Dissecting the roles of E1A and E1B in adenoviral replication and RCAd-enhanced RDAd transduction efficacy on tumor cells.

abstract：BACKGROUND:IL-24 (interleukin-24) is a promising, multi-functional anti-cancer agent able to selectively induce tumor cell apoptosis while sparing normal cells. Additionally, IL-24 can enhance the immune response to tumors and suppress tumor angiogenesis. In this study, we introduced IL-24 into the oncolytic adenovirus...

journal_title：Cancer biology & therapy

authors： Xiao LL,Wu YM,Qian J,Tan Y,Xie GL,Zhang KJ,Wang YG,Jia XY,Liu XY

更新日期：2010-08-01 00:00:00

abstract：:Multiple Myeloma (MM) is a progressive malignancy with poor prognosis, commonly treated by the use of the glucocorticoid Dexamethasone. Myeloma cells resist Dexamethasone induced apoptosis when exposed to IL-6 or IGF-1, both of which are known to activate several signaling cascades. For the first time, we show the act...

journal_title：Cancer biology & therapy

authors： Hodge DR,Xiao W,Wang LH,Li D,Farrar WL

更新日期：2004-02-01 00:00:00

abstract：:Angiogenesis inhibitors belong to a new class of drugs. Many of these drugs are in clinical trials to treat cancer, while others have recently received FDA approval. However, angiogenesis inhibitors operate by different mechanisms than conventional cytotoxic chemotherapies, and require different guidelines for their o...

journal_title：Cancer biology & therapy

authors： Folkman J

更新日期：2003-07-01 00:00:00

abstract：:The objective of the present study was to evaluate CA19-9 and CK8/18 expression patterns in pancreatic cancer cell lines induced by 5-fluorouracil (5-Fu), and in circulating tumor cells (CTCs) in peripheral blood of patients previously untreated with advanced pancreatic cancer. Furthermore, the goal was to test the re...

journal_title：Cancer biology & therapy

authors： Ren C,Han C,Zhang J,He P,Wang D,Wang B,Zhao P,Zhao X

更新日期：2011-10-15 00:00:00

abstract：:Historically, ErbB3 has been overlooked within the ErbB receptor family due to its perceived lack of tyrosine kinase activity. We have previously demonstrated that in pancreatic cancer ErbB3 is the preferred dimerization partner of EGFR, ErbB3 protein expression level directly correlates with the anti-proliferative ef...

journal_title：Cancer biology & therapy

authors： Liles JS,Arnoletti JP,Tzeng CW,Howard JH,Kossenkov AV,Kulesza P,Heslin MJ,Frolov A

更新日期：2010-09-15 00:00:00

abstract：:The epidermal growth factor receptor (EGFR) is a central regulator of tumor progression in human cancers. Cetuximab is an anti-EGFR monoclonal antibody that has been approved for use in oncology. Despite clinical success the majority of patients do not respond to cetuximab and those who initially respond frequently ac...

journal_title：Cancer biology & therapy

authors： Iida M,Brand TM,Campbell DA,Starr MM,Luthar N,Traynor AM,Wheeler DL

更新日期：2013-06-01 00:00:00

abstract：:A major problem in cancer treatment is the development of resistance to chemotherapeutic agents, multidrug resistance (MDR), associated with increased activity of transmembrane drug transporter proteins which impair cytotoxic treatment by rapidly removing the drugs from the targeted cells. Previously, it has been show...

journal_title：Cancer biology & therapy

authors： Chen Y,Scully M,Petralia G,Kakkar A

更新日期：2014-01-01 00:00:00

abstract：:The 26S proteasome is a large multi-subunit protein complex found in the cytoplasm and nucleus of mammalian cells which plays a critical role in intracellular proteolysis. It has been found that the 26S proteasome degrades multiple important substrates which are associated with tumor growth and development. Emerging e...

journal_title：Cancer biology & therapy

authors： Fribley A,Wang CY

更新日期：2006-07-01 00:00:00

abstract：:The enzyme 8-oxoguanine glycosylase 1 (OGG1) repairs 8-oxo-2-deoxyguanosine residue (8-oxodG) an oxidatively damaged promutagenic base. Genetic variations in OGG1 gene have been shown to modulate DNA repair capacity and are related risk of tumor development. However, epidemiologic findings have been inconsistent. The ...

journal_title：Cancer biology & therapy

authors： Habib SL,Danial E,Nath S,Schneider J,Jenkinson CP,Duggirala R,Abboud HE,Thameem F

更新日期：2008-01-01 00:00:00

abstract：:Ecto-5'-nucleotidase (CD73) was overexpressed in malignancies of epithelial origin and was involved in a variety of cellular processes such as cytoprotection and anti-inflammation. In the present study, human mammary T-47D cells were transfected with pcDNA-NT5E to establish a CD73 overexpressed cell model. Short small...

