Abstract:
:Animal muscles must maintain their function and structure while bearing substantial mechanical loads. How muscles withstand persistent mechanical strain is presently not well understood. Understanding the mechanisms by which tissues maintain their complex architecture is a key goal of cell biology. This dataset represents a systematic screen through the Drosophila melanogaster cytoskeleton to identify genes that are required to maintain tissue, specifically muscle, architecture. Using RNA interference (RNAi), we knocked down 238 genes in Drosophila and assayed for climbing ability with a robust behavioural assay. Here we present the summary of the screen and provide the complete results of the assays. We have uncovered a number of novel hits that would reward further study. The data are easy to use: the raw data are provided to allow researchers to perform their own analysis and analysed results are given indicating whether or not the genes are required for muscle maintenance. This dataset will allow other researchers to identify candidate genes for more detailed study and lead to better understanding of muscle maintenance.
journal_name
Sci Datajournal_title
Scientific dataauthors
Perkins AD,Lee MJ,Tanentzapf Gdoi
10.1038/sdata.2014.2subject
Has Abstractpub_date
2014-03-11 00:00:00pages
140002issn
2052-4463journal_volume
1pub_type
杂志文章相关文献
Scientific Data文献大全abstract::In the wake of the Fukushima nuclear disaster, Japan largely moved away from nuclear power generation and turned back towards an energy sector dominated by fossil fuels. As a result, the pace towards reaching emission reduction targets has largely slowed down. This situation indicates that higher emissions will contin...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/s41597-020-0571-y
更新日期:2020-07-13 00:00:00
abstract::In order to make effective decisions on sustainable development, it is essential for sugarcane-producing countries to take into account sugarcane acreage and sugarcane production dynamics. The availability of sugarcane biophysical data along the growth season is key to an effective mapping of such dynamics, especially...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/sdata.2018.150
更新日期:2018-08-07 00:00:00
abstract::The experimental dataset presented was collected in an 18 m long and 1 m wide laboratory flume. Low to high flood flows through an urbanized floodplain were modelled. The floodplain bed is rough, modelled with dense artificial grass. A square cylinder array, representing house models, was set on the rough bed. The cyl...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/s41597-020-00791-w
更新日期:2021-01-11 00:00:00
abstract::Human adenoviruses (HAdVs) are fatal to immuno-suppressed individuals, but no effective anti-HAdV therapy is available. Here, we present a novel image-based high-throughput screening (HTS) platform, which scores the full viral replication cycle from virus entry to dissemination of progeny and second-round infections. ...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/s41597-020-00604-0
更新日期:2020-08-12 00:00:00
abstract::When visual input has conflicting interpretations, conscious perception can alternate spontaneously between these possible interpretations. This is called bistable perception. Previous neuroimaging studies have indicated the involvement of two right parietal areas in resolving perceptual ambiguity (ant-SPLr and post-S...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/sdata.2016.65
更新日期:2016-08-16 00:00:00
abstract::The detection, identification, and localization of illicit nuclear materials in urban environments is of utmost importance for national security. Most often, the process of performing these operations consists of a team of trained individuals equipped with radiation detection devices that have built-in algorithms to a...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/s41597-020-00672-2
更新日期:2020-10-05 00:00:00
abstract::Gait analysis has traditionally relied on laborious and lab-based methods. Data from wearable sensors, such as Inertial Measurement Units (IMU), can be analyzed with machine learning to perform gait analysis in real-world environments. This database provides data from thirty participants (fifteen males and fifteen fem...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/s41597-020-0563-y
更新日期:2020-07-08 00:00:00
abstract::Achievements of near human-level performance in object recognition by deep neural networks (DNNs) have triggered a flood of comparative studies between the brain and DNNs. Using a DNN as a proxy for hierarchical visual representations, our recent study found that human brain activity patterns measured by functional ma...
journal_title:Scientific data
pub_type:
doi:10.1038/sdata.2019.12
更新日期:2019-02-12 00:00:00
abstract::Trait-based approaches advance ecological and evolutionary research because traits provide a strong link to an organism's function and fitness. Trait-based research might lead to a deeper understanding of the functions of, and services provided by, ecosystems, thereby improving management, which is vital in the curren...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/sdata.2016.17
更新日期:2016-03-29 00:00:00
abstract::Advances in high-throughput sequencing are reshaping how we perceive microbial communities inhabiting the human body, with implications for therapeutic interventions. Several large-scale datasets derived from hundreds of human microbiome samples sourced from multiple studies are now publicly available. However, idiosy...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/sdata.2017.35
更新日期:2017-04-11 00:00:00
abstract::We introduce and make openly accessible a comprehensive, multivariate time series (MVTS) dataset extracted from solar photospheric vector magnetograms in Spaceweather HMI Active Region Patch (SHARP) series. Our dataset also includes a cross-checked NOAA solar flare catalog that immediately facilitates solar flare pred...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/s41597-020-0548-x
更新日期:2020-07-10 00:00:00
abstract::Studies of chimpanzee vocal communication provide valuable insights into the evolution of communication in complex societies, and also comparative data for understanding the evolution of human language. One particularly valuable dataset of recordings from free-living chimpanzees was collected by Frans X. Plooij and th...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/sdata.2015.27
更新日期:2015-05-26 00:00:00
abstract::The corneal endothelium maintains corneal transparency; consequently, damage to this endothelium by a number of pathological conditions results in severe vision loss. Publicly available expression databases of human tissues are useful for investigating the pathogenesis of diseases and for developing new therapeutic mo...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/s41597-020-00754-1
更新日期:2020-11-20 00:00:00
