Comparison of membrane phospholipids of the rabbit and pig crystalline lens.

abstract：:Atropine, a non-selective muscarinic receptor antagonist, is currently the most potent agent used to prevent myopia in animal models and children. However, the ocular target tissues are not well defined. To learn more about the effect of atropine on experimental myopia, atropine was applied both intravitreally and sys...

journal_title：Experimental eye research

authors： Diether S,Schaeffel F,Lambrou GN,Fritsch C,Trendelenburg AU

更新日期：2007-02-01 00:00:00

abstract：:The suitability of the rat derived SV-40T immortalized RPE-J cell line for identifying proteome changes associated with RPE differentiation was evaluated by surveying changes in protein expression levels. Rat RPE-J cells were induced to undergo differentiation in culture by growth at the nonpermissive temperature of 4...

journal_title：Experimental eye research

authors： West KA,Yan L,Miyagi M,Crabb JS,Marmorstein AD,Marmorstein L,Crabb JW

更新日期：2001-10-01 00:00:00

abstract：:This study was designed to determine the safety and efficacy of transferrin-ricin A chain toxin (Tfr-rRA) at preventing retinal detachment in a rabbit model of proliferative vitreoretinopathy (PVR). The toxicity of intravitreal Tfr-rRA (1000-5000 ng) was determined by indirect ophthalmoscopy and electroretinography on...

journal_title：Experimental eye research

authors： Handa JT,Keithahn MA,Jaffe GJ

更新日期：1996-06-01 00:00:00

abstract：:The purpose of this study was to correlate potential mechanisms with site(s) of action for TNPA-induced ocular hypotension. In response to R(-)-2, 10, 11-trihydroxy-N-propyl-noraporphine hydrobromide (TNPA, 75 microg), a D2 dopamine receptor agonist, the intraocular pressure decreased by 4.5 and 8 mm Hg at 1 and 2 hr,...

journal_title：Experimental eye research

authors： Chu E,Chu TC,Potter DE

更新日期：1999-12-01 00:00:00

abstract：:The distribution of collagen degradation and synthesis (turnover) between the central and peripheral areas of clear corneal allografts was determined, following transplantation of 6-mm [3H]proline-labelled corneal buttons from extensively pre-labelled, young rabbits into 13 nonradioactive mature rabbits. Control, cont...

journal_title：Experimental eye research

authors： Lass JH,Baker DS,Klein LR

更新日期：1987-07-01 00:00:00

abstract：:Reactive nitrogen species, in particular, peroxynitrite (ONOO(-)) have been proposed to play an important role in the pathogenesis of endotoxin-induced uveitis (EIU). Tyrosine nitration by ONOO(-) has been shown in other model systems to inhibit the activity of the superoxide anion quenching enyzme, manganese superoxi...

journal_title：Experimental eye research

authors： Pittman KM,MacMillan-Crow LA,Peters BP,Allen JB

更新日期：2002-04-01 00:00:00

abstract：:Rituximab is a monoclonal antibody directed against the CD20 B-cell antigen and is approved for the treatment of B-cell lymphoma. We investigated the pharmacokinetics of rituximab following intravitreal administration to assess the feasibility of treating primary intraocular lymphoma. Intravitreal injections of rituxi...

journal_title：Experimental eye research

authors： Kim H,Csaky KG,Chan CC,Bungay PM,Lutz RJ,Dedrick RL,Yuan P,Rosenberg J,Grillo-Lopez AJ,Wilson WH,Robinson MR

更新日期：2006-05-01 00:00:00

abstract：:Innervated myotendinous cylinders (IMCs) in rabbit extraocular muscles (EOMs) were identified for the first time. The nature of IMC nerve terminals was demonstrated by means of electron microscopy and double fluorescent staining. The distal EOM portions of four rabbits of different age and sex were prepared for transm...

journal_title：Experimental eye research

authors： Blumer R,Wasicky R,Hötzenecker W,Lukas JR

更新日期：2001-12-01 00:00:00

abstract：:Glutamine, the end product formed by the glutamine synthetase (GS) reaction, inhibits retinal GS activity in the presence of Mn2+, but not in the presence of Mg2+. In the presence of Mg2+, Mn2+ itself inhibits retinal GS activity. Other compounds which inhibit retinal GS activity significantly are methionine sulfoximi...

journal_title：Experimental eye research

authors： Pahuja SL,Reid TW

更新日期：1985-01-01 00:00:00

abstract：:Exposure to hyposmotic solution causes release of ATP from lens cells via hemichannels. Because hemichannel opening feasibly could swamp the cells with calcium, we carried out studies to measure the magnitude of the increase in cytoplasmic calcium concentration caused by hemichannel opening. In studies on porcine lens...

