Effects of Streptococcus thermophilus TH-4 on intestinal mucositis induced by the chemotherapeutic agent, 5-Fluorouracil (5-FU).

abstract：BACKGROUND:Somatostatin receptor scintigraphy (SRS) has been reported for receptor (SSTR) screening in advanced hepatocarcinoma (aHC) prior to somatostatin analogue treatment. AIMS:To evaluate SSTR screening with SRS in aHC patients. RESULTS:Seventy aHC patients (63 men) aged 65 +/- 11 y were included, with alcohol, ...

journal_title：Cancer biology & therapy

authors： Nguyen-Khac E,Ollivier I,Aparicio T,Moullart V,Hugentobler A,Lebtahi R,Lobry C,Susini C,Duhamel C,Hommel S,Cadranel JF,Joly JP,Barbare JC,Tramier B,Dupas JL

更新日期：2009-11-01 00:00:00

abstract：:Both Pten and Nras are downstream mediators of receptor tyrosine kinase activation that plays important roles in controlling cell survival and proliferation. Here, we investigated whether and how Pten loss cross-talks with Nras activation in driving liver cancer development in mice. Somatic disruption of hepatic Pten ...

journal_title：Cancer biology & therapy

authors： Gao M,Liu D

更新日期：2017-07-03 00:00:00

abstract：:Between 1955 and 1963 millions of people were worldwide vaccinated with polio-vaccines that were contaminated with the simian virus 40 (SV40). This tumor-inducing virus has subsequently been detected in several human tumors. In Austria, polio mass vaccination started in winter 1961/62 with a presumably SV40-free Briti...

journal_title：Cancer biology & therapy

authors： Leithner A,Weinhaeusel A,Windhager R,Schlegl R,Waldner P,Lang S,Dominkus M,Zoubek A,Popper HH,Haas OA

更新日期：2002-07-01 00:00:00

abstract：:Hypoxia, a common phenomenon in human solid tumors, is associated with invasion and metastasis in various tumors. Hypoxia inducible factors (HIFs) are key molecules in the hypoxic response, and regulate the activation of specific genes, which mediate many of the adaptations to hypoxia. CC chemokine receptor 7 (CCR7) h...

journal_title：Cancer biology & therapy

authors： Li Y,Qiu X,Zhang S,Zhang Q,Wang E

更新日期：2009-02-01 00:00:00

abstract：:Epigenetics are defined, in broad-terms, as alterations in gene expression without changes in DNA sequence. While histone modifications and DNA methylation are two classical means to regulate gene expression, miRNA has also recently been documented to govern gene expression in normal as well as cancer cells. In this r...

journal_title：Cancer biology & therapy

authors： Burgess R,Jenkins R,Zhang Z

更新日期：2008-09-01 00:00:00

abstract：:The delivery of cell-based vaccines that exploit natural mechanisms of antigen presentation represents a promising approach for immunotherapy of cancer. This strategy tests the hypothesis that ex vivo manipulation and reinjection of cellular products can induce immune responses and circumvent immune incompetence to ac...

journal_title：Cancer biology & therapy

authors： Coughlin CM,Vonderheide RH

更新日期：2003-09-01 00:00:00

abstract：:Causes for the complex phenotypes of cancers, such as altered differentiation, invasion and metastasis, are not known, and multigenic defects are likely. In contrast, well-defined deficiencies, such as those affecting DNA-repair mechanisms and enzymatic pathways, are simple, typically caused by one or a few gene mutat...

journal_title：Cancer biology & therapy

authors： Dezentje DA,Arking DE,Kortenhorst MS,West K,Chakravarti A,Kern SE

更新日期：2009-02-01 00:00:00

abstract：:Adverse events in platinum-based chemotherapy for patients with advanced non-small cell lung cancer (NSCLC) are major challenges. In this study, we investigated the role of the p53 and MDM2 genes in predicting adverse events in NSCLC patients treated with platinum-based chemotherapy. Specifically, we examined the p53 ...

