Epidermal growth factor receptor plays a significant role in hepatocyte growth factor mediated biological responses in mammary epithelial cells.

abstract：:We investigated the role of vasculogenic mimicry (VM) in the progression of prostate cancer (PCa). Ninety-six patients who had undergone prostatectomy for treatment of PCa and for whom a complete record of clinical and follow-up data were available were reviewed. VM and matrix metalloproteinase-2 (MMP-2) were detected...

journal_title：Cancer biology & therapy

authors： Liu R,Yang K,Meng C,Zhang Z,Xu Y

更新日期：2012-05-01 00:00:00

abstract：:The reported incidence of pancreatic neuroendocrine tumors (PanNETs) has increased, due in large part to improvements in detection and awareness. However, therapeutic options are limited and a critical need exists for understanding a more thorough characterization of the molecular pathology underlying this disease. Th...

journal_title：Cancer biology & therapy

authors： Lin W,Francis JM,Li H,Gao X,Pedamallu CS,Ernst P,Meyerson M

更新日期：2016-12-01 00:00:00

abstract：:Multiple myeloma (MM) is an incurable B-cell malignancy characterized by accumulation of malignant plasma cells in the bone marrow and by recurrent or persistent infections. Toll-like receptors (TLRs) are essential in the host defense against infections. The aim of this study was to investigate TLR initiated responses...

journal_title：Cancer biology & therapy

authors： Bao H,Lu P,Li Y,Wang L,Li H,He D,Yang Y,Zhao Y,Yang L,Wang M,Yi Q,Cai Z

更新日期：2011-01-01 00:00:00

abstract：:5-fluorouracil (5-FU) is the major chemotherapeutic agent for treatment of colorectal carcinoma, but the molecular mechanisms of response and resistance are not understood completely. We therefore studied the 5-FU dose response and time course of gene expression transcriptome changes in colon carcinoma cell lines that...

journal_title：Cancer biology & therapy

authors： Zhang W,Ramdas L,Shen W,Song SW,Hu L,Hamilton SR

更新日期：2003-09-01 00:00:00

abstract：:IL-15 has been actively investigated for its potential in tumor immunotherapy. To enhance the anti-tumor activity of IL-15, the novel PFC-1 construct was designed, which comprises the following 3 parts: (1) IL-15Rα fused with IL-15 to enhance IL-15 activity, (2) an Fc fragment to increase protein half-life, and (3) an...

journal_title：Cancer biology & therapy

authors： Chen S,Huang Q,Liu J,Xing J,Zhang N,Liu Y,Wang Z,Li Q

更新日期：2015-01-01 00:00:00

abstract：:Acquired mutations in anaplastic lymphoma kinase (ALK) gene have been implicated as the major resistance mechanism to ALK inhibitors; however, information on the treatment options after acquiring novel ALK secondary mutations is limited. Herein, we report the efficacy of lorlatinib upon the detection of a novel ALK G1...

journal_title：Cancer biology & therapy

authors： Meng Z,Li T,Wang P,Lizaso A,Huang D

更新日期：2021-01-02 00:00:00

abstract：OBJECTIVES:To evaluate the 6-mo overall survival, safety and tolerability of lenalidomide in combination with standard gemcitabine as first-line treatment for patients with metastatic pancreatic cancer. METHODS:Eligibility included: previously untreated metastatic adenocarcinoma of the pancreas with metastases incurab...

journal_title：Cancer biology & therapy

authors： Infante JR,Arkenau HT,Bendell JC,Rubin MS,Waterhouse D,Jones GT,Spigel DR,Lane CM,Hainsworth JD,Burris HA 3rd

更新日期：2013-04-01 00:00:00

abstract：:Bevacizumab, is a humanized monoclonal antibody to vasculo-endothelial-growth-factor, with anticancer activity in non-small-cell-lung cancer (NSCLC) patients. Our previous results from a dose/finding phase I trial in NSCLC patients, demonstrated the anti-angiogenic effects and toxicity of a newest bevacizumab-based co...

journal_title：Cancer biology & therapy

authors： Correale P,Botta C,Basile A,Pagliuchi M,Licchetta A,Martellucci I,Bestoso E,Apollinari S,Addeo R,Misso G,Romano O,Abbruzzese A,Lamberti M,Luzzi L,Gotti G,Rotundo MS,Caraglia M,Tagliaferri P

更新日期：2011-07-15 00:00:00

abstract：:A number of discoveries have clarified the molecular mechanism of apoptosis, thus clarifying the link between apoptosis and therapeutic outcome. Even though apoptosis is thought to play a major role in anticancer therapy, the clinical relevance of induction of apoptosis remains uncertain, particularly in solid tumors....

journal_title：Cancer biology & therapy

authors： Kim R,Emi M,Tanabe K

更新日期：2006-11-01 00:00:00

abstract：:Bruton's tyrosine kinase (BTK) is a non-receptor tyrosine kinase that has mainly been studied in haematopoietic cells. We have investigated whether BTK is a potential therapeutic target in prostate cancer. We find that BTK is expressed in prostate cells, with the alternate BTK-C isoform predominantly expressed in pros...

