Transposon Tn5 mutagenesis of Brucella abortus.

abstract：:Several early nonspecific host defense mechanisms were examined in resistant (BALB/c) and susceptible (C3H/He) mice after intraperitoneal inoculation with Rickettsia tsutsugamushi strain Gilliam. Inflammatory exudates were formed in both mouse strains in response to rickettsial inoculation, but the inflammatory respon...

journal_title：Infection and immunity

authors： Nacy CA,Groves MG

更新日期：1981-03-01 00:00:00

abstract：:Synthetic lipid A analogs which have two amide-bound and two ester-bound (R)-3-hydroxytetradecanoyl groups at the C-2 and -2' and C-3 and -3' positions of beta(1-6)glucosamine disaccharide mono- or diphosphates showed high activities in most in vitro assays, and the lethality of a diphosphate derivative to galactosami...

journal_title：Infection and immunity

authors： Kotani S,Takada H,Tsujimoto M,Ogawa T,Harada K,Mori Y,Kawasaki A,Tanaka A,Nagao S,Tanaka S

更新日期：1984-07-01 00:00:00

abstract：:Tissues and organs provide the structural and biochemical landscapes upon which microbial pathogens and commensals function to regulate health and disease. While flat two-dimensional (2-D) monolayers composed of a single cell type have provided important insight into understanding host-pathogen interactions and infect...

journal_title：Infection and immunity

authors： Barrila J,Crabbé A,Yang J,Franco K,Nydam SD,Forsyth RJ,Davis RR,Gangaraju S,Ott CM,Coyne CB,Bissell MJ,Nickerson CA

更新日期：2018-10-25 00:00:00

abstract：:Neonatal piglets have been used as models to study human campylobacteriosis and helicobacteriosis. The purpose of this study was to determine the relative pathogenicities, on the basis of the duration of fecal shedding and colonization of tissues, of three Arcobacter species in 1-day-old cesarean-derived colostrum-dep...

journal_title：Infection and immunity

authors： Wesley IV,Baetz AL,Larson DJ

更新日期：1996-06-01 00:00:00

abstract：:We have previously reported that a wild strain of Francisella tularensis is much less efficiently killed by human polymorphonuclear leukocytes than is an attenuated strain. In the present study, the killing of the attenuated strain was found to be strictly oxygen dependent. The wild and the attenuated strains both ind...

journal_title：Infection and immunity

authors： Löfgren S,Tärnvik A,Thore M,Carlsson J

更新日期：1984-02-01 00:00:00

abstract：:Vibrio parahaemolyticus is a leading cause of seafood-borne gastroenteritis; however, its virulence mechanisms are not well understood. The identification of type III secreted proteins has provided candidate virulence factors whose functions are still being elucidated. Genotypic strain variability contributes a level ...

journal_title：Infection and immunity

authors： Casselli T,Lynch T,Southward CM,Jones BW,DeVinney R

更新日期：2008-05-01 00:00:00

abstract：:To serially examine the immunopathogenesis and histopathology of infection with Chlamydia pneumoniae, we inoculated two cynomolgus monkeys in the conjunctival sac, nose, and nasopharynx with C. pneumoniae TWAR. After inoculation, C. pneumoniae was isolated from the inoculation sites and the rectums of both monkeys for...

journal_title：Infection and immunity

authors： Holland SM,Taylor HR,Gaydos CA,Kappus EW,Quinn TC

更新日期：1990-03-01 00:00:00

abstract：:The membrane fluidity of antigen-presenting cells (APCs) has a significant bearing on T-cell-stimulating ability and is dependent on the cholesterol content of the membrane. The relationship, if any, between membrane fluidity and defective cell-mediated immunity in visceral leishmaniasis has been investigated. Systemi...

journal_title：Infection and immunity

authors： Banerjee S,Ghosh J,Sen S,Guha R,Dhar R,Ghosh M,Datta S,Raychaudhury B,Naskar K,Haldar AK,Lal CS,Pandey K,Das VN,Das P,Roy S

更新日期：2009-06-01 00:00:00

abstract：:L929 cell populations persistently infected for more than 600 days exhibited cell cycle distributions and generation times similar to those of uninfected cells. The RNA and protein contents of these long-term-infected cells, as determined by flow cytometry and correlated with the cell cycle, were likewise approximatel...

journal_title：Infection and immunity

authors： Baca OG,Crissman HA

更新日期：1987-07-01 00:00:00

abstract：:It is proposed that binding of oral streptococci to saliva-coated hydroxylapatite (SHA) surfaces is a multifactorial process involving both specific and nonspecific receptors. In this context, specific binding is described as a high-affinity, saturable interaction between the cell and binding surface. Conversely, nons...

