy

authors： Coughlin CM,Vonderheide RH

更新日期：2003-09-01 00:00:00

abstract：:It has become a cliché that cancer therapy fails because it does not target rare cancer stem cells (CSCs). Here we are discuss that this is not how therapy fails and not any cancer cell with stem-like properties is CSC. Paradoxically, CSCs must be resting to explain their resistance to therapy yet must be cycling to e...

journal_title：Cancer biology & therapy

authors： Blagosklonny MV

更新日期：2007-11-01 00:00:00