The optic fissure in the normal and microphthalmic mouse.

abstract：:Photoreceptor cell pathology was investigated in an 8-yr-old mixed-breed dog which had displayed visual symptoms of 1 month duration. An electroretinogram detected no light-evoked responses. Light and electron microscopic features showed marked thinning and atrophy of the outer both the tapetal and non-tapetal retina ...

journal_title：Experimental eye research

authors： Wiechmann AF,Font RL,Hollyfield JG

更新日期：1991-03-01 00:00:00

abstract：:Much controversy has arisen on the nature and sources of stem cells in the adult human retina. Whilst ciliary epithelium has been thought to constitute a source of neural stem cells, a population of Müller glia in the neural retina has also been shown to exhibit neurogenic characteristics. This study aimed to compare ...

journal_title：Experimental eye research

authors： Bhatia B,Jayaram H,Singhal S,Jones MF,Limb GA

更新日期：2011-12-01 00:00:00

abstract：:Omental cells (OCs) are shown to help wound healing. The purpose of this study is to investigate if OCs improve cornea repair after alkali injury by subconjunctival injection of activated OCs in rats. Forty eight hours after limbal corneal alkali injury, fresh isolated OCs were injected subconjunctivally into the reci...

journal_title：Experimental eye research

authors： Bu P,Vin AP,Sethupathi P,Ambrecht LA,Zhai Y,Nikolic N,Qiao L,Bouchard CS

更新日期：2014-04-01 00:00:00

abstract：:The heparan sulfate (HS) is a component of proteoglycans in the extracellular matrix and on cell surfaces, modulating developmental processes. The aim of this study is to investigate whether the defect of HS in the periocular mesenchyme impairs ocular morphogenesis. First, using Protein 0-Cre transgenic mice, we ablat...

journal_title：Experimental eye research

authors： Iwao K,Inatani M,Ogata-Iwao M,Yamaguchi Y,Okinami S,Tanihara H

更新日期：2010-01-01 00:00:00

abstract：:Crystallin-bound non-tryptophan fluorescence and protein cross-linking were studied in chronic galactosemia. Fluorescence (excitation/emission--370/440 nm) was significantly higher in galactosemic rats compared to controls (P less than 0.001). Accumulation of fluorescence was significantly reduced both in water solubl...

journal_title：Experimental eye research

authors： Nagaraj RH,Monnier VM

更新日期：1990-10-01 00:00:00

abstract：:To facilitate the peeling of internal limiting membrane or epiretinal membrane in vitreoretinal surgery, trypan blue (TB) and indocyanine green (ICG) have been used. However, the cytotoxicity of these dyes have been concerned. The aim of this study was to investigate the neurotoxic effects of TB on rat retinal ganglio...

journal_title：Experimental eye research

authors： Jin Y,Uchida S,Yanagi Y,Aihara M,Araie M

更新日期：2005-10-01 00:00:00

abstract：:We studied a new fluorophotometric method to determine trabecular outflow facility in man. Pilocarpine was selected to evaluate this non-invasive method, since its primary ocular hypotensive effect is to increase trabecular outflow facility. Levobunolol was used to decrease intraocular pressure and aqueous humor flow ...

journal_title：Experimental eye research

authors： Hayashi M,Yablonski ME,Novack GD

更新日期：1989-05-01 00:00:00

abstract：:Purified retinal pigment epithelial cells of bovine eyes have been fractionated by a series of buffer and detergent extractions. The electropherogram of the buffer-insoluble, Triton X-100-soluble fraction (RPE-TS) exhibits a major polypeptide band of M(r) 65 kDa and a variety of minor components. Electrophoretically p...

journal_title：Experimental eye research

authors： Broekhuyse RM,Kuhlmann ED,Winkens HJ

更新日期：1992-12-01 00:00:00

abstract：:This study sought to pharmacologically characterize bradykinin receptors on SV40-immortalized human trabecular meshwork (HTM3) cells. Phosphoinositide (PI) turnover studies were conducted using [3H]myo-inositol-labeled HTM3 cells and anion exchange chromatography to quantify [3H]inositol phosphates generated in respon...

journal_title：Experimental eye research

authors： Sharif NA,Xu SX

更新日期：1996-12-01 00:00:00

abstract：:microPx-11, a ferriheme undecapeptide proteolytic degradation product of cytochrome C is shown to be a peroxidase with broad specificity degrading H2O2 and tertiary butyl hydroperoxide. It is also capable of effectively eliminating superoxide and hydroxyl radical. The peroxidase loses activity in the presence of perox...