journal_title：Cancer biology & therapy

authors： Zhou P,Zhi X,Zhou T,Chen S,Li X,Wang L,Yin L,Shao Z,Ou Z

更新日期：2007-03-01 00:00:00

abstract：:Two peptides derived from the C1B domain of protein kinase Cγ (PKCγ) were shown to associate with classical PKC isozymes and modulate their activities. These C1B peptides are designated C1B1 (amino acid residues 101-112) and C1B5 (residues 141-151). Since PKC enzyme activity is shown to be involved in colon cancer dev...

journal_title：Cancer biology & therapy

authors： Kawabata A,Matsuzuka T,Doi C,Seiler G,Reischman J,Pickel L,Ayuzawa R,Nguyen TA,Tamura M

更新日期：2012-08-01 00:00:00

abstract：:The chemotherapeutic agents doxorubicin (dox) or 5-fluorouracil (5FU) are used to treat cancer cells as they cause irreparable DNA damage, inducing these aberrant cells to undergo cell death. The mediator of this process is presumed to be in part the tumor suppressor p53 which regulates genes involved in DNA repair an...

journal_title：Cancer biology & therapy

authors： Balmer MT,Katz RD,Liao S,Goodwine JS,Gal S

更新日期：2014-08-01 00:00:00

abstract：:Objective: Chimeric antigen receptor T (CAR-T) cell therapy has demonstrated an unprecedented therapeutic efficacy in hematological malignancies; however, its effectiveness in solid tumors remains elusive. In order to enable CAR-T cells more effective to solid tumors, a inverted chimeric cytokine receptor (ICR) was de...

journal_title：Cancer biology & therapy

authors： Weimin S,Abula A,Qianghong D,Wenguang W

更新日期：2020-06-02 00:00:00

abstract：:WNT and FGF signaling pathways cross-talk during a variety of cellular processes, such as human colorectal carcinogenesis, mouse mammary tumor virus (MMTV)-induced carcinogenesis, E2A-Pbx-induced leukemogenesis, early embryogenesis, body-axis formation, limb-bud formation, and neurogenesis. Canonical WNT signals are t...

journal_title：Cancer biology & therapy

authors： Katoh M,Katoh M

更新日期：2006-09-01 00:00:00

abstract：:To investigate the diagnostic potential of DNA methylation-based markers in tissue samples of DCIS, we examined the prevalence and extent of methylation in breast ductal carcinoma in situ (DCIS) samples from North American and Korean women. Quantitative multiplex-methylation specific PCR (QM-MSP) of ten genes was perf...

journal_title：Cancer biology & therapy

authors： Lee JS,Fackler MJ,Teo WW,Lee JH,Choi C,Park MH,Yoon JH,Zhang Z,Argani P,Sukumar S

更新日期：2008-09-01 00:00:00

abstract：:Double-strand breaks are one the most severe types of DNA damage with respect to cell survival and the preservation of genomic integrity. Therefore, cells have evolved complex mechanisms including cell cycle regulation, activation of repair pathways and in certain cases induction of apoptosis in response to these lesi...

journal_title：Cancer biology & therapy

authors： Karagiannis TC,El-Osta A

更新日期：2004-07-01 00:00:00

abstract：:Aberrant methylation of tumour suppressor genes is associated with the progression to a blast crisis in chronic myeloid leukaemia (CML). Methyl-CpG-binding domain protein 2 (MBD2) has been studied as a "reader" of DNA methylation in many cancers, but its role in CML is unclear. We constructed cell models of a homozygo...

journal_title：Cancer biology & therapy

authors： Cheng L,Tang Y,Chen X,Zhao L,Liu S,Ma Y,Wang N,Zhou K,Zhou J,Zhou M

更新日期：2018-08-03 00:00:00

abstract：:We studied the mechanism of the cytotoxic activity of BZL101, an aqueous extract from the herb Scutellaria barbata D. Don, which is currently in phase II clinical trial in patients with advanced breast cancer. The phase I trial showed favorable toxicity profile and promising efficacy. We report here that BZL101 induce...

journal_title：Cancer biology & therapy

authors： Fong S,Shoemaker M,Cadaoas J,Lo A,Liao W,Tagliaferri M,Cohen I,Shtivelman E

更新日期：2008-04-01 00:00:00

abstract：:Aggressive fibromatosis (AF) or desmoid tumors is an aggressive fibroblastic proliferation which is locally invasive but can not metastasize. The treatment of AF is challenging. Surgery was the main treatment modality for AF in the past, other strategies including radiotherapy, systemic therapies and wait-and-see poli...

journal_title：Cancer biology & therapy

authors： Yang S,Wang X,Jiang H,Wang Y,Li Z,Lu H

更新日期：2017-10-03 00:00:00

abstract：:Cytotoxic chemotherapeutic drugs, especially when used in combination, are widely employed to treat a variety of cancers in patients but often lead to serious symptoms that negatively affect physical functioning and quality of life. There is compelling evidence that implicates cytotoxic chemotherapy-induced inflammati...

