The adult zebrafish retina: In vivo optical sectioning with Confocal Scanning Laser Ophthalmoscopy and Spectral-Domain Optical Coherence Tomography.

abstract：:The aim of this study was to identify the molecular genetic cause of disease in posterior polymorphous corneal dystrophy (PPCD) probands of diverse origin and to assess the utility of massively parallel sequencing in the detection of ZEB1 mutations. We investigated a total of 12 families (five British, four Czech, one...

journal_title：Experimental eye research

authors： Dudakova L,Evans CJ,Pontikos N,Hafford-Tear NJ,Malinka F,Skalicka P,Horinek A,Munier FL,Voide N,Studeny P,Vanikova L,Kubena T,Rojas Lopez KE,Davidson AE,Hardcastle AJ,Tuft SJ,Liskova P

更新日期：2019-05-01 00:00:00

abstract：:Arf encodes an important tumor suppressor, p19(Arf), which also plays a critical role to control hyperplasia in the primary vitreous during mouse eye development. In the absence of Arf, mice are born blind and display a phenotype closely mimicking severe forms of the human eye disease, persistent hyperplastic primary ...

journal_title：Experimental eye research

authors： Iqbal NS,Devitt CC,Sung CY,Skapek SX

更新日期：2016-04-01 00:00:00

abstract：:Utilizing a human beta-actin promoter, a catalase cDNA expression vector was constructed. This construct was used to transfect two immortal cell lines, mouse alpha TN4-1 and rabbit N/N 1003A. The catalase activity was increased about 3.4 fold in the alpha TN4-1 cells and 38 fold in the N/N 1003A cells. Some changes in...

journal_title：Experimental eye research

authors： Yang Y,Spector A,Ma W,Wang RR,Larsen K,Kleiman NJ

更新日期：1998-12-01 00:00:00

abstract：:The heparan sulfate (HS) is a component of proteoglycans in the extracellular matrix and on cell surfaces, modulating developmental processes. The aim of this study is to investigate whether the defect of HS in the periocular mesenchyme impairs ocular morphogenesis. First, using Protein 0-Cre transgenic mice, we ablat...

journal_title：Experimental eye research

authors： Iwao K,Inatani M,Ogata-Iwao M,Yamaguchi Y,Okinami S,Tanihara H

更新日期：2010-01-01 00:00:00

abstract：:The interaction of keratocytes with extracellular matrix components plays an important role in the maintenance of corneal transparency and shape as well as in the healing of corneal wounds. In particular, the interaction of these cells with collagen and cell-mediated collagen contraction contribute to wound closure. E...

journal_title：Experimental eye research

authors： Nishida K,Sugioka K,Murakami J,Kodama-Takahashi A,Nanri I,Mishima H,Nishida T,Kusaka S

更新日期：2020-02-01 00:00:00

abstract：:The biosafety and efficiency of transplanting retinal pigment epithelial (RPE) cells derived from both human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) have been evaluated in phase I and phase II clinical trials. For further large-scale application, cryopreserved RPE cells must be used; th...

journal_title：Experimental eye research

authors： Li QY,Zou T,Gong Y,Chen SY,Zeng YX,Gao LX,Weng CH,Xu HW,Yin ZQ

更新日期：2021-01-01 00:00:00

abstract：:The binding of monoclonal and polyclonal antibodies to glial fibrillary acidic protein (GFAP) antigenic sites in the rabbit retina was shown to be sensitive to aldehyde fixation. In chemically unfixed retina, the polyclonal anti-GFAP labeled Müller cells, astrocytes, and unidentified profiles in the outer plexiform la...

journal_title：Experimental eye research

authors： Vaughan DK,Erickson PA,Fisher SK

更新日期：1990-04-01 00:00:00

abstract：:The purpose of this study was to investigate the effects of abnormal-cannabidiol (abn-cbd), a non-psychoactive cannabinoid agonist, on aqueous humor outflow via the trabecular meshwork (TM) of porcine eye, and to examine the involvement of a non-CB1/CB2 cannabinoid receptor and the p42/44 mitogen-activated protein kin...

journal_title：Experimental eye research

authors： Qiao Z,Kumar A,Kumar P,Song ZH

更新日期：2012-07-01 00:00:00

abstract：:A serum-free culture of chicken retinal pigmented epithelial cells has been established in order to analyse how cell-substrate interactions or environmental factors affect the process of transdifferentiation into lens cells from pigmented epithelial cells. The serum-free culture medium for chicken pigmented epithelial...

journal_title：Experimental eye research

authors： Kosaka J,Watanabe K,Eguchi G

更新日期：1992-08-01 00:00:00

abstract：:Various concentrations of three dopamine antagonists (fluphenazine, haloperidol and sulpiride) with different affinities to the receptor subtypes were applied in order to test their effect on responses from outer (isolated PIII-component of the ERG), middle (b-wave) and inner (optic nerve response, ONR) retinal layers...