journal_title：Experimental eye research

authors： Spector A,Ma W,Wang RR,Kleiman NJ

更新日期：1997-10-01 00:00:00

abstract：:Both in vivo and in vitro models were employed in the present study to assess the relative contribution of osmotic stress and increasing calcium levels to the development of sugar cataracts. In galactose cataract obtained from galactosemic weanling rats, the concentration of total calcium increased by nearly 10% at th...

journal_title：Experimental eye research

authors： Hightower KR,Misiak P

更新日期：1998-06-01 00:00:00

abstract：:The signal transduction pathways initiated by Ca(2+)-mobilizing agonists, such as prostaglandin F(2alpha)(PGF(2alpha)) and carbachol (CCh), leading to activation of cytosolic phospholipase A(2)(cPLA(2)) and arachidonic acid (AA) release in a wide variety of tissues remain obscure. To further define the role of protein...

journal_title：Experimental eye research

authors： Husain S,Abdel-Latif AA

更新日期：2001-05-01 00:00:00

abstract：:The zebrafish retina regenerates in response to acute retinal lesions, replacing damaged neurons with new neurons. In this study we test the hypothesis that chronic stress to inner retinal neurons also triggers a retinal regeneration response in the bugeye zebrafish. Mutations in the lrp2 gene in zebrafish are associa...

journal_title：Experimental eye research

authors： Sherpa T,Hunter SS,Frey RA,Robison BD,Stenkamp DL

更新日期：2011-10-01 00:00:00

abstract：:We examine the immunoreactivity of the non-receptor tyrosine kinase, c-Src kinase and its downstream molecule, signal transducer and activator of transcription 3 (pStat3) in retinoblastoma (RB), and correlation with invasiveness and differentiation. Tumor samples from 40 patients with RB were available for the study. ...

journal_title：Experimental eye research

authors： Mohan A,Mallikarjuna K,Venkatesan N,Abhyankar D,Parikh PM,Krishnakumar S

更新日期：2006-10-01 00:00:00

abstract：:Ocular rigidity (OR) is thought to play a role in the pathogenesis of glaucoma, but the lack of reliable non-invasive measurements has been a major technical challenge. We recently developed a clinical method using optical coherence tomography time-lapse imaging and automated choroidal segmentation to measure the puls...

journal_title：Experimental eye research

authors： Sayah DN,Mazzaferri J,Ghesquière P,Duval R,Rezende F,Costantino S,Lesk MR

更新日期：2020-01-01 00:00:00

abstract：:The binding of monoclonal and polyclonal antibodies to glial fibrillary acidic protein (GFAP) antigenic sites in the rabbit retina was shown to be sensitive to aldehyde fixation. In chemically unfixed retina, the polyclonal anti-GFAP labeled Müller cells, astrocytes, and unidentified profiles in the outer plexiform la...

journal_title：Experimental eye research

authors： Vaughan DK,Erickson PA,Fisher SK

更新日期：1990-04-01 00:00:00

abstract：:A duplex fluorescence assay to assess the viability of cells cultured in multi-well plates is described, which can be carried out in the original culture plate using a plate reader, without exchanges of culture or assay medium, or transfer of cells or cell supernatant. The method uses freshly prepared reagents and doe...

journal_title：Experimental eye research

authors： Pfeffer BA,Fliesler SJ

更新日期：2017-08-01 00:00:00

abstract：:The regulation of acidic amino-acid transport across the retinal pigment epithelium is of particular interest since glutamate and possibly aspartate have been identified as putative neurotransmitters in the retina, at the level of the photoreceptor cell. The present study, designed to measure the rate of acidic amino-...

journal_title：Experimental eye research

authors： Pautler EL,Tengerdy C

更新日期：1986-08-01 00:00:00

abstract：:Cochlin deposits were observed in the trabecular meshwork (TM) of 8-month-old glaucomatous DBA/2J mice, coincident with the reported onset of increased intraocular pressure and optic nerve damage. An age-dependent increase in cochlin was observed up to 10 months of age and was paralleled by a decrease in type II colla...

journal_title：Experimental eye research

authors： Bhattacharya SK,Annangudi SP,Salomon RG,Kuchtey RW,Peachey NS,Crabb JW

更新日期：2005-05-01 00:00:00

abstract：:Numerous animal studies indicate that aldose reductase inhibitors (ARIs) are beneficial for the prevention or amelioration of diabetic complications such as neuropathy, nephropathy and the ocular complications of cataract, retinopathy and keratopathy. To aid in the identification of novel potent ARIs, we have previous...

