Rational drug design: a GAGE derived peptide kills tumor cells.

abstract：:The objective of the present study was to evaluate CA19-9 and CK8/18 expression patterns in pancreatic cancer cell lines induced by 5-fluorouracil (5-Fu), and in circulating tumor cells (CTCs) in peripheral blood of patients previously untreated with advanced pancreatic cancer. Furthermore, the goal was to test the re...

journal_title：Cancer biology & therapy

authors： Ren C,Han C,Zhang J,He P,Wang D,Wang B,Zhao P,Zhao X

更新日期：2011-10-15 00:00:00

abstract：:Invariant natural killer T (iNKT) cells are a distinct subset of human T cells, which expresses an invariant T cell receptor Vα24 Jα18 and recognizes glycolipid antigens in the context of CD1d molecules. iNKT cells exert pivotal regulatory roles in many immune responses, including antitumor immune responses. Alteratio...

journal_title：Cancer biology & therapy

authors： Altomare E,Fallarini S,Biaggi G,Gattoni E,Botta M,Lombardi G

更新日期：2012-07-01 00:00:00

abstract：:Interdigitating dendritic cell sarcoma is an extremely rare tumor. The diagnosis is difficult and is based on clinical, pathological and immunohistochemical evaluation. Differential diagnosis includes melanoma, mesenchymal and hematological malignancies. The mainstay of treatment is surgery for limited disease and dif...

journal_title：Cancer biology & therapy

authors： Di Liso E,Pennelli N,Lodovichetti G,Ghiotto C,Dei Tos AP,Conte P,Bonanno L

更新日期：2015-01-01 00:00:00

abstract：:Epidemiological studies suggest that obesity increases the risk of developing several cancers, including melanoma. Obesity increases the expression of angiogenic factors, such as leptin, that may contribute to tumor growth. However, a direct cause and effect relationship between obesity and tumor growth has not been c...

journal_title：Cancer biology & therapy

authors： Brandon EL,Gu JW,Cantwell L,He Z,Wallace G,Hall JE

更新日期：2009-10-01 00:00:00

abstract：:As a kinase at the crossroads of numerous metabolic and cell growth signaling pathways, glycogen synthase kinase-3 beta (GSK-3β) is a highly desirable therapeutic target in cancer. Despite its involvement in pathways associated with the pathogenesis of several malignancies, no selective GSK-3β inhibitor has been appro...

journal_title：Cancer biology & therapy

authors： Sahin I,Eturi A,De Souza A,Pamarthy S,Tavora F,Giles FJ,Carneiro BA

更新日期：2019-01-01 00:00:00

abstract：:bcr/abl fusion gene is thought to be a promising target for chronic myelogenous leukemia (CML) patients to enhance immune response after attaining complete remission. In this study, we sought to enhance cellular immunity by co-expression of BCR/ABL and murine IL-12 gene on the tumor cell surface as a glycosyl-phosphat...

journal_title：Cancer biology & therapy

authors： Tao K,Li YJ,Wang D,Qi JY,Deng YP,Wang HX,Hu J,Feng WL

更新日期：2011-11-15 00:00:00

abstract：:To establish stable and long-term gene expression in vitro and in vivo, we developed a lentiviral vector system carrying sodium iodide symporter (hNIS) gene under UbC promoter, and transfected this into a colon cancer cell line. The in vitro and in vivo kinetics of radioiodine and [99mTc]-pertechnetate were then inves...

journal_title：Cancer biology & therapy

authors： Kim HJ,Jeon YH,Kang JH,Lee YJ,Kim KI,Chung HK,Jeong JM,Lee DS,Lee MC,Chung JK

更新日期：2007-07-01 00:00:00

abstract：:We report 3 cases of durable complete response (CR) in patients with BRAF-mutated metastatic melanoma who were initially treated unsuccessfully with sequential immunotherapies (high dose interleukin 2 followed by ipilimumab with or without concurrent radiation therapy). After progression during or post immunotherapy, ...

