IDO inhibits T-cell function through suppressing Vav1 expression and activation.

abstract：PURPOSE:genetic polymorphisms in DNA repair genes are thought to represent important determinants of platinum drug efficacy. The current study investigated whether single nucleotide polymorphisms (SNPs) in the X-ray repair cross complementing protein 1 (XRCC1) gene are associated with survival in non-small-cell lung ca...

journal_title：Cancer biology & therapy

authors： Yuan P,Liu L,Wu C,Zhong R,Yu D,Wu J,Xu Y,Nie S,Miao X,Sun Y,Xu B,Lin D

更新日期：2010-11-01 00:00:00

abstract：:Tumors with identical phenotype can have markedly different biologic behavior. The differentiation between hemangioblastoma, a benign vascular brain tumor, and renal cell carcinoma (RCC), a malignant tumor that can metastasize to the brain, is a well-known pathological quandary. We report a 59-year-old female with von...

journal_title：Cancer biology & therapy

authors： Gläsker S,Lonser RR,Okamoto H,Li J,Jaffee H,Oldfield EH,Zhuang Z,Vortmeyer AO

更新日期：2007-03-01 00:00:00

abstract：:Breast cancers often have deregulated hepatocyte growth factor (HGF) and c-Met signaling that results in increased tumor growth and invasion. Elucidating the mechanism responsible for HGF/c-Met action in breast cancer progression has been difficult as c-Met communicates with a number of secondary receptors that can le...

journal_title：Cancer biology & therapy

authors： Bonine-Summers AR,Aakre ME,Brown KA,Arteaga CL,Pietenpol JA,Moses HL,Cheng N

更新日期：2007-04-01 00:00:00

abstract：:The selectively oncolytic mtHSV, a HSV icp34.5 mutant with lacz gene insertion, was proved that it was targeted for treating tumors but not other organs, however, its oncolytic mechanism is under confirmation. The results showed that HeLa cells could be lysed efficiently by mtHSV in vitro. In the flow cytometry and We...

journal_title：Cancer biology & therapy

authors： Su Y,Zhu H,Xiao W,Xu Q,Zhu L,Zhang X,Wan Q,Zhou S,Du E,Xu H,Yao L,Lv S,Hu B,Liu Y,Qi Y

更新日期：2007-02-01 00:00:00

abstract：:Deregulated metabolism is gaining recognition as a hallmark of cancer cells, and is being explored for therapeutic potential. The Warburg effect is a metabolic phenotype that occurs in 90% of tumors, where glycolysis is favored despite the presence of oxygen. Dichloroacetate (DCA) is a pyruvate dehydrogenase kinase (P...

journal_title：Cancer biology & therapy

authors： Gang BP,Dilda PJ,Hogg PJ,Blackburn AC

更新日期：2014-01-01 00:00:00

abstract：:The small GTPase Rac1 regulates many cellular processes, including cytoskeletal reorganization, cell migration, proliferation, and survival. Additionally, Rac1 plays a major role in activating NF-κB-mediated transcription. Both Rac1 and NF-κB regulate many properties of the malignant phenotype, including anchorage-ind...

journal_title：Cancer biology & therapy

authors： Gastonguay A,Berg T,Hauser AD,Schuld N,Lorimer E,Williams CL

更新日期：2012-06-01 00:00:00

abstract：:As a kinase at the crossroads of numerous metabolic and cell growth signaling pathways, glycogen synthase kinase-3 beta (GSK-3β) is a highly desirable therapeutic target in cancer. Despite its involvement in pathways associated with the pathogenesis of several malignancies, no selective GSK-3β inhibitor has been appro...

journal_title：Cancer biology & therapy

authors： Sahin I,Eturi A,De Souza A,Pamarthy S,Tavora F,Giles FJ,Carneiro BA

更新日期：2019-01-01 00:00:00

abstract：:Cancer cells convert glucose preferentially to lactate even in the presence of oxygen (aerobic glycolysis-Warburg effect). New concepts in cancer treatment aim at inhibition of aerobic glycolysis. Pyruvate dehydrogenase converts pyruvate to acetylCoA thus preventing lactate formation. Therefore, the aim of this study ...

journal_title：Cancer biology & therapy

authors： Feuerecker B,Pirsig S,Seidl C,Aichler M,Feuchtinger A,Bruchelt G,Senekowitsch-Schmidtke R

更新日期：2012-12-01 00:00:00

abstract：:Farnesyl transferase inhibitors (FTIs) exhibit limited cytotoxic effects against human cancer cells, perhaps explaining the limited efficacy of FTIs in clinical trials. Learning how these well-tolerated drugs trigger p53-independent apoptosis in mouse models of cancer might therefore benefit efforts to leverage their ...

journal_title：Cancer biology & therapy

authors： Kamasani U,Duhadaway JB,Alberts AS,Prendergast GC

更新日期：2007-09-01 00:00:00

abstract：:Prostate cancer is the second leading cause of cancer deaths among men. The availability of animal models that represent the events and factors that exist in the natural history and biology of human prostate cancer is essential in dealing with prostate cancer. In recent decades and presently, emphasis has been directe...

