The biology of hormone refractory breast and prostate cancer: An NCI workshop report.

abstract：:Targeting FGFRs is one of the most promising therapeutic strategies in squamous non-small cell lung cancer (SQCC). However, different FGFR genomic aberrations can be associated with distinct biological characteristics that result in different clinical outcomes or therapeutic consequences. Currently, the full spectrum ...

journal_title：Cancer biology & therapy

authors： Li JJ,Yan S,Pan Y,Liu Z,Liu Y,Deng Q,Tan Q,Woodward ER,Wu N

更新日期：2018-01-01 00:00:00

abstract：:Recent research has found that long noncoding RNAs (lncRNAs) were involved in various human cancers. However, the role of these lncRNAs in cervical cancer remains unexplored. Therefore, we aimed to investigate the biological function of maternally expressed gene 3 (MEG3), a cancer-related lncRNA, and its underlying me...

journal_title：Cancer biology & therapy

authors： Zhang J,Yao T,Wang Y,Yu J,Liu Y,Lin Z

更新日期：2016-01-01 00:00:00

abstract：:Endostatin can inhibit tumor growth by blocking angiogenesis, whereas tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) may function as a soluble cytokine to selectively kill cancer cells without toxicity to most normal cells. To establish the combined anti-tumor therapeutic effect of endostatin and solu...

journal_title：Cancer biology & therapy

authors： Zhang Y,Qu ZH,Cui M,Guo C,Zhang XM,Ma CH,Sun WS

更新日期：2009-03-01 00:00:00

abstract：:DNA methylation at the 5 position of cytosine (5-mC) has emerged as a key epigenetic marker that plays essential roles in various biological and pathological processes. 5-mC can be converted to 5-hydroxymethylcytosine (5-hmC) by the ten-eleven translocation (TET) family proteins, which is now widely recognized as the ...

journal_title：Cancer biology & therapy

authors： Ye C,Li L

更新日期：2014-01-01 00:00:00

abstract：:Mortality data by geographic area and trend-based surveillance are particularly relevant in orienting public health decisions targeting specific populations. We analyzed overall and site-specific cancer mortality between 1988 and 2009 in the metropolitan area of Naples and Caserta in southern Italy. Age-standardized m...

journal_title：Cancer biology & therapy

authors： Crispo A,Barba M,Malvezzi M,Arpino G,Grimaldi M,Rosso T,Esposito E,Sergi D,Ciliberto G,Giordano A,Montella M

更新日期：2013-12-01 00:00:00

abstract：:Male germ cell tumors (GCTs) are a model for a curable solid tumor. GCTs can differentiate into mature teratomas. Embryonal carcinomas (ECs) represent the stem cell compartment of GCTs and are the malignant counterpart to embryonic stem (ES) cells. GCTs and EC cells are useful to investigate differentiation therapy an...

journal_title：Cancer biology & therapy

authors： Busch AM,Galimberti F,Nehls KE,Roengvoraphoj M,Sekula D,Li B,Guo Y,Direnzo J,Fiering SN,Spinella MJ,Robbins DJ,Memoli VA,Freemantle SJ,Dmitrovsky E

更新日期：2014-04-01 00:00:00

abstract：:The early observations by Dr Otto Warburg revealed that fundamentally metabolic differences exist between malignant tumor cells and adjacent normal cells. Many studies have further reported the relationship between altered cellular metabolism and therapeutic outcomes. These observations suggest that targeting the pecu...

journal_title：Cancer biology & therapy

authors： Zhang Y,Yang JM

更新日期：2013-02-01 00:00:00

abstract：:Hypoxia is an important phenomenon in the tumor microenvironment. Hypoxic tumors are more aggressive and resistant to anti-neoplastic treatments. HIF-1alpha plays a major role in the response of tumors to hypoxia, and it is mainly responsible for the "angiogenic switch". HIF-1alpha contributes to tumor aggressiveness,...

journal_title：Cancer biology & therapy

authors： Diaz-Gonzalez JA,Russell J,Rouzaut A,Gil-Bazo I,Montuenga L

更新日期：2005-10-01 00:00:00

abstract：:Dendritic cells (DC) operate through an immature (iDC) step (where tumor antigens are internalized) and a mature step (mDC) (where tumor antigens (TA) are cross-presented to naive TA-specific cytotoxic T lymphocyte (CTL) progenitors). Receptors by which cellbound antigens can access the DC cross-presentation pathway i...

journal_title：Cancer biology & therapy

authors： Signorino E,Brusa D,Granata R,Malavasi F,Ferrone S,Matera L

更新日期：2007-12-01 00:00:00

abstract：:Beneficial bacteria (probiotics) and probiotic-derived factors have the potential to ameliorate disorders of the intestine. The aim of this study was to compare live Streptococcus thermophilus TH-4 (TH-4), dead TH-4 and TH-4 supernatant in rats treated with 5-Fluorouracil. Rats were randomly allocated to five treatmen...

journal_title：Cancer biology & therapy

authors： Whitford EJ,Cummins AG,Butler RN,Prisciandaro LD,Fauser JK,Yazbeck R,Lawrence A,Cheah KY,Wright TH,Lymn KA,Howarth GS

