Abstract:
:Current risk stratification using clinical and pathological parameters in patients with urothelial carcinoma of the bladder (UCB) is insufficient. Additional information on the tumor biology can be derived from molecular biomarkers assessed in surgical UCB specimens and the predictive accuracy of oncologic end points may be improved. Biomarkers may also be used to predict the response to novel multimodal therapeutic approaches. Insights from the molecular pathogenesis of UCB can help identify potential biomarkers. A variety of candidate markers for future clinical use have been identified. However, results from comprehensive validation trials and prospective studies are still lacking. This precludes an application of molecular biomarkers in clinical practice at the moment. In this article, we review a selection of tissue biomarkers that are linked to important steps in molecular pathogenesis of UCB. We focused on biomarkers already tested in patient populations with potential clinical utility.
journal_name
Cancer Biol Therjournal_title
Cancer biology & therapyauthors
Bolenz C,Lotan Ydoi
10.4161/cbt.10.5.13022subject
Has Abstractpub_date
2010-09-01 00:00:00pages
407-15issue
5eissn
1538-4047issn
1555-8576pii
13022journal_volume
10pub_type
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