journal_title：Experimental eye research

authors： Mandal A,Shahidullah M,Delamere NA

更新日期：2015-03-01 00:00:00

abstract：:The binding of monoclonal and polyclonal antibodies to glial fibrillary acidic protein (GFAP) antigenic sites in the rabbit retina was shown to be sensitive to aldehyde fixation. In chemically unfixed retina, the polyclonal anti-GFAP labeled Müller cells, astrocytes, and unidentified profiles in the outer plexiform la...

journal_title：Experimental eye research

authors： Vaughan DK,Erickson PA,Fisher SK

更新日期：1990-04-01 00:00:00

abstract：:Early stages of glaucoma and optic neuropathies are thought to show inner retina remodeling and functional changes of retinal ganglion cells (RGCs) before they die. To assess RGC functional plasticity, we investigated the contrast-gain control properties of the pattern electroretinogram (PERG), a sensitive measure of ...

journal_title：Experimental eye research

authors： Chou TH,Feuer WJ,Schwartz O,Rojas MJ,Roebber JK,Porciatti V

更新日期：2016-04-01 00:00:00

abstract：:Recent epidemiological evidence in children indicates that time spent outdoors is protective against myopia. Studies in animal models (chick, macaque, tree shrew) have found that light levels (similar to being in the shade outdoors) that are mildly elevated compared to indoor levels, slow form-deprivation myopia and (...

journal_title：Experimental eye research

authors： Norton TT,Siegwart JT Jr

更新日期：2013-09-01 00:00:00

abstract：:The human lens crystallin gene CRYGC T5P is associated with Coppock-like cataract and has a phenotype of a dust-like opacity of the fetal lens nucleus and deep cortical region. Previous in vitro mutation studies indicate that the protein has changed conformation, solubility, and stability, which may make it susceptibl...

journal_title：Experimental eye research

authors： Liu BF,Song S,Hanson M,Liang JJ

更新日期：2008-12-01 00:00:00

abstract：:We have studied the growth of neurites from single retinal ganglion cells isolated from adult goldfish and maintained under various primary cell culture conditions. In 10% Leibovitz's L-15 medium at 23 degrees C, these ganglion cells remained viable for up to 10 days and generated extensive fields of neurites. We foun...

journal_title：Experimental eye research

authors： Ishida AT,Cheng MH

更新日期：1991-02-01 00:00:00

abstract：:Much controversy has arisen on the nature and sources of stem cells in the adult human retina. Whilst ciliary epithelium has been thought to constitute a source of neural stem cells, a population of Müller glia in the neural retina has also been shown to exhibit neurogenic characteristics. This study aimed to compare ...

journal_title：Experimental eye research

authors： Bhatia B,Jayaram H,Singhal S,Jones MF,Limb GA

更新日期：2011-12-01 00:00:00

abstract：:Purified retinal pigment epithelial cells of bovine eyes have been fractionated by a series of buffer and detergent extractions. The electropherogram of the buffer-insoluble, Triton X-100-soluble fraction (RPE-TS) exhibits a major polypeptide band of M(r) 65 kDa and a variety of minor components. Electrophoretically p...

journal_title：Experimental eye research

authors： Broekhuyse RM,Kuhlmann ED,Winkens HJ

更新日期：1992-12-01 00:00:00

abstract：:Myocilin is a 55-57kDa secreted glycoprotein and member of the olfactomedin family, which is mutated in some forms of primary open-angle glaucoma. To assess the effects of elevated amounts of myocilin on aqueous humor outflow dynamics in an in vivo system, transgenic betaB1-crystallin-MYOC mice have been developed tha...

journal_title：Experimental eye research

authors： Paper W,Kroeber M,Heersink S,Stephan DA,Fuchshofer R,Russell P,Tamm ER

更新日期：2008-09-01 00:00:00

abstract：:It has been suggested that human iris pigment epithelial (IPE) cells isolated from iridectomized tissue could be used as autologous cells for transplantation into the subretinal space in diseases with dysfunctional retinal pigment epithelium (RPE). RPE cells synthesize a number of cytokines and their receptors which a...

journal_title：Experimental eye research

authors： Kociok N,Heppekausen H,Schraermeyer U,Esser P,Thumann G,Grisanti S,Heimann K

更新日期：1998-08-01 00:00:00

abstract：:Basement membranes isolated from the entire neural retinae of normal cows consist of a heterogeneous mixture of polypeptides resolvable as two major populations, one collagenous and the other non-collagenous. The non-collagenous population consists of disulfide-bonded aggregates of which the major fraction is soluble ...

