Genome-wide barcoded transposon screen for cancer drug sensitivity in haploid mouse embryonic stem cells.

abstract：:Patient-specific craniofacial implants are used to repair skull bone defects after trauma or surgery. Currently, cranial implants are designed and produced by third-party suppliers, which is usually time-consuming and expensive. Recent advances in additive manufacturing made the in-hospital or in-operation-room fabric...

journal_title：Scientific data

authors： Li J,Gsaxner C,Pepe A,Morais A,Alves V,von Campe G,Wallner J,Egger J

更新日期：2021-01-29 00:00:00

abstract：:Many animal phyla have no representatives within the catalog of whole metazoan genome sequences. This dataset fills in one gap in the genome knowledge of animal phyla with a draft genome of Bugula neritina (phylum Bryozoa). Interest in this species spans ecology and biomedical sciences because B. neritina is the natur...

journal_title：Scientific data

authors： Rayko M,Komissarov A,Kwan JC,Lim-Fong G,Rhodes AC,Kliver S,Kuchur P,O'Brien SJ,Lopez JV

更新日期：2020-10-20 00:00:00

abstract：:Tardigrades are ubiquitous microscopic animals that play an important role in the study of metazoan phylogeny. Most terrestrial tardigrades can withstand extreme environments by entering an ametabolic desiccated state termed anhydrobiosis. Due to their small size and the non-axenic nature of laboratory cultures, molec...

journal_title：Scientific data

authors： Arakawa K,Yoshida Y,Tomita M

更新日期：2016-08-16 00:00:00

abstract：:The use of DNA metabarcoding to characterise the biodiversity of environmental and community samples has exploded in recent years. However, taxonomic inferences from these studies are contingent on the quality and completeness of the sequence reference database used to characterise sample species-composition. In respo...

journal_title：Scientific data

authors： Arranz V,Pearman WS,Aguirre JD,Liggins L

更新日期：2020-07-03 00:00:00

abstract：:Metastatic colorectal cancer is a leading cause of cancer death. However, current therapy options are limited to chemotherapy, with the addition of anti-EGFR antibodies for patients with RAS wild-type tumours. Novel drug targets, or drug combinations that induce a synergistic response, would be of great benefit to pat...

journal_title：Scientific data

authors： Williams SP,Barthorpe AS,Lightfoot H,Garnett MJ,McDermott U

更新日期：2017-10-03 00:00:00

abstract：:Monitoring vegetation phenology is critical for quantifying climate change impacts on ecosystems. We present an extensive dataset of 1783 site-years of phenological data derived from PhenoCam network imagery from 393 digital cameras, situated from tropics to tundra across a wide range of plant functional types, biomes...

journal_title：Scientific data

authors： Seyednasrollah B,Young AM,Hufkens K,Milliman T,Friedl MA,Frolking S,Richardson AD

更新日期：2019-10-22 00:00:00

abstract：:Phase contrast time-lapse microscopy is a non-destructive technique that generates large volumes of image-based information to quantify the behaviour of individual cells or cell populations. To guide the development of algorithms for computer-aided cell tracking and analysis, 48 time-lapse image sequences, each spanni...

journal_title：Scientific data

authors： Ker DFE,Eom S,Sanami S,Bise R,Pascale C,Yin Z,Huh SI,Osuna-Highley E,Junkers SN,Helfrich CJ,Liang PY,Pan J,Jeong S,Kang SS,Liu J,Nicholson R,Sandbothe MF,Van PT,Liu A,Chen M,Kanade T,Weiss LE,Campbell PG

更新日期：2018-11-13 00:00:00

abstract：:Fully-automated nuclear image segmentation is the prerequisite to ensure statistically significant, quantitative analyses of tissue preparations,applied in digital pathology or quantitative microscopy. The design of segmentation methods that work independently of the tissue type or preparation is complex, due to varia...

journal_title：Scientific data

authors： Kromp F,Bozsaky E,Rifatbegovic F,Fischer L,Ambros M,Berneder M,Weiss T,Lazic D,Dörr W,Hanbury A,Beiske K,Ambros PF,Ambros IM,Taschner-Mandl S

更新日期：2020-08-11 00:00:00

abstract：:Advances in high-throughput sequencing are reshaping how we perceive microbial communities inhabiting the human body, with implications for therapeutic interventions. Several large-scale datasets derived from hundreds of human microbiome samples sourced from multiple studies are now publicly available. However, idiosy...

journal_title：Scientific data

authors： Hahn AS,Altman T,Konwar KM,Hanson NW,Kim D,Relman DA,Dill DL,Hallam SJ

更新日期：2017-04-11 00:00:00

abstract：:The nuclear receptor estrogen receptor 2 (ESR2, ERβ) modulates cancer cell proliferation and tumor growth, exerting an oncosuppressive role in breast cancer (BC). Interaction proteomics by tandem affinity purification coupled to mass spectrometry was previously applied in BC cells to identify proteins acting in concer...

