The clinical significance of tumor cell-lined vasculature in ovarian carcinoma: implications for anti-vasculogenic therapy.

abstract：:Taxol (paclitaxel) and Taxotere (docetaxel) are considered as two of the most important anti-cancer chemotherapy drugs. The cytotoxic action of these drugs has been linked to their ability to inhibit microtubule depolymerization, causing growth arrest and subsequent cell death. Studies by a number of laboratories have...

journal_title：Cancer biology & therapy

authors： Yacoub A,Gilfor D,Hawkins W,Park MA,Hanna D,Hagan MP,Curiel DT,Fisher PB,Grant S,Dent P

更新日期：2006-10-01 00:00:00

abstract：:Interdigitating dendritic cell sarcoma is an extremely rare tumor. The diagnosis is difficult and is based on clinical, pathological and immunohistochemical evaluation. Differential diagnosis includes melanoma, mesenchymal and hematological malignancies. The mainstay of treatment is surgery for limited disease and dif...

journal_title：Cancer biology & therapy

authors： Di Liso E,Pennelli N,Lodovichetti G,Ghiotto C,Dei Tos AP,Conte P,Bonanno L

更新日期：2015-01-01 00:00:00

abstract：:CP-31398, a styrylquinazoline, emerged from a screen for therapeutic agents that restore a wild-type DNA-binding conformation of mutant p53 to suppress tumors in-vivo (Science 286, 2507, 1999). We investigated the growth inhibitory mechanism of CP-31398 using nine human cancer cell lines containing wild-type, mutant o...

journal_title：Cancer biology & therapy

authors： Takimoto R,Wang W,Dicker DT,Rastinejad F,Lyssikatos J,el-Deiry WS

更新日期：2002-01-01 00:00:00

abstract：:Although most researchers in biology tend to focus on very specific issues and questions about their preferred gene or pathway, sometimes we face situations in which nature presents us with a remarkable example of a gene with multiple functions. Since the discovery of the early growth response 1 (EGR1) gene in the mid...

journal_title：Cancer biology & therapy

authors： DeLigio JT,Zorio DA

更新日期：2009-10-01 00:00:00

abstract：:Recently, we showed that the metal chelator TPEN targets colon cancer cells through redox cycling of copper. Here, we studied the DNA damage potential of TPEN and deciphered the role of Chk1, ATM and DNA-PK in TPEN-induced toxicity in 3 human colon cancer cell lines, HCT116, SW480 and HT29. We also investigated the ro...

journal_title：Cancer biology & therapy

authors： Rahal ON,Fatfat M,Hankache C,Osman B,Khalife H,Machaca K,Muhtasib HG

更新日期：2016-11-01 00:00:00

abstract：:Breast cancer is one of the most commonly diagnosed malignancies in women. Despite the remarkable success of mammography screening and use of adjuvant systemic therapy, it is estimated that approximately 200,000 new diagnoses will be made this year and 40,000 deaths will occur due to this disease (American Cancer Soci...

journal_title：Cancer biology & therapy

authors： Rosca EV,Koskimaki JE,Pandey NB,Wolff AC,Popel AS

更新日期：2011-11-01 00:00:00

abstract：:Cytotoxic chemotherapeutic drugs, especially when used in combination, are widely employed to treat a variety of cancers in patients but often lead to serious symptoms that negatively affect physical functioning and quality of life. There is compelling evidence that implicates cytotoxic chemotherapy-induced inflammati...

journal_title：Cancer biology & therapy

authors： Wong J,Tran LT,Magun EA,Magun BE,Wood LJ

更新日期：2014-10-01 00:00:00

abstract：:The enzyme 8-oxoguanine glycosylase 1 (OGG1) repairs 8-oxo-2-deoxyguanosine residue (8-oxodG) an oxidatively damaged promutagenic base. Genetic variations in OGG1 gene have been shown to modulate DNA repair capacity and are related risk of tumor development. However, epidemiologic findings have been inconsistent. The ...

