High-throughput RNAi screen for essential genes and drug synergistic combinations in colorectal cancer.

abstract：:Orchid epiphytes, a group containing at least 18,000 species, thrive in habitats that often undergo periodic drought stress. However, few global gene expression profiling datasets have been published for studies addressing the drought-resistant mechanism of this special population. In this study, an experiment involvi...

journal_title：Scientific data

authors： Wan X,Zou LH,Zheng BQ,Tian YQ,Wang Y

更新日期：2018-10-30 00:00:00

abstract：:Rett syndrome is an X-linked neurodevelopmental disorder caused by mutation in the methyl-CpG-binding protein 2 gene (MECP2) in the majority of cases. We describe an RNA sequencing dataset of postmortem brain tissue samples from four females clinically diagnosed with Rett syndrome and four age-matched female donors. T...

journal_title：Scientific data

authors： Aldinger KA,Timms AE,MacDonald JW,McNamara HK,Herstein JS,Bammler TK,Evgrafov OV,Knowles JA,Levitt P

更新日期：2020-06-19 00:00:00

abstract：:Phase contrast time-lapse microscopy is a non-destructive technique that generates large volumes of image-based information to quantify the behaviour of individual cells or cell populations. To guide the development of algorithms for computer-aided cell tracking and analysis, 48 time-lapse image sequences, each spanni...

journal_title：Scientific data

authors： Ker DFE,Eom S,Sanami S,Bise R,Pascale C,Yin Z,Huh SI,Osuna-Highley E,Junkers SN,Helfrich CJ,Liang PY,Pan J,Jeong S,Kang SS,Liu J,Nicholson R,Sandbothe MF,Van PT,Liu A,Chen M,Kanade T,Weiss LE,Campbell PG

更新日期：2018-11-13 00:00:00

abstract：:Gammarids are amphipods found worldwide distributed in fresh and marine waters. They play an important role in aquatic ecosystems and are well established sentinel species in ecotoxicology. In this study, we sequenced the transcriptomes of a male individual and a female individual for seven different taxonomic groups ...

journal_title：Scientific data

authors： Cogne Y,Degli-Esposti D,Pible O,Gouveia D,François A,Bouchez O,Eché C,Ford A,Geffard O,Armengaud J,Chaumot A,Almunia C

更新日期：2019-09-27 00:00:00

abstract：:Serial electron microscopy techniques have proven to be a powerful tool in biology. Unfortunately, the data sets they generate lack robust and accurate automated segmentation algorithms. In this data descriptor publication, we introduce a serial focused ion beam scanning electron microscopy (FIB-SEM) dataset consistin...

journal_title：Scientific data

authors： Ivanchenko MV,Cicconet M,Jandal HA,Wu X,Corey DP,Indzhykulian AA

更新日期：2020-06-17 00:00:00

abstract：:This corrects the article DOI: 10.1038/sdata.2017.37. ...

journal_title：Scientific data

authors： Jungbluth SP,Amend JP,Rappé MS

更新日期：2017-07-04 00:00:00

abstract：:Between the 2011 and 2016 national censuses, the Australian Bureau of Statistics changed its anonymity policy compliance system for the distribution of census data. The new method has resulted in dramatic inconsistencies when comparing low-resolution data to aggregated high-resolution data. Hence, aggregated totals do...

journal_title：Scientific data

authors： Fair KM,Zachreson C,Prokopenko M

更新日期：2019-08-16 00:00:00

abstract：:Studies of chimpanzee vocal communication provide valuable insights into the evolution of communication in complex societies, and also comparative data for understanding the evolution of human language. One particularly valuable dataset of recordings from free-living chimpanzees was collected by Frans X. Plooij and th...

journal_title：Scientific data

authors： Plooij FX,van de Rijt-Plooij H,Fischer M,Wilson ML,Pusey A

更新日期：2015-05-26 00:00:00

abstract：:Plants use surface receptors to perceive information about many aspects of their local environment. These receptors physically interact to form both steady state and signalling competent complexes. The signalling events downstream of receptor activation impact both plant developmental and immune responses. Here, we pr...

journal_title：Scientific data

authors： Mott GA,Smakowska-Luzan E,Pasha A,Parys K,Howton TC,Neuhold J,Lehner A,Grünwald K,Stolt-Bergner P,Provart NJ,Mukhtar MS,Desveaux D,Guttman DS,Belkhadir Y

更新日期：2019-02-26 00:00:00

abstract：:Although a key driver of Earth's climate system, global land-atmosphere energy fluxes are poorly constrained. Here we use machine learning to merge energy flux measurements from FLUXNET eddy covariance towers with remote sensing and meteorological data to estimate global gridded net radiation, latent and sensible heat...

journal_title：Scientific data

authors： Jung M,Koirala S,Weber U,Ichii K,Gans F,Camps-Valls G,Papale D,Schwalm C,Tramontana G,Reichstein M

