5-hydroxymethylcytosine: a new insight into epigenetics in cancer.

abstract：:Numerous tyrosine kinase inhibitors (TKIs) targeting c-Met are currently in clinical trials for several cancers. Their efficacy is limited due to the development of resistance. The present study aims to elucidate this mechanism of c-Met TKI resistance by investigating key mTOR and Wnt signaling proteins in melanoma ce...

journal_title：Cancer biology & therapy

authors： Etnyre D,Stone AL,Fong JT,Jacobs RJ,Uppada SB,Botting GM,Rajanna S,Moravec DN,Shambannagari MR,Crees Z,Girard J,Bertram C,Puri N

更新日期：2014-09-01 00:00:00

abstract：:Angiogenesis plays an essential role in tumor growth and metastasis and is a promising target for cancer therapy. We characterized the effects of selective CIAPIN1 inhibition on the angiogenesis gastric cancer cell line SGC7901 by stable transfection of CIAPIN1 siRNA. Our study has been shown that CIAPIN1 play the det...

journal_title：Cancer biology & therapy

authors： Yan K,He LJ,Cheng W,Ji ZZ,Zhao BX,Hui XL,Cao SS,Chen B,He L,Liang SH,Miao Y

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Somatostatin receptor scintigraphy (SRS) has been reported for receptor (SSTR) screening in advanced hepatocarcinoma (aHC) prior to somatostatin analogue treatment. AIMS:To evaluate SSTR screening with SRS in aHC patients. RESULTS:Seventy aHC patients (63 men) aged 65 +/- 11 y were included, with alcohol, ...

journal_title：Cancer biology & therapy

authors： Nguyen-Khac E,Ollivier I,Aparicio T,Moullart V,Hugentobler A,Lebtahi R,Lobry C,Susini C,Duhamel C,Hommel S,Cadranel JF,Joly JP,Barbare JC,Tramier B,Dupas JL

更新日期：2009-11-01 00:00:00

abstract：:With the increasing interest in development of cytostatic anticancer drugs, the randomized discontinuation trial (RDT) design has been proved to be useful in the evaluation of their clinical activity. In the June 1, 2006 issue of the Journal of Clinical Oncology, a study by Ratain et al. uses RDT in a phase-II placebo...

journal_title：Cancer biology & therapy

authors： Jain L,Venitz J,Figg WD

更新日期：2006-10-01 00:00:00

abstract：:DNA ploidy and S phase fraction analysis by flow cytometry on breast and ovarian tumor cells continuously exposed to aloin, a natural anthraquinone, at two concentrations (20-60 microg/ml) was done. Untreated breast and ovarian tumor cells (control) showed an aneuploid pattern, with a mean DNA index of 2.10+/-0.10 and...

journal_title：Cancer biology & therapy

authors： Esmat AY,El-Gerzawy SM,Rafaat A

更新日期：2005-01-01 00:00:00

abstract：:The chemotherapeutic agents doxorubicin (dox) or 5-fluorouracil (5FU) are used to treat cancer cells as they cause irreparable DNA damage, inducing these aberrant cells to undergo cell death. The mediator of this process is presumed to be in part the tumor suppressor p53 which regulates genes involved in DNA repair an...

journal_title：Cancer biology & therapy

authors： Balmer MT,Katz RD,Liao S,Goodwine JS,Gal S

更新日期：2014-08-01 00:00:00

abstract：:The early observations by Dr Otto Warburg revealed that fundamentally metabolic differences exist between malignant tumor cells and adjacent normal cells. Many studies have further reported the relationship between altered cellular metabolism and therapeutic outcomes. These observations suggest that targeting the pecu...

journal_title：Cancer biology & therapy

authors： Zhang Y,Yang JM

更新日期：2013-02-01 00:00:00

abstract：:SUMO (small ubiquitin-related modifier) represents a class of ubiquitin-like proteins that is conjugated, like ubiquitin, by a set of enzymes to cellular regulatory proteins, including oncogenes and tumor suppressor genes, that play key roles in the control of cell growth, differentiation and apoptosis. SUMO conjugati...

