Pre-clinical evaluation of 1-nitroacridine derived chemotherapeutic agent that has preferential cytotoxic activity towards prostate cancer.

abstract：:Current knowledge of changes in the mammary epithelium relevant to breast carcinogenesis is limited to when histological changes are already present because of a lack of biomarkers needed to identify where such molecular changes might be ongoing at earlier during the of decades-long latent stages of breast carcinogene...

journal_title：Cancer biology & therapy

authors： Weisz J,Shearer DA,Murata E,Patrick SD,Han B,Berg A,Clawson GA

更新日期：2012-01-15 00:00:00

abstract：:Chewing tobacco is a common practice in certain socio-economic sections of southern Asia, particularly in the Indian subcontinent and has been well associated with head and neck squamous cell carcinoma. The molecular mechanisms of chewing tobacco which leads to malignancy remains unclear. In large majority of studies,...

journal_title：Cancer biology & therapy

authors： Nanjappa V,Renuse S,Sathe GJ,Raja R,Syed N,Radhakrishnan A,Subbannayya T,Patil A,Marimuthu A,Sahasrabuddhe NA,Guerrero-Preston R,Somani BL,Nair B,Kundu GC,Prasad TK,Califano JA,Gowda H,Sidransky D,Pandey A,Chatterje

更新日期：2015-01-01 00:00:00

abstract：:Ovarian cancer (OC) is xenogeneic that is influenced by many generated factors related to epigenetic factors to accelerate tumor metastasis. This study was conducted with the objective of investigating the effect of microRNA-23a-3p (miR-23a) on the biological characteristics of OC stem cells by targeting discs large h...

journal_title：Cancer biology & therapy

authors： Zhuang RJ,Bai XX,Liu W

更新日期：2019-01-01 00:00:00

abstract：:Docetaxel is an important anti-microtubule agent used to treat a variety of solid tumors, including breast cancer; notably, docetaxel-containing regimens improve outcomes for patients in metastatic, adjuvant, and neoadjuvant settings. However, the effectiveness of docetaxel in clinical practice can be compromised by s...

journal_title：Cancer biology & therapy

authors： Xuan L,Sun B,Meng X,Liu C,Cong Y,Wu S

更新日期：2020-11-01 00:00:00

abstract：:Nonstop proliferation and vigorous neovascularization are two prominent characteristics of cancer. Antiangiogenic therapy has emerged as an important modality in treatment of solid tumors. Our previous work demonstrated that microparticles derived from apoptotic T-lymphocytes (LMPs) not only reduced the viabilities of...

journal_title：Cancer biology & therapy

authors： Yang C,Gagnon C,Hou X,Hardy P

更新日期：2010-09-01 00:00:00

abstract：:One of the most active fields in cancer immunotherapy is the study of bispecific antibodies, which engage immune cells to kill cancer cells. However, a variety of issues are associated with most of current bispecific antibody formats. In this study, we present a novel bispecific antibody, BiSS (Bispecific antibody wit...

journal_title：Cancer biology & therapy

authors： Dong B,Zhou C,He P,Li J,Chen S,Miao J,Li Q,Wang Z

更新日期：2016-04-02 00:00:00

abstract：:Increasing evidence demonstrated that long non-coding RNA ANRIL serves as a fatal oncogene in many cancers, including nasopharyngeal carcinoma (NPC). However, little is known whether ANRIL regulated NPC cell radioresistance. Quantitative real-time PCR (qRT-PCR) was performed to examine the expression of lncRNA ANRIL a...

journal_title：Cancer biology & therapy

authors： Hu X,Jiang H,Jiang X

更新日期：2017-05-04 00:00:00

abstract：:The androgen receptor is one of the central factors in mediating prostate cancer progression and is an important target for treatment. Several possible mechanisms have been put forth as to how it promotes this process. In the January 2004 issue of Nature Medicine, Chen et al. report that the androgen receptor is consi...

journal_title：Cancer biology & therapy

authors： Singh A,Figg WD

更新日期：2004-03-01 00:00:00

abstract：:Adult brain tumors establish an immunosuppressive tumor microenvironment as a modality of immune escape, with several immunotherapies designed to overcome this barrier. However, the relationship between tumor cells and immune cells in pediatric brain tumor patients is not as well-defined. In this study, we sought to d...

journal_title：Cancer biology & therapy

authors： Haberthur K,Brennan K,Hoglund V,Balcaitis S,Chinn H,Davis A,Kreuser S,Winter C,Leary SE,Deutsch GH,Ellenbogen RG,Crane CA

更新日期：2016-12-01 00:00:00

abstract：:Recent reports have shown that cancer stem cells exist in many malignancies. Side population (SP) cells are used to enrich cancer stem-like cells in many cell lines and fresh tumor specimens. In this study, we cultured primary esophageal squamous cell carcinoma (ESCC) cells from ESCC tissue specimens. SP cells from pr...