journal_title：Cancer biology & therapy

authors： Zheng D,Chen Y,Gao C,Wei Y,Cao G,Lu N,Hou Y,Jiang X,Wang J

更新日期：2014-01-01 00:00:00

abstract：:The phosphoinositide 3-kinase (PI3K)/Akt signaling pathway is important in nasopharyngeal carcinoma (NPC) pathogenesis. Activated PI3K and its downstream target Akt are concernful signaling molecules and key survival factors involved in the control of cell proliferation, apoptosis and oncogenesis. The protein kinase A...

journal_title：Cancer biology & therapy

authors： Yang L,Xiao L,Ma X,Tang M,Weng X,Chen X,Sun L,Cao Y

更新日期：2009-02-01 00:00:00

abstract：:Objective: Chimeric antigen receptor T (CAR-T) cell therapy has demonstrated an unprecedented therapeutic efficacy in hematological malignancies; however, its effectiveness in solid tumors remains elusive. In order to enable CAR-T cells more effective to solid tumors, a inverted chimeric cytokine receptor (ICR) was de...

journal_title：Cancer biology & therapy

authors： Weimin S,Abula A,Qianghong D,Wenguang W

更新日期：2020-06-02 00:00:00

abstract：OBJECTIVE:Angiogenesis is one of the key processes in the development of malignant tumors. The vascular endothelial growth factor (VEGF) and VEGF receptor-2 (VEGFR-2) signaling pathway regulates branching angiogenesis in cancer. In this study, we analyzed the associations of VEGF/VEGFR-2 proteins and VEGFR-2 genetic va...

journal_title：Cancer biology & therapy

authors： Zhu X,Wang Y,Xue W,Wang R,Wang L,Zhu ML,Zheng L

更新日期：2019-01-01 00:00:00

abstract：:Patients with Fanconi anemia (FA) display a wide variety of defects including bone marrow failure and a high risk of developing cancer. Multiple Fanconi genes exist whose proteins form a complex that along with BRCA1 is important for the translocalization of FANCD2 to nuclear foci. With BRCA2 and RAD51, this complex i...

journal_title：Cancer biology & therapy

authors： Rogers CD,van der Heijden MS,Brune K,Yeo CJ,Hruban RH,Kern SE,Goggins M

更新日期：2004-02-01 00:00:00

abstract：:Two peptides derived from the C1B domain of protein kinase Cγ (PKCγ) were shown to associate with classical PKC isozymes and modulate their activities. These C1B peptides are designated C1B1 (amino acid residues 101-112) and C1B5 (residues 141-151). Since PKC enzyme activity is shown to be involved in colon cancer dev...

journal_title：Cancer biology & therapy

authors： Kawabata A,Matsuzuka T,Doi C,Seiler G,Reischman J,Pickel L,Ayuzawa R,Nguyen TA,Tamura M

更新日期：2012-08-01 00:00:00

abstract：:The Bin1/Amphiphysin2 gene encodes several alternately spliced BAR adapter proteins that have been implicated in membrane-associated and nuclear processes. Bin1 expression is often attenuated during tumor progression and Bin1 splice isoforms that localize to the nucleus display tumor suppressor properties. While these...

journal_title：Cancer biology & therapy

authors： Muller AJ,DuHadaway JB,Donover PS,Sutanto-Ward E,Prendergast GC

更新日期：2004-12-01 00:00:00

abstract：PURPOSE:Induction chemotherapy has shown to provide consistent benefit for local control in primary treatment of advanced oropharyngeal cancer. The beneficial role of chemoradiation following induction chemotherapy over concurrent chemoradiation has not been evaluated. Present study evaluates the same prospectively. R...

journal_title：Cancer biology & therapy

authors： Gupta D,Shukla P,Bisht SS,Dhawan A,Pant MC,Bhatt ML,Gupta S,Gupta R,Negi MP