journal_title：Scientific data

authors： Giurato G,Nassa G,Salvati A,Alexandrova E,Rizzo F,Nyman TA,Weisz A,Tarallo R

更新日期：2018-03-06 00:00:00

abstract：:In 2010, an estimated 860 million people were living in slums worldwide, with around 60 million added to the slum population between 2000 and 2010. In 2011, 200 million people in urban Indian households were considered to live in slums. In order to address and create slum development programmes and poverty alleviation...

journal_title：Scientific data

authors： Roy D,Palavalli B,Menon N,King R,Pfeffer K,Lees M,Sloot PMA

更新日期：2018-01-09 00:00:00

abstract：:With the aim to uncover the molecular pathways underlying the regulation of sleep, we recently assembled an extensive and comprehensive systems genetics dataset interrogating a genetic reference population of mice at the levels of the genome, the brain and liver transcriptomes, the plasma metabolome, and the sleep-wak...

journal_title：Scientific data

authors： Jan M,Gobet N,Diessler S,Franken P,Xenarios I

更新日期：2019-10-31 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific data

authors： Nowak RM,Jastrzębski JP,Kuśmirek W,Sałamatin R,Rydzanicz M,Sobczyk-Kopcioł A,Sulima-Celińska A,Paukszto Ł,Makowczenko KG,Płoski R,Tkach VV,Basałaj K,Młocicki D

更新日期：2020-02-10 00:00:00

abstract：:It is estimated that approximately 4-5% of national energy consumption can be saved through corrections to existing commercial building controls infrastructure and resulting improvements to efficiency. Correspondingly, automated fault detection and diagnostics (FDD) algorithms are designed to identify the presence of ...

journal_title：Scientific data

authors： Granderson J,Lin G,Harding A,Im P,Chen Y

更新日期：2020-02-24 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) and human embryonic stem cells (hESCs) differentiated into hepatocyte-like cells (HLCs) provide a defined and renewable source of cells for drug screening, toxicology and regenerative medicine. We previously reprogrammed human fetal foreskin fibroblast cells (HFF1) into iPSCs emp...

journal_title：Scientific data

authors： Wruck W,Adjaye J

更新日期：2018-03-13 00:00:00

abstract：:Bumblebees (Hymenoptera: Apidae) are important pollinating insects that play pivotal roles in crop production and natural ecosystem services. Although protein-coding genes in bumblebees have been extensively annotated, regulatory sequences of the genome, such as promoters and enhancers, have been poorly annotated. To ...

journal_title：Scientific data

authors： Zhao X,Su L,Xu W,Schaack S,Sun C

更新日期：2020-10-26 00:00:00

abstract：:The silkmoth chorion was studied extensively by F.C. Kafatos' group for almost 40 years. However, the complete structure of the chorion locus was not obtained in the genome sequence of Bombyx mori published in 2008 due to repetitive sequences, resulting in gaps and an incomplete view of the locus. To obtain the comple...

journal_title：Scientific data

authors： Chen Z,Nohata J,Guo H,Li S,Liu J,Guo Y,Yamamoto K,Kadono-Okuda K,Liu C,Arunkumar KP,Nagaraju J,Zhang Y,Liu S,Labropoulou V,Swevers L,Tsitoura P,Iatrou K,Gopinathan KP,Goldsmith MR,Xia Q,Mita K

更新日期：2015-11-10 00:00:00

abstract：:Climate change has already influenced lake temperatures globally, but understanding future change is challenging. The response of lakes to changing climate drivers is complex due to the nature of lake-atmosphere coupling, ice cover, and stratification. To better understand the diversity of lake responses to climate ch...

journal_title：Scientific data

authors： Winslow LA,Hansen GJA,Read JS,Notaro M

更新日期：2017-04-25 00:00:00

abstract：:Efforts to identify meaningful functional imaging-based biomarkers are limited by the ability to reliably characterize inter-individual differences in human brain function. Although a growing number of connectomics-based measures are reported to have moderate to high test-retest reliability, the variability in data ac...

journal_title：Scientific data

authors： Zuo XN,Anderson JS,Bellec P,Birn RM,Biswal BB,Blautzik J,Breitner JC,Buckner RL,Calhoun VD,Castellanos FX,Chen A,Chen B,Chen J,Chen X,Colcombe SJ,Courtney W,Craddock RC,Di Martino A,Dong HM,Fu X,Gong Q,Gorgolews

更新日期：2014-12-09 00:00:00

abstract：:One important use of genome-wide transcriptional profiles is to identify relationships between transcription levels and patient outcomes. These translational insights can guide the development of biomarkers for clinical application. Data from thousands of translational-biomarker studies have been deposited in public r...

journal_title：Scientific data

authors： Golightly NP,Bell A,Bischoff AI,Hollingsworth PD,Piccolo SR

更新日期：2018-04-17 00:00:00

abstract：:Populations in resource dependent economies gain well-being from the natural environment, in highly spatially and temporally variable patterns. To collect information on this, we designed and implemented a 1586-household quantitative survey in the southwest coastal zone of Bangladesh. Data were collected on material, ...