journal_title：Infection and immunity

authors： Staat RH,Peyton JC

更新日期：1984-06-01 00:00:00

abstract：:Infantile gastroenteritis virus (orbi-group) recovered from stools of infants with acute nonbacterial gastroenteritis was administered per os to germfree and conventional piglets. Virus was found subsequently in stools and in the mucosal epithelial cells of the small intestine of these animals. Some animals developed ...

journal_title：Infection and immunity

authors： Middleton PJ,Petric M,Szymanski MT

更新日期：1975-12-01 00:00:00

abstract：:Many pathogenic microbes have multiple virulence factors that can cause damage to the host and thus contribute to an overall virulence phenotype for that organism. Although current techniques are suitable for demonstrating that a particular microbial characteristic contributes to virulence, no formal approach for defi...

journal_title：Infection and immunity

authors： McClelland EE,Bernhardt P,Casadevall A

更新日期：2006-03-01 00:00:00

abstract：:The role of antibody in protection against infection with Cryptococcus neoformans is undefined. In this paper we describe the development of opsonic activity in the cerebrospinal fluid (CSF) of rabbits in response to cryptococcal meningitis. The opsonin appeared to be immunoglobulin G (IgG); the activity was heat stab...

journal_title：Infection and immunity

authors： Hobbs MM,Perfect JR,Granger DL,Durack DT

更新日期：1990-07-01 00:00:00

abstract：:Recent studies have shown that children with blood group A have increased susceptibility to enterotoxigenic Escherichia coli (ETEC) diarrhea and that Lewis blood group "a" antigen (Le(a)) may be a candidate receptor for ETEC colonization factor (CF) antigen I (CFA/I) fimbriae. Based on these findings, we have attempte...

journal_title：Infection and immunity

authors： Ahmed T,Lundgren A,Arifuzzaman M,Qadri F,Teneberg S,Svennerholm AM

更新日期：2009-05-01 00:00:00

abstract：:A GroEL-like protein from Bordetella pertussis was purified. This protein was found to have the tetradecameric subunit structure typical of the GroEL family of proteins and to contain epitopes similar to those of other members of this family, including a human GroEL-like protein. Active immunization of neonatal mice w...

journal_title：Infection and immunity

authors： Burns DL,Gould-Kostka JL,Kessel M,Arciniega JL

更新日期：1991-04-01 00:00:00

abstract：:Mice were vaccinated with plasmid DNA (pDNA) encoding antigen 85A (Ag85A), Ag85B, or PstS-3 from Mycobacterium tuberculosis either in saline or formulated for intramuscular injections in VC1052:DPyPE (aminopropyl-dimethyl-myristoleyloxy-propanaminium bromide-diphytanoylphosphatidyl-ethanolamine) (Vaxfectin; Vical, Inc...

journal_title：Infection and immunity

authors： D'Souza S,Rosseels V,Denis O,Tanghe A,De Smet N,Jurion F,Palfliet K,Castiglioni N,Vanonckelen A,Wheeler C,Huygen K

更新日期：2002-07-01 00:00:00

abstract：:When spleen cells derived from C57BL/6 mice immunized with L cells 7 days previously were cocultured with antigenic cells, immune interferon appeared in the culture fluid. We analyzed the tissue distribution of the immune interferon-producing cells (IIPC) which appeared in various lymphoid organs after allogeneic stim...

journal_title：Infection and immunity

authors： Ito Y,Aoki H,Kimura Y,Takano M,Maeno K,Shimokata K

更新日期：1980-08-01 00:00:00

abstract：:Both idiopathic and infectious forms of colitis disrupt normal intestinal epithelial cell (IEC) proliferation and differentiation, although the mechanisms involved remain unclear. Recently, we demonstrated that infection by the attaching and effacing murine pathogen Citrobacter rodentium leads to a significant reducti...

journal_title：Infection and immunity

authors： Chan JM,Bhinder G,Sham HP,Ryz N,Huang T,Bergstrom KS,Vallance BA

更新日期：2013-12-01 00:00:00

abstract：:Neutrophils are the main inflammatory cell present in lesions involving the central nervous system (CNS) during human and murine listeriosis. In this study, administration of the neutrophil-depleting monoclonal antibody RB6-8C5 during experimental murine listeriosis facilitated the multiplication of Listeria monocytog...

journal_title：Infection and immunity

authors： López S,Marco AJ,Prats N,Czuprynski CJ

更新日期：2000-08-01 00:00:00

abstract：:Mycobacterium avium subsp. paratuberculosis is the causative agent of Johne's disease in cattle. The complex, multifaceted interaction of M. avium subsp. paratuberculosis with its host includes dampening the ability of infected cells to respond to stimuli that promote M. avium subsp. paratuberculosis clearance. By dis...