journal_title：Cancer biology & therapy

authors： Wyluda EJ,Cheng J,Schell TD,Haley JS,Mallon C,Neves RI,Robertson G,Sivik J,Mackley H,Talamo G,Drabick JJ

更新日期：2015-01-01 00:00:00

abstract：:The antiproliferative effects and apoptosis inducing abilities of four 18beta-glycyrrhetinic acid (GA) derivatives, methyl 2-cyano-3,11-dioxooleana-1,12-dien-30-oate (CDODO-Me-11), methyl 2-cyano-3,12-dioxooleana-1,12-dien-30-oate (CDODO-Me-12) and their non-esters were investigated in human leukemia cells. Methyl est...

journal_title：Cancer biology & therapy

authors： Song D,Gao Y,Wang R,Liu D,Zhao L,Jing Y

更新日期：2010-01-01 00:00:00

abstract：:Tangeretin, a major phytochemicals in tangerine peels--an important Chinese herb, has been found to have anti-carcinogenic properties. To improve bioavailability and increase potency of tangeretin, its derivative, 5-acetyloxy-6,7,8,4'-tetramethoxyflavone (5-AcTMF), has been synthesized and shown potent inhibition of p...

journal_title：Cancer biology & therapy

authors： Li YR,Li S,Ho CT,Chang YH,Tan KT,Chung TW,Wang BY,Chen YK,Lin CC

更新日期：2016-01-01 00:00:00

abstract：:Any drug selects for drug resistance. But super-antagonistic drug combinations can select for drug sensitivity. This has important application not only for antibacterial therapy but also for cancer therapy: to control cancer with lesser side effects and to eliminate drug-resistant cancer cells, while sparing sensitive...

journal_title：Cancer biology & therapy

authors： Blagosklonny MV

更新日期：2007-07-01 00:00:00

abstract：:Krüppel-Like Factor 4 (KLF4) functions as a tumor suppressor in some cancers, but its molecular mechanism is not clear. Our recent study also showed that the expression of KLF4 is dramatically reduced in primary lung cancer tissues. To investigate the possible role of KLF4 in lung cancer, we stably transfected KLF4 in...

journal_title：Cancer biology & therapy

authors： Zhou Y,Hofstetter WL,He Y,Hu W,Pataer A,Wang L,Wang J,Zhou Y,Yu L,Fang B,Swisher SG

更新日期：2010-04-01 00:00:00

abstract：:DNA ploidy and S phase fraction analysis by flow cytometry on breast and ovarian tumor cells continuously exposed to aloin, a natural anthraquinone, at two concentrations (20-60 microg/ml) was done. Untreated breast and ovarian tumor cells (control) showed an aneuploid pattern, with a mean DNA index of 2.10+/-0.10 and...

journal_title：Cancer biology & therapy

authors： Esmat AY,El-Gerzawy SM,Rafaat A

更新日期：2005-01-01 00:00:00

abstract：:Recently, we showed that the metal chelator TPEN targets colon cancer cells through redox cycling of copper. Here, we studied the DNA damage potential of TPEN and deciphered the role of Chk1, ATM and DNA-PK in TPEN-induced toxicity in 3 human colon cancer cell lines, HCT116, SW480 and HT29. We also investigated the ro...

journal_title：Cancer biology & therapy

authors： Rahal ON,Fatfat M,Hankache C,Osman B,Khalife H,Machaca K,Muhtasib HG

更新日期：2016-11-01 00:00:00

abstract：:Long standing chronic pancreatitis is a risk factor for developing pancreatic cancer. Inheritance of polymorphisms in SPINK1 and CFTR are associated with an increased risk of developing pancreatitis. The aim of this study was to determine if patients who carry polymorphisms in SPINK1 and CFTR are at increased risk of ...

