The status of zinc in the development of hepatocellular cancer: an important, but neglected, clinically established relationship.

abstract：INTRODUCTION:Malignant cells are capable of an unlimited number of cell divisions, either through production of telomerase, or through the alternate lengthening of telomere (ALT) mechanism. Yeast cells with genomic instability have been shown to survive in the absence of telomerase by increased recombination events. We...

journal_title：Cancer biology & therapy

authors： Landen CN,Klingelhutz A,Coffin JE,Sorosky JI,Sood AK

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND AND AIM:H. pylori interacts with gastric epithelial cells, which may activate signaling pathways important for gastric cancer invasion. Ezrin, a membrane cytoskeletal crosslinker protein, is well documented to regulate cell adhesion and cell motility. The aim of the present study was to determine whether ezr...

journal_title：Cancer biology & therapy

authors： Fan LL,Chen DF,Lan CH,Liu KY,Fang DC

更新日期：2011-04-15 00:00:00

abstract：:The current therapy of cancer fails to completely and exclusively target tumor cells. An ideal target for cancer therapy should be expressed exclusively in tumor cells and contribute to tumorigenesis. Targeting such a candidate gene would cause cell death only in tumor cells. A cancer testis antigen, GAGE, is consider...

journal_title：Cancer biology & therapy

authors： Kular RK,Yehiely F,Deiss LP

更新日期：2010-05-15 00:00:00

abstract：:Any drug selects for drug resistance. But super-antagonistic drug combinations can select for drug sensitivity. This has important application not only for antibacterial therapy but also for cancer therapy: to control cancer with lesser side effects and to eliminate drug-resistant cancer cells, while sparing sensitive...

journal_title：Cancer biology & therapy

authors： Blagosklonny MV

更新日期：2007-07-01 00:00:00

abstract：:Recent trends in cancer therapy have begun emphasizing the use of precision medicine, especially genetic tools, in the evaluation of malignancies and decision-making. Prostate cancer is a malignancy where the benefits and utility of screening and early treatment are still heavily controversial. A recent paper in the N...

journal_title：Cancer biology & therapy

authors： Hauke RJ Jr,Sissung TM,Figg WD

更新日期：2017-08-03 00:00:00

abstract：:Phorbol 12-myristate 13-acetate (PMA) modulates cell proliferation and survival by activating several intracellular signaling pathways. Protein kinase C (PKC) plays a key role in PMA-induced growth arrest of non-small cell lung cancer (NSCLC) cells. Kruppel-like transcription factor 6 (KLF6), which is associated with ...

journal_title：Cancer biology & therapy

authors： Tahara E,Kadara H,Lacroix L,Lotan D,Lotan R

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Unlike papillary thyroid cancer (PTC), anaplastic thyroid carcinoma (ATC) is extremely aggressive and rapidly lethal without effective therapies. However, the differences of master regulators and regulatory networks between PTC and ATC remain unclear. Methods: Three representative datasets comprising 32 ATC,...

journal_title：Cancer biology & therapy

authors： Pan Z,Li L,Qian Y,Ge X,Hu X,Zhang Y,Ge M,Huang P

更新日期：2020-09-01 00:00:00

abstract：:Ecto-5'-nucleotidase (CD73) was overexpressed in malignancies of epithelial origin and was involved in a variety of cellular processes such as cytoprotection and anti-inflammation. In the present study, human mammary T-47D cells were transfected with pcDNA-NT5E to establish a CD73 overexpressed cell model. Short small...

journal_title：Cancer biology & therapy

authors： Zhou P,Zhi X,Zhou T,Chen S,Li X,Wang L,Yin L,Shao Z,Ou Z

更新日期：2007-03-01 00:00:00

abstract：:We report 3 cases of durable complete response (CR) in patients with BRAF-mutated metastatic melanoma who were initially treated unsuccessfully with sequential immunotherapies (high dose interleukin 2 followed by ipilimumab with or without concurrent radiation therapy). After progression during or post immunotherapy, ...

journal_title：Cancer biology & therapy

authors： Wyluda EJ,Cheng J,Schell TD,Haley JS,Mallon C,Neves RI,Robertson G,Sivik J,Mackley H,Talamo G,Drabick JJ

更新日期：2015-01-01 00:00:00

abstract：:Ovarian cancer (OC) is xenogeneic that is influenced by many generated factors related to epigenetic factors to accelerate tumor metastasis. This study was conducted with the objective of investigating the effect of microRNA-23a-3p (miR-23a) on the biological characteristics of OC stem cells by targeting discs large h...

journal_title：Cancer biology & therapy

authors： Zhuang RJ,Bai XX,Liu W

更新日期：2019-01-01 00:00:00

abstract：:SEPT9 is a mammalian septin family member. There is growing evidence that SEPT9 plays a role in cancer. The protein product, SEPT9_V1, associates with microtubules and interacts with hypoxia-inducible factor (HIF)-1alpha, the regulated subunit of the key transcription factor HIF-1. HIF-1 transcriptional activity is th...

