Abstract:
:To serially examine the immunopathogenesis and histopathology of infection with Chlamydia pneumoniae, we inoculated two cynomolgus monkeys in the conjunctival sac, nose, and nasopharynx with C. pneumoniae TWAR. After inoculation, C. pneumoniae was isolated from the inoculation sites and the rectums of both monkeys for a period of 5 weeks. After a second inoculation, C. pneumoniae was recovered from the inoculation sites and the rectums of both monkeys for 20 weeks. A third inoculation with C. pneumoniae caused very little productive infection at any site. Prior C. pneumoniae infection did not prevent subsequent C. trachomatis serovar E (Bour strain) infection. Clinical and histopathologic ocular responses to C. pneumoniae infection were mild compared with those to infection with C. trachomatis serovar E. Rectal infection, demonstrated by culture isolation and immunohistopathology, occurred without direct experimental inoculation. Both immunofluorescent staining of mucosal smears with monoclonal antibodies and tissue culture were able to detect C. pneumoniae infection. Experimental nonhuman primate infection with C. pneumoniae appears to be clinically and histopathologically mild and can occur at extrapulmonary sites.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Holland SM,Taylor HR,Gaydos CA,Kappus EW,Quinn TCdoi
10.1128/IAI.58.3.593-597.1990subject
Has Abstractpub_date
1990-03-01 00:00:00pages
593-7issue
3eissn
0019-9567issn
1098-5522journal_volume
58pub_type
杂志文章abstract::Attachment of Mycobacterium avium subsp. paratuberculosis to host tissue and penetration of mucosal surfaces are pivotal events in the pathogenesis of Johne's disease. Fibronectin (FN) binding is required for attachment and internalization of several mycobacteria by epithelial cells in vitro. The objective of this stu...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.4.2075-2082.2001
更新日期:2001-04-01 00:00:00
abstract::The purpose of this study was to determine the effects of human monocytes, macrophages, and polymorphonuclear neutrophils (PMN) on the fungal pathogen Blastomyces dermatitidis in vitro. Peripheral blood monocyte monolayers significantly inhibited the replication of a virulent strain (V) and an avirulent strain (AV) of...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.36.1.297-303.1982
更新日期:1982-04-01 00:00:00
abstract::Several previous findings have suggested that the cationic nature of lysozyme is a major factor in its bactericidal activity. Since a number of cationic proteins or peptides have been reported to cause membrane damage in bacteria, we investigated the effect of lysozyme on glucose fermentation and intracellular pH and ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.59.2.638-644.1991
更新日期:1991-02-01 00:00:00
abstract::Interferon regulatory factor 1-deficient (IRF-1(-/-)) mice infected with virulent Brucella abortus 2308 at 5 x 10(5) CFU developed acute hepatitis similar to many natural hosts but, unlike natural hosts, IRF-1(-/-) mice were unable to resolve infection and died. In contrast, IRF-1(-/-) mice survived when infected at 5...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.70.12.7004-7012.2002
更新日期:2002-12-01 00:00:00
abstract::Myeloid differentiation protein 88 (MyD88) is a general adaptor for the signaling cascade through receptors of the Toll/IL-1R family. When infected with Leishmania major parasites, MyD88-deficient mice displayed a dramatically enhanced parasite burden in their tissues similar to that found in susceptible BALB/c mice. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.12.7215-7218.2003
更新日期:2003-12-01 00:00:00
abstract::Trefoil family factor 2 (TFF2), also known as spasmolytic peptide, is a low-molecular-weight protein that is upregulated in gastric tissues infected with Helicobacter or having other inflammatory conditions, but a precise function is yet to be elucidated. The role of TFF2 in the development of gastritis, colitis, and ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.02039-05
更新日期:2007-01-01 00:00:00
abstract::Helicobacter pylori vacuolating cytotoxin (VacA) is a secreted protein that induces vacuolation of epithelial cells. To study VacA structure and function, we immunized mice with purified type s1-m1 VacA from H. pylori strain 60190 and generated a panel of 10 immunoglobulin G1kappa anti-VacA monoclonal antibodies. All ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.7.4329-4336.2001
更新日期:2001-07-01 00:00:00
abstract::Chlamydia pneumoniae is a causative agent for many respiratory infections and has been associated with cardiovascular diseases in humans. The pathogenicity of C. pneumoniae is thought to depend on its ability to cause persistent infection and to evade host defense. Genome sequence analysis indicates that C. pneumoniae...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.70.1.345-349.2002