journal_title：Cancer biology & therapy

authors： Habib SL,Danial E,Nath S,Schneider J,Jenkinson CP,Duggirala R,Abboud HE,Thameem F

更新日期：2008-01-01 00:00:00

abstract：:The present studies have examined approaches to suppress MCL-1 function in breast cancer cells, as a means to promote tumor cell death. Treatment of breast cancer cells with CDK inhibitors (flavopiridol; roscovitine) enhanced the lethality of the ERBB1 inhibitor lapatinib in a synergistic fashion. CDK inhibitors inter...

journal_title：Cancer biology & therapy

authors： Mitchell C,Yacoub A,Hossein H,Martin AP,Bareford MD,Eulitt P,Yang C,Nephew KP,Dent P

更新日期：2010-11-01 00:00:00

abstract：:In bone metastases, tumor cells interact with the bone microenvironment to induce osteoclastogenesis, leading to bone destruction and the growth factor release.  RANK ligand (RANKL) is essential for osteoclast formation, function, and survival.  Tumor cell-mediated osteolysis is thought to occur ultimately via inducti...

journal_title：Cancer biology & therapy

authors： Holland PM,Miller R,Jones J,Douangpanya H,Piasecki J,Roudier M,Dougall WC

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVES:We herein assessed the influence of Epidermal Growth Factor Receptor (EGFR) gene mutations on EGFR expression levels, downstream mediators such as Akt or ERK, and overall survival in patients with ovarian cancer. STUDY DESIGN:EGFR mutation status was analyzed by direct sequencing in 102 Japanese ovarian can...

journal_title：Cancer biology & therapy

authors： Tanaka Y,Terai Y,Tanabe A,Sasaki H,Sekijima T,Fujiwara S,Yamashita Y,Kanemura M,Ueda M,Sugita M,Franklin WA,Ohmichi M

更新日期：2011-01-01 00:00:00

abstract：:Bruton's tyrosine kinase (BTK) is a non-receptor tyrosine kinase that has mainly been studied in haematopoietic cells. We have investigated whether BTK is a potential therapeutic target in prostate cancer. We find that BTK is expressed in prostate cells, with the alternate BTK-C isoform predominantly expressed in pros...

journal_title：Cancer biology & therapy

authors： Kokabee L,Wang X,Sevinsky CJ,Wang WL,Cheu L,Chittur SV,Karimipoor M,Tenniswood M,Conklin DS

更新日期：2015-01-01 00:00:00

abstract：:Expression of the heparanase gene is associated with invasive, angiogenic and metastatic potential of diverse malignant tumors and cell lines. Here we used RNA interference strategies to evaluate the role of human heparanase in breast malignancy and to explore the therapeutic potential of its specific targeting. The s...

journal_title：Cancer biology & therapy

authors： Zhang ZH,Chen Y,Zhao HJ,Xie CY,Ding J,Hou YT

更新日期：2007-04-01 00:00:00

abstract：:Translocations and unique chromosome break points in melanoma will aid in the identification of the genes that are important in the neoplastic process. We have previously shown a unique translocation in malignant melanoma cells der(12)t(12;20). The transcription factor E2F1 maps to 20q11. Increased expression of E2F h...

journal_title：Cancer biology & therapy

authors： Nelson MA,Reynolds SH,Rao UN,Goulet AC,Feng Y,Beas A,Honchak B,Averill J,Lowry DT,Senft JR,Jefferson AM,Johnson RC,Sargent LM

更新日期：2006-04-01 00:00:00

abstract：:Medulloblastoma is an aggressive primitive neuroectodermal tumor of the cerebellum that is rare in adults. Medulloblastomas fall into 4 prognostically significant molecular subgroups that are best defined by experimental gene expression profiles: the WNT pathway, sonic hedgehog (SHH) pathway, and subgroups 3 and 4 (no...

