Abstract:
:Rett syndrome is an X-linked neurodevelopmental disorder caused by mutation in the methyl-CpG-binding protein 2 gene (MECP2) in the majority of cases. We describe an RNA sequencing dataset of postmortem brain tissue samples from four females clinically diagnosed with Rett syndrome and four age-matched female donors. The dataset contains 16 transcriptomes, including two brain regions, temporal and cingulate cortex, for each individual. We compared our dataset with published transcriptomic analyses of postmortem brain tissue from Rett syndrome and found consistent gene expression alterations among regions of the cerebral cortex. Our data provide a valuable resource to explore the biology of the human brain in Rett syndrome.
journal_name
Sci Datajournal_title
Scientific dataauthors
Aldinger KA,Timms AE,MacDonald JW,McNamara HK,Herstein JS,Bammler TK,Evgrafov OV,Knowles JA,Levitt Pdoi
10.1038/s41597-020-0527-2subject
Has Abstractpub_date
2020-06-19 00:00:00pages
192issue
1issn
2052-4463pii
10.1038/s41597-020-0527-2journal_volume
7pub_type
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