当前位置： SCI文献检索 > CANCER BIOLOGY & THERAPY期刊下所有文献 > Chemo-resistant melanoma sensitized by tamoxifen to low dose curcumin treatment through induction of apoptosis and autophagy.

Chemo-resistant melanoma sensitized by tamoxifen to low dose curcumin treatment through induction of apoptosis and autophagy.

Abstract：

:Melanoma is the deadliest form of skin cancer, which is notoriously aggressive and chemo-resistant, and for which there is little effective treatment available if it goes undetected. Curcumin from the turmeric spice (Curcuma longa) has long been used in Southeast Asian medicine to alleviate ailments and cure an array of diseases and disorders. It possesses anti-inflammatory, anti-oxidant and most importantly anti-carcinogenic activity. There have been contradictory reports discussing the efficacy of curcumin-induced death on melanoma. In this report we show that curcumin does induce apoptosis in A375 and the relatively resistant G361 malignant human melanoma cell lines at higher doses. Tamoxifen is an estrogen receptor (ER) blocker that is used for ER positive breast cancer treatment. Recently, tamoxifen has been shown to directly target the mitochondria. Given that curcumin is a pro oxidant and tamoxifen can act on mitochondria, we ask whether the combinatorial treatment could result in synergistic induction of apoptosis in chemo-resistant melanoma. Our results show a corresponding increase in phosphatidyl serine flipping, mitochondria depolarization and reactive oxygen species (ROS) generation by the combined treatment at lower doses. Interestingly, there was significant induction of autophagy along with apoptosis following the combined treatment. Importantly, non-cancerous cells are unaffected by the combination of these non-toxic compounds. However, once exposed to low doses of this co-treatment, melanoma cells still retain signals to commit suicide even after removal of the drugs. This combination provides a non-toxic option for combinatorial chemotherapy with great potential for future use.

journal_name

Cancer Biol Ther

journal_title

Cancer biology & therapy

authors

Chatterjee SJ,Pandey S

doi

10.4161/cbt.11.2.13798

subject

Has Abstract

pub_date

2011-01-15 00:00:00

pages

216-28

issue

2

eissn

1538-4047

issn

1555-8576

pii

13798

journal_volume

11

pub_type

杂志文章

相关文献

CANCER BIOLOGY & THERAPY文献大全
  • c-FLIP downregulation contributes to apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me) in human lung cancer cells.

    abstract：:The novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me) induces apoptosis of cancer cells, enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis, and exhibits potent anticancer activity in animal models with a favorable pharmacokinetic profile....

    journal_title：Cancer biology & therapy

    pub_type： 杂志文章

    doi：10.4161/cbt.6.10.4763

    authors： Zou W,Chen S,Liu X,Yue P,Sporn MB,Khuri FR,Sun SY

    更新日期：2007-10-01 00:00:00

  • Absence of SV40 in Austrian tumors correlates with low incidence of mesotheliomas.

    abstract：:Between 1955 and 1963 millions of people were worldwide vaccinated with polio-vaccines that were contaminated with the simian virus 40 (SV40). This tumor-inducing virus has subsequently been detected in several human tumors. In Austria, polio mass vaccination started in winter 1961/62 with a presumably SV40-free Briti...

    journal_title：Cancer biology & therapy

    pub_type： 杂志文章

    doi：

    authors： Leithner A,Weinhaeusel A,Windhager R,Schlegl R,Waldner P,Lang S,Dominkus M,Zoubek A,Popper HH,Haas OA

    更新日期：2002-07-01 00:00:00

  • Endometrial cancer with congenital uterine anomalies: 3 case reports and a literature review.

    abstract：BACKGROUND:Uterine malformation is a rare deformity in woman, and only a few cases concerning endometrial cancer arising in patients with congenital uterine anomalies have been reported. Herein, we present 3 cases of endometrial cancer with different congenital uterine anomalies, and review studies involving congenital...

