Abstract:
:Connective tissues such as tendon, ligament and skin are biological fibre composites comprising collagen fibrils reinforcing the weak proteoglycan-rich ground substance in extracellular matrix (ECM). One of the hallmarks of ageing of connective tissues is the progressive and irreversible change in the tissue mechanical properties; this is often attributed to the underlying changes to the collagen fibril structure. This dataset represents a comprehensive screen of the mechanical properties and collagen fibril structure of tendon from the tails of young to old (i.e. 1.6-35.3 month-old) C57BL6/B mice. The mechanical portion consists of the load-displacement data, as well as the derived tensile properties; the structure data consists of transmission electron micrographs of collagen fibril cross section, as well as the derived cross-sectional parameters. This dataset will allow other researchers to develop and demonstrate the utility of innovative multiscale models and approaches of the extra-cellular and physiological events of ageing of current interest to ageing research, by reducing the current reliance on conducting new mammalian experiments.
journal_name
Sci Datajournal_title
Scientific dataauthors
Goh KL,Holmes DF,Lu YH,Kadler KE,Purslow PPdoi
10.1038/sdata.2018.140subject
Has Abstractpub_date
2018-07-24 00:00:00pages
180140issn
2052-4463pii
sdata2018140journal_volume
5pub_type
杂志文章相关文献
Scientific Data文献大全abstract::Land Use Information is a key dataset required to enable an understanding of the changing nature of our landscapes and the associated influences on natural resources and regional communities. The Victorian Land Use Information System (VLUIS) data product has been created within the State Government of Victoria to supp...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/sdata.2015.70
更新日期:2015-11-24 00:00:00
abstract::In this work, we compare the resolution of V2-V3 and V3-V4 16S rRNA regions for the purposes of estimating microbial community diversity using paired-end Illumina MiSeq reads, and show that the fragment, including V2 and V3 regions, has higher resolution for lower-rank taxa (genera and species). It allows for a more p...
journal_title:Scientific data
pub_type:
doi:10.1038/sdata.2019.7
更新日期:2019-02-05 00:00:00
abstract::Climate change has already influenced lake temperatures globally, but understanding future change is challenging. The response of lakes to changing climate drivers is complex due to the nature of lake-atmosphere coupling, ice cover, and stratification. To better understand the diversity of lake responses to climate ch...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/sdata.2017.53
更新日期:2017-04-25 00:00:00
abstract::In the wake of the Fukushima nuclear disaster, Japan largely moved away from nuclear power generation and turned back towards an energy sector dominated by fossil fuels. As a result, the pace towards reaching emission reduction targets has largely slowed down. This situation indicates that higher emissions will contin...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/s41597-020-0571-y
更新日期:2020-07-13 00:00:00
abstract::One of the many ways that climate change may affect human health is by altering the nutrient content of food crops. However, previous attempts to study the effects of increased atmospheric CO2 on crop nutrition have been limited by small sample sizes and/or artificial growing conditions. Here we present data from a me...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/sdata.2015.36
更新日期:2015-07-21 00:00:00
abstract::While there is a high interest in drug combinations in cancer therapy, openly accessible datasets for drug combination responses are sparse. Here we present a dataset comprising 171 pairwise combinations of 19 individual drugs targeting signal transduction mechanisms across eight cancer cell lines, where the effect of...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/s41597-019-0255-7
更新日期:2019-10-29 00:00:00
abstract::It is estimated that approximately 4-5% of national energy consumption can be saved through corrections to existing commercial building controls infrastructure and resulting improvements to efficiency. Correspondingly, automated fault detection and diagnostics (FDD) algorithms are designed to identify the presence of ...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/s41597-020-0398-6
更新日期:2020-02-24 00:00:00
abstract::Benthic fauna refers to all fauna that live in or on the seafloor, which researchers typically divide into size classes meiobenthos (32/64 µm-0.5/1 mm), macrobenthos (250 µm-1 cm), and megabenthos (>1 cm). Benthic fauna play important roles in bioturbation activity, mineralization of organic matter, and in marine food...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/s41597-020-0551-2