更新日期:2002-01-01 00:00:00
abstract::Both interleukin-17A (IL-17A) and IL-17F are proinflammatory cytokines that have an important role in intestinal homeostasis via receptor signaling. These cytokines have been characterized in chickens, but very little is known about their receptors and their functional activity. We provide here the first description o...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.02141-14
更新日期:2014-09-01 00:00:00
abstract::Streptococcus pyogenes secretes a specific immunoglobulin G (IgG)-protease, SpeB, as well as the IgG glycan-hydrolyzing enzyme EndoS. Here we show that SpeB also degrades IgA, IgM, IgD, and IgE. We also show that EndoS only hydrolyzes the glycan moiety on native but not denatured IgG. Thus, SpeB has a broad immunoglob...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.11.7187-7189.2001
更新日期:2001-11-01 00:00:00
abstract::Specific pathogen-free guinea pigs were infected via the respiratory route with viable, attenuated Mycobacterium tuberculosis H37Ra and maintained on purified isocaloric diets. The control diet contained 30% protein (ovalbumin) and 50 ppm of added zinc (50 micrograms/g), the low protein diet contained 10% protein and ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.39.2.793-799.1983
更新日期:1983-02-01 00:00:00
abstract::We have previously reported that a wild strain of Francisella tularensis is much less efficiently killed by human polymorphonuclear leukocytes than is an attenuated strain. In the present study, the killing of the attenuated strain was found to be strictly oxygen dependent. The wild and the attenuated strains both ind...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.43.2.730-734.1984
更新日期:1984-02-01 00:00:00
abstract::Vibrio parahaemolyticus is a leading cause of seafood-borne gastroenteritis; however, its virulence mechanisms are not well understood. The identification of type III secreted proteins has provided candidate virulence factors whose functions are still being elucidated. Genotypic strain variability contributes a level ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01704-07
更新日期:2008-05-01 00:00:00
abstract::The interaction of Borrelia burgdorferi, the causative agent of Lyme borreliosis, with phagocytic cells induces the activation of NF-kappaB and the expression of proinflammatory cytokines including tumor necrosis factor alpha (TNF-alpha). B. burgdorferi-induced TNF-alpha production is also dependent on the activation ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01412-06
更新日期:2007-01-01 00:00:00
abstract::Effector mechanisms resulting from alternative complement pathway (ACP) activation cannot act efficiently against Yersinia enterocolitica serotype O3, as indicated by poor C3 to C9 consumption and by survival in EGTA (ethyleneglycoldiaminetetraacetic acid) Mg-serum. These results were not influenced by the lack or pre...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.7.1984-1989.1989
更新日期:1989-07-01 00:00:00
abstract::The response of the intracellular pathogen Rhodococcus equi to H(2)O(2) treatment, a situation potentially encountered after the oxidative burst of alveolar macrophages, was analyzed. Compared to other bacteria, including Deinococcus radiodurans, R. equi showed exceptionally high resistance to this stress. A proteomic...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.70.7.3768-3776.2002
更新日期:2002-07-01 00:00:00
abstract::We have recently reported Bacillus anthracis attenuated live vaccine strains efficiently expressing recombinant protective antigen (rPA) and have shown a direct correlation between the level of rPA secreted by these cells and efficacy (S. Cohen, I. Mendelson, Z. Altboum, D. Kobiler, E. Elhanany, T. Bino, M. Leitner, I...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.2.801-813.2003
更新日期:2003-02-01 00:00:00
abstract::CC chemokine receptor 4 (CCR4) and its two ligands, CCL17 and CCL22, are critically involved in different immune processes. In models of lipopolysaccharide-induced shock, CCR4-deficient (CCR4(-/-)) mice showed improved survival rates associated with attenuated proinflammatory cytokine release. Using CCR4(-/-) mice wit...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00310-08
更新日期:2008-11-01 00:00:00
abstract::The Lyme disease spirochete Borrelia burgdorferi reduces the expression of outer surface protein C (OspC) in response to the development of an anti-OspC humoral response, leading to the hypothesis that the ability to repress OspC expression is critical for the pathogen to proceed to chronic infection. B. burgdorferi w...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00713-06