    journal_title：Cancer biology & therapy

    pub_type： 杂志文章,评审

    doi：10.1080/15384047.2017.1281495

    authors： Gao J,Zhang J,Tian W,Teng F,Zhang H,Zhang X,Wang Y,Xue F

    更新日期：2017-03-04 00:00:00

  • Translational research in bladder cancer: from molecular pathogenesis to useful tissue biomarkers.

    abstract：:Current risk stratification using clinical and pathological parameters in patients with urothelial carcinoma of the bladder (UCB) is insufficient. Additional information on the tumor biology can be derived from molecular biomarkers assessed in surgical UCB specimens and the predictive accuracy of oncologic end points ...

    journal_title：Cancer biology & therapy

    pub_type： 杂志文章,评审

    doi：10.4161/cbt.10.5.13022

    authors： Bolenz C,Lotan Y

    更新日期：2010-09-01 00:00:00

  • Glycogen synthase kinase-3 beta inhibitors as novel cancer treatments and modulators of antitumor immune responses.

    abstract：:As a kinase at the crossroads of numerous metabolic and cell growth signaling pathways, glycogen synthase kinase-3 beta (GSK-3β) is a highly desirable therapeutic target in cancer. Despite its involvement in pathways associated with the pathogenesis of several malignancies, no selective GSK-3β inhibitor has been appro...

    journal_title：Cancer biology & therapy

    pub_type： 杂志文章,评审

    doi：10.1080/15384047.2019.1595283

    authors： Sahin I,Eturi A,De Souza A,Pamarthy S,Tavora F,Giles FJ,Carneiro BA

    更新日期：2019-01-01 00:00:00

  • Photodynamic therapy activated signaling from epidermal growth factor receptor and STAT3: Targeting survival pathways to increase PDT efficacy in ovarian and lung cancer.

    abstract：:Patients with serosal (pleural or peritoneal) spread of malignancy have few definitive treatment options and consequently have a very poor prognosis. We have previously shown that photodynamic therapy (PDT) can be an effective treatment for these patients, but that the therapeutic index is relatively narrow. Here, we ...

    journal_title：Cancer biology & therapy

    pub_type： 杂志文章

    doi：10.4161/cbt.22256

    authors： Edmonds C,Hagan S,Gallagher-Colombo SM,Busch TM,Cengel KA

    更新日期：2012-12-01 00:00:00

  • Inhibiting gastric cancer-associated angiogenesis by CIAPIN1 siRNA.

    abstract：:Angiogenesis plays an essential role in tumor growth and metastasis and is a promising target for cancer therapy. We characterized the effects of selective CIAPIN1 inhibition on the angiogenesis gastric cancer cell line SGC7901 by stable transfection of CIAPIN1 siRNA. Our study has been shown that CIAPIN1 play the det...

    journal_title：Cancer biology & therapy

    pub_type： 杂志文章

    doi：10.4161/cbt.8.11.8795

    authors： Yan K,He LJ,Cheng W,Ji ZZ,Zhao BX,Hui XL,Cao SS,Chen B,He L,Liang SH,Miao Y

    更新日期：2009-06-01 00:00:00

  • Remarkable enhancement of cytotoxicity of onconase and cepharanthine when used in combination on various tumor cell lines.

    abstract：:Onconase (Onc), a ribonuclease from oocytes or early embryos of Northern Leopard frog (Rana pipiens), is cytostatic and cytotoxic to a variety of tumor lines in vitro, inhibits growth of tumors in animal in vivo models and is currently in Phase IIIb clinical trials for malignant mesothelioma where it displays antitumo...

    journal_title：Cancer biology & therapy

    pub_type： 杂志文章

    doi：10.4161/cbt.7.7.6172

    authors： Ita M,Halicka HD,Tanaka T,Kurose A,Ardelt B,Shogen K,Darzynkiewicz Z

    更新日期：2008-07-01 00:00:00

  • The status of zinc in the development of hepatocellular cancer: an important, but neglected, clinically established relationship.

