Abstract：
:Temporal lobe epilepsy (TLE) can develop from alterations in hippocampal structure and circuit characteristics, and can be modeled in mice by administration of kainic acid (KA). Adult neurogenesis in the dentate gyrus (DG) contributes to hippocampal functions and has been reported to contribute to the development of TLE. Some of the phenotypical changes include neural stem and precursor cells (NPSC) apoptosis, shortly after their birth, before they produce hippocampal neurons. Here we explored these early phenotypical changes in the DG 3 days after a systemic injection of KA inducing status epilepticus (KA-SE), in mice. We performed a multi-omics experimental setup and analyzed DG tissue samples using proteomics, transcriptomics and microRNA profiling techniques, detecting the expression of 2327 proteins, 13401 mRNAs and 311 microRNAs. We here present a description of how these data were obtained and make them available for further analysis and validation. Our data may help to further identify and characterize molecular mechanisms involved in the alterations induced shortly after KA-SE in the mouse DG.
journal_name
Sci Datajournal_title
Scientific dataauthors
Schouten M,Bielefeld P,Fratantoni SA,Hubens CJ,Piersma SR,Pham TV,Voskuyl RA,Lucassen PJ,Jimenez CR,Fitzsimons CPdoi
10.1038/sdata.2016.68subject
Has Abstractpub_date
2016-08-16 00:00:00pages
160068issn
2052-4463pii
sdata201668journal_volume
3pub_type
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