journal_title：Cancer biology & therapy

authors： Li H,Gao Q,Guo L,Lu SH

更新日期：2011-06-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most deadly tumors. Prognosis of patients with HCC is generally poor due to the high recurrence rate. In the present study, TaqMan Real-time PCR microRNA Array was used to identify differentially expressed miRNAs from 10 tumor tissue samples (5 from recurrence group vs. 5 f...

journal_title：Cancer biology & therapy

authors： Wang L,Liu M,Zhu H,Rong W,Wu F,An S,Liu F,Feng L,Wu J,Xu N

更新日期：2015-01-01 00:00:00

abstract：:Acquired mutations in anaplastic lymphoma kinase (ALK) gene have been implicated as the major resistance mechanism to ALK inhibitors; however, information on the treatment options after acquiring novel ALK secondary mutations is limited. Herein, we report the efficacy of lorlatinib upon the detection of a novel ALK G1...

journal_title：Cancer biology & therapy

authors： Meng Z,Li T,Wang P,Lizaso A,Huang D

更新日期：2021-01-02 00:00:00

abstract：:The phosphoinositide 3-kinase (PI3K)/Akt signaling pathway is important in nasopharyngeal carcinoma (NPC) pathogenesis. Activated PI3K and its downstream target Akt are concernful signaling molecules and key survival factors involved in the control of cell proliferation, apoptosis and oncogenesis. The protein kinase A...

journal_title：Cancer biology & therapy

authors： Yang L,Xiao L,Ma X,Tang M,Weng X,Chen X,Sun L,Cao Y

更新日期：2009-02-01 00:00:00

abstract：:The presence of tumor-infiltrating lymphocytes (TILs) in epithelial ovarian cancer indicates a host antitumor response and is associated with improved survival. We wished to determine the extent to which TIL density differs from site to site within a given patient. We initially studied multiple paired metastases from ...

journal_title：Cancer biology & therapy

authors： Hagemann AR,Hagemann IS,Cadungog M,Hwang WT,Patel P,Lal P,Hammond R,Gimotty PA,Chu CS,Rubin SC,Birrer MJ,Powell DJ Jr,Feldman MD,Coukos G

更新日期：2011-08-15 00:00:00

abstract：:Melanoma is the deadliest form of skin cancer. In the early stages, melanoma can be treated successfully with surgery alone and survival rates are high, but after metastasis survival rates drop significantly. Therefore, early and correct diagnosis is key for ensuring patients have the best possible prognosis. Melanoma...

journal_title：Cancer biology & therapy

authors： Davis LE,Shalin SC,Tackett AJ

更新日期：2019-01-01 00:00:00

abstract：:Although HER2-targeted therapy has been shown to prolong the survival of patients with HER2-positive breast cancer, most patients eventually progress due to drug resistance. Novel treatment options are urgently needed to overcome resistance to HER2-targeted therapy. The VEGF/VEGFR (Vascular endothelial growth factor a...

journal_title：Cancer biology & therapy

authors： Danni L,Lingyun Z,Jian W,Hongfei Y,Lu X,Peng Y,Xiujuan Q,Yunpeng L,Yuee T

更新日期：2020-07-02 00:00:00

abstract：:Understanding molecular mechanisms involved in melanoma resistance to drugs is a big challenge. Experimental evidences suggested a correlation between mutational status in B-RAF and melanoma cell susceptibility to drugs, such as paclitaxel, doxorubicin and temozolomide, which generate an accumulation of hydrogen perox...

journal_title：Cancer biology & therapy

authors： Fico A,Alfano D,Valentino A,Vasta V,Cavalcanti E,Travali S,Patriarca EJ,Caputo E

更新日期：2015-01-01 00:00:00

abstract：:Between 1955 and 1963 millions of people were worldwide vaccinated with polio-vaccines that were contaminated with the simian virus 40 (SV40). This tumor-inducing virus has subsequently been detected in several human tumors. In Austria, polio mass vaccination started in winter 1961/62 with a presumably SV40-free Briti...

journal_title：Cancer biology & therapy

authors： Leithner A,Weinhaeusel A,Windhager R,Schlegl R,Waldner P,Lang S,Dominkus M,Zoubek A,Popper HH,Haas OA

更新日期：2002-07-01 00:00:00

abstract：:Targeting FGFRs is one of the most promising therapeutic strategies in squamous non-small cell lung cancer (SQCC). However, different FGFR genomic aberrations can be associated with distinct biological characteristics that result in different clinical outcomes or therapeutic consequences. Currently, the full spectrum ...

journal_title：Cancer biology & therapy

authors： Li JJ,Yan S,Pan Y,Liu Z,Liu Y,Deng Q,Tan Q,Woodward ER,Wu N

更新日期：2018-01-01 00:00:00

abstract：:Obesity is considered one of the risk factors for many cancers. Serum leptin levels are often elevated in obese people. Leptin has been reported to act as a mitogenic agent and promote renal cancer cell proliferation, whereas the detailed mechanisms still remain to be elucidated. The purpose of this study is to invest...