journal_title：Cancer biology & therapy

authors： Alarcon-Vargas D,Ronai Z

更新日期：2002-05-01 00:00:00

abstract：:Bruton's tyrosine kinase (BTK) is a non-receptor tyrosine kinase that has mainly been studied in haematopoietic cells. We have investigated whether BTK is a potential therapeutic target in prostate cancer. We find that BTK is expressed in prostate cells, with the alternate BTK-C isoform predominantly expressed in pros...

journal_title：Cancer biology & therapy

authors： Kokabee L,Wang X,Sevinsky CJ,Wang WL,Cheu L,Chittur SV,Karimipoor M,Tenniswood M,Conklin DS

更新日期：2015-01-01 00:00:00

abstract：:The surprising results published by FIRE-3 revealed that the overall survival (OS) of RAS wild-type metastatic colorectal cancer (mCRC) patients treated with Cetuximab(Cmab) and FOLFIRI combination was prolonged to 33.1 months. The substantial increase in testing and treatment costs, however, impose a considerable hea...

journal_title：Cancer biology & therapy

authors： Wen F,Yang Y,Zhang P,Zhang J,Zhou J,Tang R,Chen H,Zheng H,Fu P,Li Q

更新日期：2015-01-01 00:00:00

abstract：:Hypoxia is an important phenomenon in the tumor microenvironment. Hypoxic tumors are more aggressive and resistant to anti-neoplastic treatments. HIF-1alpha plays a major role in the response of tumors to hypoxia, and it is mainly responsible for the "angiogenic switch". HIF-1alpha contributes to tumor aggressiveness,...

journal_title：Cancer biology & therapy

authors： Diaz-Gonzalez JA,Russell J,Rouzaut A,Gil-Bazo I,Montuenga L

更新日期：2005-10-01 00:00:00

abstract：OBJECTIVES:To determine the effects of adenovirus-mediated transfer of p14(ARF) and p16(INK4a) on growth and apoptosis of human pancreatic carcinoma cell lines. RESULTS:Pancreatic carcinoma cell lines, PC-7, PANC-1 and MIA PaCa-2 (p14(ARF)-/- and p16(INK4a)-/-), were used. PC-7 (p53 wt) and MIA PaCa-2 (p53 mt) cells i...

journal_title：Cancer biology & therapy

authors： Chen F,Li Y,Lu Z,Gao J,Chen J

更新日期：2005-12-01 00:00:00

abstract：:Recently, some studies have placed additional research focus on microRNAs (miRNAs) in a bid to discover novel therapeutic approaches for cervical cancer (CC), which is one of the most common female reproductive tract malignancies with high rates of morbidity and mortality. Hence, the aim of the present study was to ev...

journal_title：Cancer biology & therapy

authors： Wang YF,Yang HY,Shi XQ,Wang Y

更新日期：2018-01-01 00:00:00

abstract：INTRODUCTION:Malignant cells are capable of an unlimited number of cell divisions, either through production of telomerase, or through the alternate lengthening of telomere (ALT) mechanism. Yeast cells with genomic instability have been shown to survive in the absence of telomerase by increased recombination events. We...

journal_title：Cancer biology & therapy

authors： Landen CN,Klingelhutz A,Coffin JE,Sorosky JI,Sood AK

更新日期：2004-12-01 00:00:00

abstract：:Imatinib, an ABL tyrosine kinase inhibitor (TKI), has shown clinical efficacy against chronic myeloid leukemia (CML). However, a substantial number of patients develop resistance to imatinib treatment due to the emergence of clones carrying mutations in the protein BCR-ABL. The phosphoinositide 3 kinase (PI3K)/Akt/mam...

