Oncogenic Ras modulates p38 MAPK-mediated inflammatory cytokine production in glioblastoma cells.

abstract：:Exosomes released from cancer cells support metastasis and growth of recipient cells and increase their resistance to chemotherapy. Therapeutic targeting of exosomes is a promising area in cancer research. Our aim is to test the effect of the mast cell stabilizer ketotifen on exosomes release from cancer cells and how...

journal_title：Cancer biology & therapy

authors： Khan FM,Saleh E,Alawadhi H,Harati R,Zimmermann WH,El-Awady R

更新日期：2018-01-02 00:00:00

abstract：:Resistance of tumors due to restricted drug accumulation and reversal of DNA lesions in tumor cells as well as normal tissue toxicity limit the efficacy of topoisomerase inhibition based anticancer drugs. It has been proposed that selective inhibition of energy dependent repair processes and enhanced retention of drug...

journal_title：Cancer biology & therapy

authors： Dwarakanath BS,Khaitan D,Ravindranath T

更新日期：2004-09-01 00:00:00

abstract：:Epidemiological studies suggest that obesity increases the risk of developing several cancers, including melanoma. Obesity increases the expression of angiogenic factors, such as leptin, that may contribute to tumor growth. However, a direct cause and effect relationship between obesity and tumor growth has not been c...

journal_title：Cancer biology & therapy

authors： Brandon EL,Gu JW,Cantwell L,He Z,Wallace G,Hall JE

更新日期：2009-10-01 00:00:00

abstract：:The recurrence of colorectal cancer after chemotherapy is the leading cause of its high mortality. We propose that elucidating the mechanisms of tumor regrowth after chemotherapy in tumor-bearing mice may provide new insights into tumor relapse in cancer patients. We firstly report the identification of a chemokine, C...

journal_title：Cancer biology & therapy

authors： Zhang Y,Gao J,Wang X,Deng S,Ye H,Guan W,Wu M,Zhu S,Yu Y,Han W

更新日期：2015-01-01 00:00:00

abstract：:A right amount of oxygen and nutrients is essential for a tumor to develop. The role of oxygen dependent pathways and their regulators is therefore of utmost importance although little is known about the detailed impact they can have. Recently we have shown that inhibition of the oxygen sensor PHD2 in tumor cells bloc...

journal_title：Cancer biology & therapy

authors： Klotzsche-von Ameln A,Muschter A,Heimesaat MM,Breier G,Wielockx B

更新日期：2012-02-15 00:00:00

abstract：:The molecular regulation of growth and progression of hormone refractory breast and prostate cancers remains challenging. The Division of Cancer Biology, NCI organized a small "think tank" style workshop and invited scientists in relevant areas to assess the state of science on the biology of hormone refractory tumors...

journal_title：Cancer biology & therapy

authors： Mohla S,Stearns V,Sathyamoorthy N,Rosenfeld MG,Nelson P

更新日期：2009-11-01 00:00:00

abstract：:Although most researchers in biology tend to focus on very specific issues and questions about their preferred gene or pathway, sometimes we face situations in which nature presents us with a remarkable example of a gene with multiple functions. Since the discovery of the early growth response 1 (EGR1) gene in the mid...

journal_title：Cancer biology & therapy

authors： DeLigio JT,Zorio DA

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Unlike papillary thyroid cancer (PTC), anaplastic thyroid carcinoma (ATC) is extremely aggressive and rapidly lethal without effective therapies. However, the differences of master regulators and regulatory networks between PTC and ATC remain unclear. Methods: Three representative datasets comprising 32 ATC,...

journal_title：Cancer biology & therapy

authors： Pan Z,Li L,Qian Y,Ge X,Hu X,Zhang Y,Ge M,Huang P

更新日期：2020-09-01 00:00:00

abstract：:Obesity is considered one of the risk factors for many cancers. Serum leptin levels are often elevated in obese people. Leptin has been reported to act as a mitogenic agent and promote renal cancer cell proliferation, whereas the detailed mechanisms still remain to be elucidated. The purpose of this study is to invest...

journal_title：Cancer biology & therapy

authors： Li L,Gao Y,Zhang LL,He DL

更新日期：2008-11-01 00:00:00

abstract：:Ovarian cancer (OC) is xenogeneic that is influenced by many generated factors related to epigenetic factors to accelerate tumor metastasis. This study was conducted with the objective of investigating the effect of microRNA-23a-3p (miR-23a) on the biological characteristics of OC stem cells by targeting discs large h...

journal_title：Cancer biology & therapy

authors： Zhuang RJ,Bai XX,Liu W

更新日期：2019-01-01 00:00:00

abstract：:Bevacizumab, is a humanized monoclonal antibody to vasculo-endothelial-growth-factor, with anticancer activity in non-small-cell-lung cancer (NSCLC) patients. Our previous results from a dose/finding phase I trial in NSCLC patients, demonstrated the anti-angiogenic effects and toxicity of a newest bevacizumab-based co...