journal_title：Experimental eye research

authors： Schneider T,Zrenner E

更新日期：1991-04-01 00:00:00

abstract：:A specialized microenvironment or niche, which regulates maintenance, self-renewal, activation, and proliferation of stem cells by external signals, is one of the key prerequisites for stem cell function. However, the parameters determining the limbal stem cell niche are not yet defined. In order to characterize the r...

journal_title：Experimental eye research

authors： Schlötzer-Schrehardt U,Dietrich T,Saito K,Sorokin L,Sasaki T,Paulsson M,Kruse FE

更新日期：2007-12-01 00:00:00

abstract：:Misregulation of the innate immune response and other immune-related processes have been suggested to play a critical role in the pathogenesis of a number of different neurodegenerative diseases, including age related macular degeneration. In an animal model for photoreceptor degeneration, several genes of the innate ...

journal_title：Experimental eye research

authors： Rohrer B,Demos C,Frigg R,Grimm C

更新日期：2007-01-01 00:00:00

abstract：:Sugar alcohols have been reported to accumulate in retinal pigment epithelium (RPE) of diabetic animals. This finding has raised interest in the role of RPE in diabetes-associated retinal changes such as cystoid macular edema. To confirm the presence of aldose reductase in this tissue, the NADPH-dependent enzyme was p...

journal_title：Experimental eye research

authors： Sato S,Lin LR,Reddy VN,Kador PF

更新日期：1993-08-01 00:00:00

abstract：:Crystalline lenses excised from 5-7-month-old rabbits and pigs were extracted for lipids with chloroform/methanol, 2/1 using the Folch method. The extracted crude lipids were analyzed at 202 MHz by 31P-NMR spectroscopy. Twelve membrane phospholipids were detected. Both rabbit and pig phospholipid profiles contained ph...

journal_title：Experimental eye research

authors： Meneses P,Greiner JV,Glonek T

更新日期：1990-03-01 00:00:00

abstract：:We showed previously that treatment of cultured rabbit lens epithelial cells (LECs) with hyperbaric oxygen (HBO) produced DNA strand-breaks, caused reversible inhibition of protein synthesis and induced the synthesis of a 32 kD protein. In the present work, we employed immunostaining procedures to identify the 32 kD p...

journal_title：Experimental eye research

authors： Padgaonkar VA,Giblin FJ,Fowler K,Leverenz VR,Reddan JR,Dziedzic DC

更新日期：1997-09-01 00:00:00

abstract：:With the combined purpose of facilitating useful vision over a lifetime, a number of ocular cells have evolved specialized features not found elsewhere in the body. The trabecular meshwork (TM) cell at the irido-corneal angle, which is a key regulator of intraocular pressure, is no exception. Examination of cells in c...

journal_title：Experimental eye research

authors： Stamer WD,Clark AF

更新日期：2017-05-01 00:00:00

abstract：:In keratitis, keratocytes play a vital role by releasing inflammatory cytokines and expressing intercellular cell adhesion molecule-1(ICAM-1). GC31 is a peptide derived from thrombomodulin, an endogenous protein with potential anti-inflammation properties. We evaluated the protective effect of GC31 in LPS- or poly(I:C...

journal_title：Experimental eye research

authors： Zhu S,Xu X,Liu K,Gu Q,Wei F,Jin H

更新日期：2017-11-01 00:00:00

abstract：:The C-terminal region of peripherin/rds contains three predicted alpha-helical domains. One of these domains, corresponding to amino acids 311-322, form an amphiphilic alpha-helix previously shown to promote membrane fusion. The present studies were conducted to determine how the additional alpha-helical regions of th...

journal_title：Experimental eye research

authors： Muller-Weeks S,Boesze-Battaglia K,Fitzgerald C

更新日期：2002-08-01 00:00:00

abstract：:The routine cultivation of human corneal endothelial cells, with the view to treating patients with endothelial dysfunction, remains a challenging task. While progress in this field has been buoyed by the proposed existence of progenitor cells for the corneal endothelium at the corneal limbus, strategies for exploitin...

journal_title：Experimental eye research

authors： Walshe J,Harkin DG

更新日期：2014-10-01 00:00:00

abstract：PURPOSE:To investigate the potential protective effect of novel G protein coupled estrogen receptor (GPER1) against the neurotoxicity induced by NMDA in the mouse retina. METHODS:We induce retinal ganglion cells (RGCs) toxic injury through intravitreal injection of NMDA or acute ocular hypertension (AOH) induced by an...

