Abstract：
:Waddlia chondrophila is a Gram-negative intracellular bacterial organism that is related to classical chlamydial species and has been implicated as a cause of abortion in cattle. Despite an increasing number of observational studies linking W. chondrophila infection to cattle abortion, little direct experimental evidence exists. Given this paucity of direct evidence the current study was carried out to investigate whether experimental challenge of pregnant cattle with W. chondrophila would result in infection and abortion. Nine pregnant Friesian-Holstein heifers received 2 × 108 inclusion forming units (IFU) W. chondrophila intravenously on day 105-110 of pregnancy, while four negative-control animals underwent mock challenge. Only one of the challenged animals showed pathogen-associated lesions, with the organism being detected in the diseased placenta. Importantly, the organism was re-isolated and its identity confirmed by whole genome sequencing, confirming Koch's third and fourth postulates. However, while infection of the placenta was observed, the experimental challenge in this study did not confirm the abortifacient potential of the organism.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Wheelhouse N,Flockhart A,Aitchison K,Livingstone M,Finlayson J,Flachon V,Sellal E,Dagleish MP,Longbottom Ddoi
10.1038/srep37150subject
Has Abstractpub_date
2016-11-14 00:00:00pages
37150issn
2045-2322pii
srep37150journal_volume
6pub_type
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