Proteasome inhibitor induces apoptosis through induction of endoplasmic reticulum stress.

abstract：:The present studies have examined approaches to suppress MCL-1 function in breast cancer cells, as a means to promote tumor cell death. Treatment of breast cancer cells with CDK inhibitors (flavopiridol; roscovitine) enhanced the lethality of the ERBB1 inhibitor lapatinib in a synergistic fashion. CDK inhibitors inter...

journal_title：Cancer biology & therapy

authors： Mitchell C,Yacoub A,Hossein H,Martin AP,Bareford MD,Eulitt P,Yang C,Nephew KP,Dent P

更新日期：2010-11-01 00:00:00

abstract：:Taxol (paclitaxel) and Taxotere (docetaxel) are considered as two of the most important anti-cancer chemotherapy drugs. The cytotoxic action of these drugs has been linked to their ability to inhibit microtubule depolymerization, causing growth arrest and subsequent cell death. Studies by a number of laboratories have...

journal_title：Cancer biology & therapy

authors： Yacoub A,Gilfor D,Hawkins W,Park MA,Hanna D,Hagan MP,Curiel DT,Fisher PB,Grant S,Dent P

更新日期：2006-10-01 00:00:00

abstract：:Chronic myeloid leukemia (CML) progresses from a chronic phase to a deadly blast crisis phase. While it is known that BCR-ABL initiates the disease and that secondary molecular and genetic abnormalities likely contribute to progression of the disease to blast crisis, details regarding the mechanism(s) of blast phase p...

journal_title：Cancer biology & therapy

authors： Griner LN,Reuther GW

更新日期：2010-11-15 00:00:00

abstract：:Several microRNAs (miRNA) have been implicated in H. pylori related gastric cancer (GC). However, the molecular mechanism of miRNAs in gastric cancer has not been fully understood. In this study, we reported that miR-101 is significantly down-regulated in H. pylori positive tissues and cells and in tumor tissues with ...

journal_title：Cancer biology & therapy

authors： Zhou X,Xia Y,Li L,Zhang G

更新日期：2015-01-01 00:00:00

abstract：:To investigate the diagnostic potential of DNA methylation-based markers in tissue samples of DCIS, we examined the prevalence and extent of methylation in breast ductal carcinoma in situ (DCIS) samples from North American and Korean women. Quantitative multiplex-methylation specific PCR (QM-MSP) of ten genes was perf...

journal_title：Cancer biology & therapy

authors： Lee JS,Fackler MJ,Teo WW,Lee JH,Choi C,Park MH,Yoon JH,Zhang Z,Argani P,Sukumar S

更新日期：2008-09-01 00:00:00

abstract：:Hypoxia, a common phenomenon in human solid tumors, is associated with invasion and metastasis in various tumors. Hypoxia inducible factors (HIFs) are key molecules in the hypoxic response, and regulate the activation of specific genes, which mediate many of the adaptations to hypoxia. CC chemokine receptor 7 (CCR7) h...

journal_title：Cancer biology & therapy

authors： Li Y,Qiu X,Zhang S,Zhang Q,Wang E

更新日期：2009-02-01 00:00:00

abstract：:Tangeretin, a major phytochemicals in tangerine peels--an important Chinese herb, has been found to have anti-carcinogenic properties. To improve bioavailability and increase potency of tangeretin, its derivative, 5-acetyloxy-6,7,8,4'-tetramethoxyflavone (5-AcTMF), has been synthesized and shown potent inhibition of p...

journal_title：Cancer biology & therapy

authors： Li YR,Li S,Ho CT,Chang YH,Tan KT,Chung TW,Wang BY,Chen YK,Lin CC

更新日期：2016-01-01 00:00:00

abstract：:Translocations and unique chromosome break points in melanoma will aid in the identification of the genes that are important in the neoplastic process. We have previously shown a unique translocation in malignant melanoma cells der(12)t(12;20). The transcription factor E2F1 maps to 20q11. Increased expression of E2F h...

journal_title：Cancer biology & therapy

authors： Nelson MA,Reynolds SH,Rao UN,Goulet AC,Feng Y,Beas A,Honchak B,Averill J,Lowry DT,Senft JR,Jefferson AM,Johnson RC,Sargent LM

更新日期：2006-04-01 00:00:00

abstract：:Antivascular therapy provides a promising method for anticancer therapy. But targeting to gastric cancer vessels is nonselective due in part to the lack of specific cell-surface receptors identified on target vascular cells. Herein we used in vivo screening of phage displayed peptide library to identify some peptides ...

journal_title：Cancer biology & therapy

authors： Zhi M,Wu KC,Dong L,Hao ZM,Deng TZ,Hong L,Liang SH,Zhao PT,Qiao TD,Wang Y,Xu X,Fan DM

更新日期：2004-12-01 00:00:00

abstract：:Fluids of body cavities result in a series of pathophysiological events associated with non-malignant and malignant conditions that lead to the formation of exudative effusion. Diagnosis of effusion from the patients is frequently troublesome for the cytologist because of the differentiation and biological behavior of...