更新日期:2006-09-01 00:00:00
abstract::In experiments described herein, it was observed that guinea pigs with delayed-type hypersensitivity to tuberculoproteins under various experimental conditions, with or without passive transfer of serum from immune donors, manifested no acquired immunity against aerogenically induced tuberculosis. These results are di...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.9.5.815-820.1974
更新日期:1974-05-01 00:00:00
abstract::Immunocompromised patients are more susceptible to recurrent nontyphoidal Salmonella (NTS) bacteremia. A key manifestation of HIV infection is the loss of CD4 T cells, which are crucial for immunity to Salmonella infection. We characterized the consequences of CD4 T cell depletion in mice where virulent Salmonella est...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00417-20
更新日期:2020-12-15 00:00:00
abstract::The leukotrienes and tumor necrosis factor (TNF) play an important role in the pathophysiology of septic shock, in which hypotension, leukopenia, thrombocytopenia, and hemoconcentration are observed. This study was performed to examine the effects of a 5-lipoxygenase inhibitor (AA-861), a selective leukotriene recepto...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.6.2432-2437.1992
更新日期:1992-06-01 00:00:00
abstract::Previous studies have shown that tumor necrosis factor alpha (TNF-alpha) plays a pathophysiologic role in sepsis induced in rat pups by group B streptococci (GBS). In this model, TNF-alpha is also partially responsible for the induction of interleukin-6 (IL-6). The present study was undertaken to investigate the role ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.11.4997-5002.1994
更新日期:1994-11-01 00:00:00
abstract::The effect of route of administration, dosage, and number of boosts employed during immunization with the polymyxin-release form of Escherichia coli heat-labile (LT) enterotoxin on the degree and duration of protection afforded was evaluated in rats which were challenged by the ligated loop technique. Increasing the b...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.27.1.81-86.1980
更新日期:1980-01-01 00:00:00
abstract::There are no vaccines against boutonneuse fever and Rocky Mountain spotted fever. Previous studies have identified a Rickettsia rickettsii surface protein as a vaccine candidate and shown that an antigenically related protein is present in R. conorii, which causes boutonneuse fever. The gene encoding the R. rickettsii...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.3.646-653.1990
更新日期:1990-03-01 00:00:00
abstract::The protective efficacy of antibodies to the Staphylococcus aureus type 5 capsular polysaccharide (CP5) was examined in a modified model of catheter-induced endocarditis. Rats were catheterized by surgically passing a polyethylene catheter through the right carotid artery and aortic valve into the left ventricle. The ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.10.4146-4151.1997
更新日期:1997-10-01 00:00:00
abstract::The antigenicity of Erysipelothrix rhusiopathiae T28 (serotype 2) was investigated. Antigens were solubilized from the cell surface with detergents. By means of sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting it was shown that the molecular weight of the main antigenic component--a nonprot...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.52.3.818-822.1986
更新日期:1986-06-01 00:00:00
abstract::A method was developed to test for the ability of Escherichia coli to adhere to isolated intestinal epithelial cells. Of the E. coli tested, those having either K88ac or K88ab antigens adhered to the cells, and those which did not have these antigens did not. Since some enteropathogenic E. coli did not have the abilit...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.10.4.776-782.1974
更新日期:1974-10-01 00:00:00
abstract::Neutrophils play a major role in defending the periodontium against infection by oral, gram-negative, facultative bacteria, such as Actinobacillus actinomycetemcomitans, Eikenella corrodens, and Capnocytophaga spp. We examined the sensitivity of these bacteria to a mixture of low-molecular-weight peptides and highly p...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.12.3934-3940.1990
更新日期:1990-12-01 00:00:00
abstract::Mice infected with various strains of Salmonella enteritidis and S. typhimurium were found to be more sensitive to the cell wall lipopolysaccharide (LPS) extracted from certain strains of Salmonella than noninfected mice. This hypersensitivity was induced by those smooth or rough strains which possessed a polysacchari...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.4.5.519-524.1971
更新日期:1971-11-01 00:00:00