MicroRNA-23a depletion promotes apoptosis of ovarian cancer stem cell and inhibits cell migration by targeting DLG2.

abstract：:Medulloblastoma is an aggressive primitive neuroectodermal tumor of the cerebellum that is rare in adults. Medulloblastomas fall into 4 prognostically significant molecular subgroups that are best defined by experimental gene expression profiles: the WNT pathway, sonic hedgehog (SHH) pathway, and subgroups 3 and 4 (no...

journal_title：Cancer biology & therapy

authors： Lou E,Schomaker M,Wilson JD,Ahrens M,Dolan M,Nelson AC

更新日期：2016-10-02 00:00:00

abstract：:Chemotherapy in prostate cancer (CaP) even as an adjunct has not been a success. In this communication, we report the pre-clinical efficacy of a nitroacridine derivative, C-1748 (9[2'-hydroxyethylamino]-4-methyl-1-nitroacridine) in CaP cell culture and human xenograft animal models. C-1748, a DNA intercalating agent h...

journal_title：Cancer biology & therapy

authors： Tadi K,Ashok BT,Chen Y,Banerjee D,Wysocka-Skrzela B,Konopa J,Darzynkiewicz Z,Tiwari RK

更新日期：2007-10-01 00:00:00

abstract：INTRODUCTION:Malignant cells are capable of an unlimited number of cell divisions, either through production of telomerase, or through the alternate lengthening of telomere (ALT) mechanism. Yeast cells with genomic instability have been shown to survive in the absence of telomerase by increased recombination events. We...

journal_title：Cancer biology & therapy

authors： Landen CN,Klingelhutz A,Coffin JE,Sorosky JI,Sood AK

更新日期：2004-12-01 00:00:00

abstract：PURPOSE:Optical coherence tomography (OCT) is a minimally invasive, depth-resolved imaging tool that can be implemented in a small diameter endoscope for imaging mouse models of colorectal cancer (CRC). In this study, we utilized ultrahigh resolution (UHR) OCT to serially image the lower colon of azoxymethane (AOM) tre...

journal_title：Cancer biology & therapy

authors： Hariri LP,Qiu Z,Tumlinson AR,Besselsen DG,Gerner EW,Ignatenko NA,Povazay B,Hermann B,Sattmann H,McNally J,Unterhuber A,Drexler W,Barton JK

更新日期：2007-11-01 00:00:00

abstract：:Cytotoxic chemotherapeutic drugs, especially when used in combination, are widely employed to treat a variety of cancers in patients but often lead to serious symptoms that negatively affect physical functioning and quality of life. There is compelling evidence that implicates cytotoxic chemotherapy-induced inflammati...

journal_title：Cancer biology & therapy

authors： Wong J,Tran LT,Magun EA,Magun BE,Wood LJ

更新日期：2014-10-01 00:00:00

abstract：:Sunitinib, a multi-targeted tyrosine kinase inhibitor, is frequently incorporated into the management of papillary thyroid carcinoma refractory to standard therapies. Although clinical trials are in progress, the mechanism of action in papillary thyroid carcinomas is not clear, especially regarding the effect on BRAF ...

journal_title：Cancer biology & therapy

authors： Jeong WJ,Mo JH,Park MW,Choi IJ,An SY,Jeon EH,Ahn SH

更新日期：2011-09-01 00:00:00

abstract：:Multiple Myeloma (MM) is a progressive malignancy with poor prognosis, commonly treated by the use of the glucocorticoid Dexamethasone. Myeloma cells resist Dexamethasone induced apoptosis when exposed to IL-6 or IGF-1, both of which are known to activate several signaling cascades. For the first time, we show the act...

journal_title：Cancer biology & therapy

authors： Hodge DR,Xiao W,Wang LH,Li D,Farrar WL

更新日期：2004-02-01 00:00:00

abstract：:To avoid cell cycle arrest or apoptosis, rapidly proliferating cancer cells have to promote DNA double strand break (DSB) repair to fix replication stress induced DSBs. Therefore, developing drugs blocking homologous recombination (HR) and nonhomologous end joining (NHEJ) - 2 major DSB repair pathways - holds great po...

journal_title：Cancer biology & therapy

authors： Zhang L,Zhang F,Zhang W,Chen L,Gao N,Men Y,Xu X,Jiang Y

更新日期：2015-01-01 00:00:00

abstract：:Acute promyelocytic leukemia (APL) is one of the most fatal hematological malignancies. APL during pregnancy is a rare comorbidity and can lead to adverse outcomes, such as maternal and/or fetal death, without timely and appropriate management. Medical management for APL during pregnancy remains challenging. We report...

journal_title：Cancer biology & therapy

authors： Li H,Han C,Li K,Li J,Wang Y,Xue F

更新日期：2019-01-01 00:00:00

abstract：:Antitumor imidazoacridinone C-1311 is a DNA-reactive topoisomerase II and FLT3 receptor tyrosine kinase inhibitor. Here, we demonstrate the mechanism of C-1311 inhibitory action on novel targets: hypoxia-inducible factor-1α (HIF-1α), vascular-endothelial growth factor (VEGF), and angiogenesis. In a cell-free system, C...