journal_title：Cancer biology & therapy

authors： Cora T,Acar H,Ceran S,Bodur S

更新日期：2005-02-01 00:00:00

abstract：:Colon cancer is the third most common cancer and third most common cause of cancer-related death in the USA according to 2008 American Cancer Society statistics. The carcinogenesis of colon cancer has been associated with both genetics and environmental factors. It has been found that several signal pathways, includin...

journal_title：Cancer biology & therapy

authors： Chen J,Huang XF

更新日期：2009-07-01 00:00:00

abstract：:Resistance of tumors due to restricted drug accumulation and reversal of DNA lesions in tumor cells as well as normal tissue toxicity limit the efficacy of topoisomerase inhibition based anticancer drugs. It has been proposed that selective inhibition of energy dependent repair processes and enhanced retention of drug...

journal_title：Cancer biology & therapy

authors： Dwarakanath BS,Khaitan D,Ravindranath T

更新日期：2004-09-01 00:00:00

abstract：:The alterative reading frame (ARF) protein is unique in its capacity to interact with Mdm2 thus facilitating p53-dependent cell cycle arrest and apoptosis. ARF also acts in a p53-independent manner in which it binds to Myc and interferes with transcriptional activation by Myc thereby inhibiting Myc-induced cell prolif...

journal_title：Cancer biology & therapy

authors： Sarkar D,Fisher PB

更新日期：2006-06-01 00:00:00

abstract：:Although most researchers in biology tend to focus on very specific issues and questions about their preferred gene or pathway, sometimes we face situations in which nature presents us with a remarkable example of a gene with multiple functions. Since the discovery of the early growth response 1 (EGR1) gene in the mid...

journal_title：Cancer biology & therapy

authors： DeLigio JT,Zorio DA

更新日期：2009-10-01 00:00:00

abstract：:The enzyme 8-oxoguanine glycosylase 1 (OGG1) repairs 8-oxo-2-deoxyguanosine residue (8-oxodG) an oxidatively damaged promutagenic base. Genetic variations in OGG1 gene have been shown to modulate DNA repair capacity and are related risk of tumor development. However, epidemiologic findings have been inconsistent. The ...

journal_title：Cancer biology & therapy

authors： Habib SL,Danial E,Nath S,Schneider J,Jenkinson CP,Duggirala R,Abboud HE,Thameem F

更新日期：2008-01-01 00:00:00

abstract：PURPOSE:Indoleamine 2,3-dioxygenase (IDO), a tryptophan catabolic enzyme, plays an important role in immune escape through suppressing T-cell function. Since Vav1 signaling pathway regulates T cell homeostasis, this study was designed to test the hypothesis that IDO induces T-cell immunosuppression through inhibiting V...

journal_title：Cancer biology & therapy

authors： Li R,Wei F,Yu J,Li H,Ren X,Hao X

更新日期：2009-07-01 00:00:00

abstract：:While several hypotheses have been put forward to explain how prostate tumors become resistant to androgen deprivation therapy, the mechanism by which prostate tumors have increased androgen concentrations as compared to the serum has been poorly explored. Using a stromal/epithelial cell co-culture model, Mizokami et ...

journal_title：Cancer biology & therapy

authors： Sharma H,Sissung TM,Pressler H,Figg WD

更新日期：2010-02-01 00:00:00

abstract：:GRP78, also referred to as BiP, is an essential molecular chaperone and a master regulator of the unfolded protein response. Traditionally, GRP78 is regarded as localized in the lumen of the endoplasmic reticulum (ER). However, recent findings revealed that a subfraction of GRP78 can localize to the surface of specifi...

journal_title：Cancer biology & therapy

authors： Lee AS

更新日期：2009-11-01 00:00:00

abstract：:Camptothecins are commonly used chemotherapeutics; in some models, they enhance signaling via the mitogen-activated protein kinase (MAPK) pathway through effects on upstream kinases. To evaluate the impact of camptothecin (CPT) on MAPKs in human colon cancer, we studied HCT116 and CaCo2 colon cancer cells. We found th...

journal_title：Cancer biology & therapy

authors： Lee M,Young Kim S,Kim J,Kim HS,Kim SM,Kim EJ

更新日期：2013-11-01 00:00:00

abstract：:B-cell chronic lymphocytic leukemia (CLL) is caused by the abnormal accumulation of non-functional B-cells in peripheral blood and bone marrow. However, the precise aetiology and mechanism of the disease are unclear. Recently, progress has been made in the identification of both the genetic deficiencies and environmen...

journal_title：Cancer biology & therapy

authors： Chen J,McMillan NA

更新日期：2008-02-01 00:00:00

abstract：:Bruton's tyrosine kinase (BTK) is a non-receptor tyrosine kinase that has mainly been studied in haematopoietic cells. We have investigated whether BTK is a potential therapeutic target in prostate cancer. We find that BTK is expressed in prostate cells, with the alternate BTK-C isoform predominantly expressed in pros...

