Transcriptome data of temporal and cingulate cortex in the Rett syndrome brain.

Abstract:

:Rett syndrome is an X-linked neurodevelopmental disorder caused by mutation in the methyl-CpG-binding protein 2 gene (MECP2) in the majority of cases. We describe an RNA sequencing dataset of postmortem brain tissue samples from four females clinically diagnosed with Rett syndrome and four age-matched female donors. The dataset contains 16 transcriptomes, including two brain regions, temporal and cingulate cortex, for each individual. We compared our dataset with published transcriptomic analyses of postmortem brain tissue from Rett syndrome and found consistent gene expression alterations among regions of the cerebral cortex. Our data provide a valuable resource to explore the biology of the human brain in Rett syndrome.

journal_name

Sci Data

journal_title

Scientific data

authors

Aldinger KA,Timms AE,MacDonald JW,McNamara HK,Herstein JS,Bammler TK,Evgrafov OV,Knowles JA,Levitt P

doi

10.1038/s41597-020-0527-2

subject

Has Abstract

pub_date

2020-06-19 00:00:00

pages

192

issue

1

issn

2052-4463

pii

10.1038/s41597-020-0527-2

journal_volume

7

pub_type

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