journal_title：Cancer biology & therapy

authors： Correale P,Botta C,Basile A,Pagliuchi M,Licchetta A,Martellucci I,Bestoso E,Apollinari S,Addeo R,Misso G,Romano O,Abbruzzese A,Lamberti M,Luzzi L,Gotti G,Rotundo MS,Caraglia M,Tagliaferri P

更新日期：2011-07-15 00:00:00

abstract：:This study investigated different methods of EGFR (Epithelial Growth Factor Receptor) targeting in feline squamous cell carcinoma with the ultimate aim of establishing a large animal model of human head and neck cancer. Both small molecule receptor tyrosine kinase inhibitor (TKI) and RNA interference (RNAi) techniques...

journal_title：Cancer biology & therapy

authors： Bergkvist GT,Argyle DJ,Pang LY,Muirhead R,Yool DA

更新日期：2011-06-01 00:00:00

abstract：:Telomerase is the ribonucleoprotein that enables cancer and stem cells to maintain their telomeres, resulting in unlimited proliferative potential. The catalytic component of telomerase in humans, hTERT, is upregulated in nearly 90% of all cancers, making it the most widely expressed marker of malignancy. With the exc...

journal_title：Cancer biology & therapy

authors： Nguyen B,Elmore LW,Holt SE

更新日期：2003-03-01 00:00:00

abstract：:We investigated whether expression of the IL-12 p35 subunit in membrane-bound form in tumor cells enhanced their immunogenicity. Since p35 is only secreted when associated with the IL-12 p40 subunit, we generated tumor cells expressing membrane-bound forms of p35 and p40 as chimeras with the transmembrane/cytoplasmic ...

journal_title：Cancer biology & therapy

authors： Lim HY,Ju HY,Chung HY,Kim YS

更新日期：2010-08-15 00:00:00

abstract：:Tumors with identical phenotype can have markedly different biologic behavior. The differentiation between hemangioblastoma, a benign vascular brain tumor, and renal cell carcinoma (RCC), a malignant tumor that can metastasize to the brain, is a well-known pathological quandary. We report a 59-year-old female with von...

journal_title：Cancer biology & therapy

authors： Gläsker S,Lonser RR,Okamoto H,Li J,Jaffee H,Oldfield EH,Zhuang Z,Vortmeyer AO

更新日期：2007-03-01 00:00:00

abstract：:TPCK is widely used as an inhibitor of chymotrypsin-like proteases but has recently been identified as an inhibitor of the PDK1/Akt pathway. In this study, we show that TPCK inhibits TRAIL-induced caspase activity but potentiates wortmannin-dependent caspase activity in prostatic carcinoma cell lines. The inhibitory a...

journal_title：Cancer biology & therapy

authors： Rokhlin OW,Guseva NV,Taghiyev AF,Glover RA,Cohen MB

更新日期：2004-08-01 00:00:00

abstract：:We investigated the cytotoxic interactions of romidepsin, a histone deacetylase inhibitor, and lenalidomide, an immunomodulatory agent, in a T-cell lymphoma preclinical model. Hut-78 and Karpas-299 cells were treated with romidepsin and lenalidomide alone and in combination. The interaction between romidepsin and lena...

journal_title：Cancer biology & therapy

authors： Cosenza M,Civallero M,Fiorcari S,Pozzi S,Marcheselli L,Bari A,Ferri P,Sacchi S

更新日期：2016-10-02 00:00:00

abstract：OBJECTIVES:Due to the absence of reliable and accurate biomarkers for the early detection of liver malignancy, circulating microRNAs have recently emerged as great candidates for prompt cancer identification. Therefore, the aim of this study was to investigate the potential of liver-specific circulating microRNAs as an...

journal_title：Cancer biology & therapy

authors： Mourad L,El-Ahwany E,Zoheiry M,Abu-Taleb H,Hassan M,Ouf A,Rahim AA,Hassanien M,Zada S

更新日期：2018-05-04 00:00:00

abstract：:Arsenic trioxide (As2O3) induces apoptosis in certain types of cancer cells. But the detailed mechanisms of As2O3 efficacy are not completely known. Here we demonstrate that As2O3 has a therapeutic effect on cervical cancer in vitro and in vivo. We investigated the As2O3-induced apoptosis in various cervical cancer ce...

journal_title：Cancer biology & therapy

authors： Yu J,Qian H,Li Y,Wang Y,Zhang X,Liang X,Fu M,Lin C

更新日期：2007-04-01 00:00:00

abstract：:We investigated the role of vasculogenic mimicry (VM) in the progression of prostate cancer (PCa). Ninety-six patients who had undergone prostatectomy for treatment of PCa and for whom a complete record of clinical and follow-up data were available were reviewed. VM and matrix metalloproteinase-2 (MMP-2) were detected...