更新日期：2019-05-27 00:00:00

abstract：:Temporal lobe epilepsy (TLE) can develop from alterations in hippocampal structure and circuit characteristics, and can be modeled in mice by administration of kainic acid (KA). Adult neurogenesis in the dentate gyrus (DG) contributes to hippocampal functions and has been reported to contribute to the development of T...

journal_title：Scientific data

authors： Schouten M,Bielefeld P,Fratantoni SA,Hubens CJ,Piersma SR,Pham TV,Voskuyl RA,Lucassen PJ,Jimenez CR,Fitzsimons CP

更新日期：2016-08-16 00:00:00

abstract：:We present the Tesco Grocery 1.0 dataset: a record of 420 M food items purchased by 1.6 M fidelity card owners who shopped at the 411 Tesco stores in Greater London over the course of the entire year of 2015, aggregated at the level of census areas to preserve anonymity. For each area, we report the number of transact...

journal_title：Scientific data

authors： Aiello LM,Quercia D,Schifanella R,Del Prete L

更新日期：2020-02-18 00:00:00

abstract：:Rett syndrome (RTT) is a rare neurological disorder mostly caused by a genetic variation in MECP2. Making new MECP2 variants and the related phenotypes available provides data for better understanding of disease mechanisms and faster identification of variants for diagnosis. This is, however, currently hampered by the...

journal_title：Scientific data

authors： Ehrhart F,Jacobsen A,Rigau M,Bosio M,Kaliyaperumal R,Laros JFJ,Willighagen EL,Valencia A,Roos M,Capella-Gutierrez S,Curfs LMG,Evelo CT

更新日期：2021-01-15 00:00:00

abstract：:Understanding of sequence diversity is the cornerstone of analysis of genetic disorders, population genetics, and evolutionary biology. Here, we present an update of our sequencing set to 15,220 Icelanders who we sequenced to an average genome-wide coverage of 34X. We identified 39,020,168 autosomal variants passing G...

journal_title：Scientific data

authors： Jónsson H,Sulem P,Kehr B,Kristmundsdottir S,Zink F,Hjartarson E,Hardarson MT,Hjorleifsson KE,Eggertsson HP,Gudjonsson SA,Ward LD,Arnadottir GA,Helgason EA,Helgason H,Gylfason A,Jonasdottir A,Jonasdottir A,Rafnar T,Bes

更新日期：2017-09-21 00:00:00

abstract：:Spatio-temporal data on human population and its driving factors is critical to understanding and responding to population problems. Unfortunately, such spatio-temporal data on a large scale and over the long term are often difficult to obtain. Here, we present a dataset on Chinese population distribution and its driv...

journal_title：Scientific data

authors： Wang L,Chen L

更新日期：2016-07-05 00:00:00

abstract：:Larval fishes are a useful metric of marine ecosystem state and change, as well as species-specific patterns in phenology. The high level of taxonomic expertise required to identify larval fishes to species level, and the considerable effort required to collect samples, make these data very valuable. Here we collate 3...

journal_title：Scientific data

authors： Smith JA,Miskiewicz AG,Beckley LE,Everett JD,Garcia V,Gray CA,Holliday D,Jordan AR,Keane J,Lara-Lopez A,Leis JM,Matis PA,Muhling BA,Neira FJ,Richardson AJ,Smith KA,Swadling KM,Syahailatua A,Taylor MD,van Ruth PD,W

更新日期：2018-10-16 00:00:00

abstract：:Fully-automated nuclear image segmentation is the prerequisite to ensure statistically significant, quantitative analyses of tissue preparations,applied in digital pathology or quantitative microscopy. The design of segmentation methods that work independently of the tissue type or preparation is complex, due to varia...

journal_title：Scientific data

authors： Kromp F,Bozsaky E,Rifatbegovic F,Fischer L,Ambros M,Berneder M,Weiss T,Lazic D,Dörr W,Hanbury A,Beiske K,Ambros PF,Ambros IM,Taschner-Mandl S

更新日期：2020-08-11 00:00:00

abstract：:Surveys for more than 9,500 households were conducted in the growing seasons 2002/2003 or 2003/2004 in eleven African countries: Burkina Faso, Cameroon, Ghana, Niger and Senegal in western Africa; Egypt in northern Africa; Ethiopia and Kenya in eastern Africa; South Africa, Zambia and Zimbabwe in southern Africa. Hous...

journal_title：Scientific data

authors： Waha K,Zipf B,Kurukulasuriya P,Hassan RM

更新日期：2016-05-24 00:00:00

abstract：:We performed whole-genome sequencing for eight inbred rat strains commonly used in genetic mapping studies. They are the founders of the NIH heterogeneous stock (HS) outbred colony. We provide their sequences and variant calls to the rat genomics community. When analyzing the variant calls we identified regions with u...

journal_title：Scientific data

authors： Ramdas S,Ozel AB,Treutelaar MK,Holl K,Mandel M,Woods LCS,Li JZ

更新日期：2019-04-23 00:00:00

abstract：:In 2010, an estimated 860 million people were living in slums worldwide, with around 60 million added to the slum population between 2000 and 2010. In 2011, 200 million people in urban Indian households were considered to live in slums. In order to address and create slum development programmes and poverty alleviation...