    abstract：:Liver cancer (hepatocellular carcinoma, HCC) is increasing worldwide. About 75% of HCC cases result in death generally within one year. The factors responsible for the initiation and progression of HCC remain largely unknown and speculative, thereby impeding advancements in the development of effective therapeutic age...

    journal_title：Cancer biology & therapy

    pub_type： 杂志文章,评审

    doi：10.4161/cbt.27633

    authors： Costello LC,Franklin RB

    更新日期：2014-04-01 00:00:00

  • Exploiting defects in homologous recombination repair for metastatic, castration-resistant prostate cancer.

    abstract：:The PROfound trial highlights that there is a benefit in testing genes involved in homologous recombination (HR) and forms the rationale for testing in all patients with metastatic, castration-resistant prostate cancer (mCRPC). This trial also demostrates that olaparib improves progression free survival (PFS), objecti...

    journal_title：Cancer biology & therapy

    pub_type： 杂志文章

    doi：10.1080/15384047.2020.1809913

    authors： Chau V,Madan RA,Figg WD

    更新日期：2020-10-02 00:00:00

  • Quantitative promoter hypermethylation profiles of ductal carcinoma in situ in North American and Korean women: Potential applications for diagnosis.

    abstract：:To investigate the diagnostic potential of DNA methylation-based markers in tissue samples of DCIS, we examined the prevalence and extent of methylation in breast ductal carcinoma in situ (DCIS) samples from North American and Korean women. Quantitative multiplex-methylation specific PCR (QM-MSP) of ten genes was perf...

    journal_title：Cancer biology & therapy

    pub_type： 杂志文章

    doi：10.4161/cbt.7.9.6425

    authors： Lee JS,Fackler MJ,Teo WW,Lee JH,Choi C,Park MH,Yoon JH,Zhang Z,Argani P,Sukumar S

    更新日期：2008-09-01 00:00:00

  • The histone deacetylase inhibitor romidepsin synergizes with lenalidomide and enhances tumor cell death in T-cell lymphoma cell lines.

    abstract：:We investigated the cytotoxic interactions of romidepsin, a histone deacetylase inhibitor, and lenalidomide, an immunomodulatory agent, in a T-cell lymphoma preclinical model. Hut-78 and Karpas-299 cells were treated with romidepsin and lenalidomide alone and in combination. The interaction between romidepsin and lena...

    journal_title：Cancer biology & therapy

    pub_type： 杂志文章

    doi：10.1080/15384047.2016.1219820

    authors： Cosenza M,Civallero M,Fiorcari S,Pozzi S,Marcheselli L,Bari A,Ferri P,Sacchi S

    更新日期：2016-10-02 00:00:00

  • Low density lipoprotein receptor mediates anti-VEGF effect of lymphocyte T-derived microparticles in Lewis lung carcinoma cells.

    abstract：:Nonstop proliferation and vigorous neovascularization are two prominent characteristics of cancer. Antiangiogenic therapy has emerged as an important modality in treatment of solid tumors. Our previous work demonstrated that microparticles derived from apoptotic T-lymphocytes (LMPs) not only reduced the viabilities of...

    journal_title：Cancer biology & therapy

    pub_type： 杂志文章

    doi：10.4161/cbt.10.5.12533

    authors： Yang C,Gagnon C,Hou X,Hardy P

    更新日期：2010-09-01 00:00:00

  • Proteasome inhibitor induces apoptosis through induction of endoplasmic reticulum stress.

    abstract：:The 26S proteasome is a large multi-subunit protein complex found in the cytoplasm and nucleus of mammalian cells which plays a critical role in intracellular proteolysis. It has been found that the 26S proteasome degrades multiple important substrates which are associated with tumor growth and development. Emerging e...