journal_title：Cancer biology & therapy

authors： Kokabee L,Wang X,Sevinsky CJ,Wang WL,Cheu L,Chittur SV,Karimipoor M,Tenniswood M,Conklin DS

更新日期：2015-01-01 00:00:00

abstract：:IL-15 has been actively investigated for its potential in tumor immunotherapy. To enhance the anti-tumor activity of IL-15, the novel PFC-1 construct was designed, which comprises the following 3 parts: (1) IL-15Rα fused with IL-15 to enhance IL-15 activity, (2) an Fc fragment to increase protein half-life, and (3) an...

journal_title：Cancer biology & therapy

authors： Chen S,Huang Q,Liu J,Xing J,Zhang N,Liu Y,Wang Z,Li Q

更新日期：2015-01-01 00:00:00

abstract：:Background: Associations between polymorphisms in interleukin-10 (IL-10) and hematological oncology were already explored by many genetic association studies, with controversial findings. The aim of this meta-analysis was to more comprehensively analyze associations between polymorphisms in IL-10 and hematological onc...

journal_title：Cancer biology & therapy

authors： Hong P,Feng WY,Fu LH,Jin J,Fu JP

更新日期：2020-04-02 00:00:00

abstract：:RNA-dependent protein kinase is an interferon-induced, double-stranded (ds), RNA-activated serine/threonine protein kinase involved in the eukaryotic response to viral infection. While PKR also functions in cellular differentiation, growth control and apoptosis, its role in human cancer remains poorly understood. To e...

journal_title：Cancer biology & therapy

authors： Pataer A,Swisher SG,Roth JA,Logothetis CJ,Corn PG

更新日期：2009-02-01 00:00:00

abstract：:TPCK is widely used as an inhibitor of chymotrypsin-like proteases but has recently been identified as an inhibitor of the PDK1/Akt pathway. In this study, we show that TPCK inhibits TRAIL-induced caspase activity but potentiates wortmannin-dependent caspase activity in prostatic carcinoma cell lines. The inhibitory a...

journal_title：Cancer biology & therapy

authors： Rokhlin OW,Guseva NV,Taghiyev AF,Glover RA,Cohen MB

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND AND AIM:Widespread applicability of tissue-based mRNA expression screening for Barrett esophagus (BE) is likely to require (1) accurate methods for assaying archival formalin-fixed, paraffin-embedded (FFPE) histopathology specimens taken at endoscopy, and (2) validation studies of promising biomarkers in dif...

journal_title：Cancer biology & therapy

authors： Botelho NK,Schneiders FI,Lord SJ,Freeman AK,Tyagi S,Nancarrow DJ,Hayward NK,Whiteman DC,Lord RV

更新日期：2010-07-15 00:00:00

abstract：:Ovarian cancer (OC) is xenogeneic that is influenced by many generated factors related to epigenetic factors to accelerate tumor metastasis. This study was conducted with the objective of investigating the effect of microRNA-23a-3p (miR-23a) on the biological characteristics of OC stem cells by targeting discs large h...

journal_title：Cancer biology & therapy

authors： Zhuang RJ,Bai XX,Liu W

更新日期：2019-01-01 00:00:00

abstract：:Chewing tobacco is a common practice in certain socio-economic sections of southern Asia, particularly in the Indian subcontinent and has been well associated with head and neck squamous cell carcinoma. The molecular mechanisms of chewing tobacco which leads to malignancy remains unclear. In large majority of studies,...

journal_title：Cancer biology & therapy

authors： Nanjappa V,Renuse S,Sathe GJ,Raja R,Syed N,Radhakrishnan A,Subbannayya T,Patil A,Marimuthu A,Sahasrabuddhe NA,Guerrero-Preston R,Somani BL,Nair B,Kundu GC,Prasad TK,Califano JA,Gowda H,Sidransky D,Pandey A,Chatterje

更新日期：2015-01-01 00:00:00

abstract：:Causes for the complex phenotypes of cancers, such as altered differentiation, invasion and metastasis, are not known, and multigenic defects are likely. In contrast, well-defined deficiencies, such as those affecting DNA-repair mechanisms and enzymatic pathways, are simple, typically caused by one or a few gene mutat...

journal_title：Cancer biology & therapy

authors： Dezentje DA,Arking DE,Kortenhorst MS,West K,Chakravarti A,Kern SE

更新日期：2009-02-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC), characterized by a high rate of metastasis and recurrence after surgery, is caused by malignant proliferation of hepatocytes with epigenetic and/or genetic mutations. In particular, abnormal activation of the hepatocyte growth factor (HGF)-/c-mesenchymal-epithelial transition receptor (...

journal_title：Cancer biology & therapy

authors： Zhao M,Wang Y,Liu Y,Zhang W,Liu Y,Yang X,Cao Y,Wang S

更新日期：2019-01-01 00:00:00