journal_title：Cancer biology & therapy

authors： Okabe S,Tauchi T,Tanaka Y,Kitahara T,Kimura S,Maekawa T,Ohyashiki K

更新日期：2014-02-01 00:00:00

abstract：:Although targeted therapy directed toward driver mutations has produced a significant efficacy benefit for patients with non-small cell lung cancer (NSCLC), many patients do not possess mutations associated with the approved targeted drugs. Angiogenic agents play an important role in the therapeutic strategy for advan...

journal_title：Cancer biology & therapy

authors： Wu F,Zhang S,Gao G,Zhao J,Ren S,Zhou C

更新日期：2018-03-04 00:00:00

abstract：:Long standing chronic pancreatitis is a risk factor for developing pancreatic cancer. Inheritance of polymorphisms in SPINK1 and CFTR are associated with an increased risk of developing pancreatitis. The aim of this study was to determine if patients who carry polymorphisms in SPINK1 and CFTR are at increased risk of ...

journal_title：Cancer biology & therapy

authors： Matsubayashi H,Fukushima N,Sato N,Brune K,Canto M,Yeo CJ,Hruban RH,Kern SE,Goggins M

更新日期：2003-11-01 00:00:00

abstract：OBJECTIVE:EphA2 overexpression predicts poor prognosis in endometrial cancer. To explore mechanisms for this association and assess its potential as therapeutic target, the relationship of EphA2 expression to markers of angiogenesis was examined using patient samples and an orthotopic mouse model of uterine cancer. EX...

journal_title：Cancer biology & therapy

authors： Merritt WM,Kamat AA,Hwang JY,Bottsford-Miller J,Lu C,Lin YG,Coffey D,Spannuth WA,Nugent E,Han LY,Landen CN,Nick AM,Stone RL,Coffman K,Bruckheimer E,Broaddus RR,Gershenson DM,Coleman RL,Sood AK

更新日期：2010-12-15 00:00:00

abstract：:Chronic arsenic treatment induces epithelial-mesenchymal transition (EMT) and promotes tumorigenicity, but the mechanism is unclear. MiR-100 has been shown to be involved in this biologic process. In this study, we hypothesize that inactivation of miR-100 combined with low concentration of arsenic exposure could promo...

journal_title：Cancer biology & therapy

authors： Yang J,Chen Z,Wang X,Xu M,Fang H,Li F,Liu Y,Jiang Y,Ding Y,Li J,Wang S

更新日期：2017-12-02 00:00:00

abstract：BACKGROUND:Peripheral primitive neuroectodermal tumor isolated in the heart, presenting as a primary cardiac tumor is considered as extremely rare. METHODS:We present a 53-year-old Chinese female with a cardiac tumor which was discovered by CT. RESULTS:A hypo-intense tumorous mass was shown extending from the left ve...

journal_title：Cancer biology & therapy

authors： Fan C,Kong D,Tan C,Yang J

更新日期：2017-01-02 00:00:00

abstract：:The current therapy of cancer fails to completely and exclusively target tumor cells. An ideal target for cancer therapy should be expressed exclusively in tumor cells and contribute to tumorigenesis. Targeting such a candidate gene would cause cell death only in tumor cells. A cancer testis antigen, GAGE, is consider...

journal_title：Cancer biology & therapy

authors： Kular RK,Yehiely F,Deiss LP

更新日期：2010-05-15 00:00:00

abstract：:Dendritic cells (DC) operate through an immature (iDC) step (where tumor antigens are internalized) and a mature step (mDC) (where tumor antigens (TA) are cross-presented to naive TA-specific cytotoxic T lymphocyte (CTL) progenitors). Receptors by which cellbound antigens can access the DC cross-presentation pathway i...