journal_title：Cancer biology & therapy

authors： Kokabee L,Wang X,Sevinsky CJ,Wang WL,Cheu L,Chittur SV,Karimipoor M,Tenniswood M,Conklin DS

更新日期：2015-01-01 00:00:00

abstract：:The molecular phenotype of tumor vasculature is different from normal vasculature, offering new opportunities for diagnosis and therapy of cancer, but the identification of tumor-restricted targets remains a challenge. We investigated 13 tumor vascular markers (TVMs) from 50 candidates identified through expression pr...

journal_title：Cancer biology & therapy

authors： Sasaroli D,Gimotty PA,Pathak HB,Hammond R,Kougioumtzidou E,Katsaros D,Buckanovich R,Devarajan K,Sandaltzopoulos R,Godwin AK,Scholler N,Coukos G

更新日期：2011-08-01 00:00:00

abstract：:The 26S proteasome is a large multi-subunit protein complex found in the cytoplasm and nucleus of mammalian cells which plays a critical role in intracellular proteolysis. It has been found that the 26S proteasome degrades multiple important substrates which are associated with tumor growth and development. Emerging e...

journal_title：Cancer biology & therapy

authors： Fribley A,Wang CY

更新日期：2006-07-01 00:00:00

abstract：:Celecoxib exhibits cancer preventive and therapeutic effects in animal models and clinical trials. It presumably acts through selective inhibition of cyclooxygenase-2 (COX-2) and subsequent reduction of prostaglandin (PG) synthesis. However, the concentrations of celecoxib required for growth inhibition and apoptosis ...

journal_title：Cancer biology & therapy

authors： Sun SY,Schroeder CP,Yue P,Lotan D,Hong WK,Lotan R

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVES:Due to the absence of reliable and accurate biomarkers for the early detection of liver malignancy, circulating microRNAs have recently emerged as great candidates for prompt cancer identification. Therefore, the aim of this study was to investigate the potential of liver-specific circulating microRNAs as an...

journal_title：Cancer biology & therapy

authors： Mourad L,El-Ahwany E,Zoheiry M,Abu-Taleb H,Hassan M,Ouf A,Rahim AA,Hassanien M,Zada S

更新日期：2018-05-04 00:00:00

abstract：:A major problem in cancer treatment is the development of resistance to chemotherapeutic agents, multidrug resistance (MDR), associated with increased activity of transmembrane drug transporter proteins which impair cytotoxic treatment by rapidly removing the drugs from the targeted cells. Previously, it has been show...

journal_title：Cancer biology & therapy

authors： Chen Y,Scully M,Petralia G,Kakkar A

更新日期：2014-01-01 00:00:00

abstract：:Every year, 12,000 people in the U.S. die from renal cell carcinoma. Current therapies include partial or complete nephrectomy or treatments such as administration of IFN-alpha and/or interleukins that are moderately effective, at best. Moreover, the current therapies are invasive and inefficient and new therapies are...

journal_title：Cancer biology & therapy

authors： VanOosten RL,Moore JM,Karacay B,Griffith TS

更新日期：2005-10-01 00:00:00

abstract：:Circulating tumor cells (CTC) enter the blood from many carcinomas and represent a likely source of metastatic dissemination. In contrast to the peripheral circulation, KRAS mutation- positive CTC thrive in the portal venous blood of patients with pancreatic ductal adenocarcinoma (PDAC). To analyze the essential inter...

journal_title：Cancer biology & therapy

authors： Arnoletti JP,Fanaian N,Reza J,Sause R,Almodovar AJ,Srivastava M,Patel S,Veldhuis PP,Griffith E,Shao YP,Zhu X,Litherland SA

更新日期：2018-01-01 00:00:00

abstract：:The screening for BRAF V600E mutation is employed in clinical practice for its prognostic and potentially predictive role in patients with metastatic colorectal carcinoma (mCRC). Little information is available on the sensitivity and specificity of the testing methods to detect this mutation in CRC. By using serial di...

journal_title：Cancer biology & therapy

authors： Roma C,Rachiglio AM,Pasquale R,Fenizia F,Iannaccone A,Tatangelo F,Antinolfi G,Parrella P,Graziano P,Sabatino L,Colantuoni V,Botti G,Maiello E,Normanno N

更新日期：2016-08-02 00:00:00

abstract：:Silibinin, derived from milk thistle extract, has been shown to inhibit growth factor receptor-mediated mitogenic and cell survival signaling, and to alter cell cycle regulators. Alteration in pathways regulating cell growth likely account for silibinin's inhibition of tumor growth. Since the epidermal growth factor r...

journal_title：Cancer biology & therapy

authors： Qi L,Singh RP,Lu Y,Agarwal R,Harrison GS,Franzusoff A,Glode LM

更新日期：2003-09-01 00:00:00

abstract：:Furanodiene (C15H20O), a pure compound isolated from Traditional Chinese medicine, Curcuma wenyujin, named Ezhu in Chinese, which structure was determined on the basis of NMR, MS and UV spectrum. In this study, we attempted to characterize in detail the signaling cascades resulted from furanodiene-induced apoptosis in...