journal_title：Experimental eye research

authors： Jiang M,Ma X,Zhao Q,Li Y,Xing Y,Deng Q,Shen Y

更新日期：2019-12-01 00:00:00

abstract：:In normal retina the developing photoreceptor cells first show presence of opsin over the distal ends of the ciliary protrusions. In a fully differentiated cell intense activity is seen over the rod outer-segment discs; some activity is also seen over the Golgi zone and near the distal ends of the inner segments but t...

journal_title：Experimental eye research

authors： Jansen HG,Sanyal S,De Grip WJ,Schalken JJ

更新日期：1987-03-01 00:00:00

abstract：:Anthocyanins (ACs) are phenolic compounds that are distributed widely in fruits and vegetables. Although consumption of these compounds has been shown to improve visual function, the distribution of ACs in ocular tissue has not been examined in detail. The aim of this study was therefore to evaluate the ocular distrib...

journal_title：Experimental eye research

authors： Matsumoto H,Nakamura Y,Iida H,Ito K,Ohguro H

更新日期：2006-08-01 00:00:00

abstract：:SPACRCAN is a novel proteoglycan present in the interphotoreceptor matrix (IPM) of the rat and human retina that resists aqueous extraction through its binding to hyaluronan. The purpose of this study was: to clone mouse Spacrcan; to characterize the promoter elements; to define the deduced amino acid sequence; to est...

journal_title：Experimental eye research

authors： Chen Q,Lee JW,Nishiyama K,Shadrach KG,Rayborn ME,Hollyfield JG

更新日期：2003-01-01 00:00:00

abstract：:Childhood glaucoma is an important cause of blindness world-wide. Eleven genes are currently known to cause inherited forms of glaucoma with onset before age 20. While all the early-onset glaucoma genes cause severe disease, considerable phenotypic variability is observed among mutations carriers. In particular, FOXC1...

journal_title：Experimental eye research

authors： Gauthier AC,Wiggs JL

更新日期：2020-01-01 00:00:00

abstract：:Corneal autofluorescence, as measured with a commercial scanning fluorophotometer (lambda(exc): 415-491 nm; lambda(em): 515-630 nm), is increased in patients with diabetes mellitus. However, such fluorophotometers register an average fluorescence signal over all corneal layers as a consequence of their limited axial r...

journal_title：Experimental eye research

authors： Van Schaik HJ,Coppens J,Van den Berg TJ,Van Best JA

更新日期：1999-11-01 00:00:00

abstract：:The shapes of two human lenses of different ages (27 and 46 years old) were altered by applying a stretching force to the ciliary muscle. The force was in the outward radial direction and was produced by an electronically driven stretching instrument which is described. The lenses were photographed for different degre...

journal_title：Experimental eye research

authors： Pierscionek BK

更新日期：1993-11-01 00:00:00

abstract：:The purpose of this study was to investigate the influence of molecular shape, conformability, net surface charge and tissue interaction on transscleral diffusion. Unfixed, porcine sclera was clamped in an Ussing chamber. Fluorophore-labelled neutral albumin, neutral dextran, or neutral ficoll were placed in one hemi-...

journal_title：Experimental eye research

authors： Srikantha N,Mourad F,Suhling K,Elsaid N,Levitt J,Chung PH,Somavarapu S,Jackson TL

更新日期：2012-09-01 00:00:00

abstract：:Thymic stromal lymphopoietin (TSLP) is an interleukin 7 (IL-7)-like four helix bundle cytokine that plays diverse roles in the regulation of immune responses. In fungal infection, pattern recognition receptors (PRRs), including the cell surface Toll-like receptors (TLRs) and cytoplasmic NOD-like receptors, recognize p...

journal_title：Experimental eye research

authors： Dai C,Wu J,Chen C,Wu X

更新日期：2019-05-01 00:00:00

abstract：:Platelet-rich fibrin (PRF) is a natural biomaterial and has excellent biochemical and physical properties with a history of proven biocompatibility in the field of tissue engineering and regenerative medicine. Recent reports of fibrin-based matrices have offered new opportunities to apply PRF as a supplement for in vi...

journal_title：Experimental eye research

authors： Dereli Can G,Akdere ÖE,Can ME,Aydın B,Cagil N,Gümüşderelioğlu M

更新日期：2018-08-01 00:00:00

abstract：:Recoverin is a calcium-binding protein identified as an autoantigen in a paraneoplastic degenerative disease of the human retina known as cancer-associated retinopathy (CAR). In this study we investigated whether recoverin could elicit an immune response leading to the degeneration of photoreceptor cells in a rodent r...

journal_title：Experimental eye research

authors： Adamus G,Ortega H,Witkowska D,Polans A

更新日期：1994-10-01 00:00:00