Synergistic effect of resveratrol and HSV-TK/GCV therapy on murine hepatoma cells.


:Despite its low transfer efficiency, suicide gene therapy with HSV-TK is known for its bystander killing effect. The connexin-based gap junction is believed to mediate the bystander effect. Recently, we found that resveratrol, a polyphenol compound, increased the expression of Cx26 and Cx43, which are connexins and important constituents of gap junctions, in murine hepatoma cells. Hypothetically, the resveratrol-induced upregulation of gap junctions may improve the bystander effect that HSV-TK/GCV has on hepatoma cells. Our present investigation revealed that resveratrol could enhance intercellular communication at the gap junctions in CBRH7919 hepatoma cells and thereby enhance the bystander killing effect of GCV on CBRH7919TK cells. However, inhibition of gap junction using its long-term inhibitor alpha-glycyrrhetinic acid had a negative influence on the bystander effect of gene therapy with HSV-TK/GCV. In addition, combined resveratrol and GCV treatment in tumor-bearing mice with CBRH7919TK and CBRH7919WT cells at a ratio of 2:3 resulted in a significant decrease in the volume and weight of the tumor in comparison to GCV or only resveratrol. The present results demonstrate that resveratrol can enhance the bystander effect exerted by the HSV-TK/GCV system by enhancing connexin-mediated gap junctional communication.


Cancer Biol Ther


Cancer biology & therapy


Xiao J,Wang X,Wu Y,Zhao Q,Liu X,Zhang G,Zhao Z,Ning Y,Wang K,Tan Y,Du B




Has Abstract


2019-01-01 00:00:00












  • mRNA expression profile of multidrug-resistant genes in acute lymphoblastic leukemia of children, a prognostic value for ABCA3 and ABCA2.

    abstract::Multidrug resistance (MDR) is an important cause of treatment failure in acute lymphoblastic leukemia (ALL). The ABC family of membrane transporters is proposed, albeit with controversy, to be involved in this process. The present study aims to investigate the mRNA expression profile of several genes of this family, i...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Rahgozar S,Moafi A,Abedi M,Entezar-E-Ghaem M,Moshtaghian J,Ghaedi K,Esmaeili A,Montazeri F

    更新日期:2014-01-01 00:00:00

  • Hypoxia induced CCR7 expression via HIF-1alpha and HIF-2alpha correlates with migration and invasion in lung cancer cells.

    abstract::Hypoxia, a common phenomenon in human solid tumors, is associated with invasion and metastasis in various tumors. Hypoxia inducible factors (HIFs) are key molecules in the hypoxic response, and regulate the activation of specific genes, which mediate many of the adaptations to hypoxia. CC chemokine receptor 7 (CCR7) h...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Li Y,Qiu X,Zhang S,Zhang Q,Wang E

    更新日期:2009-02-01 00:00:00

  • The mutant p53-conformation modifying drug, CP-31398, can induce apoptosis of human cancer cells and can stabilize wild-type p53 protein.

    abstract::CP-31398, a styrylquinazoline, emerged from a screen for therapeutic agents that restore a wild-type DNA-binding conformation of mutant p53 to suppress tumors in-vivo (Science 286, 2507, 1999). We investigated the growth inhibitory mechanism of CP-31398 using nine human cancer cell lines containing wild-type, mutant o...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Takimoto R,Wang W,Dicker DT,Rastinejad F,Lyssikatos J,el-Deiry WS

    更新日期:2002-01-01 00:00:00

  • BRAF V600E mutation in metastatic colorectal cancer: Methods of detection and correlation with clinical and pathologic features.

    abstract::The screening for BRAF V600E mutation is employed in clinical practice for its prognostic and potentially predictive role in patients with metastatic colorectal carcinoma (mCRC). Little information is available on the sensitivity and specificity of the testing methods to detect this mutation in CRC. By using serial di...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Roma C,Rachiglio AM,Pasquale R,Fenizia F,Iannaccone A,Tatangelo F,Antinolfi G,Parrella P,Graziano P,Sabatino L,Colantuoni V,Botti G,Maiello E,Normanno N

