Human prostate cancer ZIP1/zinc/citrate genetic/metabolic relationship in the TRAMP prostate cancer animal model.

abstract：:Mutationally activated and oncogenic versions of the ras genes were first identified in human tumors in 1982. This discovery prompted great interest in the development of anti-Ras strategies as novel, target-based approaches for cancer treatment. The three human ras genes represent the most frequently mutated oncogene...

journal_title：Cancer biology & therapy

authors： Cox AD,Der CJ

更新日期：2002-11-01 00:00:00

abstract：:5-fluorouracil (5-FU) is the major chemotherapeutic agent for treatment of colorectal carcinoma, but the molecular mechanisms of response and resistance are not understood completely. We therefore studied the 5-FU dose response and time course of gene expression transcriptome changes in colon carcinoma cell lines that...

journal_title：Cancer biology & therapy

authors： Zhang W,Ramdas L,Shen W,Song SW,Hu L,Hamilton SR

更新日期：2003-09-01 00:00:00

abstract：:The impact of environmental mutagens and carcinogens on the mammary gland has recently received a lot of attention. Among the most generally accepted carcinogenic agents identified as factors that may increase breast cancer incidence are ionizing radiation and elevated estrogen levels. However, the molecular mechanism...

journal_title：Cancer biology & therapy

authors： Kutanzi K,Kovalchuk O

更新日期：2013-07-01 00:00:00

abstract：:Cellular adhesion molecules of the cadherin, integrin, and immunoglobulin superfamilies are important to both growth and metastasis of many cancers, including malignant melanoma. Malignant melanoma is an excellent model for studying these molecules, due in part to a sequential series of five defineable stages. As the ...

journal_title：Cancer biology & therapy

authors： McGary EC,Lev DC,Bar-Eli M

更新日期：2002-09-01 00:00:00

abstract：:Ovarian cancer (OC) is xenogeneic that is influenced by many generated factors related to epigenetic factors to accelerate tumor metastasis. This study was conducted with the objective of investigating the effect of microRNA-23a-3p (miR-23a) on the biological characteristics of OC stem cells by targeting discs large h...

journal_title：Cancer biology & therapy

authors： Zhuang RJ,Bai XX,Liu W

更新日期：2019-01-01 00:00:00

abstract：:Epigenetics are defined, in broad-terms, as alterations in gene expression without changes in DNA sequence. While histone modifications and DNA methylation are two classical means to regulate gene expression, miRNA has also recently been documented to govern gene expression in normal as well as cancer cells. In this r...

journal_title：Cancer biology & therapy

authors： Burgess R,Jenkins R,Zhang Z

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND AND AIM:H. pylori interacts with gastric epithelial cells, which may activate signaling pathways important for gastric cancer invasion. Ezrin, a membrane cytoskeletal crosslinker protein, is well documented to regulate cell adhesion and cell motility. The aim of the present study was to determine whether ezr...

journal_title：Cancer biology & therapy

authors： Fan LL,Chen DF,Lan CH,Liu KY,Fang DC

更新日期：2011-04-15 00:00:00

abstract：BACKGROUND AND AIM:Widespread applicability of tissue-based mRNA expression screening for Barrett esophagus (BE) is likely to require (1) accurate methods for assaying archival formalin-fixed, paraffin-embedded (FFPE) histopathology specimens taken at endoscopy, and (2) validation studies of promising biomarkers in dif...

journal_title：Cancer biology & therapy

authors： Botelho NK,Schneiders FI,Lord SJ,Freeman AK,Tyagi S,Nancarrow DJ,Hayward NK,Whiteman DC,Lord RV

更新日期：2010-07-15 00:00:00

abstract：:Deregulated metabolism is gaining recognition as a hallmark of cancer cells, and is being explored for therapeutic potential. The Warburg effect is a metabolic phenotype that occurs in 90% of tumors, where glycolysis is favored despite the presence of oxygen. Dichloroacetate (DCA) is a pyruvate dehydrogenase kinase (P...

journal_title：Cancer biology & therapy

authors： Gang BP,Dilda PJ,Hogg PJ,Blackburn AC

更新日期：2014-01-01 00:00:00

abstract：:Rearranged during transfection (RET) fusion-positive non-small cell lung cancer (NSCLC) accounts for 1% of lung adenocarcinoma. Although small molecule agents with RET kinase inhibitory activity such as alectinib, vandetanib, and cabozantinib have been clinically evaluated in RET-fusion-positive NSCLC, an effective mo...

journal_title：Cancer biology & therapy

authors： Fujimura T,Furugaki K,Harada N,Yoshimura Y

更新日期：2020-09-01 00:00:00

abstract：:Ovarian cancer is a silent killer, and shows early extensive tumor invasion and peritoneal metastasis. The microcirculation of most tumors includes cooperation of pre-existing vessels, intussusceptive microvascular growth, postnatal vasculogenesis, glomeruloid angiogenesis and vasculogenic mimicry (VM). VM is critical...