journal_title：Scientific data

authors： Roy D,Palavalli B,Menon N,King R,Pfeffer K,Lees M,Sloot PMA

更新日期：2018-01-09 00:00:00

abstract：:With the aim to uncover the molecular pathways underlying the regulation of sleep, we recently assembled an extensive and comprehensive systems genetics dataset interrogating a genetic reference population of mice at the levels of the genome, the brain and liver transcriptomes, the plasma metabolome, and the sleep-wak...

journal_title：Scientific data

authors： Jan M,Gobet N,Diessler S,Franken P,Xenarios I

更新日期：2019-10-31 00:00:00

abstract：:This paper describes the release of the detailed building operation data, including electricity consumption and indoor environmental measurements, of the seven-story 11,700-m2 office building located in Bangkok, Thailand. The electricity consumption data (kW) are that of individual air conditioning units, lighting, an...

journal_title：Scientific data

authors： Pipattanasomporn M,Chitalia G,Songsiri J,Aswakul C,Pora W,Suwankawin S,Audomvongseree K,Hoonchareon N

更新日期：2020-07-20 00:00:00

abstract：:With electric heat pumps substituting for fossil-fueled alternatives, the temporal variability of their power consumption becomes increasingly important to the electricity system. To easily include this variability in energy system analyses, this paper introduces the "When2Heat" dataset comprising synthetic national t...

journal_title：Scientific data

authors： Ruhnau O,Hirth L,Praktiknjo A

更新日期：2019-10-01 00:00:00

abstract：:Brain atlases that encompass detailed anatomical or physiological features are instrumental in the research and surgical planning of various neurological conditions. Magnetic resonance imaging (MRI) has played important roles in neuro-image analysis while histological data remain crucial as a gold standard to guide an...

journal_title：Scientific data

authors： Xiao Y,Lau JC,Anderson T,DeKraker J,Collins DL,Peters T,Khan AR

更新日期：2019-10-17 00:00:00

abstract：:The detection, identification, and localization of illicit nuclear materials in urban environments is of utmost importance for national security. Most often, the process of performing these operations consists of a team of trained individuals equipped with radiation detection devices that have built-in algorithms to a...

journal_title：Scientific data

authors： Ghawaly JM Jr,Nicholson AD,Peplow DE,Anderson-Cook CM,Myers KL,Archer DE,Willis MJ,Quiter BJ

更新日期：2020-10-05 00:00:00

abstract：:Human adenoviruses (HAdVs) are fatal to immuno-suppressed individuals, but no effective anti-HAdV therapy is available. Here, we present a novel image-based high-throughput screening (HTS) platform, which scores the full viral replication cycle from virus entry to dissemination of progeny and second-round infections. ...

journal_title：Scientific data

authors： Georgi F,Kuttler F,Murer L,Andriasyan V,Witte R,Yakimovich A,Turcatti G,Greber UF

更新日期：2020-08-12 00:00:00

abstract：:The human HCC1806 cell line is frequently used as a preclinical model for triple negative breast cancer (TNBC). Given that dysregulated epigenetic mechanisms are involved in cancer pathogenesis, emerging therapeutic strategies target chromatin regulators, such as histone deacetylases. A comprehensive understanding of ...

journal_title：Scientific data

authors： Perreault AA,Sprunger DM,Venters BJ

更新日期：2019-03-05 00:00:00

abstract：:Land-atmosphere interactions at different temporal and spatial scales are important for our understanding of the Earth system and its modeling. The Landscape Evolution Observatory (LEO) at Biosphere 2, managed by the University of Arizona, hosts three nearly identical artificial bare-soil hillslopes with dimensions of...

journal_title：Scientific data

authors： Arevalo J,Zeng X,Durcik M,Sibayan M,Pangle L,Abramson N,Bugaj A,Ng WR,Kim M,Barron-Gafford G,van Haren J,Niu GY,Adams J,Ruiz J,Troch PA

更新日期：2020-09-15 00:00:00

abstract：:Social network analysis is an invaluable tool to understand the patterns, evolution, and consequences of sociality. Comparative studies over a range of social systems across multiple taxonomic groups are particularly valuable. Such studies however require quantitative social association or interaction data across mult...

journal_title：Scientific data

authors： Sah P,Méndez JD,Bansal S

更新日期：2019-04-29 00:00:00

abstract：:Gene expression is a biological process regulated at different molecular levels, including chromatin accessibility, transcription, and RNA maturation and transport. In addition, these regulatory mechanisms have strong links with cellular metabolism. Here we present a multi-omics dataset that captures different aspects...

journal_title：Scientific data

authors： Nuño-Cabanes C,Ugidos M,Tarazona S,Martín-Expósito M,Ferrer A,Rodríguez-Navarro S,Conesa A

更新日期：2020-02-27 00:00:00