journal_title：Cancer biology & therapy

authors： Costello LC,Franklin RB,Zou J,Feng P,Bok R,Swanson MG,Kurhanewicz J

更新日期：2011-12-15 00:00:00

abstract：:Intestinal metaplasia of the gastric mucosa is an important component in the pathway to adenocarcinoma. The mechanisms that induce the progression from intestinal metaplasia to cancer have not been elucidated. High dietary salt has been known as one of the risk factors for gastric cancer development in humans. Therefo...

journal_title：Cancer biology & therapy

authors： Xiao F,Crissey MA,Lynch JP,Kaestner KH,Silberg DG,Suh E

更新日期：2005-06-01 00:00:00

abstract：:The surprising results published by FIRE-3 revealed that the overall survival (OS) of RAS wild-type metastatic colorectal cancer (mCRC) patients treated with Cetuximab(Cmab) and FOLFIRI combination was prolonged to 33.1 months. The substantial increase in testing and treatment costs, however, impose a considerable hea...

journal_title：Cancer biology & therapy

authors： Wen F,Yang Y,Zhang P,Zhang J,Zhou J,Tang R,Chen H,Zheng H,Fu P,Li Q

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Primary brain tumors have always been associated with high morbidity and mortality. Glioma is the most common type of malignant brain tumors,with a high probability of recurrence after surgical excision and with poor prognosis.The purpose of this study was to compare the therapeutic efficacy of computed tomo...

journal_title：Cancer biology & therapy

authors： Hu X,Qiu H,Zhang L,Zhang W,Ma Y,Qiao Z,Chen D,Han J,Duan G,Zhang F

更新日期：2012-08-01 00:00:00

abstract：:To establish stable and long-term gene expression in vitro and in vivo, we developed a lentiviral vector system carrying sodium iodide symporter (hNIS) gene under UbC promoter, and transfected this into a colon cancer cell line. The in vitro and in vivo kinetics of radioiodine and [99mTc]-pertechnetate were then inves...

journal_title：Cancer biology & therapy

authors： Kim HJ,Jeon YH,Kang JH,Lee YJ,Kim KI,Chung HK,Jeong JM,Lee DS,Lee MC,Chung JK

更新日期：2007-07-01 00:00:00

abstract：:Celecoxib exhibits cancer preventive and therapeutic effects in animal models and clinical trials. It presumably acts through selective inhibition of cyclooxygenase-2 (COX-2) and subsequent reduction of prostaglandin (PG) synthesis. However, the concentrations of celecoxib required for growth inhibition and apoptosis ...

journal_title：Cancer biology & therapy

authors： Sun SY,Schroeder CP,Yue P,Lotan D,Hong WK,Lotan R

更新日期：2005-04-01 00:00:00

abstract：:Metastatic cervical cancer remains a clinical problem. The development of more efficient treatment modalities and the optimal use of chemo- and radiotherapy require better understanding of their impact on regulation of cell survival and apoptosis, but the issue is insufficiently explored. Human papillomavirus (HPV) E6...

journal_title：Cancer biology & therapy

authors： Koivusalo R,Hietanen S

更新日期：2004-11-01 00:00:00

abstract：:Understanding molecular mechanisms involved in melanoma resistance to drugs is a big challenge. Experimental evidences suggested a correlation between mutational status in B-RAF and melanoma cell susceptibility to drugs, such as paclitaxel, doxorubicin and temozolomide, which generate an accumulation of hydrogen perox...

journal_title：Cancer biology & therapy

authors： Fico A,Alfano D,Valentino A,Vasta V,Cavalcanti E,Travali S,Patriarca EJ,Caputo E

更新日期：2015-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC), characterized by a high rate of metastasis and recurrence after surgery, is caused by malignant proliferation of hepatocytes with epigenetic and/or genetic mutations. In particular, abnormal activation of the hepatocyte growth factor (HGF)-/c-mesenchymal-epithelial transition receptor (...

journal_title：Cancer biology & therapy

authors： Zhao M,Wang Y,Liu Y,Zhang W,Liu Y,Yang X,Cao Y,Wang S

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVES:Chemotherapy-induced diarrhea (CID) is a well recognized side effect of cancer treatment. However, the pathophysiology behind this debilitating side effect remains unclear. Irinotecan causes cholinergic and delayed onset diarrhea in patients, in which beta-glucuronidase produced by gut bacteria is thought to...

journal_title：Cancer biology & therapy

authors： Stringer AM,Gibson RJ,Logan RM,Bowen JM,Yeoh AS,Keefe DM

更新日期：2008-12-01 00:00:00

abstract：:Transmembrane protease/serine 4 (TMPRSS4) is a member of the type II transmembrane serine protease (TTSP) family and it was found highly expressed in several cancers. This study aims to evaluate the expression of TMPRSS4 in colorectal cancer (CRC) and investigate its role in proliferation and self-renewal of colon can...