journal_title：Cancer biology & therapy

authors： Signorino E,Brusa D,Granata R,Malavasi F,Ferrone S,Matera L

更新日期：2007-12-01 00:00:00

abstract：:Adult brain tumors establish an immunosuppressive tumor microenvironment as a modality of immune escape, with several immunotherapies designed to overcome this barrier. However, the relationship between tumor cells and immune cells in pediatric brain tumor patients is not as well-defined. In this study, we sought to d...

journal_title：Cancer biology & therapy

authors： Haberthur K,Brennan K,Hoglund V,Balcaitis S,Chinn H,Davis A,Kreuser S,Winter C,Leary SE,Deutsch GH,Ellenbogen RG,Crane CA

更新日期：2016-12-01 00:00:00

abstract：:The serine/threonine protein kinase Aurora A is known to interact with and phosphorylate tumor suppressor p53 at Serine 215 (S215), inhibiting the transcriptional activity of p53. We show that Aurora A positively regulates human p53 protein levels and, using isogenic p53 wild-type and p53-null colorectal carcinoma cel...

journal_title：Cancer biology & therapy

authors： Warnock LJ,Raines SA,Milner J

更新日期：2011-12-15 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) remains a significant cause of morbidity and mortality. There has been a great interest in finding specific genomic changes which contribute to HNSCC tumorigenesis, especially within the chromosome 3p area, where high frequency of LOH (loss of heterozygosity) has been repo...

journal_title：Cancer biology & therapy

authors： Lee DJ,Schönleben F,Banuchi VE,Qiu W,Close LG,Assaad AM,Su GH

更新日期：2010-10-01 00:00:00

abstract：:The aim of this study was to examine the cytotoxicity and mechanism of apoptosis induction of verotoxin-1 (VT-1) in human glioma cell lines. VT-1 is a member of the shiga-toxin family expressed by some serotypes of Escherichia coli and Shigella dysenteriae. Shiga-toxins have been shown to induce apoptosis by binding t...

journal_title：Cancer biology & therapy

authors： Johansson D,Johansson A,Grankvist K,Andersson U,Henriksson R,Bergström P,Brännström T,Behnam-Motlagh P

更新日期：2006-09-01 00:00:00

abstract：:Small-molecule inhibitors of cyclin-dependent kinases (CDKs) are known to induce cell cycle arrest and apoptosis in certain cancer cells. In order to evaluate the antitumor activity of one such inhibitor, GW8510, against human lung cancers, we analyzed the effects of GW8510 on six nonsmall cell lung cancer (NSCLC) cel...

journal_title：Cancer biology & therapy

authors： Dong F,Guo W,Zhang L,Wu S,Teraishi F,Davis JJ,Fang B

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:Uterine malformation is a rare deformity in woman, and only a few cases concerning endometrial cancer arising in patients with congenital uterine anomalies have been reported. Herein, we present 3 cases of endometrial cancer with different congenital uterine anomalies, and review studies involving congenital...

journal_title：Cancer biology & therapy

authors： Gao J,Zhang J,Tian W,Teng F,Zhang H,Zhang X,Wang Y,Xue F

更新日期：2017-03-04 00:00:00

abstract：:Mortality data by geographic area and trend-based surveillance are particularly relevant in orienting public health decisions targeting specific populations. We analyzed overall and site-specific cancer mortality between 1988 and 2009 in the metropolitan area of Naples and Caserta in southern Italy. Age-standardized m...

journal_title：Cancer biology & therapy

authors： Crispo A,Barba M,Malvezzi M,Arpino G,Grimaldi M,Rosso T,Esposito E,Sergi D,Ciliberto G,Giordano A,Montella M

更新日期：2013-12-01 00:00:00

abstract：:Colon cancer is the third most common cancer and third most common cause of cancer-related death in the USA according to 2008 American Cancer Society statistics. The carcinogenesis of colon cancer has been associated with both genetics and environmental factors. It has been found that several signal pathways, includin...

journal_title：Cancer biology & therapy

authors： Chen J,Huang XF

更新日期：2009-07-01 00:00:00