Abstract:
:The PROfound trial highlights that there is a benefit in testing genes involved in homologous recombination (HR) and forms the rationale for testing in all patients with metastatic, castration-resistant prostate cancer (mCRPC). This trial also demostrates that olaparib improves progression free survival (PFS), objective response rate (ORR), and time to pain progression in patients who harbor alterations in BRCA1, BRCA2, and ATM. These are groundbreaking findings - this is the first trial that demonstrates the efficacy of olaparib versus standard therapy in a genomically-selected patient population with metastatic prostate cancer. Although this trial does not demonstrate improvements in overall survival (OS), we believe that this may be an underestimation based on trial-design. Future studies of olaparib are likely to yield further promising results.
journal_name
Cancer Biol Therjournal_title
Cancer biology & therapyauthors
Chau V,Madan RA,Figg WDdoi
10.1080/15384047.2020.1809913subject
Has Abstractpub_date
2020-10-02 00:00:00pages
884-887issue
10eissn
1538-4047issn
1555-8576journal_volume
21pub_type
杂志文章abstract::Radiotherapy is a widely used local and regional modality for the treatment of cancer. Despite improved methods of radiation delivery, local recurrence accounts for treatment failure in most patients. Radiosensitizers have been studied as one approach for improving the effectiveness of radiotherapy. Few agents, howeve...
journal_title:Cancer biology & therapy
pub_type: 杂志文章,评审
doi:10.4161/cbt.2.4.495
更新日期:2003-07-01 00:00:00
abstract::One of the most active fields in cancer immunotherapy is the study of bispecific antibodies, which engage immune cells to kill cancer cells. However, a variety of issues are associated with most of current bispecific antibody formats. In this study, we present a novel bispecific antibody, BiSS (Bispecific antibody wit...
journal_title:Cancer biology & therapy
pub_type: 杂志文章
doi:10.1080/15384047.2016.1139266
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journal_title:Cancer biology & therapy
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journal_title:Cancer biology & therapy
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doi:10.4161/cbt.8.20.9596
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abstract::Resistance to apoptosis is one reason for the poor response of malignant brain tumors to therapy. The PPARgamma-modulating drug Troglitazone downregulates the anti-apoptotic FLIP protein and sensitizes glioblastoma cells to apoptosis induced by the death ligand TRAIL. To investigate the molecular basis of an experimen...
journal_title:Cancer biology & therapy
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doi:10.4161/cbt.7.12.6966
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journal_title:Cancer biology & therapy
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abstract::The alterative reading frame (ARF) protein is unique in its capacity to interact with Mdm2 thus facilitating p53-dependent cell cycle arrest and apoptosis. ARF also acts in a p53-independent manner in which it binds to Myc and interferes with transcriptional activation by Myc thereby inhibiting Myc-induced cell prolif...
journal_title:Cancer biology & therapy
pub_type: 评论,杂志文章
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journal_title:Cancer biology & therapy
pub_type: 杂志文章
doi:10.4161/15384047.2014.972799
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journal_title:Cancer biology & therapy
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journal_title:Cancer biology & therapy
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更新日期:2011-01-01 00:00:00
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journal_title:Cancer biology & therapy
pub_type: 杂志文章
doi:10.4161/cbt.3.9.1039
更新日期:2004-09-01 00:00:00
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journal_title:Cancer biology & therapy
pub_type: 杂志文章
doi:10.4161/cbt.4.12.2183
更新日期:2005-12-01 00:00:00
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journal_title:Cancer biology & therapy
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journal_title:Cancer biology & therapy
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doi:10.4161/cbt.7.11.6837
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journal_title:Cancer biology & therapy
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doi:10.1080/15384047.2018.1491497
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journal_title:Cancer biology & therapy
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doi:10.1080/15384047.2016.1139249
更新日期:2016-04-02 00:00:00
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journal_title:Cancer biology & therapy
pub_type: 杂志文章
doi:10.1080/15384047.2018.1523094
更新日期:2019-01-01 00:00:00
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journal_title:Cancer biology & therapy
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更新日期:2017-05-04 00:00:00
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journal_title:Cancer biology & therapy
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doi:10.4161/cbt.6.6.4088
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journal_title:Cancer biology & therapy
pub_type: 杂志文章
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journal_title:Cancer biology & therapy
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doi:10.1080/15384047.2018.1529122
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journal_title:Cancer biology & therapy
pub_type: 杂志文章
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journal_title:Cancer biology & therapy
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journal_title:Cancer biology & therapy
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journal_title:Cancer biology & therapy
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journal_title:Cancer biology & therapy
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pub_type: 杂志文章,随机对照试验
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