journal_title：Cancer biology & therapy

authors： Amir S,Mabjeesh NJ

更新日期：2007-12-01 00:00:00

abstract：:Hepatoblastoma (HB) is the most common liver tumor of childhood, usually occurring in children under the age of 3 y. The prognosis of patients presenting with distant metastasis, vascular invasion and advanced tumor stages remains poor and children that do survive often face severe late effects from the aggressive che...

journal_title：Cancer biology & therapy

authors： Beck A,Eberherr C,Hagemann M,Cairo S,Häberle B,Vokuhl C,von Schweinitz D,Kappler R

更新日期：2016-11-01 00:00:00

abstract：:The aim of this study was to examine the cytotoxicity and mechanism of apoptosis induction of verotoxin-1 (VT-1) in human glioma cell lines. VT-1 is a member of the shiga-toxin family expressed by some serotypes of Escherichia coli and Shigella dysenteriae. Shiga-toxins have been shown to induce apoptosis by binding t...

journal_title：Cancer biology & therapy

authors： Johansson D,Johansson A,Grankvist K,Andersson U,Henriksson R,Bergström P,Brännström T,Behnam-Motlagh P

更新日期：2006-09-01 00:00:00

abstract：:The 26S proteasome is a large multi-subunit protein complex found in the cytoplasm and nucleus of mammalian cells which plays a critical role in intracellular proteolysis. It has been found that the 26S proteasome degrades multiple important substrates which are associated with tumor growth and development. Emerging e...

journal_title：Cancer biology & therapy

authors： Fribley A,Wang CY

更新日期：2006-07-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) remains recalcitrant to effective treatment due to tumor relapse and acquired resistance. Cancer stem cells (CSCs) are believed to be one mechanism for relapse and resistance and are consequently considered promising drug targets. We report that chetomin, an active component of Chaet...

journal_title：Cancer biology & therapy

authors： Min S,Wang X,Du Q,Gong H,Yang Y,Wang T,Wu N,Liu X,Li W,Zhao C,Shen Y,Chen Y,Wang X

更新日期：2020-08-02 00:00:00

abstract：:Discovering drugs has never been an easy task. Traditionally, this task has exclusively been undertaken by large pharmaceutical companies that recovered their high research and development costs by selling expensive medications. Despite the huge amount of time and effort devoted towards drug discovery over the last de...

journal_title：Cancer biology & therapy

authors： Sager JA,Lengauer C

更新日期：2003-07-01 00:00:00

abstract：:The present studies sought to further understand how the anti-folate pemetrexed and the multi-kinase inhibitor sorafenib interact to kill tumor cells. Sorafenib activated SRC, and via SRC the drug combination activated ERK1/2. Expression of dominant negative SRC or dominant negative MEK1 abolished drug-induced ERK1/2 ...

journal_title：Cancer biology & therapy

authors： Bareford MD,Hamed HA,Allegood J,Cruickshanks N,Poklepovic A,Park MA,Ogretmen B,Spiegel S,Grant S,Dent P

更新日期：2012-07-01 00:00:00

abstract：:There is an urgent need to develop new strategies to treat ovarian cancer, the most deadly gynecologic malignancy. Histone deacetylase (HDAC) inhibitors are emerging as novel therapeutic drugs in the treatment of a variety of cancers, including those resistant to standard chemotherapy. Since there are multiple HDAC is...

journal_title：Cancer biology & therapy

authors： Khabele D,Son DS,Parl AK,Goldberg GL,Augenlicht LH,Mariadason JM,Rice VM

更新日期：2007-05-01 00:00:00

abstract：:The synergistic effect of combined drug therapy provides an enhanced treatment for advanced liver cancer. We aimed to investigate the underlying mechanism of cetuximab sensitization by rapamycin in hepatoma cells. Four hepatoma cell lines, HepG2, HuH7, SNU-387, and SNU-449, were treated with cetuximab or cetuximab plu...

journal_title：Cancer biology & therapy

authors： Chen W,Hu QD,Xia XF,Liang C,Liu H,Zhang Q,Ma T,Liang F,Liang TB

更新日期：2014-08-01 00:00:00

abstract：:Melanoma is the deadliest form of skin cancer, which is notoriously aggressive and chemo-resistant, and for which there is little effective treatment available if it goes undetected. Curcumin from the turmeric spice (Curcuma longa) has long been used in Southeast Asian medicine to alleviate ailments and cure an array ...

journal_title：Cancer biology & therapy

authors： Chatterjee SJ,Pandey S

更新日期：2011-01-15 00:00:00

abstract：:Rhabdomyosarcoma (RMS) is an aggressive childhood sarcoma with two distinct subtypes, embryonal (ERMS) and alveolar (ARMS) histologies. More effective treatment is needed to improve outcomes, beyond conventional cytotoxic chemotherapy. The pan-histone deacetylase inhibitor, Suberoylanilide Hydroxamic Acid (SAHA), has ...