更新日期：2009-02-01 00:00:00

abstract：:The synergistic effect of combined drug therapy provides an enhanced treatment for advanced liver cancer. We aimed to investigate the underlying mechanism of cetuximab sensitization by rapamycin in hepatoma cells. Four hepatoma cell lines, HepG2, HuH7, SNU-387, and SNU-449, were treated with cetuximab or cetuximab plu...

journal_title：Cancer biology & therapy

authors： Chen W,Hu QD,Xia XF,Liang C,Liu H,Zhang Q,Ma T,Liang F,Liang TB

更新日期：2014-08-01 00:00:00

abstract：:Taxol (paclitaxel) and Taxotere (docetaxel) are considered as two of the most important anti-cancer chemotherapy drugs. The cytotoxic action of these drugs has been linked to their ability to inhibit microtubule depolymerization, causing growth arrest and subsequent cell death. Studies by a number of laboratories have...

journal_title：Cancer biology & therapy

authors： Yacoub A,Gilfor D,Hawkins W,Park MA,Hanna D,Hagan MP,Curiel DT,Fisher PB,Grant S,Dent P

更新日期：2006-10-01 00:00:00

abstract：:Prostate cancer is the second leading cause of cancer-related deaths in men. Fatty acid synthase (FASN) is normally upregulated during human prostate cancer onset and metastatic progression and its expression positively correlates with the development of advanced metastatic disease. However, it remains unknown what mo...

journal_title：Cancer biology & therapy

authors： Di Vizio D,Sotgia F,Williams TM,Hassan GS,Capozza F,Frank PG,Pestell RG,Loda M,Freeman MR,Lisanti MP

更新日期：2007-08-01 00:00:00

abstract：:Chronic myeloid leukemia (CML) progresses from a chronic phase to a deadly blast crisis phase. While it is known that BCR-ABL initiates the disease and that secondary molecular and genetic abnormalities likely contribute to progression of the disease to blast crisis, details regarding the mechanism(s) of blast phase p...

journal_title：Cancer biology & therapy

authors： Griner LN,Reuther GW

更新日期：2010-11-15 00:00:00

abstract：BACKGROUND AND AIM:H. pylori interacts with gastric epithelial cells, which may activate signaling pathways important for gastric cancer invasion. Ezrin, a membrane cytoskeletal crosslinker protein, is well documented to regulate cell adhesion and cell motility. The aim of the present study was to determine whether ezr...

journal_title：Cancer biology & therapy

authors： Fan LL,Chen DF,Lan CH,Liu KY,Fang DC

更新日期：2011-04-15 00:00:00

abstract：:The selectively oncolytic mtHSV, a HSV icp34.5 mutant with lacz gene insertion, was proved that it was targeted for treating tumors but not other organs, however, its oncolytic mechanism is under confirmation. The results showed that HeLa cells could be lysed efficiently by mtHSV in vitro. In the flow cytometry and We...

journal_title：Cancer biology & therapy

authors： Su Y,Zhu H,Xiao W,Xu Q,Zhu L,Zhang X,Wan Q,Zhou S,Du E,Xu H,Yao L,Lv S,Hu B,Liu Y,Qi Y

更新日期：2007-02-01 00:00:00

abstract：:Progression of prostate cancer has been associated with EGFR and HER2 activation and to tumor-initiating cells contribution toward chemotherapy resistance. We investigated the efficacy of a dual intervention against EGFR and HER2 to deplete the tumor-initiating cells, optimize the chemotherapy management and prevent t...

journal_title：Cancer biology & therapy

authors： Rossini A,Giussani M,Ripamonti F,Aiello P,Regondi V,Balsari A,Triulzi T,Tagliabue E

更新日期：2020-05-03 00:00:00

abstract：:Despite its low transfer efficiency, suicide gene therapy with HSV-TK is known for its bystander killing effect. The connexin-based gap junction is believed to mediate the bystander effect. Recently, we found that resveratrol, a polyphenol compound, increased the expression of Cx26 and Cx43, which are connexins and im...