更新日期：2009-03-15 00:00:00

abstract：:To establish stable and long-term gene expression in vitro and in vivo, we developed a lentiviral vector system carrying sodium iodide symporter (hNIS) gene under UbC promoter, and transfected this into a colon cancer cell line. The in vitro and in vivo kinetics of radioiodine and [99mTc]-pertechnetate were then inves...

journal_title：Cancer biology & therapy

authors： Kim HJ,Jeon YH,Kang JH,Lee YJ,Kim KI,Chung HK,Jeong JM,Lee DS,Lee MC,Chung JK

更新日期：2007-07-01 00:00:00

abstract：:Telomerase is the ribonucleoprotein that enables cancer and stem cells to maintain their telomeres, resulting in unlimited proliferative potential. The catalytic component of telomerase in humans, hTERT, is upregulated in nearly 90% of all cancers, making it the most widely expressed marker of malignancy. With the exc...

journal_title：Cancer biology & therapy

authors： Nguyen B,Elmore LW,Holt SE

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:Somatostatin receptor scintigraphy (SRS) has been reported for receptor (SSTR) screening in advanced hepatocarcinoma (aHC) prior to somatostatin analogue treatment. AIMS:To evaluate SSTR screening with SRS in aHC patients. RESULTS:Seventy aHC patients (63 men) aged 65 +/- 11 y were included, with alcohol, ...

journal_title：Cancer biology & therapy

authors： Nguyen-Khac E,Ollivier I,Aparicio T,Moullart V,Hugentobler A,Lebtahi R,Lobry C,Susini C,Duhamel C,Hommel S,Cadranel JF,Joly JP,Barbare JC,Tramier B,Dupas JL

更新日期：2009-11-01 00:00:00

abstract：:We developed a DNA aptamer, Ap52, against the shared tumor-specific MAGE-A3111-125 peptide antigen that was used to target multiple types of cancer cells. Here we report the in vivo study of mice implanted with pancreatic tumor cells AsPC-1, which demonstrates accumulation of phosphorothioate-modified Ap52 (ThioAp52) ...

journal_title：Cancer biology & therapy

authors： Wang CY,Lin BL,Chen CH

更新日期：2021-01-02 00:00:00

abstract：:5-fluorouracil (5-FU) is the major chemotherapeutic agent for treatment of colorectal carcinoma, but the molecular mechanisms of response and resistance are not understood completely. We therefore studied the 5-FU dose response and time course of gene expression transcriptome changes in colon carcinoma cell lines that...

journal_title：Cancer biology & therapy

authors： Zhang W,Ramdas L,Shen W,Song SW,Hu L,Hamilton SR

更新日期：2003-09-01 00:00:00

abstract：:To investigate the diagnostic potential of DNA methylation-based markers in tissue samples of DCIS, we examined the prevalence and extent of methylation in breast ductal carcinoma in situ (DCIS) samples from North American and Korean women. Quantitative multiplex-methylation specific PCR (QM-MSP) of ten genes was perf...

journal_title：Cancer biology & therapy

authors： Lee JS,Fackler MJ,Teo WW,Lee JH,Choi C,Park MH,Yoon JH,Zhang Z,Argani P,Sukumar S

更新日期：2008-09-01 00:00:00

abstract：:Hypermethylation at certain CpG-rich promoters and hypomethylation at repeated DNA sequences are very frequently found in cancers. We provide the first report that a DNA sequence (NBL2) can be either extensively hypermethylated or hypomethylated in cancer. Previously, it was shown that NBL2, a complex tandem DNA repea...

journal_title：Cancer biology & therapy

authors： Nishiyama R,Qi L,Tsumagari K,Weissbecker K,Dubeau L,Champagne M,Sikka S,Nagai H,Ehrlich M

更新日期：2005-04-01 00:00:00

abstract：:Histone H1.2, a housekeeping protein that binds nucleosomal linkers, has recently been identified as an apoptogenic factor released from the nucleus to the cytosol in response to double strand DNA breaks. In the cytosol, it promotes the activation of proapoptotic Bcl-2 family proteins, mitochondrial cytochrome c relea...

journal_title：Cancer biology & therapy

authors： Zong WX

更新日期：2004-01-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide, and novel effective drugs against NSCLC are urgently needed. Isodon species are rich in ent-kaurane diterpenoids that have been reported to have antitumor bioactivity. Acetyl-macrocalin B (A-macB) is a novel ent-kaurane diterpen...

journal_title：Cancer biology & therapy

authors： Wang JN,Zhang ZR,Che Y,Yuan ZY,Lu ZL,Li Y,Li N,Wan J,Sun HD,Sun N,Puno PT,He J

更新日期：2018-07-03 00:00:00

abstract：:Nonstop proliferation and vigorous neovascularization are two prominent characteristics of cancer. Antiangiogenic therapy has emerged as an important modality in treatment of solid tumors. Our previous work demonstrated that microparticles derived from apoptotic T-lymphocytes (LMPs) not only reduced the viabilities of...