journal_title：Cancer biology & therapy

authors： Lou E,Schomaker M,Wilson JD,Ahrens M,Dolan M,Nelson AC

更新日期：2016-10-02 00:00:00

abstract：:Deregulated metabolism is gaining recognition as a hallmark of cancer cells, and is being explored for therapeutic potential. The Warburg effect is a metabolic phenotype that occurs in 90% of tumors, where glycolysis is favored despite the presence of oxygen. Dichloroacetate (DCA) is a pyruvate dehydrogenase kinase (P...

journal_title：Cancer biology & therapy

authors： Gang BP,Dilda PJ,Hogg PJ,Blackburn AC

更新日期：2014-01-01 00:00:00

abstract：:Angiogenesis plays an essential role in tumor growth and metastasis and is a promising target for cancer therapy. We characterized the effects of selective CIAPIN1 inhibition on the angiogenesis gastric cancer cell line SGC7901 by stable transfection of CIAPIN1 siRNA. Our study has been shown that CIAPIN1 play the det...

journal_title：Cancer biology & therapy

authors： Yan K,He LJ,Cheng W,Ji ZZ,Zhao BX,Hui XL,Cao SS,Chen B,He L,Liang SH,Miao Y

更新日期：2009-06-01 00:00:00

abstract：:Metastatic cervical cancer remains a clinical problem. The development of more efficient treatment modalities and the optimal use of chemo- and radiotherapy require better understanding of their impact on regulation of cell survival and apoptosis, but the issue is insufficiently explored. Human papillomavirus (HPV) E6...

journal_title：Cancer biology & therapy

authors： Koivusalo R,Hietanen S

更新日期：2004-11-01 00:00:00

abstract：OBJECTIVES:The biochemical response of prostatic cells to needle core biopsies is known to manifest as a rise in serum PSA. The aim of this study is to evaluate the PSA response to mechanical trauma in prostate cancer patients, when compared to benign controls. MATERIALS AND METHODS:50 consecutive patients undergoing ...

journal_title：Cancer biology & therapy

authors： Bhanot S,Gopalakrishnan R,Oliver RT

更新日期：2003-01-01 00:00:00

abstract：:Melanoma is the deadliest form of skin cancer, which is notoriously aggressive and chemo-resistant, and for which there is little effective treatment available if it goes undetected. Curcumin from the turmeric spice (Curcuma longa) has long been used in Southeast Asian medicine to alleviate ailments and cure an array ...

journal_title：Cancer biology & therapy

authors： Chatterjee SJ,Pandey S

更新日期：2011-01-15 00:00:00

abstract：EXPERIMENTAL DESIGN:To investigate the antitumor effect of sunitinib and FAK/Pyk2 tyrosine kinase inhibitor (PF-562,271)combination therapy in vivo, utilizing human hepatocellular carcinoma (HCC) cells Huh7.5. Nude rats were inoculated subcutaneously with Huh7.5 hepatoma cells. Dosing for Phase 1 was initiated on day 5...

journal_title：Cancer biology & therapy

authors： Bagi CM,Christensen J,Cohen DP,Roberts WG,Wilkie D,Swanson T,Tuthill T,Andresen CJ

更新日期：2009-05-01 00:00:00

abstract：:Beneficial bacteria (probiotics) and probiotic-derived factors have the potential to ameliorate disorders of the intestine. The aim of this study was to compare live Streptococcus thermophilus TH-4 (TH-4), dead TH-4 and TH-4 supernatant in rats treated with 5-Fluorouracil. Rats were randomly allocated to five treatmen...

journal_title：Cancer biology & therapy

authors： Whitford EJ,Cummins AG,Butler RN,Prisciandaro LD,Fauser JK,Yazbeck R,Lawrence A,Cheah KY,Wright TH,Lymn KA,Howarth GS

更新日期：2009-03-15 00:00:00

abstract：:Mutationally activated and oncogenic versions of the ras genes were first identified in human tumors in 1982. This discovery prompted great interest in the development of anti-Ras strategies as novel, target-based approaches for cancer treatment. The three human ras genes represent the most frequently mutated oncogene...