    更新日期:2016-08-02 00:00:00

  • The p53 paddy wagon: COP1, Pirh2 and MDM2 are found resisting apoptosis and growth arrest.

    abstract::For years, the growth inhibitory effects of the tumor suppressor p53 were thought to be antagonized predominantly by the ubiquitin ligase, MDM2. It has long been established that MDM2 physically associates with p53 and targets this tumor suppressor for proteasomal degradation. In light of recent findings, it now appea...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Corcoran CA,Huang Y,Sheikh MS

    更新日期:2004-08-01 00:00:00

  • The clinical significance of tumor cell-lined vasculature in ovarian carcinoma: implications for anti-vasculogenic therapy.

    abstract::Vasculogenic mimicry reflects the plasticity of aggressive tumor cells that express vascular cell markers and line tumor vasculature; such has been demonstrated in aggressive ovarian carcinoma. This study measured the clinical significance of tumor cell-lined vasculature in ovarian carcinomas (n=77), which was detecte...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Sood AK,Fletcher MS,Zahn CM,Gruman LM,Coffin JE,Seftor EA,Hendrix MJ

    更新日期:2002-11-01 00:00:00

  • Exposure to estrogen and ionizing radiation causes epigenetic dysregulation, activation of mitogen-activated protein kinase pathways, and genome instability in the mammary gland of ACI rats.

    abstract::The impact of environmental mutagens and carcinogens on the mammary gland has recently received a lot of attention. Among the most generally accepted carcinogenic agents identified as factors that may increase breast cancer incidence are ionizing radiation and elevated estrogen levels. However, the molecular mechanism...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Kutanzi K,Kovalchuk O

    更新日期:2013-07-01 00:00:00

  • Binding and inhibition of drug transport proteins by heparin: a potential drug transporter modulator capable of reducing multidrug resistance in human cancer cells.

    abstract::A major problem in cancer treatment is the development of resistance to chemotherapeutic agents, multidrug resistance (MDR), associated with increased activity of transmembrane drug transporter proteins which impair cytotoxic treatment by rapidly removing the drugs from the targeted cells. Previously, it has been show...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Chen Y,Scully M,Petralia G,Kakkar A

    更新日期:2014-01-01 00:00:00

  • Troglitazone-mediated sensitization to TRAIL-induced apoptosis is regulated by proteasome-dependent degradation of FLIP and ERK1/2-dependent phosphorylation of BAD.

    abstract::Resistance to apoptosis is one reason for the poor response of malignant brain tumors to therapy. The PPARgamma-modulating drug Troglitazone downregulates the anti-apoptotic FLIP protein and sensitizes glioblastoma cells to apoptosis induced by the death ligand TRAIL. To investigate the molecular basis of an experimen...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Grund K,Ahmadi R,Jung F,Funke V,Gdynia G,Benner A,Sykora J,Walczak H,Joos S,Felsberg J,Reifenberger G,Wiestler OD,Herold-Mende C,Roth W

    更新日期:2008-12-01 00:00:00

  • A novel bispecific antibody, BiSS, with potent anti-cancer activities.

    abstract::One of the most active fields in cancer immunotherapy is the study of bispecific antibodies, which engage immune cells to kill cancer cells. However, a variety of issues are associated with most of current bispecific antibody formats. In this study, we present a novel bispecific antibody, BiSS (Bispecific antibody wit...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Dong B,Zhou C,He P,Li J,Chen S,Miao J,Li Q,Wang Z

    更新日期:2016-04-02 00:00:00

  • PIK3R3 promotes chemotherapeutic sensitivity of colorectal cancer through PIK3R3/NF-kB/TP pathway.