journal_title：Cancer biology & therapy

authors： Wang JY,Sun T,Zhao XL,Zhang SW,Zhang DF,Gu Q,Wang XH,Zhao N,Qie S,Sun BC

更新日期：2008-05-01 00:00:00

abstract：:Recent trends in cancer therapy have begun emphasizing the use of precision medicine, especially genetic tools, in the evaluation of malignancies and decision-making. Prostate cancer is a malignancy where the benefits and utility of screening and early treatment are still heavily controversial. A recent paper in the N...

journal_title：Cancer biology & therapy

authors： Hauke RJ Jr,Sissung TM,Figg WD

更新日期：2017-08-03 00:00:00

abstract：:The colorectal cancer is the leading contributor of cancer-related mortality. Mammalian target of rapamycin (mTOR), existing in 2 complexes (mTORC1/2), is frequently dysregulated and constitutively activated in colorectal cancers. It represents an important drug target. Here we found that INK-128, the novel ATP-compet...

journal_title：Cancer biology & therapy

authors： Li C,Cui JF,Chen MB,Liu CY,Liu F,Zhang QD,Zou J,Lu PH

更新日期：2015-01-01 00:00:00

abstract：:MDM2 antagonists stabilize and activate wild-type p53, and histone methyltransferase (HMT) inhibitors reduce methylation on histone lysines and arginines. Both MDM2 antagonists and HMT inhibitors are being developed as cancer therapeutics. Wild-type p53 expressing HCT116 colon cancer cells were resistant to apoptosis ...

journal_title：Cancer biology & therapy

authors： Zhou Y,Perez RE,Duan L,Maki CG

更新日期：2018-06-03 00:00:00

abstract：:Translocations and unique chromosome break points in melanoma will aid in the identification of the genes that are important in the neoplastic process. We have previously shown a unique translocation in malignant melanoma cells der(12)t(12;20). The transcription factor E2F1 maps to 20q11. Increased expression of E2F h...

journal_title：Cancer biology & therapy

authors： Nelson MA,Reynolds SH,Rao UN,Goulet AC,Feng Y,Beas A,Honchak B,Averill J,Lowry DT,Senft JR,Jefferson AM,Johnson RC,Sargent LM

更新日期：2006-04-01 00:00:00

abstract：:Interdigitating dendritic cell sarcoma is an extremely rare tumor. The diagnosis is difficult and is based on clinical, pathological and immunohistochemical evaluation. Differential diagnosis includes melanoma, mesenchymal and hematological malignancies. The mainstay of treatment is surgery for limited disease and dif...

journal_title：Cancer biology & therapy

authors： Di Liso E,Pennelli N,Lodovichetti G,Ghiotto C,Dei Tos AP,Conte P,Bonanno L

更新日期：2015-01-01 00:00:00

abstract：:The cancer stem cell hypothesis suggests that rare populations of tumor-initiating cells may be resistant to therapy, lead to tumor relapse and contribute to poor prognosis for cancer patients. We previously demonstrated the feasibility of p53 pathway restoration in p53-deficient tumor cell populations using small mol...

journal_title：Cancer biology & therapy

authors： Huang C,Zhang XM,Tavaluc RT,Hart LS,Dicker DT,Wang W,El-Deiry WS

更新日期：2009-11-01 00:00:00

abstract：:In the immune system, activation of naïve T (Tn) cells into effector T cells (Teff) involves a metabolic switch to glycolysis to promote rapid proliferation and differentiation. In the October issue of The Journal of Clinical Investigation, Sukumar et al. have demonstrated that in CD8(+) memory T (Tems) cells glycolyt...

journal_title：Cancer biology & therapy

authors： Karthikeyan S,Geschwind JF,Ganapathy-Kanniappan S

更新日期：2014-05-01 00:00:00

abstract：PURPOSE:genetic polymorphisms in DNA repair genes are thought to represent important determinants of platinum drug efficacy. The current study investigated whether single nucleotide polymorphisms (SNPs) in the X-ray repair cross complementing protein 1 (XRCC1) gene are associated with survival in non-small-cell lung ca...

journal_title：Cancer biology & therapy

authors： Yuan P,Liu L,Wu C,Zhong R,Yu D,Wu J,Xu Y,Nie S,Miao X,Sun Y,Xu B,Lin D

更新日期：2010-11-01 00:00:00

abstract：:Bruton's tyrosine kinase (BTK) is a non-receptor tyrosine kinase that has mainly been studied in haematopoietic cells. We have investigated whether BTK is a potential therapeutic target in prostate cancer. We find that BTK is expressed in prostate cells, with the alternate BTK-C isoform predominantly expressed in pros...