journal_title：Cancer biology & therapy

authors： Cox AD,Der CJ

更新日期：2002-11-01 00:00:00

abstract：:TRA-8, a monoclonal antibody targeting death receptor, has demonstrated high therapeutic effect for triple negative breast cancer (TNBC) in preclinical models. Tamoxifen, the standard of care for ERα-positive breast cancer, induces apoptosis via ERβ, which commonly presents in TNBC cells. The current study investigate...

journal_title：Cancer biology & therapy

authors： Kim H,Samuel SL,Zhai G,Rana S,Taylor M,Umphrey HR,Oelschlager DK,Buchsbaum DJ,Zinn KR

更新日期：2014-08-01 00:00:00

abstract：:Cutaneous T-cell lymphoma (CTCL) displays immunosuppressive properties and phenotypic plasticity. The malignant T cells in CTCL can possess features of immunomodulating regulatory T cells (Treg) and IL-17-producing helper T cells (Th17) depending on the stimuli they receive from antigen presenting cells and other sour...

journal_title：Cancer biology & therapy

authors： Abraham RM,Zhang Q,Odum N,Wasik MA

更新日期：2011-12-15 00:00:00

abstract：:Arsenic trioxide (As2O3) induces apoptosis in certain types of cancer cells. But the detailed mechanisms of As2O3 efficacy are not completely known. Here we demonstrate that As2O3 has a therapeutic effect on cervical cancer in vitro and in vivo. We investigated the As2O3-induced apoptosis in various cervical cancer ce...

journal_title：Cancer biology & therapy

authors： Yu J,Qian H,Li Y,Wang Y,Zhang X,Liang X,Fu M,Lin C

更新日期：2007-04-01 00:00:00

abstract：:Objective: To investigate the clinicopathologic features and immunophenotype of invasive-stratified mucin-producing carcinoma (ISMC). Methods: We retrospectively analyzed three patients who underwent surgery for pathologically confirmed ISMC from January 2017 to December 2017 in Anyang Tumor Hospital. The pathological...

journal_title：Cancer biology & therapy

authors： Lei R

更新日期：2019-01-01 00:00:00

abstract：:Rhabdomyosarcoma (RMS) is an aggressive childhood sarcoma with two distinct subtypes, embryonal (ERMS) and alveolar (ARMS) histologies. More effective treatment is needed to improve outcomes, beyond conventional cytotoxic chemotherapy. The pan-histone deacetylase inhibitor, Suberoylanilide Hydroxamic Acid (SAHA), has ...

journal_title：Cancer biology & therapy

authors： Ghayad SE,Rammal G,Sarkis O,Basma H,Ghamloush F,Fahs A,Karam M,Harajli M,Rabeh W,Mouawad JE,Zalzali H,Saab R

更新日期：2019-01-01 00:00:00

abstract：:Chemotherapy in prostate cancer (CaP) even as an adjunct has not been a success. In this communication, we report the pre-clinical efficacy of a nitroacridine derivative, C-1748 (9[2'-hydroxyethylamino]-4-methyl-1-nitroacridine) in CaP cell culture and human xenograft animal models. C-1748, a DNA intercalating agent h...

journal_title：Cancer biology & therapy

authors： Tadi K,Ashok BT,Chen Y,Banerjee D,Wysocka-Skrzela B,Konopa J,Darzynkiewicz Z,Tiwari RK

更新日期：2007-10-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a major health problem worldwide, involving more than 620,000 new cases yearly, with chronic HBV and HCV infection being the most common causes. Because most patients are diagnosed in an advanced state which is usually not amenable to curative therapy, prevention should be the main fo...

journal_title：Cancer biology & therapy

authors： Liu Q,Song Y,Zhou Y,Qiao L

更新日期：2006-12-01 00:00:00