journal_title：Cancer biology & therapy

authors： Ghayad SE,Rammal G,Sarkis O,Basma H,Ghamloush F,Fahs A,Karam M,Harajli M,Rabeh W,Mouawad JE,Zalzali H,Saab R

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:EphA2 overexpression predicts poor prognosis in endometrial cancer. To explore mechanisms for this association and assess its potential as therapeutic target, the relationship of EphA2 expression to markers of angiogenesis was examined using patient samples and an orthotopic mouse model of uterine cancer. EX...

journal_title：Cancer biology & therapy

authors： Merritt WM,Kamat AA,Hwang JY,Bottsford-Miller J,Lu C,Lin YG,Coffey D,Spannuth WA,Nugent E,Han LY,Landen CN,Nick AM,Stone RL,Coffman K,Bruckheimer E,Broaddus RR,Gershenson DM,Coleman RL,Sood AK

更新日期：2010-12-15 00:00:00

abstract：BACKGROUND:It has recently been suggested that overexpression of palladin in sporadic pancreatic cancer may contribute to pancreatic cancer's invasive and migratory abilities. This hypothesis was based on reverse transcriptase-polymerase chain reaction analyses of bulk pancreatic tissue, yet pancreatic cancer is a comp...

journal_title：Cancer biology & therapy

authors： Salaria SN,Illei P,Sharma R,Walter KM,Klein AP,Eshleman JR,Maitra A,Schulick R,Winter J,Ouellette MM,Goggins M,Hruban R

更新日期：2007-03-01 00:00:00

abstract：:Our previous studies have demonstrated that atorvastatin induces autophagy in the androgen receptor negative prostate cancer PC3 cells through inhibition of geranylgeranyl biosynthesis [Parikh et al., Prostate. 70(9): 971-981 (2010)]. This study attempts to elucidate the molecular mechanism underlying atorvastatin-ind...

journal_title：Cancer biology & therapy

authors： Toepfer N,Childress C,Parikh A,Rukstalis D,Yang W

更新日期：2011-10-15 00:00:00

abstract：:MicroRNAs (miRNAs) are single-stranded, non-coding RNA molecules that regulate gene expression at the post-transcriptional level. Genes encoding miRNAs are located in regions of the genome that are commonly amplified, deleted or rearranged. They are commonly dysregulated in human cancers and known to act as oncogenes ...

journal_title：Cancer biology & therapy

authors： Mongroo PS,Rustgi AK

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVE:Angiogenesis is one of the key processes in the development of malignant tumors. The vascular endothelial growth factor (VEGF) and VEGF receptor-2 (VEGFR-2) signaling pathway regulates branching angiogenesis in cancer. In this study, we analyzed the associations of VEGF/VEGFR-2 proteins and VEGFR-2 genetic va...

journal_title：Cancer biology & therapy

authors： Zhu X,Wang Y,Xue W,Wang R,Wang L,Zhu ML,Zheng L

更新日期：2019-01-01 00:00:00

abstract：:Histone H1.2, a housekeeping protein that binds nucleosomal linkers, has recently been identified as an apoptogenic factor released from the nucleus to the cytosol in response to double strand DNA breaks. In the cytosol, it promotes the activation of proapoptotic Bcl-2 family proteins, mitochondrial cytochrome c relea...

journal_title：Cancer biology & therapy

authors： Zong WX

更新日期：2004-01-01 00:00:00

abstract：PURPOSE:The pelvic failure rate decreases with increase in the radiation dose but the complications increase. The four field pelvic technique has a theoretical advantage of providing a higher tumor dose with less dose to the surrounding normal tissue thus reducing the complications. RESULT:Eighty-three patients comple...

journal_title：Cancer biology & therapy

authors： Gupta D,Shukla P,Bisht SS,Aggarwal A,Dhawan A,Pant MC,Bhatt ML,Gupta R,Srivastava K,Gupta S,Srivastava M

更新日期：2009-05-01 00:00:00

abstract：:Angiogenesis inhibitors belong to a new class of drugs. Many of these drugs are in clinical trials to treat cancer, while others have recently received FDA approval. However, angiogenesis inhibitors operate by different mechanisms than conventional cytotoxic chemotherapies, and require different guidelines for their o...

journal_title：Cancer biology & therapy

authors： Folkman J

更新日期：2003-07-01 00:00:00

abstract：:A right amount of oxygen and nutrients is essential for a tumor to develop. The role of oxygen dependent pathways and their regulators is therefore of utmost importance although little is known about the detailed impact they can have. Recently we have shown that inhibition of the oxygen sensor PHD2 in tumor cells bloc...

journal_title：Cancer biology & therapy

authors： Klotzsche-von Ameln A,Muschter A,Heimesaat MM,Breier G,Wielockx B

更新日期：2012-02-15 00:00:00