All-trans-retinoic acid antagonizes the Hedgehog pathway by inducing patched.

abstract：:Progression of prostate cancer has been associated with EGFR and HER2 activation and to tumor-initiating cells contribution toward chemotherapy resistance. We investigated the efficacy of a dual intervention against EGFR and HER2 to deplete the tumor-initiating cells, optimize the chemotherapy management and prevent t...

journal_title：Cancer biology & therapy

authors： Rossini A,Giussani M,Ripamonti F,Aiello P,Regondi V,Balsari A,Triulzi T,Tagliabue E

更新日期：2020-05-03 00:00:00

abstract：:Discovering drugs has never been an easy task. Traditionally, this task has exclusively been undertaken by large pharmaceutical companies that recovered their high research and development costs by selling expensive medications. Despite the huge amount of time and effort devoted towards drug discovery over the last de...

journal_title：Cancer biology & therapy

authors： Sager JA,Lengauer C

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND AND AIM:Widespread applicability of tissue-based mRNA expression screening for Barrett esophagus (BE) is likely to require (1) accurate methods for assaying archival formalin-fixed, paraffin-embedded (FFPE) histopathology specimens taken at endoscopy, and (2) validation studies of promising biomarkers in dif...

journal_title：Cancer biology & therapy

authors： Botelho NK,Schneiders FI,Lord SJ,Freeman AK,Tyagi S,Nancarrow DJ,Hayward NK,Whiteman DC,Lord RV

更新日期：2010-07-15 00:00:00

abstract：:Prior to 2011, only 2 systemic treatments were approved for the treatment of melanoma and these had limited efficacy. In the past 4 years, 6 novel agents have received FDA approval. Herein, we will focus on 4 recently published NEJM papers reporting the results of clinical trials, comprising 4 agents targeting the MAP...

journal_title：Cancer biology & therapy

authors： Massey PR,Prasad V,Figg WD,Fojo T

更新日期：2015-01-01 00:00:00

abstract：:Chronic myeloid leukemia (CML) progresses from a chronic phase to a deadly blast crisis phase. While it is known that BCR-ABL initiates the disease and that secondary molecular and genetic abnormalities likely contribute to progression of the disease to blast crisis, details regarding the mechanism(s) of blast phase p...

journal_title：Cancer biology & therapy

authors： Griner LN,Reuther GW

更新日期：2010-11-15 00:00:00

abstract：:The hypothesis of the "liquid biopsy" using circulating tumor cells (CTCs) emerged as a minimally invasive alternative to traditional tissue biopsy to determine cancer therapy. Discordance for biomarkers expression between primary tumor tissue and circulating tumor cells (CTCs) has been widely reported, thus rendering...

journal_title：Cancer biology & therapy

authors： Raimondi C,Nicolazzo C,Gradilone A,Giannini G,De Falco E,Chimenti I,Varriale E,Hauch S,Plappert L,Cortesi E,Gazzaniga P

更新日期：2014-05-01 00:00:00

abstract：:Tangeretin, a major phytochemicals in tangerine peels--an important Chinese herb, has been found to have anti-carcinogenic properties. To improve bioavailability and increase potency of tangeretin, its derivative, 5-acetyloxy-6,7,8,4'-tetramethoxyflavone (5-AcTMF), has been synthesized and shown potent inhibition of p...

journal_title：Cancer biology & therapy

authors： Li YR,Li S,Ho CT,Chang YH,Tan KT,Chung TW,Wang BY,Chen YK,Lin CC

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVES:To determine the effects of adenovirus-mediated transfer of p14(ARF) and p16(INK4a) on growth and apoptosis of human pancreatic carcinoma cell lines. RESULTS:Pancreatic carcinoma cell lines, PC-7, PANC-1 and MIA PaCa-2 (p14(ARF)-/- and p16(INK4a)-/-), were used. PC-7 (p53 wt) and MIA PaCa-2 (p53 mt) cells i...

journal_title：Cancer biology & therapy

authors： Chen F,Li Y,Lu Z,Gao J,Chen J

更新日期：2005-12-01 00:00:00

abstract：:In a recent issue of Cancer Biology & Therapy, Vitale et al. introduced the paper of Franco et al. reporting the expression of GPER (a seven-transmembrane-spanning receptor also known as GPR30) on testicular germ cell tumors (TGCTs). The paper commented on the possible pathophysiological role of this G-protein-coupled...

journal_title：Cancer biology & therapy

authors： Chevalier N,Bouskine A,Fenichel P

更新日期：2011-07-01 00:00:00

abstract：AIMS:Oral squamous cell carcinoma (OSCC) is the most prevalent malignancy of the oral cavity resulting in severe morbidity and mortality. To date only few proteins have been suggested as potential biomarkers or targets for this type of cancer. Cancerous inhibitor of PP2A (CIP2A) is a protein expressed in epithelial tis...