journal_title：Cancer biology & therapy

authors： Huang A,Zhou H,Zhao H,Quan Y,Feng B,Zheng M

更新日期：2014-03-01 00:00:00

abstract：:Hypoxia is an important phenomenon in the tumor microenvironment. Hypoxic tumors are more aggressive and resistant to anti-neoplastic treatments. HIF-1alpha plays a major role in the response of tumors to hypoxia, and it is mainly responsible for the "angiogenic switch". HIF-1alpha contributes to tumor aggressiveness,...

journal_title：Cancer biology & therapy

authors： Diaz-Gonzalez JA,Russell J,Rouzaut A,Gil-Bazo I,Montuenga L

更新日期：2005-10-01 00:00:00

abstract：:Histone H1.2, a housekeeping protein that binds nucleosomal linkers, has recently been identified as an apoptogenic factor released from the nucleus to the cytosol in response to double strand DNA breaks. In the cytosol, it promotes the activation of proapoptotic Bcl-2 family proteins, mitochondrial cytochrome c relea...

journal_title：Cancer biology & therapy

authors： Zong WX

更新日期：2004-01-01 00:00:00

abstract：:To investigate the diagnostic potential of DNA methylation-based markers in tissue samples of DCIS, we examined the prevalence and extent of methylation in breast ductal carcinoma in situ (DCIS) samples from North American and Korean women. Quantitative multiplex-methylation specific PCR (QM-MSP) of ten genes was perf...

journal_title：Cancer biology & therapy

authors： Lee JS,Fackler MJ,Teo WW,Lee JH,Choi C,Park MH,Yoon JH,Zhang Z,Argani P,Sukumar S

更新日期：2008-09-01 00:00:00

abstract：:Fluids of body cavities result in a series of pathophysiological events associated with non-malignant and malignant conditions that lead to the formation of exudative effusion. Diagnosis of effusion from the patients is frequently troublesome for the cytologist because of the differentiation and biological behavior of...

journal_title：Cancer biology & therapy

authors： Cora T,Acar H,Ceran S,Bodur S

更新日期：2005-02-01 00:00:00

abstract：:It was well known that cancer-associated fibroblasts (CAFs) were an essential factor in tumor progression. However, the actual mechanism of stromal fibroblasts activation and tumor promoting effects remain unclear. Here, we showed that KLF5 expression was more frequently observed in gastric cancer-associated fibroblas...

journal_title：Cancer biology & therapy

authors： Yang T,Chen M,Yang X,Zhang X,Zhang Z,Sun Y,Xu B,Hua J,He Z,Song Z

更新日期：2017-10-03 00:00:00

abstract：:Telomerase is the ribonucleoprotein that enables cancer and stem cells to maintain their telomeres, resulting in unlimited proliferative potential. The catalytic component of telomerase in humans, hTERT, is upregulated in nearly 90% of all cancers, making it the most widely expressed marker of malignancy. With the exc...

journal_title：Cancer biology & therapy

authors： Nguyen B,Elmore LW,Holt SE

更新日期：2003-03-01 00:00:00

abstract：:Our previous studies have demonstrated that atorvastatin induces autophagy in the androgen receptor negative prostate cancer PC3 cells through inhibition of geranylgeranyl biosynthesis [Parikh et al., Prostate. 70(9): 971-981 (2010)]. This study attempts to elucidate the molecular mechanism underlying atorvastatin-ind...

journal_title：Cancer biology & therapy

authors： Toepfer N,Childress C,Parikh A,Rukstalis D,Yang W

更新日期：2011-10-15 00:00:00

abstract：:Current risk stratification using clinical and pathological parameters in patients with urothelial carcinoma of the bladder (UCB) is insufficient. Additional information on the tumor biology can be derived from molecular biomarkers assessed in surgical UCB specimens and the predictive accuracy of oncologic end points ...

journal_title：Cancer biology & therapy

authors： Bolenz C,Lotan Y

更新日期：2010-09-01 00:00:00

abstract：:MDM2 antagonists stabilize and activate wild-type p53, and histone methyltransferase (HMT) inhibitors reduce methylation on histone lysines and arginines. Both MDM2 antagonists and HMT inhibitors are being developed as cancer therapeutics. Wild-type p53 expressing HCT116 colon cancer cells were resistant to apoptosis ...

journal_title：Cancer biology & therapy

authors： Zhou Y,Perez RE,Duan L,Maki CG

更新日期：2018-06-03 00:00:00

abstract：:MicroRNAs (miRNAs), an important class of small regulatory molecules for gene expression, are transcribed by RNA polymerase II. But little is known about the mechanisms that control miRNA expression. Comparing miRNA expression profiles between colon cancer cell line HCT 116 and its derivative, DNA methyltransferase 1 ...

journal_title：Cancer biology & therapy

authors： Han L,Witmer PD,Casey E,Valle D,Sukumar S

更新日期：2007-08-01 00:00:00