journal_title：Cancer biology & therapy

authors： Xiao Y,Yang FQ,Li SP,Gao JL,Hu G,Lao SC,Conceição EL,Fung KP,Wangl YT,Lee SM

更新日期：2007-07-01 00:00:00

abstract：:Melanoma is the deadliest form of skin cancer, which is notoriously aggressive and chemo-resistant, and for which there is little effective treatment available if it goes undetected. Curcumin from the turmeric spice (Curcuma longa) has long been used in Southeast Asian medicine to alleviate ailments and cure an array ...

journal_title：Cancer biology & therapy

authors： Chatterjee SJ,Pandey S

更新日期：2011-01-15 00:00:00

abstract：:Although most researchers in biology tend to focus on very specific issues and questions about their preferred gene or pathway, sometimes we face situations in which nature presents us with a remarkable example of a gene with multiple functions. Since the discovery of the early growth response 1 (EGR1) gene in the mid...

journal_title：Cancer biology & therapy

authors： DeLigio JT,Zorio DA

更新日期：2009-10-01 00:00:00

abstract：:Dendritic cells (DC) operate through an immature (iDC) step (where tumor antigens are internalized) and a mature step (mDC) (where tumor antigens (TA) are cross-presented to naive TA-specific cytotoxic T lymphocyte (CTL) progenitors). Receptors by which cellbound antigens can access the DC cross-presentation pathway i...

journal_title：Cancer biology & therapy

authors： Signorino E,Brusa D,Granata R,Malavasi F,Ferrone S,Matera L

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:It has recently been suggested that overexpression of palladin in sporadic pancreatic cancer may contribute to pancreatic cancer's invasive and migratory abilities. This hypothesis was based on reverse transcriptase-polymerase chain reaction analyses of bulk pancreatic tissue, yet pancreatic cancer is a comp...

journal_title：Cancer biology & therapy

authors： Salaria SN,Illei P,Sharma R,Walter KM,Klein AP,Eshleman JR,Maitra A,Schulick R,Winter J,Ouellette MM,Goggins M,Hruban R

更新日期：2007-03-01 00:00:00

abstract：:The alterative reading frame (ARF) protein is unique in its capacity to interact with Mdm2 thus facilitating p53-dependent cell cycle arrest and apoptosis. ARF also acts in a p53-independent manner in which it binds to Myc and interferes with transcriptional activation by Myc thereby inhibiting Myc-induced cell prolif...

journal_title：Cancer biology & therapy

authors： Sarkar D,Fisher PB

更新日期：2006-06-01 00:00:00

abstract：:Heparan sulfate proteoglycans (HSPGs) play important roles in cancer initiation and progression, by interacting with the signaling pathways that affect proliferation, adhesion, invasion and angiogenesis. These roles suggest the possibility of various strategies of regulation of these molecules. In this review, we demo...

journal_title：Cancer biology & therapy

authors： Onyeisi JOS,Ferreira BZF,Nader HB,Lopes CC

更新日期：2020-12-01 00:00:00

abstract：:PRL-1 (phosphatase of regenerating liver-1), PRL-2 and PRL-3 are protein tyrosine phosphatases with a C-terminal prenylation motif that are localized to the inner leaflet of the plasma membrane and early endosomes. A variety of metastatic PRL-overexpressing cancers have been reported. Therefore, the three PRL-phosphat...

journal_title：Cancer biology & therapy

authors： Guo K,Tang JP,Tan CP,Wang H,Zeng Q

更新日期：2008-05-01 00:00:00

abstract：:Cellular adhesion molecules of the cadherin, integrin, and immunoglobulin superfamilies are important to both growth and metastasis of many cancers, including malignant melanoma. Malignant melanoma is an excellent model for studying these molecules, due in part to a sequential series of five defineable stages. As the ...

journal_title：Cancer biology & therapy

authors： McGary EC,Lev DC,Bar-Eli M

更新日期：2002-09-01 00:00:00

abstract：:The delivery of cell-based vaccines that exploit natural mechanisms of antigen presentation represents a promising approach for immunotherapy of cancer. This strategy tests the hypothesis that ex vivo manipulation and reinjection of cellular products can induce immune responses and circumvent immune incompetence to ac...

journal_title：Cancer biology & therapy

authors： Coughlin CM,Vonderheide RH

更新日期：2003-09-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) remains a significant cause of morbidity and mortality. There has been a great interest in finding specific genomic changes which contribute to HNSCC tumorigenesis, especially within the chromosome 3p area, where high frequency of LOH (loss of heterozygosity) has been repo...

journal_title：Cancer biology & therapy

authors： Lee DJ,Schönleben F,Banuchi VE,Qiu W,Close LG,Assaad AM,Su GH

更新日期：2010-10-01 00:00:00