LINC00958 regulated miR-627-5p/YBX2 axis to facilitate cell proliferation and migration in oral squamous cell carcinoma.

abstract：BACKGROUND:IL-24 (interleukin-24) is a promising, multi-functional anti-cancer agent able to selectively induce tumor cell apoptosis while sparing normal cells. Additionally, IL-24 can enhance the immune response to tumors and suppress tumor angiogenesis. In this study, we introduced IL-24 into the oncolytic adenovirus...

journal_title：Cancer biology & therapy

authors： Xiao LL,Wu YM,Qian J,Tan Y,Xie GL,Zhang KJ,Wang YG,Jia XY,Liu XY

更新日期：2010-08-01 00:00:00

abstract：:Deregulated metabolism is gaining recognition as a hallmark of cancer cells, and is being explored for therapeutic potential. The Warburg effect is a metabolic phenotype that occurs in 90% of tumors, where glycolysis is favored despite the presence of oxygen. Dichloroacetate (DCA) is a pyruvate dehydrogenase kinase (P...

journal_title：Cancer biology & therapy

authors： Gang BP,Dilda PJ,Hogg PJ,Blackburn AC

更新日期：2014-01-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) is a lethal disease with suboptimal survival outcomes. In this study, we aimed to find an independent prognostic factor of head and neck squamous cell carcinoma and investigate its effect on tumor cell proliferation, apoptosis, migration progress and cell cycle phase. Weig...

journal_title：Cancer biology & therapy

authors： Li Q,Chen W,Song M,Chen W,Yang Z,Yang A

更新日期：2019-01-01 00:00:00

abstract：AIMS:Oral squamous cell carcinoma (OSCC) is the most prevalent malignancy of the oral cavity resulting in severe morbidity and mortality. To date only few proteins have been suggested as potential biomarkers or targets for this type of cancer. Cancerous inhibitor of PP2A (CIP2A) is a protein expressed in epithelial tis...

journal_title：Cancer biology & therapy

authors： Katz J,Jakymiw A,Ducksworth MK,Stewart CM,Bhattacharyya I,Cha S,Chan EK

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:To achieve effective delivery of siRNA into target cells in vivo, we have developed a novel approach of siRNA delivery by using local drug delivery systems. RESULTS:The chitosan hydrogel (CH-HG) displayed a liquid-solid phase transition in a temperature-dependent manner and formed an endothermic hydrogel in ...

journal_title：Cancer biology & therapy

authors： Han HD,Mora EM,Roh JW,Nishimura M,Lee SJ,Stone RL,Bar-Eli M,Lopez-Berestein G,Sood AK

更新日期：2011-05-01 00:00:00

abstract：:Apoptosis induced by interferon-alpha (IFNalpha) is associated with induction of TRAIL in a number of different cell types. Here we examined whether or not TRAIL was required for apoptosis in a model human bladder cancer cell line (UM-UC-12) and defined the molecular mechanisms involved in IFNalpha-induced TRAIL expre...

journal_title：Cancer biology & therapy

authors： Papageorgiou A,Dinney CP,McConkey DJ

更新日期：2007-06-01 00:00:00

abstract：:Angiogenesis plays an essential role in tumor growth and metastasis and is a promising target for cancer therapy. We characterized the effects of selective CIAPIN1 inhibition on the angiogenesis gastric cancer cell line SGC7901 by stable transfection of CIAPIN1 siRNA. Our study has been shown that CIAPIN1 play the det...

journal_title：Cancer biology & therapy

authors： Yan K,He LJ,Cheng W,Ji ZZ,Zhao BX,Hui XL,Cao SS,Chen B,He L,Liang SH,Miao Y

更新日期：2009-06-01 00:00:00

abstract：:IL-15 has been actively investigated for its potential in tumor immunotherapy. To enhance the anti-tumor activity of IL-15, the novel PFC-1 construct was designed, which comprises the following 3 parts: (1) IL-15Rα fused with IL-15 to enhance IL-15 activity, (2) an Fc fragment to increase protein half-life, and (3) an...

journal_title：Cancer biology & therapy

authors： Chen S,Huang Q,Liu J,Xing J,Zhang N,Liu Y,Wang Z,Li Q

更新日期：2015-01-01 00:00:00

abstract：:Hypoxia, a common phenomenon in human solid tumors, is associated with invasion and metastasis in various tumors. Hypoxia inducible factors (HIFs) are key molecules in the hypoxic response, and regulate the activation of specific genes, which mediate many of the adaptations to hypoxia. CC chemokine receptor 7 (CCR7) h...

journal_title：Cancer biology & therapy

authors： Li Y,Qiu X,Zhang S,Zhang Q,Wang E

更新日期：2009-02-01 00:00:00

abstract：:Methyl-CpG binding domain protein 1 (MBD1) is a transcriptional regulator that binds methylated CpG islands of tumor suppressor genes and represses their transcription. In a former study, we found high expression of MBD1 in pancreatic cancer cell lines and tissues which may play an important role in the development of...