journal_title：Cancer biology & therapy

authors： Katz J,Jakymiw A,Ducksworth MK,Stewart CM,Bhattacharyya I,Cha S,Chan EK

更新日期：2010-10-01 00:00:00

abstract：PURPOSE:Fibroblast Activation Protein (FAP) is a tumor fibroblast protease that has been shown to potentiate colorectal cancer growth. The clinical impact of FAP inhibition was tested using Val-boroPro (Talabostat), the first clinical inhibitor of FAP enzymatic activity, in a phase II study of patients with metastatic ...

journal_title：Cancer biology & therapy

authors： Narra K,Mullins SR,Lee HO,Strzemkowski-Brun B,Magalong K,Christiansen VJ,McKee PA,Egleston B,Cohen SJ,Weiner LM,Meropol NJ,Cheng JD

更新日期：2007-11-01 00:00:00

abstract：:The enzyme 8-oxoguanine glycosylase 1 (OGG1) repairs 8-oxo-2-deoxyguanosine residue (8-oxodG) an oxidatively damaged promutagenic base. Genetic variations in OGG1 gene have been shown to modulate DNA repair capacity and are related risk of tumor development. However, epidemiologic findings have been inconsistent. The ...

journal_title：Cancer biology & therapy

authors： Habib SL,Danial E,Nath S,Schneider J,Jenkinson CP,Duggirala R,Abboud HE,Thameem F

更新日期：2008-01-01 00:00:00

abstract：:The molecular phenotype of tumor vasculature is different from normal vasculature, offering new opportunities for diagnosis and therapy of cancer, but the identification of tumor-restricted targets remains a challenge. We investigated 13 tumor vascular markers (TVMs) from 50 candidates identified through expression pr...

journal_title：Cancer biology & therapy

authors： Sasaroli D,Gimotty PA,Pathak HB,Hammond R,Kougioumtzidou E,Katsaros D,Buckanovich R,Devarajan K,Sandaltzopoulos R,Godwin AK,Scholler N,Coukos G

更新日期：2011-08-01 00:00:00

abstract：:As a kinase at the crossroads of numerous metabolic and cell growth signaling pathways, glycogen synthase kinase-3 beta (GSK-3β) is a highly desirable therapeutic target in cancer. Despite its involvement in pathways associated with the pathogenesis of several malignancies, no selective GSK-3β inhibitor has been appro...

journal_title：Cancer biology & therapy

authors： Sahin I,Eturi A,De Souza A,Pamarthy S,Tavora F,Giles FJ,Carneiro BA

更新日期：2019-01-01 00:00:00

abstract：:The screening for BRAF V600E mutation is employed in clinical practice for its prognostic and potentially predictive role in patients with metastatic colorectal carcinoma (mCRC). Little information is available on the sensitivity and specificity of the testing methods to detect this mutation in CRC. By using serial di...

journal_title：Cancer biology & therapy

authors： Roma C,Rachiglio AM,Pasquale R,Fenizia F,Iannaccone A,Tatangelo F,Antinolfi G,Parrella P,Graziano P,Sabatino L,Colantuoni V,Botti G,Maiello E,Normanno N

更新日期：2016-08-02 00:00:00

abstract：:Hes1 is one mammalian counterpart of the Hairy and Enhancer of split proteins that play a critical role in many physiological processes including cellular differentiation, cell cycle arrest, apoptosis and self-renewal ability. Recent studies have shown that Hes1 functions in the maintenance of cancer stem cells (CSCs)...

journal_title：Cancer biology & therapy

authors： Liu ZH,Dai XM,Du B

更新日期：2015-01-01 00:00:00

abstract：:Arsenic trioxide (As2O3) induces apoptosis in certain types of cancer cells. But the detailed mechanisms of As2O3 efficacy are not completely known. Here we demonstrate that As2O3 has a therapeutic effect on cervical cancer in vitro and in vivo. We investigated the As2O3-induced apoptosis in various cervical cancer ce...

journal_title：Cancer biology & therapy

authors： Yu J,Qian H,Li Y,Wang Y,Zhang X,Liang X,Fu M,Lin C

更新日期：2007-04-01 00:00:00

abstract：:We report 3 cases of durable complete response (CR) in patients with BRAF-mutated metastatic melanoma who were initially treated unsuccessfully with sequential immunotherapies (high dose interleukin 2 followed by ipilimumab with or without concurrent radiation therapy). After progression during or post immunotherapy, ...

journal_title：Cancer biology & therapy

authors： Wyluda EJ,Cheng J,Schell TD,Haley JS,Mallon C,Neves RI,Robertson G,Sivik J,Mackley H,Talamo G,Drabick JJ

更新日期：2015-01-01 00:00:00

abstract：:Recent research has found that long noncoding RNAs (lncRNAs) were involved in various human cancers. However, the role of these lncRNAs in cervical cancer remains unexplored. Therefore, we aimed to investigate the biological function of maternally expressed gene 3 (MEG3), a cancer-related lncRNA, and its underlying me...

journal_title：Cancer biology & therapy

authors： Zhang J,Yao T,Wang Y,Yu J,Liu Y,Lin Z

更新日期：2016-01-01 00:00:00

abstract：:Retinoids are used in leukemia therapy and chemoprevention of cancers. Treatment of MCF-7 breast carcinoma cells with low doses of retinoids induces gradual proliferation arrest with phenotypic markers of senescence. cDNA microarray hybridization and reverse transcription-polymerase chain reaction analysis showed that...

