A multi-omics digital research object for the genetics of sleep regulation.

Abstract:

:With the aim to uncover the molecular pathways underlying the regulation of sleep, we recently assembled an extensive and comprehensive systems genetics dataset interrogating a genetic reference population of mice at the levels of the genome, the brain and liver transcriptomes, the plasma metabolome, and the sleep-wake phenome. To facilitate a meaningful and efficient re-use of this public resource by others we designed, describe in detail, and made available a Digital Research Object (DRO), embedding data, documentation, and analytics. We present and discuss both the advantages and limitations of our multi-modal resource and analytic pipeline. The reproducibility of the results was tested by a bioinformatician not implicated in the original project and the robustness of results was assessed by re-annotating genetic and transcriptome data from the mm9 to the mm10 mouse genome assembly.

journal_name

Sci Data

journal_title

Scientific data

authors

Jan M,Gobet N,Diessler S,Franken P,Xenarios I

doi

10.1038/s41597-019-0171-x

subject

Has Abstract

pub_date

2019-10-31 00:00:00

pages

258

issue

1

issn

2052-4463

pii

10.1038/s41597-019-0171-x

journal_volume

6

pub_type

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