abstract::Motion capture is necessary to quantify gait deviations in individuals with lower-limb amputations. However, access to the patient population and the necessary equipment is limited. Here we present the first open biomechanics dataset for 18 individuals with unilateral above-knee amputations walking at different speeds...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/s41597-020-0494-7
更新日期:2020-05-21 00:00:00
abstract::It is estimated that approximately 4-5% of national energy consumption can be saved through corrections to existing commercial building controls infrastructure and resulting improvements to efficiency. Correspondingly, automated fault detection and diagnostics (FDD) algorithms are designed to identify the presence of ...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/s41597-020-0398-6
更新日期:2020-02-24 00:00:00
abstract::Transparent evaluations of FAIRness are increasingly required by a wide range of stakeholders, from scientists to publishers, funding agencies and policy makers. We propose a scalable, automatable framework to evaluate digital resources that encompasses measurable indicators, open source tools, and participation guide...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/s41597-019-0184-5
更新日期:2019-09-20 00:00:00
abstract::Rett syndrome (RTT) is a rare neurological disorder mostly caused by a genetic variation in MECP2. Making new MECP2 variants and the related phenotypes available provides data for better understanding of disease mechanisms and faster identification of variants for diagnosis. This is, however, currently hampered by the...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/s41597-020-00794-7
更新日期:2021-01-15 00:00:00
abstract::Rett syndrome is an X-linked neurodevelopmental disorder caused by mutation in the methyl-CpG-binding protein 2 gene (MECP2) in the majority of cases. We describe an RNA sequencing dataset of postmortem brain tissue samples from four females clinically diagnosed with Rett syndrome and four age-matched female donors. T...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/s41597-020-0527-2
更新日期:2020-06-19 00:00:00
abstract::With electric heat pumps substituting for fossil-fueled alternatives, the temporal variability of their power consumption becomes increasingly important to the electricity system. To easily include this variability in energy system analyses, this paper introduces the "When2Heat" dataset comprising synthetic national t...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/s41597-019-0199-y
更新日期:2019-10-01 00:00:00
abstract::Land-atmosphere interactions at different temporal and spatial scales are important for our understanding of the Earth system and its modeling. The Landscape Evolution Observatory (LEO) at Biosphere 2, managed by the University of Arizona, hosts three nearly identical artificial bare-soil hillslopes with dimensions of...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/s41597-020-00645-5
更新日期:2020-09-15 00:00:00
abstract::There is still limited information on the diversity of viruses co-circulating in humans and animals. Here, we report data obtained from a large field collection of enteric samples taken from humans, pigs, rodents and other mammal hosts in Vietnam between 2012 and 2016. Each of 2100 stool or rectal swab samples was sub...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/s41597-019-0215-2
更新日期:2019-10-15 00:00:00
abstract::Spatio-temporal data on human population and its driving factors is critical to understanding and responding to population problems. Unfortunately, such spatio-temporal data on a large scale and over the long term are often difficult to obtain. Here, we present a dataset on Chinese population distribution and its driv...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/sdata.2016.47
更新日期:2016-07-05 00:00:00
abstract::Social network analysis is an invaluable tool to understand the patterns, evolution, and consequences of sociality. Comparative studies over a range of social systems across multiple taxonomic groups are particularly valuable. Such studies however require quantitative social association or interaction data across mult...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/s41597-019-0056-z
更新日期:2019-04-29 00:00:00
abstract::Ticks carry pathogens that can cause disease in both animals and humans, and there is a need to monitor the distribution and abundance of ticks and the pathogens they carry to pinpoint potential high risk areas for tick-borne disease transmission. In a joint Scandinavian study, we measured Ixodes ricinus instar abunda...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/s41597-020-00579-y
更新日期:2020-07-16 00:00:00
abstract::In order to map global disease risk, a geographic database of human Crimean-Congo haemorrhagic fever virus (CCHFV) occurrence was produced by surveying peer-reviewed literature and case reports, as well as informal online sources. Here we present this database, comprising occurrence data linked to geographic point or ...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/sdata.2015.16
更新日期:2015-04-14 00:00:00
abstract::This paper describes the release of the detailed building operation data, including electricity consumption and indoor environmental measurements, of the seven-story 11,700-m2 office building located in Bangkok, Thailand. The electricity consumption data (kW) are that of individual air conditioning units, lighting, an...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/s41597-020-00582-3
更新日期:2020-07-20 00:00:00
abstract::The behaviors of building occupants have continued to perplex scholars for years in our attempts to develop models for energy efficient housing. Building simulations, project delivery approaches, policies, and more have fell short of their optimistic goals due to the complexity of human behavior. As a part of a multip...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/s41597-019-0275-3
更新日期:2019-11-26 00:00:00
abstract::Between the 2011 and 2016 national censuses, the Australian Bureau of Statistics changed its anonymity policy compliance system for the distribution of census data. The new method has resulted in dramatic inconsistencies when comparing low-resolution data to aggregated high-resolution data. Hence, aggregated totals do...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/s41597-019-0137-z
更新日期:2019-08-16 00:00:00
abstract::Confident identification of unknown chemicals in high resolution mass spectrometry (HRMS) screening studies requires cohesive workflows and complementary data, tools, and software. Chemistry databases, screening libraries, and chemical metadata have become fixtures in identification workflows. To increase confidence i...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/s41597-019-0145-z
更新日期:2019-08-02 00:00:00
abstract::In 2010, an estimated 860 million people were living in slums worldwide, with around 60 million added to the slum population between 2000 and 2010. In 2011, 200 million people in urban Indian households were considered to live in slums. In order to address and create slum development programmes and poverty alleviation...
journal_title:Scientific data
pub_type: 杂志文章
doi:10.1038/sdata.2017.200
更新日期:2018-01-09 00:00:00