journal_title：Cancer biology & therapy

authors： Dokmanovic M,Chang BD,Fang J,Roninson IB

更新日期：2002-01-01 00:00:00

abstract：:Adenoid cystic cancers (ACC) in the head and neck are rare yet present a clinical dilemma. Although 5-y survivals are excellent, they have a propensity for late recurrences. Most of these cancers are initially treated with surgery followed by radiation. When recurrences happen, treatment options are limited both by th...

journal_title：Cancer biology & therapy

authors： Gupta AK,Wilke WW,Taylor EN,Bodeker KL,Hoffman HT,Milhem MM,Buatti JM,Robinson RA

更新日期：2009-10-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) remains recalcitrant to effective treatment due to tumor relapse and acquired resistance. Cancer stem cells (CSCs) are believed to be one mechanism for relapse and resistance and are consequently considered promising drug targets. We report that chetomin, an active component of Chaet...

journal_title：Cancer biology & therapy

authors： Min S,Wang X,Du Q,Gong H,Yang Y,Wang T,Wu N,Liu X,Li W,Zhao C,Shen Y,Chen Y,Wang X

更新日期：2020-08-02 00:00:00

abstract：:Heparan sulfate proteoglycans (HSPGs) play important roles in cancer initiation and progression, by interacting with the signaling pathways that affect proliferation, adhesion, invasion and angiogenesis. These roles suggest the possibility of various strategies of regulation of these molecules. In this review, we demo...

journal_title：Cancer biology & therapy

authors： Onyeisi JOS,Ferreira BZF,Nader HB,Lopes CC

更新日期：2020-12-01 00:00:00

abstract：:Several microRNAs (miRNA) have been implicated in H. pylori related gastric cancer (GC). However, the molecular mechanism of miRNAs in gastric cancer has not been fully understood. In this study, we reported that miR-101 is significantly down-regulated in H. pylori positive tissues and cells and in tumor tissues with ...

journal_title：Cancer biology & therapy

authors： Zhou X,Xia Y,Li L,Zhang G

更新日期：2015-01-01 00:00:00

abstract：:Angiomyolipoma (AML) is classified as a perivascular epithelioid cell neoplasm, mostly occurring in the kidney. Twenty percent of patients with renal AML have tuberous sclerosis complex (TSC) caused by germline variation in the TSC1 or TSC2 gene. In this paper, we report the first case of renal AML harboring somatic m...

journal_title：Cancer biology & therapy

authors： Idogawa M,Hida T,Tanaka T,Ohira N,Tange S,Sasaki Y,Uhara H,Masumori N,Tokino T,Natori H

更新日期：2020-04-02 00:00:00

abstract：:The current therapy of cancer fails to completely and exclusively target tumor cells. An ideal target for cancer therapy should be expressed exclusively in tumor cells and contribute to tumorigenesis. Targeting such a candidate gene would cause cell death only in tumor cells. A cancer testis antigen, GAGE, is consider...

journal_title：Cancer biology & therapy

authors： Kular RK,Yehiely F,Deiss LP

更新日期：2010-05-15 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC), the subtype of head and neck cancers, is notorious for its high incidence and death rate. The role of long non-coding RNAs (lncRNAs) is discovered to be significant for the canceration and cancer progression. Long intergenic non-protein coding RNA 958 (LINC00958) is discovered as a...

journal_title：Cancer biology & therapy

authors： Chen F,Liu M,Yu Y,Sun Y,Li J,Hu W,Wang X,Tong D

更新日期：2019-01-01 00:00:00

abstract：:Dendritic cells (DC) operate through an immature (iDC) step (where tumor antigens are internalized) and a mature step (mDC) (where tumor antigens (TA) are cross-presented to naive TA-specific cytotoxic T lymphocyte (CTL) progenitors). Receptors by which cellbound antigens can access the DC cross-presentation pathway i...

journal_title：Cancer biology & therapy

authors： Signorino E,Brusa D,Granata R,Malavasi F,Ferrone S,Matera L

更新日期：2007-12-01 00:00:00

abstract：:Recent reports have shown that cancer stem cells exist in many malignancies. Side population (SP) cells are used to enrich cancer stem-like cells in many cell lines and fresh tumor specimens. In this study, we cultured primary esophageal squamous cell carcinoma (ESCC) cells from ESCC tissue specimens. SP cells from pr...

journal_title：Cancer biology & therapy

authors： Li H,Gao Q,Guo L,Lu SH

更新日期：2011-06-01 00:00:00

abstract：:Overall, NSCLC has a poor 5-year survival and new therapeutic approaches are urgently needed. ERBB-addicted NSCLC that have become resistant to ERBB inhibitors are often refractory to additional therapeutic interventions. The sphingosine-1-phosphate receptor modulator fingolimod (FTY720), approved for the treatment of...

journal_title：Cancer biology & therapy

authors： Booth L,Roberts JL,Spiegel S,Poklepovic A,Dent P

更新日期：2019-01-01 00:00:00