journal_title：Cancer biology & therapy

authors： Luo G,Jin C,Long J,Fu D,Yang F,Xu J,Yu X,Chen W,Ni Q

更新日期：2009-04-01 00:00:00

abstract：:CP-31398, a styrylquinazoline, emerged from a screen for therapeutic agents that restore a wild-type DNA-binding conformation of mutant p53 to suppress tumors in-vivo (Science 286, 2507, 1999). We investigated the growth inhibitory mechanism of CP-31398 using nine human cancer cell lines containing wild-type, mutant o...

journal_title：Cancer biology & therapy

authors： Takimoto R,Wang W,Dicker DT,Rastinejad F,Lyssikatos J,el-Deiry WS

更新日期：2002-01-01 00:00:00

abstract：:The greatest health threat from malignant melanoma is death due to metastatic disease. Consequently, the identification of markers predictive of metastatic disease is essential for identifying new therapeutic targets. EphA2, a protein tyrosine kinase receptor commonly expressed in epithelial cells, has been found to b...

journal_title：Cancer biology & therapy

authors： Margaryan NV,Strizzi L,Abbott DE,Seftor EA,Rao MS,Hendrix MJ,Hess AR

更新日期：2009-02-01 00:00:00

abstract：:Prostate cancer is the second leading cause of cancer deaths among men. The availability of animal models that represent the events and factors that exist in the natural history and biology of human prostate cancer is essential in dealing with prostate cancer. In recent decades and presently, emphasis has been directe...

journal_title：Cancer biology & therapy

authors： Costello LC,Franklin RB,Zou J,Feng P,Bok R,Swanson MG,Kurhanewicz J

更新日期：2011-12-15 00:00:00

abstract：:The development of microarray technology has allowed researchers to measure expression levels of thousands of genes simultaneously. Analysis of these data requires the best normalization and statistical approaches to account for the biological and technical variability inherent in the technique. To approach this probl...

journal_title：Cancer biology & therapy

authors： Singhal S,Kyvernitis CG,Johnson SW,Kaiser LR,Liebman MN,Albelda SM

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND:Peripheral primitive neuroectodermal tumor isolated in the heart, presenting as a primary cardiac tumor is considered as extremely rare. METHODS:We present a 53-year-old Chinese female with a cardiac tumor which was discovered by CT. RESULTS:A hypo-intense tumorous mass was shown extending from the left ve...

journal_title：Cancer biology & therapy

authors： Fan C,Kong D,Tan C,Yang J

更新日期：2017-01-02 00:00:00

abstract：:While several hypotheses have been put forward to explain how prostate tumors become resistant to androgen deprivation therapy, the mechanism by which prostate tumors have increased androgen concentrations as compared to the serum has been poorly explored. Using a stromal/epithelial cell co-culture model, Mizokami et ...

journal_title：Cancer biology & therapy

authors： Sharma H,Sissung TM,Pressler H,Figg WD

更新日期：2010-02-01 00:00:00

abstract：:Li-Fraumeni syndrome (LFS) is primarily characterized by development of tumors exhibiting germ-line mutations in the p53 gene. Cell lines developed from patients of a LFS family have decreased p53 activity as evidenced by the absence of apoptosis upon etoposide treatment. To test our hypothesis that changes in gene ex...

journal_title：Cancer biology & therapy

authors： Sherif ZA,Sultan AS

更新日期：2013-01-01 00:00:00

abstract：:Resistance to apoptosis is one reason for the poor response of malignant brain tumors to therapy. The PPARgamma-modulating drug Troglitazone downregulates the anti-apoptotic FLIP protein and sensitizes glioblastoma cells to apoptosis induced by the death ligand TRAIL. To investigate the molecular basis of an experimen...

journal_title：Cancer biology & therapy

authors： Grund K,Ahmadi R,Jung F,Funke V,Gdynia G,Benner A,Sykora J,Walczak H,Joos S,Felsberg J,Reifenberger G,Wiestler OD,Herold-Mende C,Roth W

更新日期：2008-12-01 00:00:00

abstract：:Mcl-1, a pro-survival member of the Bcl-2 protein family, is an attractive target for cancer therapy. We have recently identified the natural product marinopyrrole A (maritoclax) as a novel small molecule Mcl-1 inhibitor. Here, we describe the structure-activity relationship study of pyoluteorin derivatives based on m...

journal_title：Cancer biology & therapy

authors： Doi K,Gowda K,Liu Q,Lin JM,Sung SS,Dower C,Claxton D,Loughran TP Jr,Amin S,Wang HG

更新日期：2014-01-01 00:00:00

abstract：:Nonstop proliferation and vigorous neovascularization are two prominent characteristics of cancer. Antiangiogenic therapy has emerged as an important modality in treatment of solid tumors. Our previous work demonstrated that microparticles derived from apoptotic T-lymphocytes (LMPs) not only reduced the viabilities of...