    journal_title：Cancer biology & therapy

    pub_type： 杂志文章

    doi：10.4161/cbt.5.7.2971

    authors： Fribley A,Wang CY

    更新日期：2006-07-01 00:00:00

  • The signal pathways in azoxymethane-induced colon cancer and preventive implications.

    abstract：:Colon cancer is the third most common cancer and third most common cause of cancer-related death in the USA according to 2008 American Cancer Society statistics. The carcinogenesis of colon cancer has been associated with both genetics and environmental factors. It has been found that several signal pathways, includin...

    journal_title：Cancer biology & therapy

    pub_type： 杂志文章,评审

    doi：10.4161/cbt.8.14.8983

    authors： Chen J,Huang XF

    更新日期：2009-07-01 00:00:00

  • Detection of apoptotic circulating tumor cells in advanced pancreatic cancer following 5-fluorouracil chemotherapy.

    abstract：:The objective of the present study was to evaluate CA19-9 and CK8/18 expression patterns in pancreatic cancer cell lines induced by 5-fluorouracil (5-Fu), and in circulating tumor cells (CTCs) in peripheral blood of patients previously untreated with advanced pancreatic cancer. Furthermore, the goal was to test the re...

    journal_title：Cancer biology & therapy

    pub_type： 杂志文章

    doi：10.4161/cbt.12.8.15960

    authors： Ren C,Han C,Zhang J,He P,Wang D,Wang B,Zhao P,Zhao X

    更新日期：2011-10-15 00:00:00

  • Effective treatment of aggressive fibromatosis with celecoxib guided by genetic testing.

    abstract：:Aggressive fibromatosis (AF) or desmoid tumors is an aggressive fibroblastic proliferation which is locally invasive but can not metastasize. The treatment of AF is challenging. Surgery was the main treatment modality for AF in the past, other strategies including radiotherapy, systemic therapies and wait-and-see poli...

    journal_title：Cancer biology & therapy

    pub_type： 杂志文章

    doi：10.1080/15384047.2017.1373215

    authors： Yang S,Wang X,Jiang H,Wang Y,Li Z,Lu H

    更新日期：2017-10-03 00:00:00

  • Chk1 and DNA-PK mediate TPEN-induced DNA damage in a ROS dependent manner in human colon cancer cells.

    abstract：:Recently, we showed that the metal chelator TPEN targets colon cancer cells through redox cycling of copper. Here, we studied the DNA damage potential of TPEN and deciphered the role of Chk1, ATM and DNA-PK in TPEN-induced toxicity in 3 human colon cancer cell lines, HCT116, SW480 and HT29. We also investigated the ro...

    journal_title：Cancer biology & therapy

    pub_type： 杂志文章

    doi：10.1080/15384047.2016.1235658

    authors： Rahal ON,Fatfat M,Hankache C,Osman B,Khalife H,Machaca K,Muhtasib HG

    更新日期：2016-11-01 00:00:00

  • STEAP2 is down-regulated in breast cancer tissue and suppresses PI3K/AKT signaling and breast cancer cell invasion in vitro and in vivo.

    abstract：:The six-transmembrane epithelial antigen of prostate 2 (STEAP2) protein was identified in advanced prostate cancer, and is highly over-expressed in various types of cancer. This study aimed to investigate the prognostic value and the function of STEAP2 in breast cancer. STEAP2 mRNA and protein expressions in breast no...

    journal_title：Cancer biology & therapy

    pub_type： 杂志文章

    doi：10.1080/15384047.2019.1685290

    authors： Yang Q,Ji G,Li J

    更新日期：2020-01-01 00:00:00

  • The VEGFR-2 protein and the VEGFR-2 rs1870377 A>T genetic polymorphism are prognostic factors for gastric cancer.