journal_title：Scientific data

authors： Adams H,Adger WN,Ahmad S,Ahmed A,Begum D,Lázár AN,Matthews Z,Rahman MM,Streatfield PK

更新日期：2016-11-08 00:00:00

abstract：:We introduce and make openly accessible a comprehensive, multivariate time series (MVTS) dataset extracted from solar photospheric vector magnetograms in Spaceweather HMI Active Region Patch (SHARP) series. Our dataset also includes a cross-checked NOAA solar flare catalog that immediately facilitates solar flare pred...

journal_title：Scientific data

authors： Angryk RA,Martens PC,Aydin B,Kempton D,Mahajan SS,Basodi S,Ahmadzadeh A,Cai X,Filali Boubrahimi S,Hamdi SM,Schuh MA,Georgoulis MK

更新日期：2020-07-10 00:00:00

abstract：:This paper describes the release of the detailed building operation data, including electricity consumption and indoor environmental measurements, of the seven-story 11,700-m2 office building located in Bangkok, Thailand. The electricity consumption data (kW) are that of individual air conditioning units, lighting, an...

journal_title：Scientific data

authors： Pipattanasomporn M,Chitalia G,Songsiri J,Aswakul C,Pora W,Suwankawin S,Audomvongseree K,Hoonchareon N

更新日期：2020-07-20 00:00:00

abstract：:One of the many ways that climate change may affect human health is by altering the nutrient content of food crops. However, previous attempts to study the effects of increased atmospheric CO2 on crop nutrition have been limited by small sample sizes and/or artificial growing conditions. Here we present data from a me...

journal_title：Scientific data

authors： Dietterich LH,Zanobetti A,Kloog I,Huybers P,Leakey AD,Bloom AJ,Carlisle E,Fernando N,Fitzgerald G,Hasegawa T,Holbrook NM,Nelson RL,Norton R,Ottman MJ,Raboy V,Sakai H,Sartor KA,Schwartz J,Seneweera S,Usui Y,Yoshina

更新日期：2015-07-21 00:00:00

abstract：:Mesenchymal stem/stromal cells (MSCs) were identified in most tissues of an adult organism. MSCs mediate physiological renewal, as well as regulation of tissue homeostasis, reparation and regeneration. Functions of MSCs are regulated by endocrine and neuronal signals, and noradrenaline is one of the most important MSC...

journal_title：Scientific data

authors： Tyurin-Kuzmin PA,Dyikanov DT,Fadeeva JI,Sysoeva VY,Kalinina NI

更新日期：2018-10-02 00:00:00

abstract：:Long-term datasets of number and size of lakes over the Tibetan Plateau (TP) are among the most critical components for better understanding the interactions among the cryosphere, hydrosphere, and atmosphere at regional and global scales. Due to the harsh environment and the scarcity of data over the TP, data accumula...

journal_title：Scientific data

authors： Wan W,Long D,Hong Y,Ma Y,Yuan Y,Xiao P,Duan H,Han Z,Gu X

更新日期：2016-06-21 00:00:00

abstract：:With the help of the bacteria in the rumen, ruminants can effectively convert human inedible plant fiber to edible food (meat and milk). However, the understanding of rumen bacteriome in dairy cows is still limited, especially in a large population under the same diet, breed, and milking period. Here we described the ...

journal_title：Scientific data

authors： Sun HZ,Xue M,Guan LL,Liu J

更新日期：2019-01-22 00:00:00

abstract：:In prokaryotes, protein phosphorylation plays a critical role in regulating a broad spectrum of biological processes and occurs mainly on various amino acids, including serine (S), threonine (T), tyrosine (Y), arginine (R), aspartic acid (D), histidine (H) and cysteine (C) residues of protein substrates. Through liter...

journal_title：Scientific data

authors： Shi Y,Zhang Y,Lin S,Wang C,Zhou J,Peng D,Xue Y

更新日期：2020-05-29 00:00:00

abstract：:While there is a high interest in drug combinations in cancer therapy, openly accessible datasets for drug combination responses are sparse. Here we present a dataset comprising 171 pairwise combinations of 19 individual drugs targeting signal transduction mechanisms across eight cancer cell lines, where the effect of...

journal_title：Scientific data

authors： Flobak Å,Niederdorfer B,Nakstad VT,Thommesen L,Klinkenberg G,Lægreid A

更新日期：2019-10-29 00:00:00

abstract：:There is still limited information on the diversity of viruses co-circulating in humans and animals. Here, we report data obtained from a large field collection of enteric samples taken from humans, pigs, rodents and other mammal hosts in Vietnam between 2012 and 2016. Each of 2100 stool or rectal swab samples was sub...

journal_title：Scientific data

authors： Woolhouse M,Ashworth J,Bogaardt C,Tue NT,Baker S,Thwaites G,Phuc TM

更新日期：2019-10-15 00:00:00