journal_title：Cancer biology & therapy

authors： Kokabee L,Wang X,Sevinsky CJ,Wang WL,Cheu L,Chittur SV,Karimipoor M,Tenniswood M,Conklin DS

更新日期：2015-01-01 00:00:00

abstract：:Melanoma is the deadliest form of skin cancer, which is notoriously aggressive and chemo-resistant, and for which there is little effective treatment available if it goes undetected. Curcumin from the turmeric spice (Curcuma longa) has long been used in Southeast Asian medicine to alleviate ailments and cure an array ...

journal_title：Cancer biology & therapy

authors： Chatterjee SJ,Pandey S

更新日期：2011-01-15 00:00:00

abstract：:Mcl-1, a pro-survival member of the Bcl-2 protein family, is an attractive target for cancer therapy. We have recently identified the natural product marinopyrrole A (maritoclax) as a novel small molecule Mcl-1 inhibitor. Here, we describe the structure-activity relationship study of pyoluteorin derivatives based on m...

journal_title：Cancer biology & therapy

authors： Doi K,Gowda K,Liu Q,Lin JM,Sung SS,Dower C,Claxton D,Loughran TP Jr,Amin S,Wang HG

更新日期：2014-01-01 00:00:00

abstract：:Fluids of body cavities result in a series of pathophysiological events associated with non-malignant and malignant conditions that lead to the formation of exudative effusion. Diagnosis of effusion from the patients is frequently troublesome for the cytologist because of the differentiation and biological behavior of...

journal_title：Cancer biology & therapy

authors： Cora T,Acar H,Ceran S,Bodur S

更新日期：2005-02-01 00:00:00

abstract：:Metastatic cervical cancer remains a clinical problem. The development of more efficient treatment modalities and the optimal use of chemo- and radiotherapy require better understanding of their impact on regulation of cell survival and apoptosis, but the issue is insufficiently explored. Human papillomavirus (HPV) E6...

journal_title：Cancer biology & therapy

authors： Koivusalo R,Hietanen S

更新日期：2004-11-01 00:00:00

abstract：:Recent research has found that long noncoding RNAs (lncRNAs) were involved in various human cancers. However, the role of these lncRNAs in cervical cancer remains unexplored. Therefore, we aimed to investigate the biological function of maternally expressed gene 3 (MEG3), a cancer-related lncRNA, and its underlying me...

journal_title：Cancer biology & therapy

authors： Zhang J,Yao T,Wang Y,Yu J,Liu Y,Lin Z

更新日期：2016-01-01 00:00:00

abstract：:The intrinsic or acquired resistance to multiple drugs (MDR) of cancer cells remains one of the main obstacles for chemotherapy. Development of small molecule targeting to hypoxia inducible factor-1 (HIF-1) has been recently proposed as strategy for treatments of drug-resistant solid tumors. In the present study, emod...

journal_title：Cancer biology & therapy

authors： Huang XZ,Wang J,Huang C,Chen YY,Shi GY,Hu QS,Yi J

更新日期：2008-03-01 00:00:00

abstract：:Caspases play a key role in the apoptotic pathway by virtue of their ability to cleave key protein substrates within the dying cell. Caspases are produced as inactive zymogens, and need to become proteolytically processed in order to become active. A key executioner caspase, caspase-3, has previously been found to exi...

journal_title：Cancer biology & therapy

authors： Frank AK,Pietsch EC,Dumont P,Tao J,Murphy ME

更新日期：2011-04-15 00:00:00

abstract：:The hypoxia-inducible factor 1alpha (HIF-1alpha) plays a major role in cancer progression. The role of this transcription factor in prostate cancer development and its transition to a metastatic and androgen refractory state remains to be elucidated. Previous reports have identified the existence of single nucleotide ...

journal_title：Cancer biology & therapy

authors： Chau CH,Permenter MG,Steinberg SM,Retter AS,Dahut WL,Price DK,Figg WD

更新日期：2005-11-01 00:00:00

abstract：:Tangeretin, a major phytochemicals in tangerine peels--an important Chinese herb, has been found to have anti-carcinogenic properties. To improve bioavailability and increase potency of tangeretin, its derivative, 5-acetyloxy-6,7,8,4'-tetramethoxyflavone (5-AcTMF), has been synthesized and shown potent inhibition of p...

journal_title：Cancer biology & therapy

authors： Li YR,Li S,Ho CT,Chang YH,Tan KT,Chung TW,Wang BY,Chen YK,Lin CC

更新日期：2016-01-01 00:00:00

abstract：:Although most researchers in biology tend to focus on very specific issues and questions about their preferred gene or pathway, sometimes we face situations in which nature presents us with a remarkable example of a gene with multiple functions. Since the discovery of the early growth response 1 (EGR1) gene in the mid...

journal_title：Cancer biology & therapy

authors： DeLigio JT,Zorio DA

更新日期：2009-10-01 00:00:00