更新日期:2020-06-29 00:00:00
abstract::Long-term datasets of number and size of lakes over the Tibetan Plateau (TP) are among the most critical components for better understanding the interactions among the cryosphere, hydrosphere, and atmosphere at regional and global scales. Due to the harsh environment and the scarcity of data over the TP, data accumula...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/sdata.2016.39
更新日期:2016-06-21 00:00:00
abstract::The big-headed turtle, Platysternon megacephalum, as the sole member of the monotypic family Platysternidae, has a number of distinct characteristics including an extra-large head, long tail, flat carapace, and a preference for low water temperature environments. We performed whole genome sequencing, assembly, and gen...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/s41597-019-0067-9
更新日期:2019-05-16 00:00:00
abstract::The behaviors of building occupants have continued to perplex scholars for years in our attempts to develop models for energy efficient housing. Building simulations, project delivery approaches, policies, and more have fell short of their optimistic goals due to the complexity of human behavior. As a part of a multip...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/s41597-019-0275-3
更新日期:2019-11-26 00:00:00
abstract::Bats, including African straw-coloured fruit bats (Eidolon helvum), have been highlighted as reservoirs of many recently emerged zoonotic viruses. This common, widespread and ecologically important species was the focus of longitudinal and continent-wide studies of the epidemiological and ecology of Lagos bat virus, h...
journal_title:Scientific data
pub_type: 评论,杂志文章
doi:10.1038/sdata.2016.49
更新日期:2016-08-01 00:00:00
abstract::The detection, identification, and localization of illicit nuclear materials in urban environments is of utmost importance for national security. Most often, the process of performing these operations consists of a team of trained individuals equipped with radiation detection devices that have built-in algorithms to a...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/s41597-020-00672-2
更新日期:2020-10-05 00:00:00
abstract::This article presents a practical roadmap for scholarly data repositories to implement data citation in accordance with the Joint Declaration of Data Citation Principles, a synopsis and harmonization of the recommendations of major science policy bodies. The roadmap was developed by the Repositories Expert Group, as p...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/s41597-019-0031-8
更新日期:2019-04-10 00:00:00
abstract::Animal muscles must maintain their function and structure while bearing substantial mechanical loads. How muscles withstand persistent mechanical strain is presently not well understood. Understanding the mechanisms by which tissues maintain their complex architecture is a key goal of cell biology. This dataset repres...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/sdata.2014.2
更新日期:2014-03-11 00:00:00
abstract::In order to map global disease risk, a geographic database of human Crimean-Congo haemorrhagic fever virus (CCHFV) occurrence was produced by surveying peer-reviewed literature and case reports, as well as informal online sources. Here we present this database, comprising occurrence data linked to geographic point or ...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/sdata.2015.16
更新日期:2015-04-14 00:00:00
abstract::Patient-specific craniofacial implants are used to repair skull bone defects after trauma or surgery. Currently, cranial implants are designed and produced by third-party suppliers, which is usually time-consuming and expensive. Recent advances in additive manufacturing made the in-hospital or in-operation-room fabric...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/s41597-021-00806-0
更新日期:2021-01-29 00:00:00
abstract::This study assessed 24 adult patients, suffering from severe chronic unilateral pain diagnosed as temporomandibular joint (TMJ) disorder (TMD). The full dentate patients had normal occlusion and had never received an occlusal therapy, i.e., were with natural dental evolution/maturation. The following functional and dy...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/sdata.2017.168
更新日期:2017-11-07 00:00:00
abstract::Medical augmented reality (AR) is an increasingly important topic in many medical fields. AR enables x-ray vision to see through real world objects. In medicine, this offers pre-, intra- or post-interventional visualization of "hidden" structures. In contrast to a classical monitor view, AR applications provide visual...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/s41597-019-0327-8