journal_title：Cancer biology & therapy

authors： Yang C,Gagnon C,Hou X,Hardy P

更新日期：2010-09-01 00:00:00

abstract：:Heparan sulfate proteoglycans (HSPGs) play important roles in cancer initiation and progression, by interacting with the signaling pathways that affect proliferation, adhesion, invasion and angiogenesis. These roles suggest the possibility of various strategies of regulation of these molecules. In this review, we demo...

journal_title：Cancer biology & therapy

authors： Onyeisi JOS,Ferreira BZF,Nader HB,Lopes CC

更新日期：2020-12-01 00:00:00

abstract：:Discovering drugs has never been an easy task. Traditionally, this task has exclusively been undertaken by large pharmaceutical companies that recovered their high research and development costs by selling expensive medications. Despite the huge amount of time and effort devoted towards drug discovery over the last de...

journal_title：Cancer biology & therapy

authors： Sager JA,Lengauer C

更新日期：2003-07-01 00:00:00

abstract：:The efficient treatment of lung carcinomas with chemotherapeutics still poses a challenge for anti-cancer therapy. Since stromal cells of the tumor may alter the responsiveness of tumor cells to chemotherapeutics, we studied the impact of lung fibroblasts (WI-38) on the chemotherapy-induced death of non-small cell lun...

journal_title：Cancer biology & therapy

authors： Bartling B,Hofmann HS,Silber RE,Simm A

更新日期：2008-08-01 00:00:00

abstract：:To avoid cell cycle arrest or apoptosis, rapidly proliferating cancer cells have to promote DNA double strand break (DSB) repair to fix replication stress induced DSBs. Therefore, developing drugs blocking homologous recombination (HR) and nonhomologous end joining (NHEJ) - 2 major DSB repair pathways - holds great po...

journal_title：Cancer biology & therapy

authors： Zhang L,Zhang F,Zhang W,Chen L,Gao N,Men Y,Xu X,Jiang Y

更新日期：2015-01-01 00:00:00

abstract：:Ovarian cancer ranks fifth in cancer related deaths for women in USA. The high mortality rate associated with ovarian cancer is due to diagnosis at later stages of disease and the high recurrence rate of 60-80%. Recurrent ovarian cancers are more likely to present as multidrug resistance (MDR) leading to unfavorable r...

journal_title：Cancer biology & therapy

authors： Patel NR,Piroyan A,Ganta S,Morse AB,Candiloro KM,Solon AL,Nack AH,Galati CA,Bora C,Maglaty MA,O'Brien SW,Litwin S,Davis B,Connolly DC,Coleman TP

更新日期：2018-07-03 00:00:00

abstract：BACKGROUND:Intestinal mucositis is a common and debilitating side-effect of chemotherapy, associated with severe small intestinal inflammation. Marine oils, such as Lyprinol, a lipid extract derived from New Zealand Green-lipped Mussels, rich in long-chain omega-3 polyunsaturated fatty acids (n-3 PUFA), have demonstrat...

journal_title：Cancer biology & therapy

authors： Torres DM,Tooley KL,Butler RN,Smith CL,Geier MS,Howarth GS

更新日期：2008-02-01 00:00:00

abstract：:Several microRNAs (miRNA) have been implicated in H. pylori related gastric cancer (GC). However, the molecular mechanism of miRNAs in gastric cancer has not been fully understood. In this study, we reported that miR-101 is significantly down-regulated in H. pylori positive tissues and cells and in tumor tissues with ...

journal_title：Cancer biology & therapy

authors： Zhou X,Xia Y,Li L,Zhang G

更新日期：2015-01-01 00:00:00

abstract：:Every year, 12,000 people in the U.S. die from renal cell carcinoma. Current therapies include partial or complete nephrectomy or treatments such as administration of IFN-alpha and/or interleukins that are moderately effective, at best. Moreover, the current therapies are invasive and inefficient and new therapies are...

journal_title：Cancer biology & therapy

authors： VanOosten RL,Moore JM,Karacay B,Griffith TS

更新日期：2005-10-01 00:00:00

abstract：:The Chemohormonal Therapy vs Androgen Ablation Randomized Trial for Extensive Disease in Prostate Cancer (CHAARTED) was a randomized phase III trial that evaluated the outcomes of men with metastatic prostate cancer who received castration with or without docetaxel. Patients from this trial were genotyped in a recent ...

journal_title：Cancer biology & therapy

authors： Handy WF,Schmidt KT,Price DK,Figg WD

更新日期：2020-09-01 00:00:00

abstract：:Fluids of body cavities result in a series of pathophysiological events associated with non-malignant and malignant conditions that lead to the formation of exudative effusion. Diagnosis of effusion from the patients is frequently troublesome for the cytologist because of the differentiation and biological behavior of...

journal_title：Cancer biology & therapy

authors： Cora T,Acar H,Ceran S,Bodur S

更新日期：2005-02-01 00:00:00