    abstract：OBJECTIVE:Angiogenesis is one of the key processes in the development of malignant tumors. The vascular endothelial growth factor (VEGF) and VEGF receptor-2 (VEGFR-2) signaling pathway regulates branching angiogenesis in cancer. In this study, we analyzed the associations of VEGF/VEGFR-2 proteins and VEGFR-2 genetic va...

    journal_title：Cancer biology & therapy

    pub_type： 杂志文章

    doi：10.1080/15384047.2018.1537575

    authors： Zhu X,Wang Y,Xue W,Wang R,Wang L,Zhu ML,Zheng L

    更新日期：2019-01-01 00:00:00

  • The p53 paddy wagon: COP1, Pirh2 and MDM2 are found resisting apoptosis and growth arrest.

    abstract：:For years, the growth inhibitory effects of the tumor suppressor p53 were thought to be antagonized predominantly by the ubiquitin ligase, MDM2. It has long been established that MDM2 physically associates with p53 and targets this tumor suppressor for proteasomal degradation. In light of recent findings, it now appea...

    journal_title：Cancer biology & therapy

    pub_type： 杂志文章

    doi：10.4161/cbt.3.8.1068

    authors： Corcoran CA,Huang Y,Sheikh MS

    更新日期：2004-08-01 00:00:00

  • Increased gene copy number of the transcription factor E2F1 in malignant melanoma.

    abstract：:Translocations and unique chromosome break points in melanoma will aid in the identification of the genes that are important in the neoplastic process. We have previously shown a unique translocation in malignant melanoma cells der(12)t(12;20). The transcription factor E2F1 maps to 20q11. Increased expression of E2F h...

    journal_title：Cancer biology & therapy

    pub_type： 杂志文章

    doi：10.4161/cbt.5.4.2512

    authors： Nelson MA,Reynolds SH,Rao UN,Goulet AC,Feng Y,Beas A,Honchak B,Averill J,Lowry DT,Senft JR,Jefferson AM,Johnson RC,Sargent LM

    更新日期：2006-04-01 00:00:00

  • Regulation of Myc function by ARF: checkpoint for Myc-induced oncogenesis.

    abstract：:The alterative reading frame (ARF) protein is unique in its capacity to interact with Mdm2 thus facilitating p53-dependent cell cycle arrest and apoptosis. ARF also acts in a p53-independent manner in which it binds to Myc and interferes with transcriptional activation by Myc thereby inhibiting Myc-induced cell prolif...

    journal_title：Cancer biology & therapy

    pub_type： 评论,杂志文章

    doi：10.4161/cbt.5.6.2939

    authors： Sarkar D,Fisher PB

    更新日期：2006-06-01 00:00:00

  • Small interfering RNA-induced CHFR silencing sensitizes oral squamous cell cancer cells to microtubule inhibitors.

    abstract：:Alterations in the function of cell cycle checkpoints are frequently detected in oral squamous cell carcinomas (OSCCs), and are often associated with the sensitivity of the cancer cells to chemotherapeutic drugs. Recently, a mitotic checkpoint gene, Chfr, was shown to be inactivated by promoter methylation and point m...

    journal_title：Cancer biology & therapy

    pub_type： 杂志文章

    doi：10.4161/cbt.4.7.1896

    authors： Ogi K,Toyota M,Mita H,Satoh A,Kashima L,Sasaki Y,Suzuki H,Akino K,Nishikawa N,Noguchi M,Shinomura Y,Imai K,Hiratsuka H,Tokino T

    更新日期：2005-07-01 00:00:00

  • Histone, H1.2: another housekeeping protein that kills.

    abstract：:Histone H1.2, a housekeeping protein that binds nucleosomal linkers, has recently been identified as an apoptogenic factor released from the nucleus to the cytosol in response to double strand DNA breaks. In the cytosol, it promotes the activation of proapoptotic Bcl-2 family proteins, mitochondrial cytochrome c relea...