journal_title：Experimental eye research

authors： Sun G,Ma Y,Gao X,König S,Fales HM,Kador PF

更新日期：2004-12-01 00:00:00

abstract：:Fungal keratitis is a common disease that causes blindness. An effective animal model for fungal keratitis is essential for advancing research on this disease. Our objective is to develop a novel mouse model of Fusarium solani keratitis through the inoculation of fluorescent-labeled fungi into the cornea to facilitate...

journal_title：Experimental eye research

authors： Zhang H,Wang L,Li Z,Liu S,Xie Y,He S,Deng X,Yang B,Liu H,Chen G,Zhao H,Zhang J

更新日期：2013-05-01 00:00:00

abstract：:The sarcoplasmic-endoplasmic reticulum calcium ATPase (SERCA) is a key intracellular calcium transporter, which regulates cellular calcium concentration [Ca2+] by transporting Ca2+ ions from the cytosol into the endoplasmic reticulum. SERCA-mediated Ca2+ sequestration controls proper folding of newly synthesized prote...

journal_title：Experimental eye research

authors： Krizaj D

更新日期：2005-12-01 00:00:00

abstract：:The pre-retinal vitreous space of the eye of albino rabbits was perfused in vivo via a dialysis probe in order to measure the concentration of endogenous amino acids. Studies of isotope concentrations in the vitreal effluent following intracarotid injections of 3HOH and [14C]mannitol demonstrated that entrance of 3HOH...

journal_title：Experimental eye research

authors： Gunnarson G,Jakobsson AK,Hamberger A,Sjöstrand J

更新日期：1987-02-01 00:00:00

abstract：:The CLN2 form of neuronal ceroid lipofuscinosis is an autosomal recessively inherited lysosomal storage disease that is characterized by progressive vision loss culminating in blindness, cognitive and motor decline, neurodegeneration, and premature death. CLN2 disease results from mutations in the gene that encodes th...

journal_title：Experimental eye research

authors： Whiting RE,Pearce JW,Castaner LJ,Jensen CA,Katz RJ,Gilliam DH,Katz ML

更新日期：2015-05-01 00:00:00

abstract：:The reversible phosphorylation of proteins plays essential roles in regulating various cellular events, and is regulated by the opposing actions of protein kinases and protein phosphatases. Protein kinases in the lens system have been well studied, but very little is known about lens protein phosphatases. Protein phos...

journal_title：Experimental eye research

authors： Umeda IO,Nakata H,Nishigori H

更新日期：2004-12-01 00:00:00

abstract：:Crystalline lenses excised from 5-7-month-old rabbits and pigs were extracted for lipids with chloroform/methanol, 2/1 using the Folch method. The extracted crude lipids were analyzed at 202 MHz by 31P-NMR spectroscopy. Twelve membrane phospholipids were detected. Both rabbit and pig phospholipid profiles contained ph...

journal_title：Experimental eye research

authors： Meneses P,Greiner JV,Glonek T

更新日期：1990-03-01 00:00:00

abstract：:A technology has recently been developed that allows for the rapid transduction of full-length functionally active proteins into intact tissue through intravenous injection and into cultured cells. This technology involves the fusion of an 11 amino acid sequence of the HIV TAT protein to the protein of interest. In th...

journal_title：Experimental eye research

authors： Guo X,Hutcheon AE,Zieske JD

更新日期：2004-05-01 00:00:00

abstract：:Vitreous from bovine, human and chick embryo has been found to contain a trypsin inhibitory activity. Chymotrypsin-inhibitory activity was also identified in bovine and chick embryo vitreous. Following either ultrafiltration or Bio Gel P-10 chromatography, these activities appear in fractions having a molecular weight...

journal_title：Experimental eye research

authors： Jacobson B,Dorfman T,Basu PK,Hasany SM

更新日期：1985-11-01 00:00:00

abstract：:Bombina variegata 8 (Bv8), also known as prokineticin-2 (PK-2), is a potent pro-angiogenic factor. However, its role in retinal neovascularization (RNV) remains unknown. In this study, we explored the role of Bv8 in the pathogenesis of RNV. We found that the expression of Bv8 was significantly increased in two differe...

journal_title：Experimental eye research

authors： Yao Y,Yao Y,Demetriades AM,Sui A,Su T,Zhu Y,Shen X,Xie B

更新日期：2020-04-01 00:00:00

abstract：PURPOSE:To characterize multilamellar bodies (MLBs), determine their distribution along the optic axis and predict their potential Mie scattering within human age-related nuclear cataracts. Previous studies restricted to the equatorial plane have shown that MLBs are rare spherical objects that are 1-4 microm in diamete...

journal_title：Experimental eye research

authors： Gilliland KO,Freel CD,Johnsen S,Craig Fowler W,Costello MJ

更新日期：2004-10-01 00:00:00