journal_title：Cancer biology & therapy

authors： Li L,Gao Y,Zhang LL,He DL

更新日期：2008-11-01 00:00:00

abstract：:Cell adhesion molecules (CAMs) are glycoproteins expressed on the surface of cell membranes. In normal cells, CAMs participate in a variety of biological processes including cell proliferation, migration and differentiation. In tumor cells, CAMs have been reported to function as oncogenes or tumor suppressors, in sign...

journal_title：Cancer biology & therapy

authors： Yoon KJ,Danks MK

更新日期：2009-02-01 00:00:00

abstract：:To investigate the diagnostic potential of DNA methylation-based markers in tissue samples of DCIS, we examined the prevalence and extent of methylation in breast ductal carcinoma in situ (DCIS) samples from North American and Korean women. Quantitative multiplex-methylation specific PCR (QM-MSP) of ten genes was perf...

journal_title：Cancer biology & therapy

authors： Lee JS,Fackler MJ,Teo WW,Lee JH,Choi C,Park MH,Yoon JH,Zhang Z,Argani P,Sukumar S

更新日期：2008-09-01 00:00:00

abstract：:Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), such as gefitinib and erlotinib, are the first targeted therapy drugs approved for the treatment of advanced non-small-cell lung cancer (NSCLC). Interestingly, treatment with these small molecule, reversible EGFR-TKIs leads to more positive respo...

journal_title：Cancer biology & therapy

authors： Xu Y,Liu H,Chen J,Zhou Q

更新日期：2010-04-15 00:00:00

abstract：:The pathogenesis of sporadic colorectal cancer involves distinct pathways, with characteristic genomic alterations. The first pathway, chromosome instability (CIN), is driven by APC mutations and is typified by Kras mutations, p53 mutation/loss of heterozygosity, and deletions at chromosome 18q. The second pathway is ...

journal_title：Cancer biology & therapy

authors： Ye Y,Madison B,Wu X,Rustgi AK

更新日期：2012-12-01 00:00:00

abstract：:Epigenetics are defined, in broad-terms, as alterations in gene expression without changes in DNA sequence. While histone modifications and DNA methylation are two classical means to regulate gene expression, miRNA has also recently been documented to govern gene expression in normal as well as cancer cells. In this r...

journal_title：Cancer biology & therapy

authors： Burgess R,Jenkins R,Zhang Z

更新日期：2008-09-01 00:00:00

abstract：:WNT and FGF signaling pathways cross-talk during a variety of cellular processes, such as human colorectal carcinogenesis, mouse mammary tumor virus (MMTV)-induced carcinogenesis, E2A-Pbx-induced leukemogenesis, early embryogenesis, body-axis formation, limb-bud formation, and neurogenesis. Canonical WNT signals are t...

journal_title：Cancer biology & therapy

authors： Katoh M,Katoh M

更新日期：2006-09-01 00:00:00

abstract：:Aggressive fibromatosis (AF) or desmoid tumors is an aggressive fibroblastic proliferation which is locally invasive but can not metastasize. The treatment of AF is challenging. Surgery was the main treatment modality for AF in the past, other strategies including radiotherapy, systemic therapies and wait-and-see poli...

journal_title：Cancer biology & therapy

authors： Yang S,Wang X,Jiang H,Wang Y,Li Z,Lu H

更新日期：2017-10-03 00:00:00

abstract：:Circulating tumor cells (CTC) enter the blood from many carcinomas and represent a likely source of metastatic dissemination. In contrast to the peripheral circulation, KRAS mutation- positive CTC thrive in the portal venous blood of patients with pancreatic ductal adenocarcinoma (PDAC). To analyze the essential inter...

journal_title：Cancer biology & therapy

authors： Arnoletti JP,Fanaian N,Reza J,Sause R,Almodovar AJ,Srivastava M,Patel S,Veldhuis PP,Griffith E,Shao YP,Zhu X,Litherland SA

更新日期：2018-01-01 00:00:00

abstract：:Furanodiene (C15H20O), a pure compound isolated from Traditional Chinese medicine, Curcuma wenyujin, named Ezhu in Chinese, which structure was determined on the basis of NMR, MS and UV spectrum. In this study, we attempted to characterize in detail the signaling cascades resulted from furanodiene-induced apoptosis in...

journal_title：Cancer biology & therapy

authors： Xiao Y,Yang FQ,Li SP,Gao JL,Hu G,Lao SC,Conceição EL,Fung KP,Wangl YT,Lee SM

更新日期：2007-07-01 00:00:00

abstract：:Male germ cell tumors (GCTs) are a model for a curable solid tumor. GCTs can differentiate into mature teratomas. Embryonal carcinomas (ECs) represent the stem cell compartment of GCTs and are the malignant counterpart to embryonic stem (ES) cells. GCTs and EC cells are useful to investigate differentiation therapy an...

journal_title：Cancer biology & therapy

authors： Busch AM,Galimberti F,Nehls KE,Roengvoraphoj M,Sekula D,Li B,Guo Y,Direnzo J,Fiering SN,Spinella MJ,Robbins DJ,Memoli VA,Freemantle SJ,Dmitrovsky E

更新日期：2014-04-01 00:00:00