Abstract：
:Hypoadiponectinemia and adiponectin resistance are implicated in the aetiology of obesity-related cardiometabolic disorders, hence represent a potential therapeutic axis. Here we characterised the effects of in vivo electrotransfer-mediated overexpression of the adiponectin receptors, AdipoR1 or AdipoR2, into tibialis anterior muscle (TAM) of lean or obese mice. In lean mice, TAM-specific overexpression of AdipoR1 (TAMR1) or AdipoR2 (TAMR2) increased phosphorylation of AMPK, AKT and ERK and expression of the insulin responsive glucose transporter glut4. In contrast, only TAMR2 increased pparα and a target gene acox1. These effects were decreased in obese mice despite no reduction in circulating adiponectin levels. TAMR2 also increased expression of adipoQ in TAM of lean and obese mice. Furthermore, in obese mice TAMR2 promoted systemic effects including; decreased weight gain; reduced epididymal fat mass and inflammation; increased epididymal adipoQ expression; increased circulating adiponectin. Collectively, these results demonstrate that AdipoR1 and AdipoR2 exhibit overlapping and distinct effects in skeletal muscle consistent with enhanced adiponectin sensitivity but these appear insufficient to ameliorate established obesity-induced adiponectin resistance. We also identify systemic effects upon TAMR2 in obese mice and postulate these are mediated by altered myokine production. Further studies are warranted to investigate this possibility which may reveal novel therapeutic approaches.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Keshvari S,Henstridge DC,Ng C,Febbraio MA,Whitehead JPdoi
10.1038/srep41792subject
Has Abstractpub_date
2017-02-01 00:00:00pages
41792issn
2045-2322pii
srep41792journal_volume
7pub_type
杂志文章abstract：:Iron-based superconductors have been found to exhibit an intimate interplay of orbital, spin, and lattice degrees of freedom, dramatically affecting their low-energy electronic properties, including superconductivity. Albeit the precise pairing mechanism remains unidentified, several candidate interactions have been s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18620
更新日期：2016-01-05 00:00:00
abstract：:Tissue-resident memory T (TRM) cells are characterized by their surface expression of CD69 and can be subdivided in CD103+ and CD103- TRM cells. The origin and functional characteristics of TRM cells in the renal allograft are largely unknown. To determine these features we studied TRM cells in transplant nephrectomie...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42401-9
更新日期：2019-04-12 00:00:00
abstract：:Anatase TiO2 is a typical photocatalyst, and its excellent performance is limited in ultraviolet light range due to its wide band gap of 3.2 eV. A series of Se-doped TiO2 nanoparticles in anatase structure with various Se concentrations up to 17.1 at.% were prepared using sol-gel method. The doped Se ions are confirme...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27135-4
更新日期：2018-06-08 00:00:00
abstract：:Tyrosinase efficiently catalyzes the ortho-hydroxylation of monophenols and the oxidation of diphenols without any additional cofactors. Although it is of significant interest for the biosynthesis of catechol derivatives, the rapid catechol oxidase activity and inactivation of tyrosinase have hampered its practical ut...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17635-0
更新日期：2017-12-08 00:00:00
abstract：:Over 80% of perinatal mortality in Japan is due to stillbirths after 22 weeks of gestation, with one in 300 families experiencing fetal loss every year. This study aimed to assess causes and risk factors for singleton stillbirth in Japan. A retrospective cross-sectional study was conducted using the Japan Society of O...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章,多中心研究
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更新日期：2018-03-07 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35459-4
更新日期：2018-11-26 00:00:00
abstract：:Environmental contamination of arsenic (As) and its accumulation in rice (Oryza sativa L.) is of serious human health concern. In planta speciation of As is an important tool to understand As metabolism in plants. In the present study, we investigated root to shoot As translocation and speciation in rice exposed to in...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40522
更新日期：2017-01-17 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54187-x
更新日期：2019-11-29 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10589
更新日期：2015-06-12 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04955-4
更新日期：2017-07-11 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48578-3
更新日期：2019-08-28 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00904
更新日期：2012-01-01 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39781
更新日期：2017-01-03 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09576-5
更新日期：2017-08-24 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34056-9
更新日期：2018-10-22 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12074
更新日期：2015-07-13 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11183
更新日期：2015-06-25 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39738-6
更新日期：2019-02-28 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13556-0
更新日期：2017-10-12 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19319-9
更新日期：2018-01-22 00:00:00
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journal_title：Scientific reports
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2015-02-16 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01650
更新日期：2013-01-01 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16084-z
更新日期：2017-11-17 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07882
更新日期：2015-01-20 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11373-z
更新日期：2017-09-12 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31827
更新日期：2016-08-22 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17760-w
更新日期：2017-12-15 00:00:00
abstract：:Editor's Note: this Article has been retracted; the Retraction Note is available at https://www.nature.com/articles/s41598-020-73758-x. ...
journal_title：Scientific reports
pub_type： 已发布勘误,撤回出版物
doi：10.1038/s41598-020-73758-x
更新日期：2020-09-29 00:00:00
abstract：:The expression level of folate receptor alpha (FRα) is located highly rate in ovarian cancer though it is remained absent in normal tissues. This highly tumor restricted expression profile makes FRα a promising target for tumor therapy and diagnosis. In this research we report a FRα binding peptide C7(Met-His-Thr-Ala-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26683-z
更新日期：2018-05-30 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17389
更新日期：2015-11-30 00:00:00