更新日期:2019-12-09 00:00:00
abstract::Human adenoviruses (HAdVs) are fatal to immuno-suppressed individuals, but no effective anti-HAdV therapy is available. Here, we present a novel image-based high-throughput screening (HTS) platform, which scores the full viral replication cycle from virus entry to dissemination of progeny and second-round infections. ...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/s41597-020-00604-0
更新日期:2020-08-12 00:00:00
abstract::Metastatic colorectal cancer is a leading cause of cancer death. However, current therapy options are limited to chemotherapy, with the addition of anti-EGFR antibodies for patients with RAS wild-type tumours. Novel drug targets, or drug combinations that induce a synergistic response, would be of great benefit to pat...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/sdata.2017.139
更新日期:2017-10-03 00:00:00
abstract::Estuaries are crucial ecosystems where human activities deeply affect numerous ecological functions. Here we present a survey dataset based on the monitoring of fish nursery grounds of the Seine estuary and eastern bay of Seine collected once a year using a beam trawl during three distinct periods (1995-2002, 2008-201...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/s41597-020-0572-x
更新日期:2020-07-13 00:00:00
abstract::We provide a detailed description of a gadoteridol-derivatized lysozyme (gadolinium lysozyme) two-colour serial femtosecond crystallography (SFX) dataset for multiple wavelength anomalous dispersion (MAD) structure determination. The data was collected at the Spring-8 Angstrom Compact free-electron LAser (SACLA) facil...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/sdata.2017.188
更新日期:2017-12-12 00:00:00
abstract::The zooplankter Calanus finmarchicus is a member of the so-called "Calanus Complex", a group of copepods that constitutes a key element of the Arctic polar marine ecosystem, providing a crucial link between primary production and higher trophic levels. Climate change induces the shift of C. finmarchicus to higher lati...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/s41597-020-00751-4
更新日期:2020-11-24 00:00:00
abstract::The mammalian innate immune system senses many bacterial stimuli through the toll-like receptor (TLR) family. Activation of the TLR4 receptor by bacterial lipopolysaccharide (LPS) is the most widely studied TLR pathway due to its central role in host responses to gram-negative bacterial infection and its contribution ...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/sdata.2017.7
更新日期:2017-03-01 00:00:00
abstract::We present an ultra-high resolution MRI dataset of an ex vivo human brain specimen. The brain specimen was donated by a 58-year-old woman who had no history of neurological disease and died of non-neurological causes. After fixation in 10% formalin, the specimen was imaged on a 7 Tesla MRI scanner at 100 µm isotropic ...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/s41597-019-0254-8
更新日期:2019-10-30 00:00:00
abstract::Human motion capture is commonly used in various fields, including sport, to analyze, understand, and synthesize kinematic and kinetic data. Specialized computer vision and marker-based optical motion capture techniques constitute the gold-standard for accurate and robust human motion capture. The dataset presented co...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/s41597-021-00801-5
更新日期:2021-01-18 00:00:00
abstract::This paper describes the release of the detailed building operation data, including electricity consumption and indoor environmental measurements, of the seven-story 11,700-m2 office building located in Bangkok, Thailand. The electricity consumption data (kW) are that of individual air conditioning units, lighting, an...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/s41597-020-00582-3
更新日期:2020-07-20 00:00:00
abstract::Magnetic resonance imaging (MRI) captures the dynamics of brain development with multiple modalities that quantify both structure and function. These measurements may yield valuable insights into the neural patterns that mark healthy maturation or that identify early risk for psychiatric disorder. The Pediatric Templa...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/sdata.2015.3
更新日期:2015-02-03 00:00:00
abstract::Sepsis is a syndrome with physiologic, pathologic, and biochemical abnormalities induced by infection. Sepsis can induce the dysregulation of systemic coagulation and fibrinolytic systems, resulting in disseminated intravascular coagulation (DIC), which is associated with a high mortality rate. Although there is no in...
journal_title:Scientific data
pub_type:
doi:10.1038/sdata.2018.243
更新日期:2018-12-11 00:00:00