    abstract::Phosphoinositide-3-kinase regulatory subunit 3(PIK3R3) is overexpressed in different types of human cancer. We previously reported the important role of PIK3R3 in colorectal cancer (CRC). However, the prognosis effect of PIK3R3 in CRC is still remaining unclear. In this study, we explored online clinical databases to ...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Ibrahim S,Li G,Hu F,Hou Z,Chen Q,Li G,Luo X,Hu J,Feng Y

    更新日期:2018-03-04 00:00:00

  • Significant response to apatinib monotherapy in heavily pretreated advanced HER2-positive breast cancer: a case report and literature review.

    abstract::Although HER2-targeted therapy has been shown to prolong the survival of patients with HER2-positive breast cancer, most patients eventually progress due to drug resistance. Novel treatment options are urgently needed to overcome resistance to HER2-targeted therapy. The VEGF/VEGFR (Vascular endothelial growth factor a...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Danni L,Lingyun Z,Jian W,Hongfei Y,Lu X,Peng Y,Xiujuan Q,Yunpeng L,Yuee T

    更新日期:2020-07-02 00:00:00

  • Furanodiene induces G2/M cell cycle arrest and apoptosis through MAPK signaling and mitochondria-caspase pathway in human hepatocellular carcinoma cells.

    abstract::Furanodiene (C15H20O), a pure compound isolated from Traditional Chinese medicine, Curcuma wenyujin, named Ezhu in Chinese, which structure was determined on the basis of NMR, MS and UV spectrum. In this study, we attempted to characterize in detail the signaling cascades resulted from furanodiene-induced apoptosis in...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Xiao Y,Yang FQ,Li SP,Gao JL,Hu G,Lao SC,Conceição EL,Fung KP,Wangl YT,Lee SM

    更新日期:2007-07-01 00:00:00

  • Identification of mammary epithelial cells subject to chronic oxidative stress in mammary epithelium of young women and teenagers living in USA: implication for breast carcinogenesis.

    abstract::Current knowledge of changes in the mammary epithelium relevant to breast carcinogenesis is limited to when histological changes are already present because of a lack of biomarkers needed to identify where such molecular changes might be ongoing at earlier during the of decades-long latent stages of breast carcinogene...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Weisz J,Shearer DA,Murata E,Patrick SD,Han B,Berg A,Clawson GA

    更新日期:2012-01-15 00:00:00

  • Use of methotrexate-based peptide substrates to characterize the substrate specificity of prostate-specific membrane antigen (PSMA).

    abstract::Prostate-Specific Membrane Antigen (PSMA) is a glutamate carboxypeptidase II that is highly expressed by both normal and malignant prostate epithelial cells and by the neovasculature of many tumor types but is not expressed by endothelial cells in normal tissue. PSMA possesses the hydrolytic properties of an N-acetyla...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Mhaka A,Gady AM,Rosen DM,Lo KM,Gillies SD,Denmeade SR

    更新日期:2004-06-01 00:00:00

  • A LIN28B polymorphism predicts for colon cancer survival.

    abstract::The pathogenesis of sporadic colorectal cancer involves distinct pathways, with characteristic genomic alterations. The first pathway, chromosome instability (CIN), is driven by APC mutations and is typified by Kras mutations, p53 mutation/loss of heterozygosity, and deletions at chromosome 18q. The second pathway is ...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Ye Y,Madison B,Wu X,Rustgi AK

    更新日期:2012-12-01 00:00:00

  • Oncogenic Ras modulates p38 MAPK-mediated inflammatory cytokine production in glioblastoma cells.

    abstract::Inflammation is an important factor promoting the progression of glioblastoma. In the present study we examined the contribution of Ras signaling and TNFα/IL-1β cytokines to the development of the glioblastoma inflammatory microenvironment. Enhanced activation of Ras through de-regulated activation of receptor tyrosin...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Munoz L,Yeung YT,Grewal T

    更新日期:2016-04-02 00:00:00

  • Cancer-testis gene expression profiling in esophageal squamous cell carcinoma: identification of specific tumor marker and potential targets for immunotherapy.