journal_title：Cancer biology & therapy

authors： Paradziej-Łukowicz J,Skwarska A,Peszyńska-Sularz G,Brillowska-Dąbrowska A,Konopa J

更新日期：2011-10-01 00:00:00

abstract：:The reported incidence of pancreatic neuroendocrine tumors (PanNETs) has increased, due in large part to improvements in detection and awareness. However, therapeutic options are limited and a critical need exists for understanding a more thorough characterization of the molecular pathology underlying this disease. Th...

journal_title：Cancer biology & therapy

authors： Lin W,Francis JM,Li H,Gao X,Pedamallu CS,Ernst P,Meyerson M

更新日期：2016-12-01 00:00:00

abstract：:Both Pten and Nras are downstream mediators of receptor tyrosine kinase activation that plays important roles in controlling cell survival and proliferation. Here, we investigated whether and how Pten loss cross-talks with Nras activation in driving liver cancer development in mice. Somatic disruption of hepatic Pten ...

journal_title：Cancer biology & therapy

authors： Gao M,Liu D

更新日期：2017-07-03 00:00:00

abstract：:There is an urgent need to develop new strategies to treat ovarian cancer, the most deadly gynecologic malignancy. Histone deacetylase (HDAC) inhibitors are emerging as novel therapeutic drugs in the treatment of a variety of cancers, including those resistant to standard chemotherapy. Since there are multiple HDAC is...

journal_title：Cancer biology & therapy

authors： Khabele D,Son DS,Parl AK,Goldberg GL,Augenlicht LH,Mariadason JM,Rice VM

更新日期：2007-05-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) is a lethal disease with suboptimal survival outcomes. In this study, we aimed to find an independent prognostic factor of head and neck squamous cell carcinoma and investigate its effect on tumor cell proliferation, apoptosis, migration progress and cell cycle phase. Weig...

journal_title：Cancer biology & therapy

authors： Li Q,Chen W,Song M,Chen W,Yang Z,Yang A

更新日期：2019-01-01 00:00:00

abstract：:The intrinsic or acquired resistance to multiple drugs (MDR) of cancer cells remains one of the main obstacles for chemotherapy. Development of small molecule targeting to hypoxia inducible factor-1 (HIF-1) has been recently proposed as strategy for treatments of drug-resistant solid tumors. In the present study, emod...

journal_title：Cancer biology & therapy

authors： Huang XZ,Wang J,Huang C,Chen YY,Shi GY,Hu QS,Yi J

更新日期：2008-03-01 00:00:00

abstract：:Tumor formation in immunocompetent hosts is believed to be dependent on the ability of tumor cells to evade the immune system, as suggested by the alterations of expression of the major histocompatibility complex (MHC) and related molecules in a number of cancers. Our previous serial analysis of gene expression (SAGE)...

journal_title：Cancer biology & therapy

authors： Rangel LB,Agarwal R,Sherman-Baust CA,Mello-Coelho Vd,Pizer ES,Ji H,Taub DD,Morin PJ

更新日期：2004-10-01 00:00:00

abstract：:Objective: Chimeric antigen receptor T (CAR-T) cell therapy has demonstrated an unprecedented therapeutic efficacy in hematological malignancies; however, its effectiveness in solid tumors remains elusive. In order to enable CAR-T cells more effective to solid tumors, a inverted chimeric cytokine receptor (ICR) was de...

journal_title：Cancer biology & therapy

authors： Weimin S,Abula A,Qianghong D,Wenguang W

更新日期：2020-06-02 00:00:00

abstract：:The F-box protein Fbw7/Sel-10/hCdc4/Ago, which is known to regulate ubiquitination and degradation of numerous important regulators of cell division and death including Notch, cyclin E, c-Jun and c-Myc, has been recently rediscovered as a p53-dependent tumor suppressor. Delineation of the mechanisms of Fbw7 anti-oncog...

journal_title：Cancer biology & therapy

authors： Fuchs SY

更新日期：2005-05-01 00:00:00

abstract：:Hypoxia, a common phenomenon in human solid tumors, is associated with invasion and metastasis in various tumors. Hypoxia inducible factors (HIFs) are key molecules in the hypoxic response, and regulate the activation of specific genes, which mediate many of the adaptations to hypoxia. CC chemokine receptor 7 (CCR7) h...

journal_title：Cancer biology & therapy

authors： Li Y,Qiu X,Zhang S,Zhang Q,Wang E

更新日期：2009-02-01 00:00:00

abstract：:Exosomes released from cancer cells support metastasis and growth of recipient cells and increase their resistance to chemotherapy. Therapeutic targeting of exosomes is a promising area in cancer research. Our aim is to test the effect of the mast cell stabilizer ketotifen on exosomes release from cancer cells and how...