journal_title：Cancer biology & therapy

authors： Matsubayashi H,Fukushima N,Sato N,Brune K,Canto M,Yeo CJ,Hruban RH,Kern SE,Goggins M

更新日期：2003-11-01 00:00:00

abstract：:In order to demonstrate the role of the pituitary tumor transforming gene 1 (PTTG1) in the development of hepatocellular carcinoma (HCC) and its value as a molecular target for cancer therapy, we analyzed the expression of PTTG1 mRNA and protein, and their relation to clinicopathological characteristics and basic fibr...

journal_title：Cancer biology & therapy

authors： Liang M,Chen X,Liu W,Li S,Li C,Jiang L,Lv S

更新日期：2011-02-01 00:00:00

abstract：:Camptothecins are commonly used chemotherapeutics; in some models, they enhance signaling via the mitogen-activated protein kinase (MAPK) pathway through effects on upstream kinases. To evaluate the impact of camptothecin (CPT) on MAPKs in human colon cancer, we studied HCT116 and CaCo2 colon cancer cells. We found th...

journal_title：Cancer biology & therapy

authors： Lee M,Young Kim S,Kim J,Kim HS,Kim SM,Kim EJ

更新日期：2013-11-01 00:00:00

abstract：:Radiotherapy is a widely used local and regional modality for the treatment of cancer. Despite improved methods of radiation delivery, local recurrence accounts for treatment failure in most patients. Radiosensitizers have been studied as one approach for improving the effectiveness of radiotherapy. Few agents, howeve...

journal_title：Cancer biology & therapy

authors： Kufe D,Weichselbaum R

更新日期：2003-07-01 00:00:00

abstract：:Rhabdomyosarcoma (RMS) is an aggressive childhood sarcoma with two distinct subtypes, embryonal (ERMS) and alveolar (ARMS) histologies. More effective treatment is needed to improve outcomes, beyond conventional cytotoxic chemotherapy. The pan-histone deacetylase inhibitor, Suberoylanilide Hydroxamic Acid (SAHA), has ...

journal_title：Cancer biology & therapy

authors： Ghayad SE,Rammal G,Sarkis O,Basma H,Ghamloush F,Fahs A,Karam M,Harajli M,Rabeh W,Mouawad JE,Zalzali H,Saab R

更新日期：2019-01-01 00:00:00

abstract：:Colorectal cancer remains the second leading cause of cancer-related mortality in the United States. Although surgical resection is still the primary treatment for colorectal cancer, in recent years, there has been a remarkable progress in the development of new therapies to treat colorectal cancer. Response rates hav...

journal_title：Cancer biology & therapy

authors： Cubas R,Li M,Chen C,Yao Q

更新日期：2007-01-01 00:00:00

abstract：:CP-31398, a styrylquinazoline, emerged from a screen for therapeutic agents that restore a wild-type DNA-binding conformation of mutant p53 to suppress tumors in-vivo (Science 286, 2507, 1999). We investigated the growth inhibitory mechanism of CP-31398 using nine human cancer cell lines containing wild-type, mutant o...

journal_title：Cancer biology & therapy

authors： Takimoto R,Wang W,Dicker DT,Rastinejad F,Lyssikatos J,el-Deiry WS

更新日期：2002-01-01 00:00:00

abstract：:There is an urgent need to develop new strategies to treat ovarian cancer, the most deadly gynecologic malignancy. Histone deacetylase (HDAC) inhibitors are emerging as novel therapeutic drugs in the treatment of a variety of cancers, including those resistant to standard chemotherapy. Since there are multiple HDAC is...

journal_title：Cancer biology & therapy

authors： Khabele D,Son DS,Parl AK,Goldberg GL,Augenlicht LH,Mariadason JM,Rice VM

