Abstract：
:The nuclear receptor estrogen receptor 2 (ESR2, ERβ) modulates cancer cell proliferation and tumor growth, exerting an oncosuppressive role in breast cancer (BC). Interaction proteomics by tandem affinity purification coupled to mass spectrometry was previously applied in BC cells to identify proteins acting in concert with ERβ to control key cellular functions, including gene transcription, RNA splicing and post-transcriptional mRNA regulation. These studies revealed an involvement of RNA in ERβ interactome assembly and functions. By applying native protein complex purification followed by nano LC-MS/MS before and after in vitro RNA removal, we generated a large dataset of newly identified nuclear ERβ interactors, including a subset associating with the receptor via RNA bridging. These datasets will be useful to investigate further the role of ERβ, nuclear RNAs and the other proteins identified here in BC and other cell types.
journal_name
Sci Datajournal_title
Scientific dataauthors
Giurato G,Nassa G,Salvati A,Alexandrova E,Rizzo F,Nyman TA,Weisz A,Tarallo Rdoi
10.1038/sdata.2018.31subject
Has Abstractpub_date
2018-03-06 00:00:00pages
180031issn
2052-4463pii
sdata201831journal_volume
5pub_type
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