journal_title：Cancer biology & therapy

authors： Liu R,Yang K,Meng C,Zhang Z,Xu Y

更新日期：2012-05-01 00:00:00

abstract：:Ovarian cancer ranks fifth in cancer related deaths for women in USA. The high mortality rate associated with ovarian cancer is due to diagnosis at later stages of disease and the high recurrence rate of 60-80%. Recurrent ovarian cancers are more likely to present as multidrug resistance (MDR) leading to unfavorable r...

journal_title：Cancer biology & therapy

authors： Patel NR,Piroyan A,Ganta S,Morse AB,Candiloro KM,Solon AL,Nack AH,Galati CA,Bora C,Maglaty MA,O'Brien SW,Litwin S,Davis B,Connolly DC,Coleman TP

更新日期：2018-07-03 00:00:00

abstract：:Melanoma is the deadliest form of skin cancer, which is notoriously aggressive and chemo-resistant, and for which there is little effective treatment available if it goes undetected. Curcumin from the turmeric spice (Curcuma longa) has long been used in Southeast Asian medicine to alleviate ailments and cure an array ...

journal_title：Cancer biology & therapy

authors： Chatterjee SJ,Pandey S

更新日期：2011-01-15 00:00:00

abstract：:Invariant natural killer T (iNKT) cells are a distinct subset of human T cells, which expresses an invariant T cell receptor Vα24 Jα18 and recognizes glycolipid antigens in the context of CD1d molecules. iNKT cells exert pivotal regulatory roles in many immune responses, including antitumor immune responses. Alteratio...

journal_title：Cancer biology & therapy

authors： Altomare E,Fallarini S,Biaggi G,Gattoni E,Botta M,Lombardi G

更新日期：2012-07-01 00:00:00

abstract：:Gemcitabine based treatment is currently a standard first line treatment for patients with advanced pancreatic cancer, however overall survival remains poor, and few options are available for patients that fail gemcitabine based therapy. To identify potential molecular targets in gemcitabine refractory pancreatic canc...

journal_title：Cancer biology & therapy

authors： Samulitis BK,Pond KW,Pond E,Cress AE,Patel H,Wisner L,Patel C,Dorr RT,Landowski TH

更新日期：2015-01-01 00:00:00

abstract：:Current knowledge of changes in the mammary epithelium relevant to breast carcinogenesis is limited to when histological changes are already present because of a lack of biomarkers needed to identify where such molecular changes might be ongoing at earlier during the of decades-long latent stages of breast carcinogene...

journal_title：Cancer biology & therapy

authors： Weisz J,Shearer DA,Murata E,Patrick SD,Han B,Berg A,Clawson GA

更新日期：2012-01-15 00:00:00

abstract：:Transmembrane protease/serine 4 (TMPRSS4) is a member of the type II transmembrane serine protease (TTSP) family and it was found highly expressed in several cancers. This study aims to evaluate the expression of TMPRSS4 in colorectal cancer (CRC) and investigate its role in proliferation and self-renewal of colon can...

journal_title：Cancer biology & therapy

authors： Huang A,Zhou H,Zhao H,Quan Y,Feng B,Zheng M

更新日期：2014-03-01 00:00:00

abstract：:To avoid cell cycle arrest or apoptosis, rapidly proliferating cancer cells have to promote DNA double strand break (DSB) repair to fix replication stress induced DSBs. Therefore, developing drugs blocking homologous recombination (HR) and nonhomologous end joining (NHEJ) - 2 major DSB repair pathways - holds great po...

journal_title：Cancer biology & therapy

authors： Zhang L,Zhang F,Zhang W,Chen L,Gao N,Men Y,Xu X,Jiang Y

更新日期：2015-01-01 00:00:00

abstract：:Bone metastases are a common occurrence in patients with breast cancer, lung cancer and prostate cancer. Bone metastases cause considerable morbidity including pain, impaired mobility, pathologic fracture, spinal cord or nerve root compression, bone marrow infiltration and hypercalcemia of malignancy. These complicati...

journal_title：Cancer biology & therapy

authors： Berenson JR,Rajdev L,Broder M

更新日期：2006-09-01 00:00:00

abstract：:While several hypotheses have been put forward to explain how prostate tumors become resistant to androgen deprivation therapy, the mechanism by which prostate tumors have increased androgen concentrations as compared to the serum has been poorly explored. Using a stromal/epithelial cell co-culture model, Mizokami et ...

journal_title：Cancer biology & therapy

authors： Sharma H,Sissung TM,Pressler H,Figg WD

更新日期：2010-02-01 00:00:00

abstract：:Li-Fraumeni syndrome (LFS) is primarily characterized by development of tumors exhibiting germ-line mutations in the p53 gene. Cell lines developed from patients of a LFS family have decreased p53 activity as evidenced by the absence of apoptosis upon etoposide treatment. To test our hypothesis that changes in gene ex...

journal_title：Cancer biology & therapy

authors： Sherif ZA,Sultan AS

更新日期：2013-01-01 00:00:00