journal_title：Cancer biology & therapy

authors： Xiao J,Wang X,Wu Y,Zhao Q,Liu X,Zhang G,Zhao Z,Ning Y,Wang K,Tan Y,Du B

更新日期：2019-01-01 00:00:00

abstract：:Ovarian cancer ranks fifth in cancer related deaths for women in USA. The high mortality rate associated with ovarian cancer is due to diagnosis at later stages of disease and the high recurrence rate of 60-80%. Recurrent ovarian cancers are more likely to present as multidrug resistance (MDR) leading to unfavorable r...

journal_title：Cancer biology & therapy

authors： Patel NR,Piroyan A,Ganta S,Morse AB,Candiloro KM,Solon AL,Nack AH,Galati CA,Bora C,Maglaty MA,O'Brien SW,Litwin S,Davis B,Connolly DC,Coleman TP

更新日期：2018-07-03 00:00:00

abstract：:Methyl-CpG binding domain protein 1 (MBD1) is a transcriptional regulator that binds methylated CpG islands of tumor suppressor genes and represses their transcription. In a former study, we found high expression of MBD1 in pancreatic cancer cell lines and tissues which may play an important role in the development of...

journal_title：Cancer biology & therapy

authors： Luo G,Jin C,Long J,Fu D,Yang F,Xu J,Yu X,Chen W,Ni Q

更新日期：2009-04-01 00:00:00

abstract：:Discovering drugs has never been an easy task. Traditionally, this task has exclusively been undertaken by large pharmaceutical companies that recovered their high research and development costs by selling expensive medications. Despite the huge amount of time and effort devoted towards drug discovery over the last de...

journal_title：Cancer biology & therapy

authors： Sager JA,Lengauer C

更新日期：2003-07-01 00:00:00

abstract：:Tumor formation in immunocompetent hosts is believed to be dependent on the ability of tumor cells to evade the immune system, as suggested by the alterations of expression of the major histocompatibility complex (MHC) and related molecules in a number of cancers. Our previous serial analysis of gene expression (SAGE)...

journal_title：Cancer biology & therapy

authors： Rangel LB,Agarwal R,Sherman-Baust CA,Mello-Coelho Vd,Pizer ES,Ji H,Taub DD,Morin PJ

更新日期：2004-10-01 00:00:00

abstract：:More than a decade has passed since BRCA1, breast cancer tumor suppressor 1, was isolated by reverse genetics in 1994. Its molecular structure and potential function have been extensively studied; both mouse genetics and a cell culture system revealed that BRCA1 is a 220,240 kD nuclear phosphoprotein, it regulates tra...

journal_title：Cancer biology & therapy

authors： Ouchi T

更新日期：2006-05-01 00:00:00

abstract：:Our previous studies have demonstrated that atorvastatin induces autophagy in the androgen receptor negative prostate cancer PC3 cells through inhibition of geranylgeranyl biosynthesis [Parikh et al., Prostate. 70(9): 971-981 (2010)]. This study attempts to elucidate the molecular mechanism underlying atorvastatin-ind...

journal_title：Cancer biology & therapy

authors： Toepfer N,Childress C,Parikh A,Rukstalis D,Yang W

更新日期：2011-10-15 00:00:00

abstract：:CP-31398, a styrylquinazoline, emerged from a screen for therapeutic agents that restore a wild-type DNA-binding conformation of mutant p53 to suppress tumors in-vivo (Science 286, 2507, 1999). We investigated the growth inhibitory mechanism of CP-31398 using nine human cancer cell lines containing wild-type, mutant o...

journal_title：Cancer biology & therapy

authors： Takimoto R,Wang W,Dicker DT,Rastinejad F,Lyssikatos J,el-Deiry WS

更新日期：2002-01-01 00:00:00