journal_title：Infection and immunity

authors： Arsenault RJ,Li Y,Maattanen P,Scruten E,Doig K,Potter A,Griebel P,Kusalik A,Napper S

更新日期：2013-01-01 00:00:00

abstract：:Clostridium perfringens enterotoxin caused a 26 to 41% reduction in the rate of oxygen consumption by rat liver mitochondria when various tricarboxylic acid cycle intermediates were used as substrate. However, P/O ratios were unaltered. ...

journal_title：Infection and immunity

authors： McDonel JL,Duncan CL

更新日期：1977-03-01 00:00:00

abstract：:Hypoferremia, the reduction of plasma transferrin iron levels during infection, has been shown to control Neisseria meningitidis infection in mice. The exact nature of the mechanism that regulates this response has been obscure. We have previously shown that hypoferremia does not result from an accelerated removal of ...

journal_title：Infection and immunity

authors： Letendre ED,Holbein BE

更新日期：1984-05-01 00:00:00

abstract：:The adherence of Treponema denticola GM-1, TD-4, and MS25 to human gingival fibroblasts (HGFs) was studied to serve as an introduction to investigations into the interactions of these oral bacteria with human host cells. Under both aerobic (5% CO2) and anaerobic (85% N2 plus 10% H2 plus 5% CO2) environments, the inter...

journal_title：Infection and immunity

authors： Weinberg A,Holt SC

更新日期：1990-06-01 00:00:00

abstract：:Secretory immunoglobulin A (SIgA) antibodies directed against the O antigen of lipopolysaccharide (LPS) are the primary determinants of mucosal immunity to gram-negative enteric pathogens. However, the underlying mechanisms by which these antibodies interfere with bacterial colonization and invasion of intestinal epit...

journal_title：Infection and immunity

authors： Forbes SJ,Eschmann M,Mantis NJ

更新日期：2008-09-01 00:00:00

abstract：:Vibrio parahaemolyticus, a gram-negative marine bacterium, is an important pathogen causing food-borne gastroenteritis or septicemia. Recent genome sequencing of the RIMD2210633 strain (a Kanagawa phenomenon-positive clinical isolate of serotype O3:K6) revealed that the strain has two sets of gene clusters that encode...

journal_title：Infection and immunity

authors： Ono T,Park KS,Ueta M,Iida T,Honda T

更新日期：2006-02-01 00:00:00

abstract：:Rabbit lymphoid cells from spleen, peripheral blood, and peritoneal cavity lacked killer (K)-cell activity against cell lines of rabbit and human origin, including virus-infected human tumor cells. This lack of activity was not affected by antibody concentration, source of antibodies, effector/target cell ratio, or le...

journal_title：Infection and immunity

authors： Karavodin LM,Sidell N,Woan MC,Tompkins WA

更新日期：1982-02-01 00:00:00

abstract：:Staphylococcus aureus can produce a wide variety of exotoxins, including toxic shock syndrome toxin 1 (TSST-1), staphylococcal enterotoxins, and staphylococcal enterotoxin-like toxins. These toxins share superantigenic activity. To investigate the beta chain (Vbeta) specificities of each of these toxins, TSST-1 and al...

journal_title：Infection and immunity

authors： Thomas D,Dauwalder O,Brun V,Badiou C,Ferry T,Etienne J,Vandenesch F,Lina G

更新日期：2009-05-01 00:00:00

abstract：:Penetration of the intestinal mucosa at areas of Peyer's patches is an important first step for Salmonella typhimurium to produce lethal systemic disease in mice. However, mutations in genes that are important for intestinal invasion result in only moderately decreased virulence of S. typhimurium for mice. Here we rep...

journal_title：Infection and immunity

authors： Bäumler AJ,Tsolis RM,Valentine PJ,Ficht TA,Heffron F

更新日期：1997-06-01 00:00:00

abstract：:Protozoan parasites of the genus Leishmania exist as obligatory intracellular amastigotes and invade macrophages and Langerhans cells, the dendritic cells of the skin. Langerhans cells are much more efficient in presenting Leishmania major antigen to T cells than macrophages are and have the unique ability to retain p...

journal_title：Infection and immunity

authors： Flohé S,Lang T,Moll H

更新日期：1997-08-01 00:00:00

abstract：:Outbred Swiss mice were inoculated intraperitoneally or intravenously with one 90 to 100% lethal dose of Escherichia coli O:18, Proteus mirabilis, or Klebsiella pneumoniae. After carefully timed intervals, aminoglycoside antibiotics were begun at dosages nnd intervals predetermined to constitute optimal therapy. With ...

journal_title：Infection and immunity

authors： Greisman SE,DuBuy JB,Woodward CL

更新日期：1979-08-01 00:00:00