journal_title：Experimental eye research

authors： Duhamel RC,Meezan E,Brendel K

更新日期：1983-02-01 00:00:00

abstract：:Cathepsin D is a ubiquitous enzyme which plays an important role in the catabolism of proteins. Enzymatic studies showed that cathepsin D is the most important lysosomal enzyme in the proteolysis of opsin. The importance of cathepsin D in the lysosomal digestion of phagocytosed photoreceptor outer segments by the reti...

journal_title：Experimental eye research

authors： Rakoczy PE,Sarks SH,Daw N,Constable IJ

更新日期：1999-10-01 00:00:00

abstract：:Transmural electrical properties of the isolated rabbit iris-ciliary body (I-CB) were measured in Ussing-Zerahn-type chambers. Control p.d. across the preparation was -1.2 +/- 0.1 mV, with the ciliary process (aqueous)-side consistently negative with respect to the ciliary body (blood)-side and the short-circuit curre...

journal_title：Experimental eye research

authors： Krupin T,Reinach PS,Candia OA,Podos SM

更新日期：1984-02-01 00:00:00

abstract：:Thymic stromal lymphopoietin (TSLP) is an interleukin 7 (IL-7)-like four helix bundle cytokine that plays diverse roles in the regulation of immune responses. In fungal infection, pattern recognition receptors (PRRs), including the cell surface Toll-like receptors (TLRs) and cytoplasmic NOD-like receptors, recognize p...

journal_title：Experimental eye research

authors： Dai C,Wu J,Chen C,Wu X

更新日期：2019-05-01 00:00:00

abstract：:Lactate dehydrogenase (LDH) and glucose-6-phosphate dehydrogenase (G-6-PDH) activities were studied during corneal epithelial growth and differentiation in cell culture. LDH and G-6-PDH activities increased up to 60 and 150-fold, respectively, when corneal epithelial cells constituted a differentiated four to five lay...

journal_title：Experimental eye research

authors： Hernández-Quintero M,García-Villegas R,Castro-Muñozledo F

更新日期：2002-01-01 00:00:00

abstract：:There are few previous estimates of the size of the human lens epithelium. In this study the lens epithelium is measured by specular reflex photography with a macro camera. The results are corrected for cornea magnification. One hundred subjects were studied ranging in age from 11 to 75 and including 20 diabetics and ...

journal_title：Experimental eye research

authors： Brown NA,Bron AJ

更新日期：1987-06-01 00:00:00

abstract：:The aim of this study was to investigate the developmental potential of embryonic stem (ES) cell-derived eye-like structures as a replacement cell therapy model for retinas with N-methyl-d-aspartate (NMDA)-induced damage. For this purpose mouse ES cells were induced to differentiate into eye-like structures in vitro f...

journal_title：Experimental eye research

authors： Aoki H,Hara A,Niwa M,Motohashi T,Suzuki T,Kunisada T

更新日期：2007-05-01 00:00:00

abstract：:Glutamate is an excitatory neurotransmitter in the central and peripheral nervous systems of the vertebrate. The previous studies show the presence of mRNAs of AMPA-type glutamate receptors, GluR1 and GluR2, in the optic tectum of the pigeon, suggesting glutamatergic input from the retina. The present study examined l...

journal_title：Experimental eye research

authors： Islam MR,Atoji Y

更新日期：2009-09-01 00:00:00

abstract：:We sought to determine the effects of exogenous epidermal growth factor (EGF), heparin-binding EGF (HB-EGF), transforming growth factor alpha (TGF-alpha), single-chain precursor hepatocyte growth factor (SC-HGF), double-chain mature HGF (DC-HGF), and keratinocyte growth factor (KGF) on proliferation, motility, and dif...

journal_title：Experimental eye research

authors： Wilson SE,He YG,Weng J,Zieske JD,Jester JV,Schultz GS

更新日期：1994-12-01 00:00:00

abstract：:Electrical field stimulation produced contractions of the rabbit isolated iris sphincter muscle which were completely blocked by tetrodotoxin (10(-6) M). Low frequency (0.16-5 Hz) responses were atropine-resistant, but were prevented by sensory (trigeminal) denervation, and were considered to be owing to antidromic st...

journal_title：Experimental eye research

authors： Zhang SQ,Butler JM,Cole DF

更新日期：1984-02-01 00:00:00

abstract：:The purpose of this investigation was to explore the combined effects of single nucleotide polymorphisms (SNPs) within LFA-1/ICAM-1/GSK-3β pathway and environmental hazards on susceptibility to Graves' opthalmopathy (GO) among a Chinese Han population. Altogether 305 GO patients and 283 Graves' disease (GD) subjects w...

journal_title：Experimental eye research

authors： Yang G,Fu Y,Lu X,Wang M,Dong H,Li Q

更新日期：2018-09-01 00:00:00