    journal_title：Cancer biology & therapy

    pub_type： 杂志文章

    doi：10.4161/cbt.3.1.738

    authors： Zong WX

    更新日期：2004-01-01 00:00:00

  • Inhibition of exosome release by ketotifen enhances sensitivity of cancer cells to doxorubicin.

    abstract：:Exosomes released from cancer cells support metastasis and growth of recipient cells and increase their resistance to chemotherapy. Therapeutic targeting of exosomes is a promising area in cancer research. Our aim is to test the effect of the mast cell stabilizer ketotifen on exosomes release from cancer cells and how...

    journal_title：Cancer biology & therapy

    pub_type： 杂志文章

    doi：10.1080/15384047.2017.1394544

    authors： Khan FM,Saleh E,Alawadhi H,Harati R,Zimmermann WH,El-Awady R

    更新日期：2018-01-02 00:00:00

  • Development of a biomimetic peptide derived from collagen IV with anti-angiogenic activity in breast cancer.

    abstract：:Breast cancer is one of the most commonly diagnosed malignancies in women. Despite the remarkable success of mammography screening and use of adjuvant systemic therapy, it is estimated that approximately 200,000 new diagnoses will be made this year and 40,000 deaths will occur due to this disease (American Cancer Soci...

    journal_title：Cancer biology & therapy

    pub_type： 杂志文章

    doi：10.4161/cbt.12.9.17677

    authors： Rosca EV,Koskimaki JE,Pandey NB,Wolff AC,Popel AS

    更新日期：2011-11-01 00:00:00

  • Sunitinib and PF-562,271 (FAK/Pyk2 inhibitor) effectively block growth and recovery of human hepatocellular carcinoma in a rat xenograft model.

    abstract：EXPERIMENTAL DESIGN:To investigate the antitumor effect of sunitinib and FAK/Pyk2 tyrosine kinase inhibitor (PF-562,271)combination therapy in vivo, utilizing human hepatocellular carcinoma (HCC) cells Huh7.5. Nude rats were inoculated subcutaneously with Huh7.5 hepatoma cells. Dosing for Phase 1 was initiated on day 5...

    journal_title：Cancer biology & therapy

    pub_type： 杂志文章

    doi：10.4161/cbt.8.9.8246

    authors： Bagi CM,Christensen J,Cohen DP,Roberts WG,Wilkie D,Swanson T,Tuthill T,Andresen CJ

    更新日期：2009-05-01 00:00:00

  • Activation of IL-8 via PI3K/Akt-dependent pathway is involved in leptin-mediated epithelial-mesenchymal transition in human breast cancer cells.

    abstract：BACKGROUND INFORMATION:Previous studies have revealed that leptin may be involved in epithelial-mesenchymal transition (EMT), a crucial initiator of cancer progression to facilitate metastatic cascade, increase tumor recurrence, and ultimately cause poor prognosis. However, the underlying mechanism remains unclear. The...

    journal_title：Cancer biology & therapy

    pub_type： 杂志文章

    doi：10.1080/15384047.2015.1056409

    authors： Wang L,Tang C,Cao H,Li K,Pang X,Zhong L,Dang W,Tang H,Huang Y,Wei L,Su M,Chen T

    更新日期：2015-01-01 00:00:00

  • Drug-induced inactivation or gene silencing of class I histone deacetylases suppresses ovarian cancer cell growth: implications for therapy.

    abstract：:There is an urgent need to develop new strategies to treat ovarian cancer, the most deadly gynecologic malignancy. Histone deacetylase (HDAC) inhibitors are emerging as novel therapeutic drugs in the treatment of a variety of cancers, including those resistant to standard chemotherapy. Since there are multiple HDAC is...

    journal_title：Cancer biology & therapy

    pub_type： 杂志文章

    doi：10.4161/cbt.6.5.4007

    authors： Khabele D,Son DS,Parl AK,Goldberg GL,Augenlicht LH,Mariadason JM,Rice VM

    更新日期：2007-05-01 00:00:00