journal_title：Cancer biology & therapy

authors： Khan FM,Saleh E,Alawadhi H,Harati R,Zimmermann WH,El-Awady R

更新日期：2018-01-02 00:00:00

abstract：:Intestinal metaplasia of the gastric mucosa is an important component in the pathway to adenocarcinoma. The mechanisms that induce the progression from intestinal metaplasia to cancer have not been elucidated. High dietary salt has been known as one of the risk factors for gastric cancer development in humans. Therefo...

journal_title：Cancer biology & therapy

authors： Xiao F,Crissey MA,Lynch JP,Kaestner KH,Silberg DG,Suh E

更新日期：2005-06-01 00:00:00

abstract：:The efficient treatment of lung carcinomas with chemotherapeutics still poses a challenge for anti-cancer therapy. Since stromal cells of the tumor may alter the responsiveness of tumor cells to chemotherapeutics, we studied the impact of lung fibroblasts (WI-38) on the chemotherapy-induced death of non-small cell lun...

journal_title：Cancer biology & therapy

authors： Bartling B,Hofmann HS,Silber RE,Simm A

更新日期：2008-08-01 00:00:00

abstract：:RNA-dependent protein kinase is an interferon-induced, double-stranded (ds), RNA-activated serine/threonine protein kinase involved in the eukaryotic response to viral infection. While PKR also functions in cellular differentiation, growth control and apoptosis, its role in human cancer remains poorly understood. To e...

journal_title：Cancer biology & therapy

authors： Pataer A,Swisher SG,Roth JA,Logothetis CJ,Corn PG

更新日期：2009-02-01 00:00:00

abstract：:Cancer cells convert glucose preferentially to lactate even in the presence of oxygen (aerobic glycolysis-Warburg effect). New concepts in cancer treatment aim at inhibition of aerobic glycolysis. Pyruvate dehydrogenase converts pyruvate to acetylCoA thus preventing lactate formation. Therefore, the aim of this study ...

journal_title：Cancer biology & therapy

authors： Feuerecker B,Pirsig S,Seidl C,Aichler M,Feuchtinger A,Bruchelt G,Senekowitsch-Schmidtke R

更新日期：2012-12-01 00:00:00

abstract：:Taxol (paclitaxel) and Taxotere (docetaxel) are considered as two of the most important anti-cancer chemotherapy drugs. The cytotoxic action of these drugs has been linked to their ability to inhibit microtubule depolymerization, causing growth arrest and subsequent cell death. Studies by a number of laboratories have...

journal_title：Cancer biology & therapy

authors： Yacoub A,Gilfor D,Hawkins W,Park MA,Hanna D,Hagan MP,Curiel DT,Fisher PB,Grant S,Dent P

更新日期：2006-10-01 00:00:00

abstract：:Fluids of body cavities result in a series of pathophysiological events associated with non-malignant and malignant conditions that lead to the formation of exudative effusion. Diagnosis of effusion from the patients is frequently troublesome for the cytologist because of the differentiation and biological behavior of...

journal_title：Cancer biology & therapy

authors： Cora T,Acar H,Ceran S,Bodur S

更新日期：2005-02-01 00:00:00

abstract：:DNA methylation at the 5 position of cytosine (5-mC) has emerged as a key epigenetic marker that plays essential roles in various biological and pathological processes. 5-mC can be converted to 5-hydroxymethylcytosine (5-hmC) by the ten-eleven translocation (TET) family proteins, which is now widely recognized as the ...

journal_title：Cancer biology & therapy

authors： Ye C,Li L

更新日期：2014-01-01 00:00:00

abstract：:While several hypotheses have been put forward to explain how prostate tumors become resistant to androgen deprivation therapy, the mechanism by which prostate tumors have increased androgen concentrations as compared to the serum has been poorly explored. Using a stromal/epithelial cell co-culture model, Mizokami et ...

journal_title：Cancer biology & therapy

authors： Sharma H,Sissung TM,Pressler H,Figg WD

更新日期：2010-02-01 00:00:00

abstract：:Cellular adhesion molecules of the cadherin, integrin, and immunoglobulin superfamilies are important to both growth and metastasis of many cancers, including malignant melanoma. Malignant melanoma is an excellent model for studying these molecules, due in part to a sequential series of five defineable stages. As the ...

journal_title：Cancer biology & therapy

authors： McGary EC,Lev DC,Bar-Eli M

更新日期：2002-09-01 00:00:00

abstract：:In the immune system, activation of naïve T (Tn) cells into effector T cells (Teff) involves a metabolic switch to glycolysis to promote rapid proliferation and differentiation. In the October issue of The Journal of Clinical Investigation, Sukumar et al. have demonstrated that in CD8(+) memory T (Tems) cells glycolyt...

journal_title：Cancer biology & therapy

authors： Karthikeyan S,Geschwind JF,Ganapathy-Kanniappan S

更新日期：2014-05-01 00:00:00