journal_title：Cancer biology & therapy

authors： Yang C,Gagnon C,Hou X,Hardy P

更新日期：2010-09-01 00:00:00

abstract：:Hepatoblastoma (HB) is the most common liver tumor of childhood, usually occurring in children under the age of 3 y. The prognosis of patients presenting with distant metastasis, vascular invasion and advanced tumor stages remains poor and children that do survive often face severe late effects from the aggressive che...

journal_title：Cancer biology & therapy

authors： Beck A,Eberherr C,Hagemann M,Cairo S,Häberle B,Vokuhl C,von Schweinitz D,Kappler R

更新日期：2016-11-01 00:00:00

abstract：:Resistance of tumors due to restricted drug accumulation and reversal of DNA lesions in tumor cells as well as normal tissue toxicity limit the efficacy of topoisomerase inhibition based anticancer drugs. It has been proposed that selective inhibition of energy dependent repair processes and enhanced retention of drug...

journal_title：Cancer biology & therapy

authors： Dwarakanath BS,Khaitan D,Ravindranath T

更新日期：2004-09-01 00:00:00

abstract：:Chronic myeloid leukemia (CML) progresses from a chronic phase to a deadly blast crisis phase. While it is known that BCR-ABL initiates the disease and that secondary molecular and genetic abnormalities likely contribute to progression of the disease to blast crisis, details regarding the mechanism(s) of blast phase p...

journal_title：Cancer biology & therapy

authors： Griner LN,Reuther GW

更新日期：2010-11-15 00:00:00

abstract：:Arsenic trioxide (As2O3) induces apoptosis in certain types of cancer cells. But the detailed mechanisms of As2O3 efficacy are not completely known. Here we demonstrate that As2O3 has a therapeutic effect on cervical cancer in vitro and in vivo. We investigated the As2O3-induced apoptosis in various cervical cancer ce...

journal_title：Cancer biology & therapy

authors： Yu J,Qian H,Li Y,Wang Y,Zhang X,Liang X,Fu M,Lin C

更新日期：2007-04-01 00:00:00

abstract：:Recently, we showed that the metal chelator TPEN targets colon cancer cells through redox cycling of copper. Here, we studied the DNA damage potential of TPEN and deciphered the role of Chk1, ATM and DNA-PK in TPEN-induced toxicity in 3 human colon cancer cell lines, HCT116, SW480 and HT29. We also investigated the ro...

journal_title：Cancer biology & therapy

authors： Rahal ON,Fatfat M,Hankache C,Osman B,Khalife H,Machaca K,Muhtasib HG

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVES:We herein assessed the influence of Epidermal Growth Factor Receptor (EGFR) gene mutations on EGFR expression levels, downstream mediators such as Akt or ERK, and overall survival in patients with ovarian cancer. STUDY DESIGN:EGFR mutation status was analyzed by direct sequencing in 102 Japanese ovarian can...

journal_title：Cancer biology & therapy

authors： Tanaka Y,Terai Y,Tanabe A,Sasaki H,Sekijima T,Fujiwara S,Yamashita Y,Kanemura M,Ueda M,Sugita M,Franklin WA,Ohmichi M

更新日期：2011-01-01 00:00:00

abstract：:Colorectal cancer (CRC) is the second most prevalent and deadly cancer worldwide. Due to the mortality and morbidity associated with chemotherapeutic regimes, research is turning to natural product enhancement of the acute apoptotic response to genotoxic carcinogens (AARGC). Although Tyrian purple dye pigments and pre...

journal_title：Cancer biology & therapy

authors： Westley CB,McIver CM,Abbott CA,Le Leu RK,Benkendorff K

更新日期：2010-03-01 00:00:00

abstract：:Adenoid cystic carcinoma (ACC), a rare salivary gland malignancy, is a histogenetic, morphologic, and clinical heterogeneous disease. Extensive efforts have been made to characterize molecular events associated with these tumors, including the identification of prognostic and predictive biomarkers. Increased copy numb...

journal_title：Cancer biology & therapy

authors： Bell D,Ferrarotto R,Fox MD,Roberts D,Hanna EY,Weber RS,El-Naggar AK

更新日期：2015-01-01 00:00:00

abstract：:Although HER2-targeted therapy has been shown to prolong the survival of patients with HER2-positive breast cancer, most patients eventually progress due to drug resistance. Novel treatment options are urgently needed to overcome resistance to HER2-targeted therapy. The VEGF/VEGFR (Vascular endothelial growth factor a...

journal_title：Cancer biology & therapy

authors： Danni L,Lingyun Z,Jian W,Hongfei Y,Lu X,Peng Y,Xiujuan Q,Yunpeng L,Yuee T

更新日期：2020-07-02 00:00:00

abstract：:The impact of environmental mutagens and carcinogens on the mammary gland has recently received a lot of attention. Among the most generally accepted carcinogenic agents identified as factors that may increase breast cancer incidence are ionizing radiation and elevated estrogen levels. However, the molecular mechanism...

journal_title：Cancer biology & therapy

authors： Kutanzi K,Kovalchuk O

更新日期：2013-07-01 00:00:00