更新日期：2007-05-01 00:00:00

abstract：:The colorectal cancer is the leading contributor of cancer-related mortality. Mammalian target of rapamycin (mTOR), existing in 2 complexes (mTORC1/2), is frequently dysregulated and constitutively activated in colorectal cancers. It represents an important drug target. Here we found that INK-128, the novel ATP-compet...

journal_title：Cancer biology & therapy

authors： Li C,Cui JF,Chen MB,Liu CY,Liu F,Zhang QD,Zou J,Lu PH

更新日期：2015-01-01 00:00:00

abstract：:The phosphoinositide 3-kinase (PI3K)/Akt signaling pathway is important in nasopharyngeal carcinoma (NPC) pathogenesis. Activated PI3K and its downstream target Akt are concernful signaling molecules and key survival factors involved in the control of cell proliferation, apoptosis and oncogenesis. The protein kinase A...

journal_title：Cancer biology & therapy

authors： Yang L,Xiao L,Ma X,Tang M,Weng X,Chen X,Sun L,Cao Y

更新日期：2009-02-01 00:00:00

abstract：:E2F-1, a key transcription factor necessary for cell growth, DNA repair, and differentiation, is an attractive target for development of anticancer drugs in tumors that are E2F "oncogene addicted". We identified a peptide isolated from phage clones that bound tightly to the E2F-1 promoter consensus sequence. The pepti...

journal_title：Cancer biology & therapy

authors： Xie X,Kerrigan JE,Minko T,Garbuzenko O,Lee KC,Scarborough A,Abali EE,Budak-Alpdogan T,Johnson-Farley N,Banerjee D,Scotto KW,Bertino JR

更新日期：2013-08-01 00:00:00

abstract：:Apoptosis induced by interferon-alpha (IFNalpha) is associated with induction of TRAIL in a number of different cell types. Here we examined whether or not TRAIL was required for apoptosis in a model human bladder cancer cell line (UM-UC-12) and defined the molecular mechanisms involved in IFNalpha-induced TRAIL expre...

journal_title：Cancer biology & therapy

authors： Papageorgiou A,Dinney CP,McConkey DJ

更新日期：2007-06-01 00:00:00

abstract：:The alterative reading frame (ARF) protein is unique in its capacity to interact with Mdm2 thus facilitating p53-dependent cell cycle arrest and apoptosis. ARF also acts in a p53-independent manner in which it binds to Myc and interferes with transcriptional activation by Myc thereby inhibiting Myc-induced cell prolif...

journal_title：Cancer biology & therapy

authors： Sarkar D,Fisher PB

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND AND AIM:Widespread applicability of tissue-based mRNA expression screening for Barrett esophagus (BE) is likely to require (1) accurate methods for assaying archival formalin-fixed, paraffin-embedded (FFPE) histopathology specimens taken at endoscopy, and (2) validation studies of promising biomarkers in dif...

journal_title：Cancer biology & therapy

authors： Botelho NK,Schneiders FI,Lord SJ,Freeman AK,Tyagi S,Nancarrow DJ,Hayward NK,Whiteman DC,Lord RV

更新日期：2010-07-15 00:00:00

abstract：:We developed a DNA aptamer, Ap52, against the shared tumor-specific MAGE-A3111-125 peptide antigen that was used to target multiple types of cancer cells. Here we report the in vivo study of mice implanted with pancreatic tumor cells AsPC-1, which demonstrates accumulation of phosphorothioate-modified Ap52 (ThioAp52) ...

journal_title：Cancer biology & therapy

authors： Wang CY,Lin BL,Chen CH

更新日期：2021-01-02 00:00:00

abstract：:Poor oxygenation is a unique and prevalent feature of solid tumors associated with poor patient prognosis. In part, this is caused by a series of adaptive cellular responses that together have a large impact on gene expression and cell phenotype. HIF plays a key role in this response by activating a transcriptional pr...

journal_title：Cancer biology & therapy

authors： van den Beucken T,Koritzinsky M,Wouters BG

更新日期：2006-07-01 00:00:00