    abstract::Cancer-testis antigens (CTAs) are often specifically expressed in cancer cells and under normal conditions are only considered to be expressed in the germ line cells and the placenta. CTAs are potential targets for cancer immunotherapy and therefore necessitates their expression profiling. The expression profile of LA...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Forghanifard MM,Gholamin M,Farshchian M,Moaven O,Memar B,Forghani MN,Dadkhah E,Naseh H,Moghbeli M,Raeisossadati R,Abbaszadegan MR

    更新日期:2011-08-01 00:00:00

  • Pancreatic and bile duct cancer circulating tumor cells (CTC) form immune-resistant multi-cell type clusters in the portal venous circulation.

    abstract::Circulating tumor cells (CTC) enter the blood from many carcinomas and represent a likely source of metastatic dissemination. In contrast to the peripheral circulation, KRAS mutation- positive CTC thrive in the portal venous blood of patients with pancreatic ductal adenocarcinoma (PDAC). To analyze the essential inter...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Arnoletti JP,Fanaian N,Reza J,Sause R,Almodovar AJ,Srivastava M,Patel S,Veldhuis PP,Griffith E,Shao YP,Zhu X,Litherland SA

    更新日期:2018-01-01 00:00:00

  • Tumor suppressor p53 status does not determine the differentiation-associated G₁ cell cycle arrest induced in leukemia cells by 1,25-dihydroxyvitamin D₃ and antioxidants.

    abstract::Vitamin D derivatives can induce differentiation of human acute myeloid leukemia (AML) cells. Here, we investigated if the G₁ cell cycle block associated with monocytic differentiation is modulated by the p53 status of the cells treated with 1,25D, alone or with plant antioxidants carnosic acid (C) or silibinin (S), a...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Thompson T,Danilenko M,Vassilev L,Studzinski GP

    更新日期:2010-08-15 00:00:00

  • The genetics of FANCC and FANCG in familial pancreatic cancer.

    abstract::Patients with Fanconi anemia (FA) display a wide variety of defects including bone marrow failure and a high risk of developing cancer. Multiple Fanconi genes exist whose proteins form a complex that along with BRCA1 is important for the translocalization of FANCD2 to nuclear foci. With BRCA2 and RAD51, this complex i...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Rogers CD,van der Heijden MS,Brune K,Yeo CJ,Hruban RH,Kern SE,Goggins M

    更新日期:2004-02-01 00:00:00

  • The antitumor efficacy of IL-24 mediated by E1A and E1B triple regulated oncolytic adenovirus.

    abstract:BACKGROUND:IL-24 (interleukin-24) is a promising, multi-functional anti-cancer agent able to selectively induce tumor cell apoptosis while sparing normal cells. Additionally, IL-24 can enhance the immune response to tumors and suppress tumor angiogenesis. In this study, we introduced IL-24 into the oncolytic adenovirus...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Xiao LL,Wu YM,Qian J,Tan Y,Xie GL,Zhang KJ,Wang YG,Jia XY,Liu XY

    更新日期:2010-08-01 00:00:00

  • Gene expression alterations in formalin-fixed, paraffin-embedded Barrett esophagus and esophageal adenocarcinoma tissues.

    abstract:BACKGROUND AND AIM:Widespread applicability of tissue-based mRNA expression screening for Barrett esophagus (BE) is likely to require (1) accurate methods for assaying archival formalin-fixed, paraffin-embedded (FFPE) histopathology specimens taken at endoscopy, and (2) validation studies of promising biomarkers in dif...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Botelho NK,Schneiders FI,Lord SJ,Freeman AK,Tyagi S,Nancarrow DJ,Hayward NK,Whiteman DC,Lord RV

    更新日期:2010-07-15 00:00:00

  • Tangeretin derivative, 5-acetyloxy-6,7,8,4'-tetramethoxyflavone induces G2/M arrest, apoptosis and autophagy in human non-small cell lung cancer cells in vitro and in vivo.