journal_title：Cancer biology & therapy

authors： Wong J,Tran LT,Magun EA,Magun BE,Wood LJ

更新日期：2014-10-01 00:00:00

abstract：:Taxol (paclitaxel) and Taxotere (docetaxel) are considered as two of the most important anti-cancer chemotherapy drugs. The cytotoxic action of these drugs has been linked to their ability to inhibit microtubule depolymerization, causing growth arrest and subsequent cell death. Studies by a number of laboratories have...

journal_title：Cancer biology & therapy

authors： Yacoub A,Gilfor D,Hawkins W,Park MA,Hanna D,Hagan MP,Curiel DT,Fisher PB,Grant S,Dent P

更新日期：2006-10-01 00:00:00

abstract：:Mcl-1, a pro-survival member of the Bcl-2 protein family, is an attractive target for cancer therapy. We have recently identified the natural product marinopyrrole A (maritoclax) as a novel small molecule Mcl-1 inhibitor. Here, we describe the structure-activity relationship study of pyoluteorin derivatives based on m...

journal_title：Cancer biology & therapy

authors： Doi K,Gowda K,Liu Q,Lin JM,Sung SS,Dower C,Claxton D,Loughran TP Jr,Amin S,Wang HG

更新日期：2014-01-01 00:00:00

abstract：:Retinoids are used in leukemia therapy and chemoprevention of cancers. Treatment of MCF-7 breast carcinoma cells with low doses of retinoids induces gradual proliferation arrest with phenotypic markers of senescence. cDNA microarray hybridization and reverse transcription-polymerase chain reaction analysis showed that...

journal_title：Cancer biology & therapy

authors： Dokmanovic M,Chang BD,Fang J,Roninson IB

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Somatostatin receptor scintigraphy (SRS) has been reported for receptor (SSTR) screening in advanced hepatocarcinoma (aHC) prior to somatostatin analogue treatment. AIMS:To evaluate SSTR screening with SRS in aHC patients. RESULTS:Seventy aHC patients (63 men) aged 65 +/- 11 y were included, with alcohol, ...

journal_title：Cancer biology & therapy

authors： Nguyen-Khac E,Ollivier I,Aparicio T,Moullart V,Hugentobler A,Lebtahi R,Lobry C,Susini C,Duhamel C,Hommel S,Cadranel JF,Joly JP,Barbare JC,Tramier B,Dupas JL

更新日期：2009-11-01 00:00:00

abstract：:Genes playing a role in carcinogenesis have often been identified through analysis of recurrent chromosomal rearrangements. Although such rearrangements are well known in leukemias, lymphomas, and sarcomas, they have not been well characterized in carcinomas. In the October 28, 2005 issue of Science, a study by Tomlin...

journal_title：Cancer biology & therapy

authors： Ahlers CM,Figg WD

更新日期：2006-03-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is a critical early event in tumorigenesis. The contribution of heparan sulfate (HS) to EMT has not been fully elucidated. HS D-glucosaminyl 3-O-sulfotransferase-3B1 (3-OST-3B1) participates in the final step of HS fine structure biosynthesis, whose involvement in cancer has yet...

journal_title：Cancer biology & therapy

authors： Song K,Li Q,Jiang ZZ,Guo CW,Li P

更新日期：2011-09-01 00:00:00

abstract：:The phosphoinositide 3-kinase (PI3K)/Akt signaling pathway is important in nasopharyngeal carcinoma (NPC) pathogenesis. Activated PI3K and its downstream target Akt are concernful signaling molecules and key survival factors involved in the control of cell proliferation, apoptosis and oncogenesis. The protein kinase A...

journal_title：Cancer biology & therapy

authors： Yang L,Xiao L,Ma X,Tang M,Weng X,Chen X,Sun L,Cao Y

更新日期：2009-02-01 00:00:00

abstract：:Discovering drugs has never been an easy task. Traditionally, this task has exclusively been undertaken by large pharmaceutical companies that recovered their high research and development costs by selling expensive medications. Despite the huge amount of time and effort devoted towards drug discovery over the last de...

journal_title：Cancer biology & therapy

authors： Sager JA,Lengauer C

更新日期：2003-07-01 00:00:00

abstract：:The clinical use of EGFR-targeted therapy, in triple negative breast cancer patients, has been limited by the development of resistance to these drugs. Although activated signaling molecules contribute to this process, the molecular mechanisms remain relatively unknown. We have previously reported that the small GTPas...

journal_title：Cancer biology & therapy

authors： Haines E,Schlienger S,Claing A

更新日期：2015-01-01 00:00:00

abstract：:The delivery of cell-based vaccines that exploit natural mechanisms of antigen presentation represents a promising approach for immunotherapy of cancer. This strategy tests the hypothesis that ex vivo manipulation and reinjection of cellular products can induce immune responses and circumvent immune incompetence to ac...

journal_title：Cancer biology & therapy

authors： Coughlin CM,Vonderheide RH

更新日期：2003-09-01 00:00:00