Abstract:
:Although HER2-targeted therapy has been shown to prolong the survival of patients with HER2-positive breast cancer, most patients eventually progress due to drug resistance. Novel treatment options are urgently needed to overcome resistance to HER2-targeted therapy. The VEGF/VEGFR (Vascular endothelial growth factor and its receptors) pathway is essential in tumor angiogenesis, which may be a promising target in HER2-positive breast cancer providing a rationale for the use of tyrosine kinase inhibitors (TKIs) targeting VEGFR. Here, we present a case of a heavily pretreated advanced breast cancer patient who did not respond to HER2-targeted therapy and developed resistance to multiple lines of HER2-targeted treatment. The patient was treated with apatinib at a dose of 500 mg daily, and obtained partial remission (PR) with a progression-free-stage (PFS) of 6 months. Our case indicates that apatinib might have anti-tumor activity in patients with HER2-positive breast cancer with HER2-targeted resistance. This case is of value which may provide new insights into strategies for HER2-targeted therapy resistance options in the clinic.
journal_name
Cancer Biol Therjournal_title
Cancer biology & therapyauthors
Danni L,Lingyun Z,Jian W,Hongfei Y,Lu X,Peng Y,Xiujuan Q,Yunpeng L,Yuee Tdoi
10.1080/15384047.2020.1743159subject
Has Abstractpub_date
2020-07-02 00:00:00pages
590-596issue
7eissn
1538-4047issn
1555-8576journal_volume
21pub_type
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journal_title:Cancer biology & therapy
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