    abstract::Tangeretin, a major phytochemicals in tangerine peels--an important Chinese herb, has been found to have anti-carcinogenic properties. To improve bioavailability and increase potency of tangeretin, its derivative, 5-acetyloxy-6,7,8,4'-tetramethoxyflavone (5-AcTMF), has been synthesized and shown potent inhibition of p...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Li YR,Li S,Ho CT,Chang YH,Tan KT,Chung TW,Wang BY,Chen YK,Lin CC

    更新日期:2016-01-01 00:00:00

  • Inhibition of exosome release by ketotifen enhances sensitivity of cancer cells to doxorubicin.

    abstract::Exosomes released from cancer cells support metastasis and growth of recipient cells and increase their resistance to chemotherapy. Therapeutic targeting of exosomes is a promising area in cancer research. Our aim is to test the effect of the mast cell stabilizer ketotifen on exosomes release from cancer cells and how...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Khan FM,Saleh E,Alawadhi H,Harati R,Zimmermann WH,El-Awady R

    更新日期:2018-01-02 00:00:00

  • Molecular functions of BRCA1 in the DNA damage response.

    abstract::Ten years ago, a concerted effort from several labs resulted in the cloning of BRCA1, the first of two major hereditary breast/ovarian cancer predisposition genes. Since that time, BRCA1 has been linked to several key nuclear functions connected with the prevention of genomic instability. In particular, BRCA1 function...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章,评审


    authors: Scully R,Xie A,Nagaraju G

    更新日期:2004-06-01 00:00:00

  • Targeting c-Met in melanoma: mechanism of resistance and efficacy of novel combinatorial inhibitor therapy.

    abstract::Numerous tyrosine kinase inhibitors (TKIs) targeting c-Met are currently in clinical trials for several cancers. Their efficacy is limited due to the development of resistance. The present study aims to elucidate this mechanism of c-Met TKI resistance by investigating key mTOR and Wnt signaling proteins in melanoma ce...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Etnyre D,Stone AL,Fong JT,Jacobs RJ,Uppada SB,Botting GM,Rajanna S,Moravec DN,Shambannagari MR,Crees Z,Girard J,Bertram C,Puri N

    更新日期:2014-09-01 00:00:00

  • FBXO4 loss facilitates carcinogen induced papilloma development in mice.

    abstract::Cyclin D1 is frequently overexpressed in esophageal squamous cell carcinoma (ESCC) and is considered a key driver of this disease. Mutations in FBXO4, F-box specificity factor that directs SCF-mediated ubiquitylation of cyclin D1, occur in ESCC with concurrent overexpression of cyclin D1 suggesting a potential tumor s...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Lian Z,Lee EK,Bass AJ,Wong KK,Klein-Szanto AJ,Rustgi AK,Diehl JA

    更新日期:2015-01-01 00:00:00

  • Chimeric cytokine receptor enhancing PSMA-CAR-T cell-mediated prostate cancer regression.

    abstract::Objective: Chimeric antigen receptor T (CAR-T) cell therapy has demonstrated an unprecedented therapeutic efficacy in hematological malignancies; however, its effectiveness in solid tumors remains elusive. In order to enable CAR-T cells more effective to solid tumors, a inverted chimeric cytokine receptor (ICR) was de...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Weimin S,Abula A,Qianghong D,Wenguang W

    更新日期:2020-06-02 00:00:00

  • Effective treatment of aggressive fibromatosis with celecoxib guided by genetic testing.

    abstract::Aggressive fibromatosis (AF) or desmoid tumors is an aggressive fibroblastic proliferation which is locally invasive but can not metastasize. The treatment of AF is challenging. Surgery was the main treatment modality for AF in the past, other strategies including radiotherapy, systemic therapies and wait-and-see poli...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Yang S,Wang X,Jiang H,Wang Y,Li Z,Lu H

    更新日期:2017-10-03 00:00:00